TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 268.31 | Formula: C16H16N2O2
H donors: 1 H acceptors: 2 LogP: 3.23 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C1OC(c2c1c(ncc2)NCc1ccccc1)(C)C
InChi: 1S/C16H16N2O2/c1-16(2)12-8-9-17-14(13(12)15(19)20-16)18-10-11-6-4-3-5-7-11/h3-9H,10H2,1-2H3,(H,17,18)
InChiKey: VXLRPUBURYXJIK-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	proteasome (prosome, macropain) subunit, beta type, 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	proteasome subunit	Get druggable targets OG5_127834	All targets in OG5_127834
Plasmodium vivax	proteasome subunit beta type-1, putative	Get druggable targets OG5_127834	All targets in OG5_127834
Leishmania infantum	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	Get druggable targets OG5_127834	All targets in OG5_127834
Giardia lamblia	Proteasome subunit beta type 1	Get druggable targets OG5_127834	All targets in OG5_127834
Entamoeba histolytica	proteasome subunit beta type 1, putative	Get druggable targets OG5_127834	All targets in OG5_127834
Plasmodium berghei	proteasome subunit beta type-1, putative	Get druggable targets OG5_127834	All targets in OG5_127834
Toxoplasma gondii	proteasome subunit beta type 1, putative	Get druggable targets OG5_127834	All targets in OG5_127834
Theileria parva	proteasome beat subunit, putative	Get druggable targets OG5_127834	All targets in OG5_127834
Cryptosporidium hominis	proteasome subunit beta type 1 (20S proteasome alpha subunit F) (20S proteasome subunit beta-6)	Get druggable targets OG5_127834	All targets in OG5_127834
Loa Loa (eye worm)	proteasome subunit beta type 1	Get druggable targets OG5_127834	All targets in OG5_127834
Leishmania mexicana	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	Get druggable targets OG5_127834	All targets in OG5_127834
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	Get druggable targets OG5_127834	All targets in OG5_127834
Neospora caninum	hypothetical protein	Get druggable targets OG5_127834	All targets in OG5_127834
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	Get druggable targets OG5_127834	All targets in OG5_127834
Plasmodium falciparum	proteasome subunit beta type-1, putative	Get druggable targets OG5_127834	All targets in OG5_127834
Trypanosoma cruzi	proteasome beta 6 subunit, putative	Get druggable targets OG5_127834	All targets in OG5_127834
Trypanosoma brucei gambiense	proteasome beta 6 subunit,20S proteasome beta 6 subunit, putative	Get druggable targets OG5_127834	All targets in OG5_127834
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	Get druggable targets OG5_127834	All targets in OG5_127834
Plasmodium yoelii	proteasome subunit beta type 1-related	Get druggable targets OG5_127834	All targets in OG5_127834
Leishmania donovani	proteasome beta 6 subunit, putative	Get druggable targets OG5_127834	All targets in OG5_127834
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	Get druggable targets OG5_127834	All targets in OG5_127834
Brugia malayi	proteasome subunit beta type 1	Get druggable targets OG5_127834	All targets in OG5_127834
Babesia bovis	proteasome A-type and B-type family protein	Get druggable targets OG5_127834	All targets in OG5_127834
Echinococcus granulosus	proteasome prosome macropain subunit beta	Get druggable targets OG5_127834	All targets in OG5_127834
Schistosoma japonicum	ko:K02732 20S proteasome subunit beta 6, putative	Get druggable targets OG5_127834	All targets in OG5_127834
Leishmania braziliensis	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	Get druggable targets OG5_127834	All targets in OG5_127834
Plasmodium knowlesi	proteasome subunit beta type-1, putative	Get druggable targets OG5_127834	All targets in OG5_127834
Trypanosoma congolense	proteasome beta 6 subunit	Get druggable targets OG5_127834	All targets in OG5_127834
Trypanosoma cruzi	proteasome beta 6 subunit, putative	Get druggable targets OG5_127834	All targets in OG5_127834
Cryptosporidium parvum	proteasome subunit beta type 1, putative	Get druggable targets OG5_127834	All targets in OG5_127834
Candida albicans	proteasome subunit	Get druggable targets OG5_127834	All targets in OG5_127834
Trypanosoma brucei	proteasome beta 6 subunit	Get druggable targets OG5_127834	All targets in OG5_127834

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	proteasome subunit beta type-5	proteasome (prosome, macropain) subunit, beta type, 1	241 aa	194 aa	27.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tyrosine protein kinase csk	0.0022	0.0856	0.1682
Echinococcus granulosus	c src tyrosine kinase	0.0022	0.0856	0.1682
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0022	0.0856	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0856	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0856	0.0856
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0022	0.0856	0.1682
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0022	0.0856	0.1682
Brugia malayi	intermediate filament protein	0.0027	0.1352	0.1193
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0856	0.0856
Brugia malayi	SH2 domain containing protein	0.0022	0.0856	0.0688
Loa Loa (eye worm)	TK/CSK protein kinase	0.0022	0.0856	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0856	0.0856
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0064	0.486	1
Echinococcus multilocularis	transfer RNA-Thr	0.0022	0.0856	0.1682
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.1352	0.1193
Echinococcus granulosus	lamin	0.0027	0.1352	0.2713
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0022	0.0856	0.1682
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0022	0.0856	0.0688
Echinococcus granulosus	kinase suppressor of Ras 1	0.0022	0.0856	0.1682
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0022	0.0856	0.1682
Echinococcus granulosus	tyrosine protein kinase csk	0.0022	0.0856	0.1682
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0064	0.486	1
Echinococcus multilocularis	tyrosine kinase	0.0022	0.0856	0.1682
Echinococcus granulosus	tyrosine protein kinase shark	0.0022	0.0856	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0856	0.0856
Echinococcus multilocularis	tyrosine protein kinase	0.0022	0.0856	0.1682
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0022	0.0856	0.1682
Echinococcus multilocularis	activin receptor type	0.0022	0.0856	0.1682
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0022	0.0856	0.1682
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0856	0.0856
Loa Loa (eye worm)	TK/Met protein kinase	0.0022	0.0856	0.0856
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0022	0.0856	0.1682
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0022	0.0856	0.1682
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0856	0.0856
Echinococcus granulosus	activated cdc42 kinase 1	0.0022	0.0856	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0027	0.1352	0.1352
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0022	0.0856	0.1682
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0856	0.0856
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0064	0.486	1
Echinococcus multilocularis	protein tyrosine kinase	0.0022	0.0856	0.1682
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0022	0.0856	0.1682
Echinococcus multilocularis	insulin receptor	0.0022	0.0856	0.1682
Loa Loa (eye worm)	TK protein kinase	0.0022	0.0856	0.0856
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0022	0.0856	0.1682
Echinococcus multilocularis	tyrosine protein kinase shark	0.0022	0.0856	0.1682
Echinococcus granulosus	tyrosine protein kinase Blk	0.0022	0.0856	0.1682
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0856	0.0856
Loa Loa (eye worm)	TK protein kinase	0.0022	0.0856	0.0856
Echinococcus multilocularis	FL cytokine receptor	0.0022	0.0856	0.1682
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0064	0.486	0.486
Giardia lamblia	Proteasome subunit beta type 1	0.0064	0.486	1
Brugia malayi	hypothetical protein	0.0022	0.0856	0.0688
Echinococcus multilocularis	tyrosine protein kinase csk	0.0022	0.0856	0.1682
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0856	0.0856
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0022	0.0856	0.0856
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0022	0.0856	0.1682
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0856	0.0856
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0022	0.0856	0.1682
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0022	0.0856	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0856	0.0856
Echinococcus multilocularis	tyrosine protein kinase csk	0.0022	0.0856	0.1682
Echinococcus multilocularis	tyrosine kinase	0.0022	0.0856	0.1682
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0022	0.0856	0.0856
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0856	0.0856
Trypanosoma brucei	proteasome beta 6 subunit	0.0064	0.486	1
Echinococcus multilocularis	protein kinase	0.0022	0.0856	0.1682
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0064	0.486	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0022	0.0856	0.1682
Echinococcus multilocularis	integrin linked protein kinase	0.0022	0.0856	0.1682
Echinococcus multilocularis	lamin	0.0027	0.1352	0.2713
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0022	0.0856	0.0856
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0022	0.0856	0.0856
Onchocerca volvulus		0.0027	0.1352	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0022	0.0856	0.1682
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0856	0.0856
Brugia malayi	Raf kinase	0.0022	0.0856	0.0688
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0856	0.0688
Brugia malayi	hypothetical protein	0.0022	0.0856	0.0688
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0022	0.0856	0.0688
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0022	0.0856	0.1682
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0856	0.0688
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0022	0.0856	0.1682
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.1352	0.1352
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0856	0.0856
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0022	0.0856	0.1682
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0856	0.0856
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0022	0.0856	0.1682
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Brugia malayi	hypothetical protein	0.0022	0.0856	0.0688
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0022	0.0856	0.0856
Loa Loa (eye worm)	TK protein kinase	0.0022	0.0856	0.0856
Echinococcus multilocularis	musashi	0.0027	0.1352	0.2713
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0022	0.0856	0.1682
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.018	0.018
Schistosoma mansoni	lamin	0.0027	0.1352	0.1239
Loa Loa (eye worm)	TK protein kinase	0.0022	0.0856	0.0856
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0022	0.0856	0.1682
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0022	0.0856	0.1682
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0022	0.0856	0.1682
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0022	0.0856	0.1682
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0022	0.0856	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0856	0.0856
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0022	0.0856	0.1682
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0022	0.0856	0.1682
Echinococcus granulosus	epidermal growth factor receptor	0.0022	0.0856	0.1682
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0022	0.0856	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0856	0.0856
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0022	0.0856	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0856	0.0856
Brugia malayi	Receptor family ligand binding region containing protein	0.0022	0.0856	0.0688
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0022	0.0856	0.1682
Loa Loa (eye worm)	TK protein kinase	0.0022	0.0856	0.0856
Echinococcus multilocularis	tyrosine protein kinase csk	0.0022	0.0856	0.1682
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0022	0.0856	0.0856
Echinococcus granulosus	tyrosine kinase	0.0022	0.0856	0.1682
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0022	0.0856	0.1682
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0022	0.0856	0.1682
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0022	0.0856	0.0856
Loa Loa (eye worm)	SRC-1	0.0022	0.0856	0.0856
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	1	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0022	0.0856	0.1682
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0022	0.0856	0.1682
Brugia malayi	Guanylyl cyclase protein 23	0.0022	0.0856	0.0688
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.1352	0.1352
Echinococcus granulosus	natriuretic peptide receptor 1	0.0022	0.0856	0.1682
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0022	0.0856	0.1682
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Loa Loa (eye worm)	TK protein kinase	0.0022	0.0856	0.0856
Loa Loa (eye worm)	TK/ACK protein kinase	0.0022	0.0856	0.0856
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0064	0.486	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0022	0.0856	0.1682
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Loa Loa (eye worm)	TK protein kinase	0.0022	0.0856	0.0856
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0022	0.0856	0.1682
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0022	0.0856	0.1682
Echinococcus granulosus	tyrosine kinase	0.0022	0.0856	0.1682
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0022	0.0856	0.1682
Brugia malayi	integrin-linked kinase	0.0022	0.0856	0.0688
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0022	0.0856	0.1682
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0022	0.0856	0.1682
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Echinococcus granulosus	tyrosine protein kinase csk	0.0022	0.0856	0.1682
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0022	0.0856	0.1682
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0064	0.486	1
Echinococcus multilocularis	heat shock protein 70	0.0022	0.0856	0.1682
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0022	0.0856	0.1682
Echinococcus multilocularis	c src tyrosine kinase	0.0022	0.0856	0.1682
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0022	0.0856	0.1682
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0022	0.0856	0.1682
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0022	0.0856	0.1682
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Loa Loa (eye worm)	TK/DDR protein kinase	0.0022	0.0856	0.0856
Echinococcus granulosus	integrin linked protein kinase	0.0022	0.0856	0.1682
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0022	0.0856	0.0688
Loa Loa (eye worm)	TK/ROR protein kinase	0.0022	0.0856	0.0856
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0022	0.0856	0.0688
Brugia malayi	Tyrosine-protein kinase abl-1	0.0022	0.0856	0.0688
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0022	0.0856	0.0688
Echinococcus granulosus	lamin dm0	0.0027	0.1352	0.2713
Loa Loa (eye worm)	TK protein kinase	0.0022	0.0856	0.0856
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0022	0.0856	0.1682
Echinococcus granulosus	tyrosine protein kinase	0.0022	0.0856	0.1682
Brugia malayi	protein-tyrosine kinase	0.0022	0.0856	0.0688
Brugia malayi	C-terminal src kinase protein 1	0.0022	0.0856	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1306	0.1306
Echinococcus granulosus	protein tyrosine kinase	0.0022	0.0856	0.1682
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0064	0.486	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0856	0.0856
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Loa Loa (eye worm)	TK/EPH protein kinase	0.0022	0.0856	0.0856
Echinococcus multilocularis	epidermal growth factor receptor	0.0022	0.0856	0.1682
Loa Loa (eye worm)	TK/ALK protein kinase	0.0022	0.0856	0.0856
Echinococcus granulosus	receptor type guanylyl cyclase	0.0022	0.0856	0.1682
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0064	0.486	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0022	0.0856	0.1682
Echinococcus granulosus	tyrosine kinase	0.0022	0.0856	0.1682
Echinococcus granulosus	tyrosine protein kinase pr2	0.0022	0.0856	0.1682
Echinococcus multilocularis	epidermal growth factor receptor	0.0022	0.0856	0.1682
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0022	0.0856	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0856	0.0856
Echinococcus granulosus	intermediate filament protein	0.0027	0.1352	0.2713
Echinococcus granulosus	tyrosine protein kinase csk	0.0022	0.0856	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0856	0.0856
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0022	0.0856	0.0688
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0856	0.0856
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0022	0.0856	0.1682
Echinococcus granulosus	tyrosine protein kinase Srms	0.0022	0.0856	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0046	0.0046
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0022	0.0856	0.1682
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0022	0.0856	0.0856
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0064	0.486	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0022	0.0856	0.1682
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0022	0.0856	0.1682
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0856	0.0856
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0022	0.0856	0.1682
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0022	0.0856	0.1682
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0022	0.0856	0.1682
Onchocerca volvulus		0.0027	0.1352	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0022	0.0856	0.0688
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Loa Loa (eye worm)	TK/ABL protein kinase	0.0022	0.0856	0.0856
Echinococcus granulosus	activated cdc42 kinase 1	0.0022	0.0856	0.1682
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0856	0.0856
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0022	0.0856	0.1682
Echinococcus granulosus	ephrin type A receptor 4 A	0.0022	0.0856	0.1682
Echinococcus granulosus	protein kinase	0.0022	0.0856	0.1682
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0022	0.0856	0.1682
Brugia malayi	SRC-1	0.0022	0.0856	0.0688
Echinococcus granulosus	raf serine:threonine protein kinase	0.0022	0.0856	0.1682
Echinococcus granulosus	activin receptor type	0.0022	0.0856	0.1682
Loa Loa (eye worm)	TK protein kinase	0.0022	0.0856	0.0856
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0022	0.0856	0.1682
Loa Loa (eye worm)	TK/RYK protein kinase	0.0022	0.0856	0.0856
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0022	0.0856	0.1682
Echinococcus granulosus	epidermal growth factor receptor	0.0022	0.0856	0.1682
Loa Loa (eye worm)	TK/FAK protein kinase	0.0022	0.0856	0.0856
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0022	0.0856	0.1682
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0022	0.0856	0.0856
Loa Loa (eye worm)	TK/INSR protein kinase	0.0022	0.0856	0.0856
Brugia malayi	Tyrosine-protein kinase PR2	0.0022	0.0856	0.0688
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0064	0.486	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0856	0.0856
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0022	0.0856	0.0856
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0856	0.0856
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Schistosoma mansoni	intermediate filament proteins	0.0027	0.1352	0.1239
Schistosoma mansoni	lamin	0.0027	0.1352	0.1239
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0022	0.0856	0.0856
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0856	0.0856
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0022	0.0856	0.1682
Brugia malayi	Furin-like cysteine rich region family protein	0.0022	0.0856	0.0688
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0022	0.0856	0.0856
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688
Echinococcus multilocularis	lamin dm0	0.0027	0.1352	0.2713
Brugia malayi	proteasome subunit beta type 1	0.0064	0.486	0.4765
Loa Loa (eye worm)	serine/threonine protein kinase	0.0022	0.0856	0.0856
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0022	0.0856	0.1682
Echinococcus granulosus	insulin receptor	0.0022	0.0856	0.1682
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0064	0.486	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0022	0.0856	0.0856
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0022	0.0856	0.0856
Brugia malayi	ephrin receptor 1 precursor	0.0022	0.0856	0.0688
Echinococcus multilocularis	protein kinase	0.0022	0.0856	0.1682
Loa Loa (eye worm)	TK protein kinase	0.0022	0.0856	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0856	0.0856
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	1	1
Brugia malayi	SH2 domain containing protein	0.0022	0.0856	0.0688
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0022	0.0856	0.1682
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0022	0.0856	0.1682
Echinococcus multilocularis	activated cdc42 kinase 1	0.0022	0.0856	0.1682
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0022	0.0856	0.0856
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0022	0.0856	0.1682
Brugia malayi	Protein kinase domain containing protein	0.0022	0.0856	0.0688

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.6 uM	Inhibition of 20s immunoproteasome beta 1 subunit caspase-like activity in human blood monocytes using Z-LLE-betaNA as substrate at 2 uM preincubated for 2 mins followed by substrate addition by fluorescence assay	ChEMBL.	24534487
IC50 (binding)	= 11.6 uM	Inhibition of 20s proteasome beta 1 subunit caspase-like activity in human HeLa cells using Z-nLPnLD as substrate after 17 hrs by chemiluminescence assay	ChEMBL.	24534487
Inhibition (binding)		Inhibition of human calpain-1 using Suc-LLVY-AMC as substrate by fluorescence assay	ChEMBL.	24534487
Inhibition (binding)		Inhibition of 20s immunoproteasome beta 5 subunit chymotrypsin-like activity in human blood monocytes using Suc-LLVY-AMC as substrate at 100 to 2000 nM preincubated for 2 mins followed by substrate addition by fluorescence assay	ChEMBL.	24534487
Inhibition (binding)		Inhibition of human cathepsin B using Z-RR-AMC as substrate by fluorescence assay	ChEMBL.	24534487
Inhibition (binding)		Inhibition of 20s immunoproteasome beta 2 subunit trypsin-like activity in human blood monocytes using Boc-LRR-AMC as substrate at 100 to 2000 nM preincubated for 2 mins followed by substrate addition by fluorescence assay	ChEMBL.	24534487
Inhibition (ADMET)	= 35 %	Cytotoxicity against human HeLa cells assessed as inhibition of mitochondrial dehydrogenase activity at 50 uM after 18 to 72 hrs by XTT assay relative to control	ChEMBL.	24534487

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3128141

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1828202