Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | proteasome beta 6 subunit | 0.0126 | 0.7224 | 0.7224 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0078 | 0.3546 | 0.3546 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.0078 | 0.3546 | 0.3546 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.0078 | 0.3546 | 0.3546 |
Brugia malayi | proteasome subunit beta type 1 | 0.0126 | 0.7224 | 0.7224 |
Trypanosoma cruzi | 20S proteasome subunit | 0.0078 | 0.3546 | 0.3546 |
Echinococcus granulosus | proteasome prosome macropain | 0.0162 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0126 | 0.7224 | 0.7224 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0162 | 1 | 1 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0126 | 0.7224 | 0.7224 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0126 | 0.7224 | 0.7224 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.0078 | 0.3546 | 0.3546 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0126 | 0.7224 | 0.7224 |
Brugia malayi | proteasome subunit beta type 2 | 0.0078 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0126 | 0.7224 | 0.7224 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0162 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0162 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.0078 | 0.3546 | 0.3546 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.0078 | 0.3546 | 0.3546 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0162 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0126 | 0.7224 | 0.7224 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0162 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0126 | 0.7224 | 0.7224 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0162 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0078 | 0.3546 | 0.3546 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0162 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0078 | 0.3546 | 0.3546 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0126 | 0.7224 | 0.7224 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0162 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0162 | 1 | 1 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0126 | 0.7224 | 0.7224 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0078 | 0.3546 | 0.3546 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0162 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0032 | 0 | 0.5 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0126 | 0.7224 | 0.7224 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0126 | 0.7224 | 0.7224 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0078 | 0.3546 | 0.3546 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0162 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0126 | 0.7224 | 0.7224 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0162 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.0078 | 0.3546 | 0.3546 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0078 | 0.3546 | 0.3546 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0162 | 1 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0162 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0078 | 0.3546 | 0.3546 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0162 | 1 | 1 |
Onchocerca volvulus | Notchless protein homolog | 0.0032 | 0 | 0.5 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.0078 | 0.3546 | 0.3546 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0078 | 0.3546 | 0.3546 |
Mycobacterium ulcerans | proteasome PrcB | 0.0162 | 1 | 1 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0126 | 0.7224 | 0.7224 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 74 % | Afffinity for adenosine A2a receptor of rat striatal membrane using [3H]-CGS- 21680 at 10e-5 M | ChEMBL. | 9371242 |
Inhibition (binding) | = 74 % | Afffinity for adenosine A2a receptor of rat striatal membrane using [3H]-CGS- 21680 at 10e-5 M | ChEMBL. | 9371242 |
Ki (binding) | = 0.15 uM | Afffinity for adenosine A1 receptor was determined, in the presence of GTP in rat brain cortex | ChEMBL. | 9371242 |
Ki (binding) | = 0.15 uM | Afffinity for adenosine A1 receptor was determined, in the presence of GTP in rat brain cortex | ChEMBL. | 9371242 |
Ki (binding) | = 0.19 uM | Afffinity for adenosine A1 receptor was determined, in the absence of GTP in rat cortical membrane. | ChEMBL. | 9371242 |
Ki (binding) | = 0.19 uM | Afffinity for adenosine A1 receptor was determined, in the absence of GTP in rat cortical membrane. | ChEMBL. | 9371242 |
Ratio (binding) | = 0.8 | GTP shift ratio of the apparent Ki values in the presence and absence of GTP. | ChEMBL. | 9371242 |
Ratio (binding) | = 0.8 | GTP shift ratio of the apparent Ki values in the presence and absence of GTP. | ChEMBL. | 9371242 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.