Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.1016 | 0.7224 | 0.7224 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.1016 | 0.7224 | 0.7224 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.063 | 0.3546 | 0.3546 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.063 | 0.3546 | 0.3546 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.063 | 0.3546 | 0.3546 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.063 | 0.3546 | 0.3546 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.1308 | 1 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.1308 | 1 | 1 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0465 | 0.1977 | 0.1977 |
Echinococcus granulosus | proteasome prosome macropain | 0.1308 | 1 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.1308 | 1 | 1 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.1016 | 0.7224 | 0.7224 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.063 | 0.3546 | 0.3546 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.1308 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.1308 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.063 | 0.3546 | 0.3546 |
Onchocerca volvulus | Notchless protein homolog | 0.0257 | 0 | 0.5 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.1016 | 0.7224 | 0.7224 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.063 | 0.3546 | 0.3546 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.063 | 0.3546 | 0.3546 |
Leishmania major | proteasome beta 2 subunit, putative | 0.063 | 0.3546 | 0.3546 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.1016 | 0.7224 | 0.7224 |
Brugia malayi | proteasome subunit beta type 2 | 0.063 | 0.3546 | 0.3546 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.1016 | 0.7224 | 0.7224 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.1308 | 1 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.1308 | 1 | 1 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.1016 | 0.7224 | 0.7224 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0257 | 0 | 0.5 |
Brugia malayi | proteasome subunit beta type 1 | 0.1016 | 0.7224 | 0.7224 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.1016 | 0.7224 | 0.7224 |
Mycobacterium ulcerans | proteasome PrcB | 0.1308 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.063 | 0.3546 | 0.3546 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0465 | 0.1977 | 0.1977 |
Trypanosoma cruzi | 20S proteasome subunit | 0.063 | 0.3546 | 0.3546 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.1308 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.063 | 0.3546 | 0.3546 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.1016 | 0.7224 | 0.7224 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.1308 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.1308 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.1016 | 0.7224 | 0.7224 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.1016 | 0.7224 | 0.7224 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.1016 | 0.7224 | 0.7224 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.1308 | 1 | 1 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0465 | 0.1977 | 0.1977 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.063 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.1016 | 0.7224 | 0.7224 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.1308 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.1308 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.063 | 0.3546 | 0.3546 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.063 | 0.3546 | 0.3546 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.1308 | 1 | 1 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0465 | 0.1977 | 0.1977 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.063 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.1308 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.1016 | 0.7224 | 0.7224 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LED (functional) | = 0.1 mgP kg-1 | Bone resorption activity in rats. | ChEMBL. | 12086477 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.