Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Serotonin receptor | 0.104 | 0.9181 | 0.9181 |
Mycobacterium ulcerans | proteasome PrcB | 0.1113 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0536 | 0.3546 | 0.3546 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.1113 | 1 | 1 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0536 | 0.3546 | 0.3546 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.1113 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0865 | 0.7224 | 0.7224 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.1113 | 1 | 1 |
Onchocerca volvulus | Notchless protein homolog | 0.0219 | 0 | 0.5 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.1113 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.1113 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0536 | 0.3546 | 0.3546 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0536 | 0.3546 | 0.3546 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.0536 | 0.3546 | 0.3546 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0865 | 0.7224 | 0.7224 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.0536 | 0.3546 | 0.3546 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0865 | 0.7224 | 0.7224 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0865 | 0.7224 | 0.7224 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0865 | 0.7224 | 0.7224 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0865 | 0.7224 | 0.7224 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.1113 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.1113 | 1 | 1 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0865 | 0.7224 | 0.7224 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.0536 | 0.3546 | 0.3546 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0865 | 0.7224 | 0.7224 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0536 | 0.3546 | 0.3546 |
Brugia malayi | proteasome subunit beta type 2 | 0.0536 | 0.3546 | 0.3546 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0536 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.1113 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0865 | 0.7224 | 0.7224 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.1113 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.0536 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.0536 | 0.3546 | 0.3546 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0219 | 0 | 0.5 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0536 | 0.3546 | 0.3546 |
Leishmania major | proteasome beta 5 subunit, putative | 0.1113 | 1 | 1 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0865 | 0.7224 | 0.7224 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0865 | 0.7224 | 0.7224 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.1113 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.1113 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.0536 | 0.3546 | 0.3546 |
Echinococcus granulosus | proteasome prosome macropain | 0.1113 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0536 | 0.3546 | 0.3546 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0865 | 0.7224 | 0.7224 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.1113 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.0536 | 0.3546 | 0.3546 |
Trypanosoma cruzi | 20S proteasome subunit | 0.0536 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.1113 | 1 | 1 |
Brugia malayi | proteasome subunit beta type 1 | 0.0865 | 0.7224 | 0.7224 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0865 | 0.7224 | 0.7224 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0865 | 0.7224 | 0.7224 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.1113 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
No. of cured mice (functional) | = 5 | Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 80 mg/kg dose | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 20 mg/kg dose | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 40 mg/kg dose | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity was measured in mice infected with Plasmodium berghei by subcutaneous administraton of 160 mg/kg | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity measured against mice infected with Plasmodium berghei by subcutaneous administraton of 320 mg/kg dose | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity measured in mice infected with Plasmodium berghei by subcutaneous administraton of 640 mg/kg | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity measured in mice infected with Plasmodium berghei by subcutaneous administraton of 640 mg/kg | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity measured against mice infected with Plasmodium berghei by subcutaneous administraton of 320 mg/kg dose | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity was measured in mice infected with Plasmodium berghei by subcutaneous administraton of 160 mg/kg | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 80 mg/kg dose | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 40 mg/kg dose | ChEMBL. | 1404226 |
No. of cured mice (functional) | = 5 | Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 20 mg/kg dose | ChEMBL. | 1404226 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.