Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | proteasome beta 5 subunit, putative | 0.0092 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.0044 | 0.3701 | 0.3546 |
Brugia malayi | proteasome subunit beta type 2 | 0.0044 | 0.3701 | 0.3546 |
Echinococcus multilocularis | proteasome subunit alpha type 6 | 0.0018 | 0.0241 | 0.0241 |
Echinococcus multilocularis | Proteasome subunit alpha type 7 | 0.0018 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | proteasome subunit alpha type 6 | 0.0018 | 0.0241 | 0.0241 |
Echinococcus multilocularis | Proteasome subunit alpha type 7 | 0.0018 | 0.0241 | 0.0241 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0092 | 1 | 1 |
Echinococcus granulosus | 20S proteasome subunit alpha 6 | 0.0018 | 0.0241 | 0.0241 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.0044 | 0.3701 | 0.3546 |
Echinococcus granulosus | proteasome subunit beta type 7 | 0.0018 | 0.0241 | 0.0241 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0044 | 0.3701 | 0.3546 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0092 | 1 | 1 |
Loa Loa (eye worm) | proteasome subunit alpha type 2 | 0.0018 | 0.0241 | 0.0241 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0071 | 0.7291 | 0.7291 |
Echinococcus granulosus | proteasome subunit beta t family | 0.0018 | 0.0241 | 0.0241 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0071 | 0.7291 | 0.7224 |
Schistosoma mansoni | proteasome subunit alpha 6 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0071 | 0.7291 | 0.7291 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0092 | 1 | 1 |
Loa Loa (eye worm) | proteasome subunit alpha type 1 | 0.0018 | 0.0241 | 0.0241 |
Brugia malayi | proteasome subunit beta type 1 | 0.0071 | 0.7291 | 0.7224 |
Schistosoma mansoni | proteasome subunit alpha 2 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0092 | 1 | 1 |
Loa Loa (eye worm) | proteasome subunit beta type 3 | 0.0018 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | proteasome subunit alpha type 3 | 0.0018 | 0.0241 | 0.0241 |
Echinococcus granulosus | proteasome prosome macropain subunit alpha | 0.0018 | 0.0241 | 0.0241 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0092 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0092 | 1 | 1 |
Echinococcus multilocularis | proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta | 0.0018 | 0.0241 | 0.0241 |
Schistosoma mansoni | proteasome subunit beta 3 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Schistosoma mansoni | proteasome subunit alpha 4 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.0044 | 0.3701 | 0.3546 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.0044 | 0.3701 | 0.3546 |
Echinococcus multilocularis | 20S proteasome subunit alpha 6 | 0.0018 | 0.0241 | 0.0241 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0071 | 0.7291 | 0.7224 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0071 | 0.7291 | 0.7224 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0018 | 0.0241 | 0.0241 |
Echinococcus granulosus | Proteasome subunit alpha beta | 0.0018 | 0.0241 | 0.0241 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0044 | 0.3701 | 0.3546 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.0044 | 0.3701 | 0.3546 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0071 | 0.7291 | 0.7224 |
Schistosoma mansoni | proteasome subunit alpha 7 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0092 | 1 | 1 |
Echinococcus granulosus | proteasome subunit alpha type 6 | 0.0018 | 0.0241 | 0.0241 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0071 | 0.7291 | 0.7224 |
Schistosoma mansoni | proteasome catalytic subunit 2 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0044 | 0.3701 | 0.3701 |
Echinococcus granulosus | proteasome prosome macropain subunit beta type | 0.0018 | 0.0241 | 0.0241 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.0044 | 0.3701 | 0.3546 |
Schistosoma mansoni | proteasome subunit alpha 3 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0044 | 0.3701 | 0.3701 |
Schistosoma mansoni | subfamily T1A non-peptidase homologue (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Echinococcus multilocularis | proteasome (prosome macropain) subunit beta type | 0.0018 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | proteasome subunit alpha type 7-1 | 0.0018 | 0.0241 | 0.0241 |
Echinococcus multilocularis | proteasome subunit beta type 6 | 0.0018 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | PAS-3 protein | 0.0018 | 0.0241 | 0.0241 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0092 | 1 | 1 |
Echinococcus granulosus | subfamily T1A non peptidase ue | 0.0018 | 0.0241 | 0.0241 |
Onchocerca volvulus | Notchless protein homolog | 0.0018 | 0.0241 | 0.5 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0071 | 0.7291 | 0.7224 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0044 | 0.3701 | 0.3701 |
Echinococcus granulosus | proteasome subunit beta type 6 | 0.0018 | 0.0241 | 0.0241 |
Mycobacterium ulcerans | proteasome PrcB | 0.0092 | 1 | 1 |
Echinococcus granulosus | proteasome subunit alpha type 2 | 0.0018 | 0.0241 | 0.0241 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0071 | 0.7291 | 0.7291 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0092 | 1 | 1 |
Echinococcus multilocularis | Proteasome subunit alpha type 7 | 0.0018 | 0.0241 | 0.0241 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0071 | 0.7291 | 0.7224 |
Schistosoma mansoni | proteasome subunit alpha 1 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0071 | 0.7291 | 0.7224 |
Schistosoma mansoni | subfamily T1A non-peptidase homologue (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0092 | 1 | 1 |
Echinococcus multilocularis | Proteasome, subunit alpha beta | 0.0018 | 0.0241 | 0.0241 |
Echinococcus multilocularis | proteasome subunit beta type 7 | 0.0018 | 0.0241 | 0.0241 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.0044 | 0.3701 | 0.3546 |
Trypanosoma cruzi | 20S proteasome subunit | 0.0044 | 0.3701 | 0.3546 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0092 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0018 | 0.0241 | 0.5 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0044 | 0.3701 | 0.3701 |
Echinococcus granulosus | Proteasome subunit alpha type 7 | 0.0018 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0044 | 0.3701 | 0.3701 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0082 | 0.8753 | 0.8753 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0092 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.0092 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 3 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0092 | 1 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0018 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | 20S proteasome alpha5 subunit | 0.0018 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0018 | 0.0241 | 0.0241 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0071 | 0.7291 | 0.7224 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0044 | 0.3701 | 0.3546 |
Echinococcus multilocularis | proteasome subunit alpha type 2 | 0.0018 | 0.0241 | 0.0241 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0071 | 0.7291 | 0.7224 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0082 | 0.8753 | 0.8753 |
Echinococcus multilocularis | subfamily T1A non peptidase ue | 0.0018 | 0.0241 | 0.0241 |
Schistosoma mansoni | subfamily T1A non-peptidase homologue (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Echinococcus multilocularis | proteasome (prosome macropain) subunit alpha | 0.0018 | 0.0241 | 0.0241 |
Schistosoma mansoni | proteasome subunit beta 4 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Schistosoma mansoni | proteasome catalytic subunit 1 (T01 family) | 0.0018 | 0.0241 | 0.0241 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0071 | 0.7291 | 0.7291 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0092 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 71.4 % | Antidepressant activity in Swiss albino mouse assessed as decrease in immobility duration at 0.5 mg/kg, ip administered 30 mins prior to test measured after 30 mins by tail suspension test (Rvb = 79.9%) | ChEMBL. | 21377878 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.