Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | proteasome prosome macropain | 0.0255 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0198 | 0.7224 | 0.7224 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0255 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0198 | 0.7224 | 0.7224 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0198 | 0.7224 | 0.7224 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0198 | 0.7224 | 0.7224 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.0123 | 0.3546 | 0.3546 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.0123 | 0.3546 | 0.3546 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0123 | 0.3546 | 0.3546 |
Brugia malayi | proteasome subunit beta type 1 | 0.0198 | 0.7224 | 0.7224 |
Trypanosoma cruzi | 20S proteasome subunit | 0.0123 | 0.3546 | 0.3546 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0255 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0198 | 0.7224 | 0.7224 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0255 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0123 | 0.3546 | 0.3546 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0255 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0198 | 0.7224 | 0.7224 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0123 | 0.3546 | 0.3546 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0255 | 1 | 1 |
Brugia malayi | proteasome subunit beta type 2 | 0.0123 | 0.3546 | 0.3546 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0198 | 0.7224 | 0.7224 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0198 | 0.7224 | 0.7224 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.0123 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0255 | 1 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0255 | 1 | 1 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.0123 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.0123 | 0.3546 | 0.3546 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0123 | 0.3546 | 0.3546 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0255 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0255 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.0123 | 0.3546 | 0.3546 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0198 | 0.7224 | 0.7224 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0123 | 0.3546 | 0.3546 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0255 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0198 | 0.7224 | 0.7224 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0255 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0123 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0198 | 0.7224 | 0.7224 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0255 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0198 | 0.7224 | 0.7224 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0198 | 0.7224 | 0.7224 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0255 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0198 | 0.7224 | 0.7224 |
Mycobacterium ulcerans | proteasome PrcB | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0255 | 1 | 1 |
Onchocerca volvulus | Notchless protein homolog | 0.005 | 0 | 0.5 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.0123 | 0.3546 | 0.3546 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0123 | 0.3546 | 0.3546 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0255 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0123 | 0.3546 | 0.3546 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.