Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0388 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0187 | 0.3546 | 0.3546 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.0187 | 0.3546 | 0.3546 |
Onchocerca volvulus | Notchless protein homolog | 0.0076 | 0 | 0.5 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0388 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0187 | 0.3546 | 0.3546 |
Mycobacterium ulcerans | proteasome PrcB | 0.0388 | 1 | 1 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0301 | 0.7224 | 0.7224 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0388 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0301 | 0.7224 | 0.7224 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0301 | 0.7224 | 0.7224 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0301 | 0.7224 | 0.7224 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0076 | 0 | 0.5 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0388 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0187 | 0.3546 | 0.3546 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0388 | 1 | 1 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0301 | 0.7224 | 0.7224 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0187 | 0.3546 | 0.3546 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0388 | 1 | 1 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0187 | 0.3546 | 0.3546 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0388 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0388 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.0187 | 0.3546 | 0.3546 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0301 | 0.7224 | 0.7224 |
Brugia malayi | proteasome subunit beta type 2 | 0.0187 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0301 | 0.7224 | 0.7224 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0301 | 0.7224 | 0.7224 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.0187 | 0.3546 | 0.3546 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.0187 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.0187 | 0.3546 | 0.3546 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0388 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0388 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0388 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0301 | 0.7224 | 0.7224 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0388 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0187 | 0.3546 | 0.3546 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0388 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0187 | 0.3546 | 0.3546 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0388 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0301 | 0.7224 | 0.7224 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.0187 | 0.3546 | 0.3546 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.0187 | 0.3546 | 0.3546 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0187 | 0.3546 | 0.3546 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0301 | 0.7224 | 0.7224 |
Trypanosoma cruzi | 20S proteasome subunit | 0.0187 | 0.3546 | 0.3546 |
Brugia malayi | proteasome subunit beta type 1 | 0.0301 | 0.7224 | 0.7224 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0388 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0301 | 0.7224 | 0.7224 |
Echinococcus granulosus | proteasome prosome macropain | 0.0388 | 1 | 1 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0301 | 0.7224 | 0.7224 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0301 | 0.7224 | 0.7224 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 173 uM | Concentration required to reduce the viability of mock-infected MT-4 cells by 50% (4 days) | ChEMBL. | 7523675 |
CC50 (functional) | > 173 uM | Concentration required to reduce the viability of mock-infected MT-4 cells by 50% (4 days) | ChEMBL. | 7523675 |
EC50 (functional) | > 173 uM | Effective concentration required to achieve 50% protection of MT-4 cells against cytopathic effect of HIV-1 (4 days) | ChEMBL. | 7523675 |
EC50 (functional) | > 173 uM | Effective concentration required to achieve 50% protection of MT-4 cells against cytopathic effect of HIV-2 (8 days) | ChEMBL. | 7523675 |
EC50 (functional) | > 173 uM | Effective concentration required to achieve 50% protection of MT-4 cells against cytopathic effect of HIV-1 (4 days) | ChEMBL. | 7523675 |
EC50 (functional) | > 173 uM | Effective concentration required to achieve 50% protection of MT-4 cells against cytopathic effect of HIV-2 (8 days) | ChEMBL. | 7523675 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.