TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 321.373 | Formula: C19H19N3O2
H donors: 1 H acceptors: 2 LogP: 2.09 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Nc1ccc2c3c1cccc3c(=O)n(c2=O)[C@H]1CN2CCC1CC2
InChi: 1S/C19H19N3O2/c20-15-5-4-14-17-12(15)2-1-3-13(17)18(23)22(19(14)24)16-10-21-8-6-11(16)7-9-21/h1-5,11,16H,6-10,20H2/t16-/m0/s1
InChiKey: GGQMXMGHFNPCQV-INIZCTEOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Serotonin 3 (5-HT3) receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus	39S ribosomal protein L13, mitochondrial homolog	Serotonin 3 (5-HT3) receptor	483 aa	490 aa	31.0 %
Onchocerca volvulus		Serotonin 3 (5-HT3) receptor	483 aa	477 aa	26.6 %
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	Serotonin 3 (5-HT3) receptor	483 aa	503 aa	22.3 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type des-2 homolog	Serotonin 3 (5-HT3) receptor	483 aa	464 aa	24.8 %
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	Serotonin 3 (5-HT3) receptor	483 aa	478 aa	25.1 %
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	Serotonin 3 (5-HT3) receptor	483 aa	470 aa	26.8 %
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	Serotonin 3 (5-HT3) receptor	483 aa	482 aa	23.9 %
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	Serotonin 3 (5-HT3) receptor	483 aa	457 aa	26.7 %
Onchocerca volvulus		Serotonin 3 (5-HT3) receptor	483 aa	489 aa	31.3 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	Serotonin 3 (5-HT3) receptor	483 aa	388 aa	21.9 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	Serotonin 3 (5-HT3) receptor	483 aa	482 aa	25.1 %
Schistosoma japonicum	Neuronal acetylcholine receptor subunit alpha-3 precursor, putative	Serotonin 3 (5-HT3) receptor	483 aa	505 aa	21.2 %
Schistosoma japonicum	Neuronal acetylcholine receptor subunit alpha-9-II precursor, putative	Serotonin 3 (5-HT3) receptor	483 aa	457 aa	24.7 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	Serotonin 3 (5-HT3) receptor	483 aa	465 aa	27.3 %
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	Serotonin 3 (5-HT3) receptor	483 aa	457 aa	26.9 %
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	Serotonin 3 (5-HT3) receptor	483 aa	445 aa	25.6 %
Onchocerca volvulus	Large subunit GTPase 1 homolog	Serotonin 3 (5-HT3) receptor	483 aa	394 aa	19.3 %
Onchocerca volvulus		Serotonin 3 (5-HT3) receptor	483 aa	461 aa	24.3 %
Drosophila melanogaster	nicotinic Acetylcholine Receptor alpha2	Serotonin 3 (5-HT3) receptor	483 aa	541 aa	25.5 %
Onchocerca volvulus		Serotonin 3 (5-HT3) receptor	483 aa	452 aa	29.2 %
Onchocerca volvulus		Serotonin 3 (5-HT3) receptor	483 aa	473 aa	27.5 %
Echinococcus multilocularis	nAChR subunit	Serotonin 3 (5-HT3) receptor	483 aa	495 aa	24.2 %
Brugia malayi	Cation transporter family protein	Serotonin 3 (5-HT3) receptor	483 aa	507 aa	28.2 %
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	Serotonin 3 (5-HT3) receptor	483 aa	445 aa	25.4 %
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	Serotonin 3 (5-HT3) receptor	483 aa	463 aa	26.8 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	Serotonin 3 (5-HT3) receptor	483 aa	465 aa	27.3 %
Onchocerca volvulus	Putative zinc finger protein	Serotonin 3 (5-HT3) receptor	483 aa	489 aa	25.8 %
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	Serotonin 3 (5-HT3) receptor	483 aa	470 aa	27.7 %
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	Serotonin 3 (5-HT3) receptor	483 aa	514 aa	23.2 %
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	Serotonin 3 (5-HT3) receptor	483 aa	387 aa	25.6 %
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	Serotonin 3 (5-HT3) receptor	483 aa	484 aa	26.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0065	0.0619	0.0023
Echinococcus granulosus	proteasome subunit alpha type 2	0.0065	0.0619	0.0619
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0048	0.0347	0.0347
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0048	0.0347	0.0921
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0159	0.2081	0.356
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0065	0.0619	0.0619
Brugia malayi	20S proteasome alpha5 subunit	0.0065	0.0619	0.1306
Echinococcus granulosus	FTZ F1 alpha	0.0048	0.0347	0.0347
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0048	0.0347	0.0347
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0065	0.0619	0.0023
Schistosoma mansoni	coup transcription factor	0.0048	0.0347	0.0347
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0065	0.0619	0.0619
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0331	0.4742	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0048	0.0347	0.0347
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0065	0.0619	0.1194
Brugia malayi	photoreceptor-specific nuclear receptor	0.0048	0.0347	0.0733
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0065	0.0619	0.1306
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0347	0.0733
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0065	0.0619	0.0619
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0048	0.0347	0.0347
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0257	0.3597	0.3597
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0065	0.0619	0.1194
Schistosoma mansoni	thyroid hormone receptor	0.017	0.2243	0.2243
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0065	0.0619	0.0023
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0065	0.0619	0.0619
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0331	0.4742	1
Leishmania major	proteasome beta 2 subunit, putative	0.0065	0.0619	0.0023
Giardia lamblia	Proteasome subunit beta type 1	0.0257	0.3597	0.7224
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0257	0.3597	0.7224
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0347	0.0733
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0065	0.0619	0.1306
Schistosoma mansoni	glutamate receptor kainate	0.0054	0.0452	0.0452
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0065	0.0619	0.0023
Leishmania major	proteasome beta-1 subunit, putative	0.0065	0.0619	0.0023
Echinococcus granulosus	glutamate receptor 2	0.0029	0.0059	0.0059
Onchocerca volvulus	Protein ultraspiracle homolog	0.0048	0.0347	0.0921
Onchocerca volvulus		0.0048	0.0347	0.0921
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.006	0.006
Echinococcus granulosus	proteasome prosome macropain	0.0331	0.4742	0.4742
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0065	0.0619	0.0023
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0065	0.0619	0.0619
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0048	0.0347	0.0347
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0065	0.0619	0.0023
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0159	0.2081	0.3546
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0065	0.0619	0.1306
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0159	0.2081	0.3546
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0122	0.1506	0.1506
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0065	0.0619	0.0619
Brugia malayi	Proteasome A-type and B-type family protein	0.0331	0.4742	1
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0065	0.0619	0.1194
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0331	0.4742	1
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0065	0.0619	0.1306
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0065	0.0619	0.0619
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0065	0.0619	0.1194
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0065	0.0619	0.0619
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0065	0.0619	0.0023
Leishmania major	proteasome alpha 7 subunit, putative	0.0065	0.0619	0.0023
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0065	0.0619	0.1306
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0048	0.0347	0.0733
Echinococcus granulosus	proteasome subunit beta type 6	0.0065	0.0619	0.0619
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0065	0.0619	0.0619
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0029	0.0059	0.0059
Loa Loa (eye worm)	steroid hormone receptor	0.0048	0.0347	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0029	0.006	0.0127
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0257	0.3597	0.723
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0048	0.0347	0.0347
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0159	0.2081	0.4316
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0048	0.0347	0.0733
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0065	0.0619	0.0023
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0124	0.0261
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0065	0.0619	0.1194
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0065	0.0619	0.0023
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0048	0.0347	0.0733
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0159	0.2081	0.3546
Echinococcus granulosus	ecdysone induced protein 78C	0.0048	0.0347	0.0347
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0065	0.0619	0.1194
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.006	0.006
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0065	0.0619	0.0023
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0331	0.4742	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0048	0.0347	0.0347
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0065	0.0619	0.0619
Trypanosoma brucei	proteasome beta 6 subunit	0.0257	0.3597	0.723
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0065	0.0619	0.0619
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0048	0.0347	0.0347
Mycobacterium ulcerans	proteasome PrcB	0.0331	0.4742	1
Brugia malayi	nuclear hormone receptor	0.0048	0.0347	0.0733
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.006	0.006
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.006	0.006
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0331	0.4742	1
Echinococcus granulosus	proteasome subunit beta t family	0.0065	0.0619	0.0619
Brugia malayi	Pre-SET motif family protein	0.0029	0.006	0.0127
Trypanosoma brucei	proteasome beta 7 subunit	0.0065	0.0619	0.0023
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0159	0.2081	0.4388
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0048	0.0347	0.0347
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.006	0.006
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0065	0.0619	0.1306
Giardia lamblia	Proteasome subunit beta type 2	0.0159	0.2081	0.3546
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0065	0.0619	0.1194
Echinococcus granulosus	proteasome subunit beta type 7	0.0065	0.0619	0.0619
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0065	0.0619	0.1194
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0065	0.0619	0.0619
Trichomonas vaginalis	set domain proteins, putative	0.023	0.3177	0.6204
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0065	0.0619	0.0023
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0048	0.0347	0.0347
Leishmania major	proteasome beta 7 subunit, putative	0.0065	0.0619	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0124	0.0261
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0065	0.0619	0.1306
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0064	0.061	0.061
Onchocerca volvulus	Bile acid receptor homolog	0.0048	0.0347	0.0921
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0048	0.0347	0.0347
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0257	0.3597	0.723
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0065	0.0619	0.0619
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0048	0.0347	0.0733
Brugia malayi	proteasome subunit beta type 1	0.0257	0.3597	0.7586
Onchocerca volvulus	Notchless protein homolog	0.0065	0.0619	0.1793
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0331	0.4742	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0189	0.2538	0.5352
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0065	0.0619	0.0619
Leishmania major	proteasome alpha 1 subunit, putative	0.0065	0.0619	0.0023
Loa Loa (eye worm)	PAS-3 protein	0.0065	0.0619	0.1306
Brugia malayi	Proteasome subunit alpha type 1	0.0065	0.0619	0.1306
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0065	0.0619	0.0023
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0065	0.0619	0.0023
Echinococcus multilocularis	NMDA receptor	0.0039	0.0215	0.0215
Brugia malayi	Proteasome A-type and B-type family protein	0.0065	0.0619	0.1306
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0065	0.0619	0.0023
Brugia malayi	proteasome subunit alpha type 2	0.0065	0.0619	0.1306
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0064	0.061	0.1174
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.0039	0.0215	0.0215
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0048	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0347	0.0733
Leishmania major	proteasome alpha 3 subunit, putative	0.0065	0.0619	0.0023
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0159	0.2081	0.2081
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0048	0.0347	0.0733
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0048	0.0347	0.0733
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0065	0.0619	0.0619
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0065	0.0619	0.0023
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.0039	0.0215	0.0215
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0065	0.0619	0.0619
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.006	0.006
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0065	0.0619	0.0023
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0065	0.0619	0.0023
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0065	0.0619	0.0023
Echinococcus multilocularis	microtubule associated protein 2	0.067	1	1
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0159	0.2081	0.3546
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0361	0.0762
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0065	0.0619	0.0023
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0065	0.0619	0.0023
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0065	0.0619	0.1194
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0257	0.3597	0.7586
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0048	0.0347	0.0733
Schistosoma mansoni	glutamate receptor kainate	0.0054	0.0452	0.0452
Brugia malayi	proteasome subunit alpha type 6	0.0065	0.0619	0.1306
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0159	0.2081	0.4316
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0189	0.2538	0.2538
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0331	0.4742	1
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0065	0.0619	0.0619
Brugia malayi	proteasome subunit alpha type 4	0.0065	0.0619	0.1306
Schistosoma mansoni	glutamate receptor NMDA	0.0029	0.0059	0.0059
Brugia malayi	Pre-SET motif family protein	0.0202	0.2744	0.5787
Toxoplasma gondii	proteasome beta subunit	0.0065	0.0619	0.1194
Brugia malayi	steroid hormone receptor	0.0048	0.0347	0.0733
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0065	0.0619	0.1194
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0059	0.0524	0.0524
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0048	0.0347	0.0733
Brugia malayi	proteasome subunit beta type 2	0.0159	0.2081	0.4388
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0048	0.0347	0.0733
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0065	0.0619	0.0619
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0048	0.0347	0.0733
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0044	0.0044
Loa Loa (eye worm)	PDE1B protein	0.0189	0.2538	0.5352
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0065	0.0619	0.0619
Echinococcus granulosus	proteasome subunit alpha type 6	0.0065	0.0619	0.0619
Leishmania major	proteasome alpha 1 subunit, putative	0.0065	0.0619	0.0023
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0065	0.0619	0.1306
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0159	0.2081	0.2081
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0048	0.0347	0.0347
Brugia malayi	Nuclear hormone receptor-like 1	0.0048	0.0347	0.0733
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0065	0.0619	0.1194
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0048	0.0347	0.0347
Trypanosoma cruzi	20S proteasome subunit	0.0159	0.2081	0.356
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0257	0.3597	0.723
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0048	0.0347	0.0733
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0065	0.0619	0.0619
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0048	0.0347	0.0347
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0048	0.0347	0.0347
Toxoplasma gondii	proteasome subunit	0.0065	0.0619	0.1194
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0064	0.061	0.1174
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0257	0.3597	0.7224
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0048	0.0347	0.0347
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0029	0.0059	0.0059
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0331	0.4742	0.4742
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0065	0.0619	0.0023
Schistosoma mansoni	hypothetical protein	0.0033	0.0124	0.0124
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0189	0.2538	0.2538
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0064	0.061	0.061
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0065	0.0619	0.1194
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0065	0.0619	0.1194
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.006	0.006
Brugia malayi	nuclear receptor NHR-88	0.0048	0.0347	0.0733
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0065	0.0619	0.0619
Echinococcus granulosus	Proteasome subunit alpha beta	0.0065	0.0619	0.0619
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0065	0.0619	0.1194
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0065	0.0619	0.0023
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0065	0.0619	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0347	0.0733
Schistosoma mansoni	nuclear hormone receptor	0.0048	0.0347	0.0347
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0039	0.0215	0.0215
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0361	0.0762
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0065	0.0619	0.0023
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0065	0.0619	0.0023
Echinococcus multilocularis	FTZ F1 alpha	0.0048	0.0347	0.0347
Brugia malayi	Steroid receptor seven-up type 2	0.0048	0.0347	0.0733
Brugia malayi	proteasome subunit beta type 3	0.0065	0.0619	0.1306
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0331	0.4742	1
Brugia malayi	proteasome subunit alpha type 1	0.0065	0.0619	0.1306
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0347	0.0733
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0048	0.0347	0.0347
Echinococcus multilocularis	proteasome subunit beta type 6	0.0065	0.0619	0.0619
Schistosoma mansoni	retinoic acid receptor RXR	0.0048	0.0347	0.0347
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0048	0.0347	0.0733
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0048	0.0347	0.0733
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0059	0.0524	0.0524
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0065	0.0619	0.0023
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.0039	0.0215	0.0215
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0189	0.2538	0.2538
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0331	0.4742	0.4742
Brugia malayi	Proteasome A-type and B-type family protein	0.0065	0.0619	0.1306
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0065	0.0619	0.0619
Brugia malayi	Proteasome A-type and B-type family protein	0.0065	0.0619	0.1306
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0065	0.0619	0.0023
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0065	0.0619	0.0023
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0257	0.3597	0.7555
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0159	0.2081	0.2081
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0048	0.0347	0.0733
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0065	0.0619	0.0619
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0065	0.0619	0.1306
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0065	0.0619	0.5
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0048	0.0347	0.0347
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0065	0.0619	0.0619
Schistosoma mansoni	RAR-like nuclear receptor	0.0048	0.0347	0.0347
Leishmania major	proteasome alpha 2 subunit, putative	0.0065	0.0619	0.0023
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0065	0.0619	0.0023
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0065	0.0619	0.0619
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0065	0.0619	0.0023
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0065	0.0619	0.0023
Schistosoma mansoni	thyroid hormone receptor	0.017	0.2243	0.2243
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0065	0.0619	0.0023
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0065	0.0619	0.1194
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0048	0.0347	0.0733
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0065	0.0619	0.0023
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0065	0.0619	0.0023
Brugia malayi	ecdysteroid receptor	0.0048	0.0347	0.0733
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0059	0.0524	0.0524
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0048	0.0347	0.0733
Echinococcus multilocularis	glutamate receptor 2	0.0029	0.0059	0.0059
Leishmania major	proteasome beta 5 subunit, putative	0.0331	0.4742	1
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0122	0.1506	0.1506
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0065	0.0619	0.0023
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0059	0.0524	0.0524
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0065	0.0619	0.0619
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0048	0.0347	0.0733
Leishmania major	proteasome beta 2 subunit, putative	0.0159	0.2081	0.356
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0065	0.0619	0.1194
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0065	0.0619	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0347	0.0733
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0065	0.0619	0.0619
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0065	0.0619	0.0619
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0331	0.4742	1
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0059	0.0524	0.0524
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0048	0.0347	0.0733
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0048	0.0347	0.0347
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0065	0.0619	0.1306
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0048	0.0347	0.0733
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0257	0.3597	0.7555
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0065	0.0619	0.0619
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0048	0.0347	0.0733
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0257	0.3597	0.3597
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.2744	0.5787
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0059	0.0524	0.0524
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0065	0.0619	0.0023
Onchocerca volvulus		0.023	0.3177	1
Brugia malayi	proteasome subunit alpha type 3	0.0065	0.0619	0.1306
Schistosoma mansoni	microtubule-associated protein tau	0.067	1	1
Trypanosoma brucei	proteasome alpha 7 subunit	0.0065	0.0619	0.0023
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0361	0.0762
Echinococcus multilocularis	ecdysone induced protein 78C	0.0048	0.0347	0.0347
Brugia malayi	Proteasome subunit alpha type 7-1	0.0065	0.0619	0.1306
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0361	0.0762
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0331	0.4742	1
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0159	0.2081	0.2081
Leishmania major	proteasome beta 3 subunit, putative	0.0065	0.0619	0.0023
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0065	0.0619	0.0023
Plasmodium falciparum	proteasome subunit beta type-5	0.0331	0.4742	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0347	0.0733
Echinococcus multilocularis	thyroid hormone receptor alpha	0.017	0.2243	0.2243
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0065	0.0619	0.0023
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0065	0.0619	0.0619
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0065	0.0619	0.1194
Schistosoma mansoni	hypothetical protein	0.0122	0.1506	0.1506
Echinococcus multilocularis	proteasome subunit beta type 7	0.0065	0.0619	0.0619
Toxoplasma gondii	heat shock protein hslv, putative	0.0065	0.0619	0.1194
Toxoplasma gondii	proteasome subunit beta type, putative	0.0331	0.4742	1
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0257	0.3597	0.7224
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0159	0.2081	0.356
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0065	0.0619	0.1194
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0065	0.0619	0.1194
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0065	0.0619	0.0023
Leishmania major	proteasome alpha 7 subunit, putative	0.0065	0.0619	0.0023
Toxoplasma gondii	peptidase, T1 family protein	0.0065	0.0619	0.1194
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0347	0.0733
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0064	0.061	0.1174
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0257	0.3597	0.3597

Activities

Activity type	Activity value	Assay description	Source	Reference
ID50 (functional)	= 1.6 ug kg-1	Antagonism of the bradycardia induced by iv injection of 5-HT(10-30 microg/kg) was evaluated by the compound administration in rat; 0.7-3.6	ChEMBL.	No reference
Ki (binding)	= 0.15 nM	Binding affinity at 5-hydroxytryptamine 3 receptor in rat posterior cortex by [3H]-BRL 43694 displacement.	ChEMBL.	No reference
Ki (binding)	= 0.15 nM	Binding affinity of the compound to 5-hydroxytryptamine 3 receptor in rat entorhinal cortex using [3H]-BRL 43694 as radioligand	ChEMBL.	No reference
Ki (binding)	= 0.15 nM	Binding affinity at 5-hydroxytryptamine 3 receptor in rat posterior cortex by [3H]-BRL 43694 displacement.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL350824
PubChem: 10448753

Bibliographic References

No literature references available for this target.

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Detailed information for compound 274117