Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0487 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0317 | 0.5971 | 0.591 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0146 | 0.1897 | 0.1774 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0146 | 0.1897 | 0.1774 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0487 | 1 | 1 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0146 | 0.1897 | 0.1897 |
Mycobacterium ulcerans | proteasome PrcB | 0.0487 | 1 | 1 |
Trypanosoma brucei | prolyl endopeptidase | 0.0146 | 0.1897 | 0.1897 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0487 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0487 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0189 | 0.2915 | 0.2808 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0317 | 0.5971 | 0.5028 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0073 | 0.0149 | 0.0149 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0487 | 1 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0189 | 0.2915 | 0.2808 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0189 | 0.2915 | 0.2808 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0487 | 1 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0118 | 0.1236 | 0.1236 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0189 | 0.2915 | 0.1256 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0487 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain | 0.0487 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0317 | 0.5971 | 0.591 |
Toxoplasma gondii | prolyl endopeptidase | 0.0146 | 0.1897 | 0.1774 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0487 | 1 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0073 | 0.0149 | 0.0149 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0487 | 1 | 1 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0317 | 0.5971 | 0.5971 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0487 | 1 | 1 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0317 | 0.5971 | 0.5971 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0487 | 1 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0146 | 0.1897 | 0.1774 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0073 | 0.0149 | 0.0149 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0487 | 1 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0487 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0073 | 0.0149 | 0.0149 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0317 | 0.5971 | 0.591 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0317 | 0.5971 | 0.5971 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0146 | 0.1897 | 0.1897 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0317 | 0.5971 | 0.591 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0317 | 0.5971 | 0.5971 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0487 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0487 | 1 | 1 |
Brugia malayi | proteasome subunit beta type 1 | 0.0317 | 0.5971 | 0.591 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0189 | 0.2915 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0146 | 0.1897 | 0.1774 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0073 | 0.0149 | 0.0149 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0146 | 0.1897 | 0.1774 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0189 | 0.2915 | 0.2808 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.