Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0099 | 0.1564 | 0.1564 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0335 | 1 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0335 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.076 | 0.076 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0153 | 0.3483 | 0.2275 |
Echinococcus granulosus | proteasome prosome macropain | 0.0335 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0335 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0153 | 0.3483 | 0.3483 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.076 | 0.076 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.076 | 0.076 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0335 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0335 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.076 | 0.076 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0153 | 0.3483 | 0.3483 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0153 | 0.3483 | 0.2275 |
Brugia malayi | RNA binding protein | 0.0076 | 0.076 | 0.076 |
Brugia malayi | proteasome subunit beta type 1 | 0.0153 | 0.3483 | 0.3483 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0153 | 0.3483 | 0.3483 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0335 | 1 | 1 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0153 | 0.3483 | 0.2275 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0335 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.076 | 0.076 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0153 | 0.3483 | 0.2275 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.076 | 0.076 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0099 | 0.1564 | 0.1564 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0099 | 0.1564 | 0.1564 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0153 | 0.3483 | 0.2275 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0153 | 0.3483 | 0.2275 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0335 | 1 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.076 | 0.076 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.076 | 0.076 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.076 | 0.076 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0099 | 0.1564 | 0.1564 |
Mycobacterium ulcerans | proteasome PrcB | 0.0335 | 1 | 0.5 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0335 | 1 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0335 | 1 | 0.5 |
Brugia malayi | proteasome subunit beta type 2 | 0.0099 | 0.1564 | 0.1564 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0099 | 0.1564 | 0.1564 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0335 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0153 | 0.3483 | 0.2275 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0335 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.076 | 0.076 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0153 | 0.3483 | 0.2275 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0153 | 0.3483 | 0.2275 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.076 | 0.076 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0335 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.076 | 0.076 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0335 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0153 | 0.3483 | 0.3483 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0335 | 1 | 1 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0153 | 0.3483 | 0.2275 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.