Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | proteasome beta 6 subunit | 0.0066 | 0.3266 | 0.3793 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.2019 | 0.2345 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.012 | 0.6763 | 0.2987 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0108 | 0.5976 | 0.6942 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0148 | 0.8609 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0148 | 0.8609 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0047 | 0.2019 | 0.2345 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0066 | 0.3266 | 0.3793 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0148 | 0.8609 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0148 | 0.8609 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Brugia malayi | glutathione reductase | 0.0047 | 0.2019 | 0.2345 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.2019 | 0.2345 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0148 | 0.8609 | 1 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0148 | 0.8609 | 1 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0066 | 0.3266 | 0.3793 |
Echinococcus granulosus | proteasome prosome macropain | 0.0148 | 0.8609 | 0.8609 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0066 | 0.3266 | 0.3266 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0108 | 0.5976 | 0.6942 |
Brugia malayi | proteasome subunit beta type 1 | 0.0066 | 0.3266 | 0.3793 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0066 | 0.3266 | 0.3266 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.2019 | 0.2019 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0108 | 0.5976 | 0.6942 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.2019 | 0.2345 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.2019 | 0.2345 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.012 | 0.6763 | 0.7855 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0148 | 0.8609 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.0148 | 0.8609 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0148 | 0.8609 | 0.8609 |
Mycobacterium tuberculosis | Probable reductase | 0.0108 | 0.5976 | 0.6942 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.2019 | 0.2345 |
Treponema pallidum | NADH oxidase | 0.0016 | 0 | 0.5 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0148 | 0.8609 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0148 | 0.8609 | 1 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0066 | 0.3266 | 0.3793 |
Leishmania major | trypanothione reductase | 0.0047 | 0.2019 | 0.2345 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0066 | 0.3266 | 0.3793 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0066 | 0.3266 | 0.3793 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0016 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0148 | 0.8609 | 0.8609 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.012 | 0.6763 | 0.7855 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0148 | 0.8609 | 1 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0148 | 0.8609 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0148 | 0.8609 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0108 | 0.5976 | 0.6942 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0066 | 0.3266 | 0.3266 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0148 | 0.8609 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.2019 | 0.2345 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0066 | 0.3266 | 0.3793 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0108 | 0.5976 | 0.6942 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0066 | 0.3266 | 0.1892 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.012 | 0.6763 | 0.7855 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0066 | 0.3266 | 0.3793 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.2019 | 0.2345 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.2019 | 0.2019 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0148 | 0.8609 | 1 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0066 | 0.3266 | 0.3793 |
Echinococcus multilocularis | geminin | 0.0169 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.2019 | 0.2345 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.