Detailed information for compound 1042877

Basic information

Technical information
  • TDR Targets ID: 1042877
  • Name: 1-(cyclohexylmethyl)-6-(3,5-dimethylphenyl)su lfanyl-5-ethylpyrimidine-2,4-dione
  • MW: 372.524 | Formula: C21H28N2O2S
  • H donors: 1 H acceptors: 2 LogP: 5.39 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1c(=O)[nH]c(=O)n(c1Sc1cc(C)cc(c1)C)CC1CCCCC1
  • InChi: 1S/C21H28N2O2S/c1-4-18-19(24)22-21(25)23(13-16-8-6-5-7-9-16)20(18)26-17-11-14(2)10-15(3)12-17/h10-12,16H,4-9,13H2,1-3H3,(H,22,24,25)
  • InChiKey: DXEHAYVNEFZGRQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(cyclohexylmethyl)-6-(3,5-dimethylphenyl)sulfanyl-5-ethyl-pyrimidine-2,4-dione
  • 1-(cyclohexylmethyl)-6-[(3,5-dimethylphenyl)thio]-5-ethylpyrimidine-2,4-dione
  • 1-(cyclohexylmethyl)-6-[(3,5-dimethylphenyl)thio]-5-ethyl-pyrimidine-2,4-quinone
  • AIDS351829
  • 2,4(1H,3H)-Pyrimidinedione, 1-(cyclohexylmethyl)-6-[(3,5-dimethylphenyl)thio]-5-ethyl-
  • AIDS-351829

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Reverse transcriptase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Plasmodium yoelii integrase-related Get druggable targets OG5_139608 All targets in OG5_139608
Schistosoma mansoni hypothetical protein Get druggable targets OG5_139608 All targets in OG5_139608
Trypanosoma brucei RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) Reverse transcriptase   259 aa 208 aa 26.4 %
Dictyostelium discoideum hypothetical protein Reverse transcriptase   259 aa 245 aa 25.7 %
Dictyostelium discoideum hypothetical protein Reverse transcriptase   259 aa 222 aa 22.5 %
Trypanosoma congolense Retroviral aspartyl protease/Reverse transcriptase (RNA-dependent DNA polymerase)/RNase H, putative Reverse transcriptase   259 aa 237 aa 29.1 %
Dictyostelium discoideum hypothetical protein Reverse transcriptase   259 aa 226 aa 24.3 %
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) Reverse transcriptase   259 aa 227 aa 26.4 %
Candida albicans hypothetical protein Reverse transcriptase   259 aa 223 aa 29.1 %
Candida albicans ReverseTranscriptase similar to fruit fly Tom element Reverse transcriptase   259 aa 244 aa 27.9 %
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) Reverse transcriptase   259 aa 227 aa 26.4 %
Candida albicans polyprotein of retrotransposon Tca8 Reverse transcriptase   259 aa 238 aa 26.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis potassium voltage gated channel protein 0.0042 0.0236 0.0236
Echinococcus granulosus single minded 2 0.0058 0.0363 0.0363
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0128 0.0896 0.0896
Entamoeba histolytica cysteine protease, putative 0.0196 0.1414 0.2035
Loa Loa (eye worm) cysteine protease 0.0908 0.6854 0.6854
Giardia lamblia Cathepsin L-like protease 0.0196 0.1414 0.3436
Leishmania major protein kinase, putative 0.0086 0.0576 0.0839
Brugia malayi Cathepsin L-like precursor 0.0619 0.4649 0.4649
Onchocerca volvulus 0.0908 0.6854 1
Loa Loa (eye worm) hypothetical protein 0.0619 0.4649 0.4649
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0042 0.0236 0.0236
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0289 0.2123 0.2123
Trichomonas vaginalis guanylate cyclase, putative 0.0058 0.0363 0.0497
Onchocerca volvulus 0.0908 0.6854 1
Trichomonas vaginalis adenylate cyclase, putative 0.0058 0.0363 0.0497
Entamoeba histolytica cysteine proteinase 2 0.0484 0.3619 0.5264
Schistosoma mansoni cathepsin F (C01 family) 0.0619 0.4649 0.4649
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0006 0.0006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0006 0.0006
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0128 0.0896 0.1277
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0543 0.4069 0.4069
Trypanosoma brucei hypothetical protein, conserved 0.01 0.0683 0.0994
Loa Loa (eye worm) hypothetical protein 0.0196 0.1414 0.1414
Mycobacterium leprae Conserved hypothetical protein 0.0086 0.0576 0.6676
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0061 0.038 0.038
Trichomonas vaginalis adenylate cyclase type, putative 0.0058 0.0363 0.0497
Trichomonas vaginalis guanylate cyclase beta 2 subunit, putative 0.0058 0.0363 0.0497
Echinococcus granulosus sodium channel protein 0.0042 0.0236 0.0236
Onchocerca volvulus Cathepsin F homolog 0.0908 0.6854 1
Trichomonas vaginalis adenylate cyclase type VI, putative 0.0058 0.0363 0.0497
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0186 0.1342 0.1342
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0006 0.0006
Schistosoma mansoni transient receptor potential channel 0.0042 0.0236 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0908 0.6854 1
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0042 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0236
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0024 0.0024
Brugia malayi beta-lactamase family protein 0.01 0.0683 0.0683
Trichomonas vaginalis adenylate cyclase type III, putative 0.0058 0.0363 0.0497
Loa Loa (eye worm) hypothetical protein 0.0619 0.4649 0.4649
Trichomonas vaginalis guanylate cyclase, putative 0.0058 0.0363 0.0497
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0576 0.0576
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0196 0.1414 0.1414
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0105 0.0151
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0908 0.6854 0.6854
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0172 0.0249
Plasmodium falciparum serine repeat antigen 4 0.0196 0.1414 0.2061
Leishmania major importin beta-1 subunit, putative 0.0027 0.0124 0.0179
Onchocerca volvulus 0.0908 0.6854 1
Brugia malayi ion channel NompC 0.0042 0.0236 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0908 0.6854 1
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0086 0.0576 0.0575
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.01 0.0683 0.0683
Brugia malayi Papain family cysteine protease containing protein 0.0484 0.3619 0.3619
Brugia malayi Cathepsin L-like precursor 0.0908 0.6854 0.6854
Onchocerca volvulus Cathepsin L homolog 0.0908 0.6854 1
Echinococcus granulosus transient receptor potential gamma protein 0.0042 0.0236 0.0236
Echinococcus granulosus hypothetical protein 0.0042 0.0236 0.0236
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0042 0.0236 0.0236
Brugia malayi Papain family cysteine protease containing protein 0.0196 0.1414 0.1414
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0637 0.4789 0.4789
Mycobacterium ulcerans esterase/lipase LipP 0.01 0.0683 1
Loa Loa (eye worm) cathepsin B 0.0543 0.4069 0.4069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0619 0.4649 0.6771
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0128 0.0896 0.0896
Plasmodium falciparum serine repeat antigen 8 0.0196 0.1414 0.2061
Schistosoma mansoni voltage-gated potassium channel 0.01 0.0682 0.0682
Mycobacterium tuberculosis Conserved protein 0.01 0.0683 0.1417
Trichomonas vaginalis adenylate cyclase, putative 0.0058 0.0363 0.0497
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0006 0.0006
Echinococcus granulosus ryanodine receptor 44f 0.0042 0.0236 0.0236
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0086 0.0576 0.0576
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0006 0.0006
Mycobacterium ulcerans transmembrane transport protein 0.0086 0.0576 0.8387
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0484 0.3619 0.528
Trypanosoma brucei cAMP response protein 1, putative 0.0086 0.0576 0.0839
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1319 1 1
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0086 0.0576 0.1196
Mycobacterium tuberculosis Conserved protein 0.01 0.0683 0.1417
Giardia lamblia Hypothetical protein 0.0196 0.1414 0.3436
Echinococcus multilocularis potassium voltage gated channel protein 0.0042 0.0236 0.0236
Schistosoma mansoni voltage-dependent calcium channel 0.0042 0.0236 0.0236
Entamoeba histolytica cysteine protease, putative 0.0196 0.1414 0.2035
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0042 0.0236 0.0236
Trypanosoma cruzi cAMP response protein 1, putative 0.0086 0.0576 0.0575
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0086 0.0576 0.0576
Loa Loa (eye worm) hypothetical protein 0.0086 0.0576 0.0576
Loa Loa (eye worm) hypothetical protein 0.0908 0.6854 0.6854
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0196 0.1413 0.1413
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0058 0.0363 0.0497
Trichomonas vaginalis conserved hypothetical protein 0.0196 0.1414 0.2035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0908 0.6854 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.064 0.4809 1
Onchocerca volvulus 0.0086 0.0576 0.0832
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0105 0.0105
Leishmania major hypothetical protein, unknown function 0.0086 0.0576 0.0839
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0058 0.0363 0.0497
Schistosoma mansoni 60S ribosomal protein L21 0.01 0.0682 0.0682
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0236
Brugia malayi Papain family cysteine protease containing protein 0.0484 0.3619 0.3619
Plasmodium vivax serine-repeat antigen (SERA) 0.0196 0.1414 0.2061
Loa Loa (eye worm) hypothetical protein 0.0289 0.2123 0.2123
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0236
Schistosoma mansoni ran 0.0025 0.0105 0.0105
Giardia lamblia Hypothetical protein 0.0196 0.1414 0.3436
Echinococcus multilocularis snurportin 1 0.0356 0.2641 0.2641
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0006 0.0006
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0042 0.0236 0.0343
Plasmodium vivax importin-beta 2, putative 0.0033 0.0172 0.0249
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0086 0.0576 0.0576
Brugia malayi cation channel family protein 0.0042 0.0236 0.0236
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0042 0.0236 0.0236
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0086 0.0576 0.0576
Brugia malayi Cathepsin L-like precursor 0.0908 0.6854 0.6854
Schistosoma mansoni cathepsin s 0.0289 0.2123 0.2123
Echinococcus multilocularis shaker cognate 0.0042 0.0236 0.0236
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0024 0.0024
Echinococcus multilocularis cathepsin L cysteine protease 0.0908 0.6854 0.6854
Leishmania major cathepsin L-like protease 0.0908 0.6854 1
Giardia lamblia Cathepsin B precursor 0.0543 0.4069 1
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0086 0.0576 0.0809
Brugia malayi beta-lactamase 0.01 0.0683 0.0683
Mycobacterium tuberculosis Probable hydrolase 0.01 0.0683 0.1417
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0363 0.0497
Echinococcus multilocularis two pore calcium channel protein 2 0.0042 0.0236 0.0236
Schistosoma mansoni two-pore calcium channel 0.0042 0.0236 0.0236
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0196 0.1414 0.2061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0908 0.6854 1
Entamoeba histolytica cysteine protease, putative 0.0484 0.3619 0.5264
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0006 0.0006
Echinococcus multilocularis potassium voltage gated channel protein 0.0042 0.0236 0.0236
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0128 0.0896 0.0896
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0086 0.0576 0.0576
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0086 0.0576 0.0576
Entamoeba histolytica cysteine protease, putative 0.0484 0.3619 0.5264
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.01 0.0683 0.0683
Giardia lamblia Cysteine protease 0.0196 0.1414 0.3436
Brugia malayi Cathepsin L-like precursor 0.0289 0.2123 0.2123
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0086 0.0576 0.0576
Onchocerca volvulus 0.0908 0.6854 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0058 0.0363 0.0497
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0006 0.0006
Echinococcus multilocularis transient receptor potential cation channel 0.0042 0.0236 0.0236
Trypanosoma cruzi cruzipain precursor, putative 0.0908 0.6854 0.6854
Trypanosoma cruzi cruzipain precursor, putative 0.0289 0.2123 0.2122
Trypanosoma cruzi cAMP response protein 1 0.0086 0.0576 0.0575
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.01 0.0683 0.1417
Brugia malayi isocitrate dehydrogenase 0.0011 0.0001 0.0001
Toxoplasma gondii cathepsin CPC1 0.0196 0.1414 0.2061
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0058 0.0363 0.0497
Echinococcus granulosus voltage gated potassium channel 0.0186 0.1342 0.1342
Plasmodium falciparum serine repeat antigen 9 0.0196 0.1414 0.2061
Loa Loa (eye worm) isocitrate dehydrogenase 0.0011 0.0001 0.0001
Trypanosoma brucei RNA helicase, putative 0.0167 0.1191 0.1736
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0196 0.1414 0.3436
Trypanosoma cruzi cysteine peptidase, putative 0.0908 0.6854 0.6854
Brugia malayi Papain family cysteine protease containing protein 0.0908 0.6854 0.6854
Schistosoma mansoni ryanodine receptor related 0.0042 0.0236 0.0236
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0908 0.6854 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0543 0.4069 0.5923
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0908 0.6854 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0196 0.1414 0.1414
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0484 0.3619 0.5264
Schistosoma mansoni hypothetical protein 0.0167 0.1191 0.1191
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0014 0.0024 0.0047
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0086 0.0576 0.0576
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.01 0.0683 0.0683
Echinococcus multilocularis potassium large conductance calcium activated 0.0042 0.0236 0.0236
Echinococcus multilocularis potassium voltage gated channel protein 0.0042 0.0236 0.0236
Echinococcus granulosus potassium voltage gated channel protein 0.0042 0.0236 0.0236
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0196 0.1414 0.1414
Loa Loa (eye worm) voltage-gated potassium channel 0.0042 0.0236 0.0236
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0236 0.0236
Trichomonas vaginalis guanylate cyclase, putative 0.0058 0.0363 0.0497
Leishmania major cathepsin L-like protease 0.0908 0.6854 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0006 0.0006
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0042 0.0236 0.0236
Echinococcus granulosus shaker cognate 0.0042 0.0236 0.0236
Trichomonas vaginalis guanylate cyclase, putative 0.0058 0.0363 0.0497
Echinococcus granulosus sodium leak channel non selective protein 0.0042 0.0236 0.0236
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0086 0.0576 0.0809
Loa Loa (eye worm) ctsf protein 0.0908 0.6854 0.6854
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0006 0.0006
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0042 0.0236 0.0236
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0576 0.0576
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0086 0.0576 0.0576
Trichomonas vaginalis guanylate cyclase, putative 0.0058 0.0363 0.0497
Brugia malayi Cathepsin L-like precursor 0.0908 0.6854 0.6854
Echinococcus granulosus transient receptor potential cation channel 0.0042 0.0236 0.0236
Trichomonas vaginalis penicillin-binding protein, putative 0.01 0.0683 0.0965
Leishmania major cathepsin L-like protease 0.0908 0.6854 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0596 0.4469 0.6509
Schistosoma mansoni importin beta-1 0.0033 0.0172 0.0172
Echinococcus granulosus patatin phospholipase domain containing protein 0.0086 0.0576 0.0576
Entamoeba histolytica cysteine protease, putative 0.0484 0.3619 0.5264
Toxoplasma gondii ABC1 family protein 0.01 0.0683 0.0994
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0196 0.1414 0.1414
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0086 0.0576 0.0839
Mycobacterium ulcerans transcriptional regulatory protein 0.0086 0.0576 0.8387
Plasmodium falciparum cysteine proteinase falcipain 3 0.0908 0.6854 1
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0363 0.0497
Loa Loa (eye worm) beta-lactamase 0.01 0.0683 0.0683
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0042 0.0236 0.0236
Trypanosoma cruzi cysteine proteinase, putative 0.0484 0.3619 0.3618
Schistosoma mansoni hypothetical protein 0.0228 0.1657 0.1657
Echinococcus granulosus potassium voltage gated channel protein 0.0042 0.0236 0.0236
Trypanosoma brucei Flagellar Member 6 0.0086 0.0576 0.0839
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0042 0.0236 0.0236
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0908 0.6854 1
Mycobacterium leprae Probable lipase LipE 0.01 0.0683 1
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0086 0.0576 0.0809
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0006 0.0006
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0172 0.0172
Echinococcus granulosus snurportin 1 0.0356 0.2641 0.2641
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0006 0.0006
Leishmania major DNA polymerase eta, putative 0.0014 0.0024 0.0033
Entamoeba histolytica cysteine proteinase, putative 0.0484 0.3619 0.5264
Loa Loa (eye worm) fibroinase 0.0908 0.6854 0.6854
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0086 0.0576 0.0576
Plasmodium falciparum serine repeat antigen 3 0.0196 0.1414 0.2061
Echinococcus granulosus voltage gated hydrogen channel 1 0.0042 0.0236 0.0236
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0596 0.4469 0.6509
Leishmania major hypothetical protein, conserved 0.0086 0.0576 0.0839
Giardia lamblia Cathepsin L precursor 0.0196 0.1414 0.3436
Brugia malayi cation channel family protein 0.0042 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.01 0.0683 0.0683
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0042 0.0236 0.0236
Echinococcus multilocularis sodium leak channel non selective protein 0.0042 0.0236 0.0236
Plasmodium falciparum serine repeat antigen 2 0.0196 0.1414 0.2061
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0058 0.0363 0.0497
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0024 0.0033
Echinococcus granulosus short transient receptor potential channel 6 0.0042 0.0236 0.0236
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0637 0.4789 0.4789
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0042 0.0236 0.0236
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0196 0.1414 0.2061
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0024 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0908 0.6854 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0006
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.0024 0.0024
Trichomonas vaginalis guanylate cyclase, putative 0.0058 0.0363 0.0497
Treponema pallidum catabolite gene activator 0.0086 0.0576 0.5
Trypanosoma cruzi DNA polymerase eta, putative 0.0014 0.0024 0.0022
Loa Loa (eye worm) hypothetical protein 0.0033 0.0172 0.0172
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0011 0.0001 0.0001
Echinococcus multilocularis cysteine protease 0.0908 0.6854 0.6854
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0128 0.0896 0.1277
Trypanosoma cruzi hypothetical protein, conserved 0.0086 0.0576 0.0575
Echinococcus granulosus voltage dependent calcium channel 0.0042 0.0236 0.0236
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0086 0.0576 0.0839
Brugia malayi voltage-dependent calcium channel 0.0042 0.0236 0.0236
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0196 0.1414 0.2035
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0086 0.0576 0.0576
Echinococcus multilocularis cathepsin L 0.0484 0.3619 0.3619
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0619 0.4649 0.4648
Mycobacterium ulcerans hypothetical protein 0.0086 0.0576 0.8387
Echinococcus multilocularis cathepsin b 0.1319 1 1
Trichomonas vaginalis guanylate cyclase, putative 0.0058 0.0363 0.0497
Leishmania major hypothetical protein, conserved 0.01 0.0683 0.0994
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0196 0.1414 0.2035
Leishmania major protein kinase A regulatory subunit, putative 0.0086 0.0576 0.0839
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0908 0.6854 1
Mycobacterium ulcerans hypothetical protein 0.0086 0.0576 0.8387
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0086 0.0576 0.5
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0058 0.0363 0.0497
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0908 0.6854 1
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0042 0.0236 0.0236
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0042 0.0236 0.0236
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0025 0.0105 0.02
Plasmodium falciparum cysteine proteinase falcipain 1 0.0484 0.3619 0.528
Echinococcus multilocularis cathepsin b 0.1319 1 1
Schistosoma mansoni hypothetical protein 0.0228 0.1657 0.1657
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0196 0.1414 0.2035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0908 0.6854 1
Giardia lamblia Cysteine protease 0.0196 0.1414 0.3436
Toxoplasma gondii transporter, cation channel family protein 0.0042 0.0236 0.0343
Mycobacterium ulcerans hypothetical protein 0.0086 0.0576 0.8387
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0006 0.0006
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0042 0.0236 0.0343
Leishmania major cathepsin L-like protease 0.0908 0.6854 1
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0042 0.0236 0.0236
Entamoeba histolytica cysteine protease, putative 0.0196 0.1414 0.2035
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0236
Entamoeba histolytica cysteine protease, putative 0.0484 0.3619 0.5264
Treponema pallidum cyclic nucleotide binding protein 0.0086 0.0576 0.5
Echinococcus granulosus TRP transient receptor potential channel 0.0042 0.0236 0.0236
Giardia lamblia Cathepsin L precursor 0.0196 0.1414 0.3436
Giardia lamblia Cysteine protease 0.0196 0.1414 0.3436
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0236
Loa Loa (eye worm) ion channel NompC 0.0042 0.0236 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0908 0.6854 1
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0088 0.0586 0.0586
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0058 0.0363 0.0497
Entamoeba histolytica cysteine proteinase, putative 0.0484 0.3619 0.5264
Echinococcus multilocularis calcium activated potassium channel 0.0042 0.0236 0.0236
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0042 0.0236 0.0336
Entamoeba histolytica cysteine protease, putative 0.0484 0.3619 0.5264
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0908 0.6854 1
Mycobacterium tuberculosis Probable lipase LipE 0.01 0.0683 0.1417
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0908 0.6854 0.6854
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0058 0.0363 0.0497
Toxoplasma gondii cathepsin B 0.0543 0.4069 0.5936
Schistosoma mansoni voltage-gated potassium channel 0.0696 0.5235 0.5235
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0086 0.0576 0.0576
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0006 0.0006
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0196 0.1414 0.1414
Leishmania major cysteine peptidase A (CPA) 0.0908 0.6854 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0236
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0014 0.0024 0.0033
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0001 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0576 0.0576
Trichomonas vaginalis guanylate cyclase, putative 0.0058 0.0363 0.0497
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0236 0.0236
Trypanosoma brucei protein kinase A regulatory subunit 0.0086 0.0576 0.0839
Echinococcus granulosus potassium voltage gated channel protein 0.0042 0.0236 0.0236
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0042 0.0236 0.0236
Brugia malayi hypothetical protein 0.0042 0.0236 0.0236
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0011 0.0001 0.0001
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0042 0.0236 0.0236
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0024 0.0022
Echinococcus multilocularis isocitrate dehydrogenase 0.0011 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0086 0.0576 0.0839
Onchocerca volvulus 0.0908 0.6854 1
Echinococcus granulosus importin subunit beta 1 0.0033 0.0172 0.0172
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0042 0.0236 0.0236
Trichomonas vaginalis penicillin-binding protein, putative 0.01 0.0683 0.0965
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0086 0.0576 0.0839
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0196 0.1414 0.2035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0908 0.6854 1
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0086 0.0576 0.0839
Trichomonas vaginalis adenylyl cyclase type V, putative 0.0058 0.0363 0.0497
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0042 0.0236 0.0236
Echinococcus multilocularis hyperpolarization activated cyclic 0.0128 0.0896 0.0896
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1047 0.7922 0.7922
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0086 0.0576 0.0576
Entamoeba histolytica cysteine proteinase, putative 0.0908 0.6854 1
Trichomonas vaginalis adenylate cyclase type, putative 0.0058 0.0363 0.0497
Schistosoma mansoni coup transcription factor 0.0012 0.0006 0.0006
Echinococcus multilocularis cysteine protease 0.0908 0.6854 0.6854
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0128 0.0896 0.0896
Mycobacterium tuberculosis Probable esterase LipL 0.01 0.0683 0.1417
Loa Loa (eye worm) hypothetical protein 0.01 0.0683 0.0683
Echinococcus multilocularis transfer RNA-Gly 0.0042 0.0236 0.0236
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0061 0.038 0.038
Brugia malayi fibroinase precursor 0.0196 0.1414 0.1414
Entamoeba histolytica cysteine protease, putative 0.0484 0.3619 0.5264
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1319 1 1
Loa Loa (eye worm) AGC/PKG protein kinase 0.0086 0.0576 0.0576
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.01 0.0683 0.0683
Giardia lamblia Cathepsin L precursor 0.0196 0.1414 0.3436
Toxoplasma gondii preprocathepsin c precursor, putative 0.0196 0.1414 0.2061
Echinococcus granulosus hyperpolarization activated cyclic 0.0128 0.0896 0.0896
Echinococcus granulosus cathepsin l1 0.0908 0.6854 0.6854
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0128 0.0896 0.0896
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0006 0.0006
Brugia malayi Egg laying defective protein 4 0.0086 0.0576 0.0576
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0006 0.0006
Trichomonas vaginalis adenylate cyclase, putative 0.0058 0.0363 0.0497
Brugia malayi Papain family cysteine protease containing protein 0.0196 0.1414 0.1414
Echinococcus multilocularis hyperpolarization activated cyclic 0.0128 0.0896 0.0896
Echinococcus multilocularis geminin 0.0228 0.1657 0.1657
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0061 0.038 0.038
Echinococcus granulosus cathepsin b 0.1319 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0196 0.1414 0.1414
Loa Loa (eye worm) hypothetical protein 0.0551 0.4129 0.4129
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0006 0.0006
Entamoeba histolytica cysteine protease, putative 0.0484 0.3619 0.5264
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0042 0.0236 0.0336
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0196 0.1414 0.1414
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0236
Echinococcus granulosus two pore calcium channel protein 1 0.0042 0.0236 0.0236
Trichomonas vaginalis adenylate cyclase, putative 0.0058 0.0363 0.0497
Loa Loa (eye worm) hypothetical protein 0.0196 0.1414 0.1414
Giardia lamblia Cathepsin B precursor 0.0196 0.1414 0.3436
Onchocerca volvulus 0.01 0.0683 0.0988
Loa Loa (eye worm) hypothetical protein 0.1319 1 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0042 0.0236 0.0236
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0058 0.0363 0.0497
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0908 0.6854 1
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0042 0.0236 0.0235
Entamoeba histolytica cysteine protease, putative 0.0196 0.1414 0.2035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0006 0.0006
Mycobacterium tuberculosis Conserved hypothetical protein 0.0086 0.0576 0.1196
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0196 0.1414 0.2035
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0236
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0042 0.0236 0.0236
Mycobacterium tuberculosis Conserved protein 0.0086 0.0576 0.1196
Trichomonas vaginalis intestinal guanylate cyclase, putative 0.0058 0.0363 0.0497
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0236
Plasmodium falciparum serine repeat antigen 6 0.0196 0.1414 0.2061
Loa Loa (eye worm) hypothetical protein 0.0128 0.0896 0.0896
Mycobacterium leprae conserved hypothetical protein 0.01 0.0683 1
Echinococcus multilocularis ryanodine receptor 44f 0.0042 0.0236 0.0236
Toxoplasma gondii hypothetical protein 0.0042 0.0236 0.0343
Schistosoma mansoni DNA polymerase eta 0.0014 0.0024 0.0024
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0908 0.6854 1
Trichomonas vaginalis guanylate cyclase, putative 0.0058 0.0363 0.0497
Trichomonas vaginalis ran, putative 0.0025 0.0105 0.0119
Plasmodium vivax unspecified product 0.0289 0.2123 0.3095
Loa Loa (eye worm) hypothetical protein 0.0289 0.2123 0.2123
Giardia lamblia Cathepsin B precursor 0.0196 0.1414 0.3436
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0058 0.0363 0.0497
Schistosoma mansoni cathepsin C 0.0196 0.1414 0.1414
Brugia malayi nuclear hormone receptor 0.0012 0.0006 0.0006
Echinococcus multilocularis transient receptor potential gamma protein 0.0042 0.0236 0.0236
Trypanosoma cruzi cysteine proteinase, putative 0.0484 0.3619 0.3618
Echinococcus granulosus cathepsin L 0.0484 0.3619 0.3619
Brugia malayi N-terminal motif family protein 0.0196 0.1413 0.1413
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0196 0.1414 0.1414
Leishmania major protein kinase, putative 0.0086 0.0576 0.0839
Echinococcus granulosus potassium large conductance calcium activated 0.0042 0.0236 0.0236
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0196 0.1414 0.3436
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0042 0.0236 0.0236
Schistosoma mansoni hypothetical protein 0.0058 0.0363 0.0363
Echinococcus granulosus potassium voltage gated channel protein 0.0042 0.0236 0.0236
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0006
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0006 0.0006
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0042 0.0236 0.0236
Trichomonas vaginalis guanylate cyclase, putative 0.0058 0.0363 0.0497
Mycobacterium ulcerans beta-lactamase 0.01 0.0683 1
Echinococcus granulosus beta LACTamase domain containing family member 0.01 0.0683 0.0683
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0128 0.0896 0.0896
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0061 0.038 0.038
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0058 0.0363 0.0497
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0024 0.0024
Leishmania major cathepsin L-like protease 0.0908 0.6854 1
Trichomonas vaginalis guanylate cyclase, putative 0.0058 0.0363 0.0497
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0006
Brugia malayi cathepsin Z-like cysteine proteinase 0.0196 0.1414 0.1414
Echinococcus granulosus transient receptor potential cation channel 0.0042 0.0236 0.0236
Toxoplasma gondii transporter, cation channel family protein 0.0042 0.0236 0.0343
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0236 0.0236
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0006 0.0006
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0042 0.0236 0.0236
Brugia malayi cathepsin F-like cysteine proteinase 0.0289 0.2123 0.2123
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0042 0.0236 0.0236
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0124 0.0147
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0908 0.6854 1
Leishmania major DNA polymerase kappa, putative 0.0014 0.0024 0.0033
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0006 0.0006
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0196 0.1414 0.2061
Echinococcus multilocularis expressed conserved protein 0.0086 0.0576 0.0576
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0196 0.1414 0.2035
Entamoeba histolytica cysteine protease, putative 0.0484 0.3619 0.5264
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0908 0.6854 1
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0576 0.0809
Giardia lamblia Cathepsin B precursor 0.0543 0.4069 1
Entamoeba histolytica cysteine proteinase, putative 0.0484 0.3619 0.5264
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0637 0.4789 0.4789
Plasmodium vivax vivapain-3 0.0484 0.3619 0.528
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0236 0.0236
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0196 0.1414 0.2061
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0086 0.0576 0.0576
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0908 0.6854 0.6854
Trypanosoma cruzi cAMP binding protein, putative 0.0086 0.0576 0.0575
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0006 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0908 0.6854 1
Leishmania major GTP-binding protein, putative 0.0025 0.0105 0.0151
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0172 0.0249
Trypanosoma brucei DNA polymerase eta, putative 0.0014 0.0024 0.0033
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0236 0.0236
Brugia malayi Isocitrate dehydrogenase 0.0011 0.0001 0.0001
Entamoeba histolytica cysteine protease, putative 0.0484 0.3619 0.5264
Trichomonas vaginalis adenylate cyclase, putative 0.0058 0.0363 0.0497
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0363 0.0497
Trichomonas vaginalis D-aminoacylase, putative 0.01 0.0683 0.0965
Brugia malayi Papain family cysteine protease containing protein 0.0196 0.1414 0.1414
Onchocerca volvulus Cathepsin L homolog 0.0196 0.1414 0.2055
Entamoeba histolytica hypothetical protein 0.0196 0.1414 0.2035
Trypanosoma cruzi Flagellar Member 6 0.0086 0.0576 0.0575
Trichomonas vaginalis adenylate cyclase, putative 0.0058 0.0363 0.0497
Schistosoma mansoni cathepsin F (C01 family) 0.0908 0.6854 0.6854
Mycobacterium tuberculosis Probable lipase LipD 0.01 0.0683 0.1417
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.0024 0.0033
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0086 0.0576 0.0576
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0196 0.1414 0.2035
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0186 0.1342 0.1342
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0006 0.0006
Schistosoma mansoni voltage-gated cation channel 0.0042 0.0236 0.0236
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0042 0.0236 0.0236
Brugia malayi steroid hormone receptor 0.0012 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0908 0.6854 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0042 0.0236 0.0236
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0061 0.038 0.038
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0128 0.0896 0.0896
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0128 0.0896 0.0896
Trypanosoma cruzi cysteine peptidase, putative 0.0484 0.3619 0.3618
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0042 0.0236 0.0236
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0006 0.0006
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0006 0.0006
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0196 0.1414 0.2061
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0196 0.1414 0.1414
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0196 0.1414 0.1414
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0196 0.1414 0.2035
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0042 0.0236 0.0236
Brugia malayi Transient-receptor-potential like protein 0.0042 0.0236 0.0236
Mycobacterium tuberculosis Conserved hypothetical protein 0.0086 0.0576 0.1196
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0908 0.6854 1
Schistosoma mansoni hypothetical protein 0.0356 0.2641 0.2641
Trichomonas vaginalis guanylate cyclase, putative 0.0058 0.0363 0.0497
Schistosoma mansoni vesicular amine transporter 0.0042 0.0236 0.0236
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0236
Trypanosoma cruzi cysteine peptidase, putative 0.0908 0.6854 0.6854
Onchocerca volvulus 0.0908 0.6854 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0128 0.0896 0.0896
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0908 0.6854 1
Brugia malayi Importin beta-1 subunit 0.0033 0.0172 0.0172
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0006 0.0006
Echinococcus granulosus cathepsin L 0.0196 0.1414 0.1414
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0006 0.0006
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0196 0.1414 0.2061
Echinococcus granulosus calcium activated potassium channel 0.0042 0.0236 0.0236
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0024 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0196 0.1414 0.2035
Echinococcus multilocularis short transient receptor potential channel 6 0.0042 0.0236 0.0236
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1319 1 1
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0086 0.0576 0.1196
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0105 0.0105
Schistosoma mansoni cathepsin B (C01 family) 0.0196 0.1414 0.1414
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0196 0.1414 0.2035
Brugia malayi Cathepsin L-like precursor 0.0908 0.6854 0.6854
Entamoeba histolytica cysteine protease, putative 0.0484 0.3619 0.5264
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0196 0.1414 0.1414
Onchocerca volvulus 0.0196 0.1414 0.2055
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0024 0.0033
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0006 0.0006
Trichomonas vaginalis D-aminoacylase, putative 0.01 0.0683 0.0965
Echinococcus granulosus transient receptor potential cation channel 0.0042 0.0236 0.0236
Plasmodium falciparum cGMP-dependent protein kinase 0.0086 0.0576 0.0839
Onchocerca volvulus 0.01 0.0683 0.0988
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0042 0.0236 0.0236
Mycobacterium tuberculosis Probable conserved lipoprotein 0.01 0.0683 0.1417
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0024
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0484 0.3619 0.3619
Entamoeba histolytica cysteine protease, putative 0.0908 0.6854 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0058 0.0363 0.0497
Leishmania major regulatory subunit of protein kinase a-like protein 0.0086 0.0576 0.0839
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0024 0.0033
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.0024 0.0024
Loa Loa (eye worm) voltage-gated potassium channel 0.0042 0.0236 0.0236
Trypanosoma cruzi cysteine peptidase, putative 0.0908 0.6854 0.6854
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0001 0.0001
Entamoeba histolytica cysteine proteinase, putative 0.0619 0.4649 0.6771
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0196 0.1414 0.2061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0908 0.6854 1
Brugia malayi nuclear receptor NHR-88 0.0012 0.0006 0.0006
Loa Loa (eye worm) voltage-gated calcium channel 0.0042 0.0236 0.0236
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0363 0.0497
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0006 0.0006
Entamoeba histolytica cysteine proteinase 1, putative 0.0484 0.3619 0.5264
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0086 0.0576 0.0576
Trypanosoma brucei cysteine peptidase C (CPC) 0.0543 0.4069 0.5936
Trichomonas vaginalis adenylate cyclase type vIII, putative 0.0058 0.0363 0.0497
Brugia malayi beta-lactamase family protein 0.01 0.0683 0.0683
Mycobacterium ulcerans regulatory protein 0.0086 0.0576 0.8387
Giardia lamblia Cathepsin B precursor 0.0543 0.4069 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0042 0.0236 0.0236
Echinococcus granulosus geminin 0.0228 0.1657 0.1657
Echinococcus granulosus cysteine protease 0.0484 0.3619 0.3619
Loa Loa (eye worm) MH2 domain-containing protein 0.016 0.1136 0.1136
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0086 0.0576 0.0576
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0042 0.0236 0.0236
Brugia malayi cathepsin F-like cysteine proteinase 0.0196 0.1414 0.1414
Plasmodium vivax vivapain-1 0.0484 0.3619 0.528
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0042 0.0236 0.0236
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0196 0.1414 0.1414
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0908 0.6854 0.6854
Trichomonas vaginalis adenylate cyclase, putative 0.0058 0.0363 0.0497
Trichomonas vaginalis adenylate cyclase, putative 0.0058 0.0363 0.0497
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0042 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0006
Brugia malayi MH2 domain containing protein 0.016 0.1136 0.1136
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0086 0.0576 0.0839
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0086 0.0576 0.1196
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0086 0.0576 0.0576
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0128 0.0896 0.0896
Onchocerca volvulus 0.0042 0.0236 0.0336
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0042 0.0236 0.0236
Plasmodium vivax hypothetical protein, conserved 0.01 0.0683 0.0994
Onchocerca volvulus Cathepsin L homolog 0.0908 0.6854 1
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0086 0.0576 0.0839
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0196 0.1414 0.2035
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0042 0.0236 0.0236
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0042 0.0236 0.0236
Trichomonas vaginalis guanylate cyclase, putative 0.0058 0.0363 0.0497
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0908 0.6854 1
Brugia malayi Cathepsin L-like precursor 0.0908 0.6854 0.6854
Echinococcus granulosus cGMP dependent protein kinase 0.0086 0.0576 0.0576
Brugia malayi cathepsin L-like precursor 0.0619 0.4649 0.4649
Trypanosoma cruzi hypothetical protein, conserved 0.01 0.0683 0.0682
Loa Loa (eye worm) transcription factor SMAD2 0.016 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0196 0.1414 0.1414
Loa Loa (eye worm) hypothetical protein 0.01 0.0683 0.0683
Entamoeba histolytica cysteine protease, putative 0.0484 0.3619 0.5264
Schistosoma mansoni voltage-gated potassium channel 0.0128 0.0896 0.0896
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0006 0.0006
Trichomonas vaginalis D-aminoacylase, putative 0.01 0.0683 0.0965
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0042 0.0236 0.0236
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0042 0.0236 0.0236
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1319 1 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0289 0.2123 0.2123
Entamoeba histolytica Ran family GTPase 0.0025 0.0105 0.0119
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0086 0.0576 0.0839
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0024 0.0033
Trypanosoma cruzi protein kinase A regulatory subunit 0.0086 0.0576 0.0575
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0196 0.1414 0.2035
Leishmania major hypothetical protein, unknown function 0.0042 0.0236 0.0343
Echinococcus multilocularis dna polymerase eta 0.0014 0.0024 0.0024
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0042 0.0236 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0908 0.6854 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0128 0.0896 0.0896
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0042 0.0236 0.0236
Toxoplasma gondii cathepsin CPL 0.0908 0.6854 1
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.0024 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0196 0.1414 0.2035
Loa Loa (eye worm) hypothetical protein 0.01 0.0683 0.0683
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0908 0.6854 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0196 0.1414 0.2061
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0543 0.4069 0.4068
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0196 0.1414 0.1414
Leishmania major cathepsin L-like protease 0.0908 0.6854 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0196 0.1414 0.1414
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0086 0.0576 0.0576
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0124 0.0147
Loa Loa (eye worm) hypothetical protein 0.0289 0.2123 0.2123
Echinococcus multilocularis transient receptor potential cation channel 0.0042 0.0236 0.0236
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0124 0.0123
Schistosoma mansoni voltage-gated potassium channel 0.0186 0.1342 0.1342
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0006
Loa Loa (eye worm) calcium channel 0.0042 0.0236 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0006 0.0006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0024 0.0022
Trichomonas vaginalis esterase, putative 0.01 0.0683 0.0965
Trypanosoma cruzi major cysteine proteinase, putative 0.0196 0.1414 0.1413
Brugia malayi Cathepsin L-like precursor 0.0619 0.4649 0.4649
Echinococcus multilocularis two pore calcium channel protein 1 0.0042 0.0236 0.0236
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0042 0.0236 0.0236
Giardia lamblia Cathepsin B precursor 0.0196 0.1414 0.3436
Echinococcus granulosus cathepsin L cysteine protease 0.0484 0.3619 0.3619
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0637 0.4789 0.4789
Echinococcus granulosus cGMP dependent protein kinase 1 0.0086 0.0576 0.0576
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0363 0.0497
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0236
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0086 0.0576 0.0839
Onchocerca volvulus 0.01 0.0683 0.0988
Treponema pallidum cyclic nucleotide binding protein 0.0086 0.0576 0.5
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0196 0.1414 0.1414
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0001 0.0001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0006 0.0006
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0058 0.0363 0.0497
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0619 0.4649 0.6771
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0024 0.0022
Loa Loa (eye worm) hypothetical protein 0.01 0.0683 0.0683
Trichomonas vaginalis guanylate cyclase, putative 0.0058 0.0363 0.0497
Giardia lamblia Encystation-specific protease 0.0196 0.1414 0.3436
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0086 0.0576 0.0576
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0196 0.1414 0.2035
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0086 0.0576 0.0576
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0006
Entamoeba histolytica hypothetical protein 0.0027 0.0124 0.0147
Trichomonas vaginalis adenylate cyclase, putative 0.0058 0.0363 0.0497
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0484 0.3619 0.3618
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0543 0.4069 0.5936
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0061 0.038 0.038
Loa Loa (eye worm) hypothetical protein 0.01 0.0683 0.0683
Entamoeba histolytica cysteine proteinase, putative 0.0484 0.3619 0.5264
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0006 0.0006
Entamoeba histolytica cysteine protease, putative 0.0196 0.1414 0.2035
Plasmodium vivax vivapain-2 0.0908 0.6854 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0196 0.1414 0.3436
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0086 0.0576 0.0575
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0086 0.0576 0.0839
Onchocerca volvulus 0.0086 0.0576 0.0832
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0042 0.0236 0.0236
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0086 0.0576 0.0576
Trichomonas vaginalis guanylate cyclase, putative 0.0058 0.0363 0.0497
Echinococcus multilocularis cathepsin L 0.0196 0.1414 0.1414
Mycobacterium tuberculosis Conserved protein 0.01 0.0683 0.1417
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0484 0.3619 0.5264
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0236
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0128 0.0896 0.0896
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0024 0.0033
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0006 0.0006
Trichomonas vaginalis guanylate cyclase, putative 0.0058 0.0363 0.0497
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0236 0.0236
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0196 0.1414 0.2061
Trypanosoma brucei unspecified product 0.0014 0.0024 0.0033
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.01 0.0683 0.1417
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0006 0.0006
Leishmania major hypothetical protein, conserved 0.0042 0.0236 0.0343
Schistosoma mansoni cathepsin S (C01 family) 0.0196 0.1414 0.1414
Echinococcus granulosus short transient receptor potential channel 6 0.0042 0.0236 0.0236
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0908 0.6854 1
Echinococcus granulosus voltage dependent calcium channel 0.0042 0.0236 0.0236
Plasmodium vivax unspecified product 0.0484 0.3619 0.528
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0058 0.0363 0.0363
Trypanosoma brucei DNA polymerase IV, putative 0.0014 0.0024 0.0033
Mycobacterium ulcerans hypothetical protein 0.01 0.0683 1
Loa Loa (eye worm) hypothetical protein 0.0186 0.1342 0.1342
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0128 0.0896 0.0896
Giardia lamblia Cathepsin L-like protease 0.0196 0.1414 0.3436
Echinococcus multilocularis transient receptor potential cation channel 0.0042 0.0236 0.0236
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0105 0.0151
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0236 0.0236
Schistosoma mansoni calcium-activated potassium channel 0.0042 0.0236 0.0236
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0196 0.1414 0.2035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0908 0.6854 1
Schistosoma mansoni cathepsin F (C01 family) 0.0908 0.6854 0.6854
Trypanosoma cruzi cysteine peptidase, putative 0.0289 0.2123 0.2122
Schistosoma mansoni hypothetical protein 0.0086 0.0576 0.0576
Echinococcus granulosus dna polymerase eta 0.0014 0.0024 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0908 0.6854 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0484 0.3619 0.528
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0484 0.3619 0.3619
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0363 0.0497
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0058 0.0363 0.0497
Brugia malayi olfactory channel protein osm-9 0.0042 0.0236 0.0236
Mycobacterium ulcerans hypothetical protein 0.0086 0.0576 0.8387
Echinococcus granulosus two pore calcium channel protein 2 0.0042 0.0236 0.0236
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0086 0.0576 0.0839
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0105 0.0105
Trypanosoma cruzi cysteine protease, putative 0.0484 0.3619 0.3618
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0908 0.6854 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0908 0.6854 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0042 0.0236 0.0236
Trichomonas vaginalis adenylate cyclase, putative 0.0058 0.0363 0.0497
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0908 0.6854 1
Schistosoma mansoni voltage-gated potassium channel 0.0696 0.5235 0.5235
Echinococcus granulosus cathepsin l1 0.0619 0.4649 0.4649
Echinococcus multilocularis voltage gated potassium channel 0.0186 0.1342 0.1342
Toxoplasma gondii transporter, cation channel family protein 0.0042 0.0236 0.0343
Brugia malayi ecdysteroid receptor 0.0012 0.0006 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.01 0.0683 0.0682
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.01 0.0683 1
Toxoplasma gondii hypothetical protein 0.0042 0.0236 0.0343
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0086 0.0576 0.0576
Trichomonas vaginalis adenylate cyclase, putative 0.0058 0.0363 0.0497
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0236 0.0236
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0086 0.0576 0.0576
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0086 0.0576 0.0575
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0042 0.0236 0.0236
Entamoeba histolytica cysteine proteinase, putative 0.0908 0.6854 1
Giardia lamblia Cathepsin L precursor 0.0196 0.1414 0.3436
Plasmodium falciparum serine repeat antigen 1 0.0196 0.1414 0.2061
Schistosoma mansoni hypothetical protein 0.0042 0.0236 0.0236
Echinococcus multilocularis sodium channel protein 0.0042 0.0236 0.0236
Schistosoma mansoni transient receptor potential channel 0.0042 0.0236 0.0236
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0061 0.038 0.038
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0006 0.0006
Trypanosoma cruzi cysteine peptidase, putative 0.0908 0.6854 0.6854
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0086 0.0576 0.1196
Giardia lamblia Cathepsin L precursor 0.0196 0.1414 0.3436
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0058 0.0363 0.0497
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0196 0.1414 0.2061
Echinococcus multilocularis transient receptor potential cation channel 0.0042 0.0236 0.0236
Echinococcus multilocularis voltage gated potassium channel 0.0042 0.0236 0.0236
Trichomonas vaginalis hypothetical protein 0.0058 0.0363 0.0497
Trichomonas vaginalis adenylate cyclase, putative 0.0058 0.0363 0.0497
Onchocerca volvulus 0.0619 0.4649 0.6779
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0196 0.1414 0.2035
Loa Loa (eye worm) ryanodine receptor 0.0042 0.0236 0.0236
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0105 0.0103
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0042 0.0236 0.0236
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1319 1 1
Trypanosoma brucei cAMP binding protein, putative 0.0086 0.0576 0.0839
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0908 0.6854 1
Echinococcus multilocularis voltage dependent calcium channel 0.0042 0.0236 0.0236
Plasmodium falciparum serine repeat antigen 7 0.0196 0.1414 0.2061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0006 0.0006
Entamoeba histolytica cysteine protease, putative 0.0484 0.3619 0.5264
Plasmodium vivax serine-repeat antigen (SERA) 0.0196 0.1414 0.2061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0908 0.6854 1
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0006
Leishmania major cathepsin L-like protease 0.0908 0.6854 1
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0086 0.0576 0.0576
Giardia lamblia Cysteine protease 0.0196 0.1414 0.3436
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0363 0.0497
Onchocerca volvulus 0.0908 0.6854 1
Plasmodium falciparum serine repeat antigen 5 0.0196 0.1414 0.2061
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0236
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0014 0.0024 0.0024
Mycobacterium tuberculosis Conserved hypothetical protein 0.0014 0.0024 0.0047
Leishmania major hypothetical protein, conserved 0.0086 0.0576 0.0839
Brugia malayi cathepsin L precursor 0.0196 0.1414 0.1414
Trichomonas vaginalis guanylate cyclase, putative 0.0058 0.0363 0.0497
Echinococcus multilocularis beta LACTamase domain containing family member 0.01 0.0683 0.0683
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0086 0.0576 0.0839
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0105 0.0103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0908 0.6854 1
Giardia lamblia Cathepsin B precursor 0.0196 0.1414 0.3436
Brugia malayi Cathepsin L-like precursor 0.0908 0.6854 0.6854
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0908 0.6854 1
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0086 0.0576 0.0576
Echinococcus multilocularis transient receptor potential cation channel 0.0042 0.0236 0.0236
Echinococcus granulosus cathepsin b 0.1319 1 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0196 0.1414 0.2061
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0011 0.0001 0.0001
Brugia malayi Cyclic-nucleotide gated cation channel 0.0128 0.0896 0.0896
Echinococcus multilocularis cathepsin L cysteine protease 0.0908 0.6854 0.6854
Echinococcus granulosus cGMP dependent protein kinase 1 0.0086 0.0576 0.0576
Trichomonas vaginalis adenylate cyclase type III, putative 0.0058 0.0363 0.0497
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0024 0.0033
Trichomonas vaginalis guanylate cyclase beta 1 subunit, putative 0.0058 0.0363 0.0497
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0196 0.1413 0.2055
Giardia lamblia Cathepsin L precursor 0.0196 0.1414 0.3436
Schistosoma mansoni ran 0.0025 0.0105 0.0105
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0042 0.0236 0.0235
Plasmodium falciparum importin beta, putative 0.0033 0.0172 0.0249
Echinococcus granulosus cathepsin L cysteine proteinase 0.0908 0.6854 0.6854
Echinococcus multilocularis transient receptor potential cation channel 0.0042 0.0236 0.0236
Toxoplasma gondii cathepsin CPC2 0.0196 0.1414 0.2061
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0236 0.0236
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0006 0.0006
Brugia malayi cathepsin Z-like cysteine proteinase 0.0196 0.1414 0.1414
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0006 0.0006
Trypanosoma cruzi major cysteine proteinase, putative 0.0196 0.1414 0.1413
Loa Loa (eye worm) hypothetical protein 0.0196 0.1414 0.1414
Echinococcus granulosus cathepsin l cysteine peptidase 0.0908 0.6854 0.6854
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0363 0.0497
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0006 0.0006
Echinococcus multilocularis voltage dependent calcium channel 0.0042 0.0236 0.0236
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0196 0.1414 0.2061
Trichomonas vaginalis adenylate cyclase, putative 0.0058 0.0363 0.0497
Plasmodium vivax unspecified product 0.0196 0.1414 0.2061
Schistosoma mansoni transient receptor potential channel 4 0.0042 0.0236 0.0236
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0058 0.0363 0.0497
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0042 0.0236 0.0236
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0058 0.0363 0.0497
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0196 0.1414 0.2035
Loa Loa (eye worm) voltage-dependent calcium channel 0.0042 0.0236 0.0236
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0042 0.0236 0.0236
Mycobacterium ulcerans lipase LipD 0.01 0.0683 1
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0042 0.0236 0.0343
Giardia lamblia Cathepsin B precursor 0.0196 0.1414 0.3436
Echinococcus granulosus voltage gated potassium channel 0.0042 0.0236 0.0236
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0172 0.0249
Echinococcus multilocularis dna polymerase kappa 0.0014 0.0024 0.0024
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0356 0.2641 0.2641
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0236
Echinococcus granulosus transient receptor potential cation channel 0.0042 0.0236 0.0236
Brugia malayi RNA, U transporter 1 0.0095 0.0642 0.0642
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0086 0.0576 0.1366
Leishmania major cyclic nucleotide-binding protein-like protein 0.0086 0.0576 0.0839
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0024 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0061 0.038 0.038
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0006 0.0006
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0124 0.0147
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0236
Entamoeba histolytica cysteine protease, putative 0.0196 0.1414 0.2035
Brugia malayi Cathepsin L-like cysteine proteinase 0.0619 0.4649 0.4649
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0363 0.0497
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0196 0.1414 0.2035
Echinococcus multilocularis conserved hypothetical protein 0.0042 0.0236 0.0236
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0908 0.6854 1
Entamoeba histolytica cysteine protease, putative 0.0484 0.3619 0.5264
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0196 0.1414 0.3436
Loa Loa (eye worm) hypothetical protein 0.0042 0.0236 0.0236
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0058 0.0363 0.0497
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0086 0.0576 0.0576
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0236 0.0236
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0058 0.0363 0.0528
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0128 0.0896 0.0896
Echinococcus granulosus transient receptor potential cation channel 0.0042 0.0236 0.0236
Echinococcus granulosus transient receptor potential cation channel 0.0042 0.0236 0.0236
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0363 0.0497
Echinococcus multilocularis short transient receptor potential channel 6 0.0042 0.0236 0.0236
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0006 0.0006
Plasmodium vivax vivapain-2 0.0908 0.6854 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0186 0.1342 0.1342
Schistosoma mansoni transient receptor potential channel 0.0042 0.0236 0.0236
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0042 0.0236 0.0343
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0908 0.6854 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0024 0.0033
Treponema pallidum catabolite gene activator (Crp) 0.0086 0.0576 0.5
Trichomonas vaginalis adenylate cyclase, putative 0.0058 0.0363 0.0497
Loa Loa (eye worm) hypothetical protein 0.0619 0.4649 0.4649
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0128 0.0896 0.0896
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0024 0.0033
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0196 0.1414 0.2061
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0484 0.3619 0.3619
Trichomonas vaginalis adenylate cyclase type, putative 0.0058 0.0363 0.0497
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0105 0.0151
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0196 0.1414 0.2035
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0086 0.0576 0.0809
Loa Loa (eye worm) hypothetical protein 0.0196 0.1414 0.1414
Schistosoma mansoni voltage-gated ion channel 0.0042 0.0236 0.0236
Trichomonas vaginalis guanylate cyclase, putative 0.0058 0.0363 0.0497
Schistosoma mansoni voltage-gated potassium channel 0.0186 0.1342 0.1342
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0042 0.0236 0.0343
Leishmania major cathepsin L-like protease 0.0908 0.6854 1
Echinococcus granulosus dna polymerase kappa 0.0014 0.0024 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0196 0.1414 0.2035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0061 0.038 0.038
Trichomonas vaginalis guanylate cyclase, putative 0.0058 0.0363 0.0497
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0236 0.0236
Echinococcus granulosus potassium voltage gated channel protein 0.0042 0.0236 0.0236
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0105 0.0151
Trichomonas vaginalis guanylate cyclase, putative 0.0058 0.0363 0.0497
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0042 0.0236 0.0236

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.152 uM Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand ChEMBL. 17967909
TC50 (ADMET) = 71.7 uM Cytotoxicity against human CEM-SS cells by XTT assay ChEMBL. 17967909
TC50 (ADMET) = 71.7 uM Cytotoxicity against human HeLa cells expressing CD4-LTR by XTT assay ChEMBL. 17967909

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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