pI: 7.6656 |
Length (AA): 761 |
MW (Da): 85478 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 469 | 3lnm (D) | 31 | 413 | 50.00 | 0 | 1 | 0.513166 | 2.05 |
4 | 106 | 3kvt (A) | 9 | 111 | 92.00 | 0 | 1 | 1.29785 | -1.48 |
280 | 469 | 2a79 (B) | 222 | 417 | 55.00 | 0 | 0.66 | 0.324171 | 2.86 |
343 | 465 | 1orq (C) | 113 | 235 | 31.00 | 0.0000000000066 | 0.15 | 0.324129 | 1.47 |
543 | 758 | 4k6j (A) | 800 | 1032 | 6.00 | 0 | 0 | 0.380937 | -0.56 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129143)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_00905 | Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit |
Brugia malayi | Bm1_00900 | Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit |
Caenorhabditis elegans | CELE_R07A4.1 | Protein EGL-36 |
Caenorhabditis elegans | CELE_F14F11.1 | Protein SHW-1, isoform A |
Caenorhabditis elegans | CELE_R186.5 | Protein SHW-3 |
Drosophila melanogaster | Dmel_CG2822 | Shaker cognate w |
Echinococcus granulosus | EgrG_000323700 | Potassium voltage gated channel protein Shaw |
Echinococcus granulosus | EgrG_000570000 | potassium voltage gated channel subfamily D |
Echinococcus granulosus | EgrG_001009000 | voltage gated potassium channel |
Echinococcus multilocularis | EmuJ_000570000 | potassium voltage gated channel subfamily D |
Echinococcus multilocularis | EmuJ_001009000 | voltage gated potassium channel |
Echinococcus multilocularis | EmuJ_000323700 | transfer RNA-Gly |
Homo sapiens | 3749 | potassium voltage-gated channel, Shaw-related subfamily, member 4 |
Homo sapiens | ENSG00000131398 | potassium voltage-gated channel, Shaw-related subfamily, member 3 |
Homo sapiens | ENSG00000129159 | potassium voltage-gated channel, Shaw-related subfamily, member 1 |
Homo sapiens | ENSG00000166006 | potassium voltage-gated channel, Shaw-related subfamily, member 2 |
Loa Loa (eye worm) | LOAG_15921 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15437 | voltage-gated potassium channel |
Loa Loa (eye worm) | LOAG_14361 | hypothetical protein |
Loa Loa (eye worm) | LOAG_01086 | hypothetical protein |
Loa Loa (eye worm) | LOAG_01085 | hypothetical protein |
Mus musculus | ENSMUSG00000058975 | potassium voltage gated channel, Shaw-related subfamily, member 1 |
Mus musculus | ENSMUSG00000062785 | potassium voltage gated channel, Shaw-related subfamily, member 3 |
Mus musculus | ENSMUSG00000027895 | potassium voltage gated channel, Shaw-related subfamily, member 4 |
Mus musculus | ENSMUSG00000035681 | potassium voltage gated channel, Shaw-related subfamily, member 2 |
Onchocerca volvulus | OVOC10843 |
|
Schistosoma japonicum | Sjp_0044910 | Potassium voltage-gated channel protein Shaw, putative |
Schistosoma japonicum | Sjp_0063830 | Potassium voltage-gated channel protein Shaw, putative |
Schistosoma japonicum | Sjp_0044920 | ko:K05320 potassium voltage-gated channel, Shaw-related subfamily C,, putative |
Schistosoma mansoni | Smp_163090.2 | voltage-gated potassium channel |
Schistosoma mansoni | Smp_163090.1 | voltage-gated potassium channel |
Schmidtea mediterranea | mk4.004189.02 | Putative vesicular amine transporter |
Schmidtea mediterranea | mk4.007176.00 | |
Schmidtea mediterranea | mk4.026594.00 | |
Schmidtea mediterranea | mk4.024763.01 | Voltage-gated potassium channel, putative |
Schmidtea mediterranea | mk4.020848.00 | |
Schmidtea mediterranea | mk4.003802.00 | |
Schmidtea mediterranea | mk4.014959.01 | |
Schmidtea mediterranea | mk4.020018.00 | |
Schmidtea mediterranea | mk4.004189.01 | Voltage-gated potassium channel, putative |
Schmidtea mediterranea | mk4.009243.00 | |
Schmidtea mediterranea | mk4.024763.00 | Voltage-gated potassium channel, putative |
Schmidtea mediterranea | mk4.020042.01 | Putative vesicular amine transporter |
Schmidtea mediterranea | mk4.007226.00 | |
Schmidtea mediterranea | mk4.019585.01 | |
Schmidtea mediterranea | mk4.000491.03 | Voltage-gated potassium channel, putative |
Schmidtea mediterranea | mk4.000713.09 | |
Schmidtea mediterranea | mk4.027019.00 | Voltage-gated potassium channel, putative |
Schmidtea mediterranea | mk4.000164.05 | |
Schmidtea mediterranea | mk4.000713.08 | |
Schmidtea mediterranea | mk4.020848.01 | |
Schmidtea mediterranea | mk4.000164.06 | |
Schmidtea mediterranea | mk4.005153.06 | |
Schmidtea mediterranea | mk4.001790.01 | |
Schmidtea mediterranea | mk4.006807.01 | Voltage-gated potassium channel, putative |
Schmidtea mediterranea | mk4.009017.03 | Putative vesicular amine transporter |
Schmidtea mediterranea | mk4.000899.05 | Voltage-gated potassium channel, putative |
Schmidtea mediterranea | mk4.017592.00 | |
Schmidtea mediterranea | mk4.029124.00 | |
Schmidtea mediterranea | mk4.003802.01 | |
Schmidtea mediterranea | mk4.020092.00 | Putative vesicular amine transporter |
Schmidtea mediterranea | mk4.009243.01 | |
Schmidtea mediterranea | mk4.020042.00 | Voltage-gated potassium channel, putative |
Schmidtea mediterranea | mk4.000491.04 | |
Schmidtea mediterranea | mk4.000012.14 | |
Schmidtea mediterranea | mk4.029656.00 | |
Schmidtea mediterranea | mk4.000491.07 | Voltage-gated potassium channel, putative |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Rattus norvegicus | Potassium voltage-gated channel subfamily C member 1 | Compounds | References |