Detailed information for compound 1740756

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 377.418 | Formula: C16H19N5O4S
  • H donors: 4 H acceptors: 6 LogP: -0.44 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H]([C@@H](C(=O)NS(=O)(=O)/C=C/c1cccc(c1)c1ncnc(c1)N)N)O
  • InChi: 1S/C16H19N5O4S/c1-10(22)15(18)16(23)21-26(24,25)6-5-11-3-2-4-12(7-11)13-8-14(17)20-9-19-13/h2-10,15,22H,18H2,1H3,(H,21,23)(H2,17,19,20)/b6-5+/t10-,15+/m1/s1
  • InChiKey: KUPGDBTUKULRSA-ISPAPPPSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Yersinia pestis Threonine--tRNA ligase Starlite/ChEMBL References
Homo sapiens threonyl-tRNA synthetase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis threonyl-tRNA synthetase Get druggable targets OG5_126764 All targets in OG5_126764
Entamoeba histolytica threonyl-tRNA synthetase, putative Get druggable targets OG5_126764 All targets in OG5_126764
Echinococcus granulosus Threonyl tRNA synthetase C Get druggable targets OG5_126764 All targets in OG5_126764
Theileria parva threonyl-tRNA synthetase, putative Get druggable targets OG5_126764 All targets in OG5_126764
Leishmania infantum threonyl-tRNA synthetase, putative Get druggable targets OG5_126764 All targets in OG5_126764
Treponema pallidum threonyl-tRNA synthetase Get druggable targets OG5_126764 All targets in OG5_126764
Trypanosoma cruzi threonyl-tRNA synthetase, putative Get druggable targets OG5_126764 All targets in OG5_126764
Mycobacterium ulcerans threonyl-tRNA synthetase Get druggable targets OG5_126764 All targets in OG5_126764
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase Get druggable targets OG5_126764 All targets in OG5_126764
Plasmodium yoelii threonyl-tRNA synthetase, putative Get druggable targets OG5_126764 All targets in OG5_126764
Trypanosoma congolense threonyl-tRNA synthetase, putative Get druggable targets OG5_126764 All targets in OG5_126764
Schistosoma mansoni threonyl-tRNA synthetase Get druggable targets OG5_126764 All targets in OG5_126764
Plasmodium falciparum threonine--tRNA ligase Get druggable targets OG5_126764 All targets in OG5_126764
Leishmania braziliensis threonyl-tRNA synthetase, putative Get druggable targets OG5_126764 All targets in OG5_126764
Brugia malayi threonyl-tRNA synthetase, cytoplasmic Get druggable targets OG5_126764 All targets in OG5_126764
Toxoplasma gondii threonyl-tRNA synthetase family protein Get druggable targets OG5_126764 All targets in OG5_126764
Loa Loa (eye worm) threonyl-tRNA synthetase Get druggable targets OG5_126764 All targets in OG5_126764
Giardia lamblia Threonyl-tRNA synthetase Get druggable targets OG5_126764 All targets in OG5_126764
Plasmodium knowlesi threonine--tRNA ligase, putative Get druggable targets OG5_126764 All targets in OG5_126764
Leishmania donovani threonyl-tRNA synthetase, putative Get druggable targets OG5_126764 All targets in OG5_126764
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) Get druggable targets OG5_126764 All targets in OG5_126764
Leishmania mexicana threonyl-tRNA synthetase, putative Get druggable targets OG5_126764 All targets in OG5_126764
Trypanosoma brucei threonyl-tRNA synthetase, putative Get druggable targets OG5_126764 All targets in OG5_126764
Echinococcus multilocularis Threonyl tRNA synthetase, C Get druggable targets OG5_126764 All targets in OG5_126764
Leishmania major threonyl-tRNA synthetase, putative Get druggable targets OG5_126764 All targets in OG5_126764
Trichomonas vaginalis threonyl-tRNA synthetase, putative Get druggable targets OG5_126764 All targets in OG5_126764
Candida albicans similar to S. cerevisiae THS1 (YIL078W) cytoplasmic threonyl-tRNA synthetase Get druggable targets OG5_126764 All targets in OG5_126764
Babesia bovis threonyl-tRNA synthetase, putative Get druggable targets OG5_126764 All targets in OG5_126764
Cryptosporidium parvum threonyl-tRNA synthetase (RNA binding domain TGS+HxxxH+tRNA synthetase) Get druggable targets OG5_126764 All targets in OG5_126764
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) Get druggable targets OG5_126764 All targets in OG5_126764
Schistosoma japonicum ko:K01868 threonyl-tRNA synthetase [EC6.1.1.3], putative Get druggable targets OG5_126764 All targets in OG5_126764
Plasmodium berghei threonine--tRNA ligase, putative Get druggable targets OG5_126764 All targets in OG5_126764
Plasmodium vivax threonine--tRNA ligase, putative Get druggable targets OG5_126764 All targets in OG5_126764
Trypanosoma brucei gambiense threonyl-tRNA synthetase, putative Get druggable targets OG5_126764 All targets in OG5_126764
Chlamydia trachomatis threonine--tRNA ligase Get druggable targets OG5_126764 All targets in OG5_126764
Neospora caninum hypothetical protein Get druggable targets OG5_126764 All targets in OG5_126764
Trypanosoma cruzi threonyl-tRNA synthetase, putative Get druggable targets OG5_126764 All targets in OG5_126764
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Threonine--tRNA ligase   642 aa 630 aa 39.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0089 1 0.5
Echinococcus granulosus shaker cognate 0.0089 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 1 1
Echinococcus multilocularis voltage dependent calcium channel 0.0089 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0089 1 1
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0089 1 1
Schistosoma mansoni voltage-dependent calcium channel 0.0089 1 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0089 1 1
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0089 1 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0089 1 1
Echinococcus granulosus voltage gated potassium channel 0.0089 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0089 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0089 1 1
Toxoplasma gondii hypothetical protein 0.0089 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 1 1
Echinococcus multilocularis transient receptor potential gamma protein 0.0089 1 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0089 1 1
Brugia malayi Cyclic-nucleotide gated cation channel 0.0089 1 1
Echinococcus granulosus short transient receptor potential channel 6 0.0089 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.0089 1 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0089 1 1
Schistosoma mansoni ryanodine receptor related 0.0089 1 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0089 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0089 1 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0089 1 1
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0089 1 1
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0089 1 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0089 1 1
Toxoplasma gondii transporter, cation channel family protein 0.0089 1 1
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0089 1 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0089 1 1
Echinococcus multilocularis potassium large conductance calcium activated 0.0089 1 1
Echinococcus granulosus transient receptor potential cation channel 0.0089 1 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0089 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 1 1
Echinococcus granulosus transient receptor potential gamma protein 0.0089 1 1
Loa Loa (eye worm) ion channel NompC 0.0089 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0089 1 1
Echinococcus multilocularis sodium channel protein 0.0089 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0089 1 1
Echinococcus granulosus hypothetical protein 0.0089 1 1
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0089 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0089 1 1
Echinococcus granulosus transient receptor potential cation channel 0.0089 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0089 1 1
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0089 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.0089 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0089 1 1
Echinococcus multilocularis two pore calcium channel protein 2 0.0089 1 1
Schistosoma mansoni calcium-activated potassium channel 0.0089 1 1
Echinococcus granulosus transient receptor potential cation channel 0.0089 1 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0089 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 1 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0089 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0089 1 1
Brugia malayi cation channel family protein 0.0089 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 1 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0089 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0089 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0089 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0089 1 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0089 1 1
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0089 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0089 1 1
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0089 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0089 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0089 1 1
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0089 1 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0089 1 1
Schistosoma mansoni hypothetical protein 0.0089 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0089 1 1
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0089 1 1
Echinococcus multilocularis voltage gated potassium channel 0.0089 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.0089 1 1
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0059 0.1591 0.5
Loa Loa (eye worm) hypothetical protein 0.0089 1 1
Onchocerca volvulus 0.0089 1 0.5
Echinococcus granulosus potassium voltage gated channel protein 0.0089 1 1
Echinococcus granulosus potassium large conductance calcium activated 0.0089 1 1
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0089 1 1
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0089 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0089 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0089 1 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0089 1 1
Loa Loa (eye worm) voltage-gated potassium channel 0.0089 1 1
Loa Loa (eye worm) voltage-gated potassium channel 0.0089 1 1
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0089 1 1
Echinococcus granulosus calcium activated potassium channel 0.0089 1 1
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0089 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0089 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0089 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 1 1
Echinococcus multilocularis conserved hypothetical protein 0.0089 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0089 1 1
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0089 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0089 1 1
Schistosoma mansoni 60S ribosomal protein L21 0.0089 1 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0089 1 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0089 1 1
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0059 0.1591 0.5
Echinococcus granulosus voltage gated hydrogen channel 1 0.0089 1 1
Toxoplasma gondii transporter, cation channel family protein 0.0089 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 1 1
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0059 0.1591 0.5
Echinococcus granulosus potassium voltage gated channel protein 0.0089 1 1
Echinococcus granulosus two pore calcium channel protein 1 0.0089 1 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0089 1 1
Echinococcus granulosus transient receptor potential cation channel 0.0089 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 1 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0089 1 1
Toxoplasma gondii hypothetical protein 0.0089 1 1
Loa Loa (eye worm) voltage-gated calcium channel 0.0089 1 1
Brugia malayi hypothetical protein 0.0089 1 1
Brugia malayi voltage-dependent calcium channel 0.0089 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0089 1 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0089 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 1 1
Schistosoma mansoni vesicular amine transporter 0.0089 1 1
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0089 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 1 1
Schistosoma mansoni transient receptor potential channel 0.0089 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0089 1 1
Echinococcus granulosus sodium channel protein 0.0089 1 1
Plasmodium vivax threonine--tRNA ligase, putative 0.0059 0.1591 0.5
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0089 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 1 1
Echinococcus multilocularis calcium activated potassium channel 0.0089 1 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0089 1 1
Plasmodium falciparum threonine--tRNA ligase 0.0059 0.1591 0.5
Loa Loa (eye worm) hypothetical protein 0.0089 1 1
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0089 1 1
Loa Loa (eye worm) voltage-dependent calcium channel 0.0089 1 1
Echinococcus granulosus potassium voltage gated channel protein 0.0089 1 1
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0089 1 1
Echinococcus granulosus ryanodine receptor 44f 0.0089 1 1
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0089 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 1 1
Echinococcus granulosus two pore calcium channel protein 2 0.0089 1 1
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0059 0.1591 0.5
Echinococcus granulosus TRP transient receptor potential channel 0.0089 1 1
Echinococcus multilocularis two pore calcium channel protein 1 0.0089 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0089 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.0089 1 1
Echinococcus granulosus short transient receptor potential channel 6 0.0089 1 1
Treponema pallidum threonyl-tRNA synthetase 0.0059 0.1591 0.5
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0089 1 1
Echinococcus multilocularis ryanodine receptor 44f 0.0089 1 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0089 1 1
Echinococcus multilocularis sodium leak channel non selective protein 0.0089 1 1
Schistosoma mansoni voltage-gated ion channel 0.0089 1 1
Schistosoma mansoni transient receptor potential channel 0.0089 1 1
Leishmania major hypothetical protein, unknown function 0.0089 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.0089 1 1
Echinococcus granulosus voltage dependent calcium channel 0.0089 1 1
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0089 1 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0089 1 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0089 1 1
Loa Loa (eye worm) ryanodine receptor 0.0089 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0089 1 1
Brugia malayi ion channel NompC 0.0089 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0089 1 1
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0089 1 0.5
Echinococcus multilocularis voltage gated potassium channel 0.0089 1 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0089 1 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0089 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0089 1 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0089 1 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0089 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 1 1
Echinococcus granulosus transient receptor potential cation channel 0.0089 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0089 1 1
Schistosoma mansoni transient receptor potential channel 4 0.0089 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0089 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0089 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0089 1 1
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0089 1 1
Schistosoma mansoni voltage-gated cation channel 0.0089 1 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0089 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0089 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0089 1 1
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0089 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 1 1
Giardia lamblia Threonyl-tRNA synthetase 0.0059 0.1591 0.5
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0089 1 1
Echinococcus granulosus voltage gated potassium channel 0.0089 1 1
Toxoplasma gondii transporter, cation channel family protein 0.0089 1 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0089 1 1
Loa Loa (eye worm) hypothetical protein 0.0089 1 1
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0059 0.1591 0.5
Echinococcus multilocularis transfer RNA-Gly 0.0089 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.0089 1 1
Echinococcus granulosus potassium voltage gated channel protein 0.0089 1 1
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0089 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0089 1 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0089 1 1
Leishmania major hypothetical protein, conserved 0.0089 1 1
Echinococcus granulosus voltage dependent calcium channel 0.0089 1 1
Brugia malayi Transient-receptor-potential like protein 0.0089 1 1
Echinococcus granulosus potassium voltage gated channel protein 0.0089 1 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0089 1 1
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0089 1 1
Echinococcus granulosus sodium leak channel non selective protein 0.0089 1 1
Echinococcus multilocularis shaker cognate 0.0089 1 1
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0089 1 1
Schistosoma mansoni transient receptor potential channel 0.0089 1 1
Echinococcus multilocularis voltage dependent calcium channel 0.0089 1 1
Loa Loa (eye worm) calcium channel 0.0089 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0089 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0089 1 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0089 1 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0089 1 1
Echinococcus granulosus transient receptor potential cation channel 0.0089 1 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0089 1 1
Schistosoma mansoni two-pore calcium channel 0.0089 1 1
Brugia malayi cation channel family protein 0.0089 1 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0089 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0089 1 1
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0089 1 1
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0089 1 1
Chlamydia trachomatis threonine--tRNA ligase 0.0067 0.3813 0.5

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.8 nM Binding affinity to Yersinia pestis ThrRS by coupled spectrophotometry ChEMBL. 23362938
Ki (binding) = 4.1 nM Binding affinity to human cytoplasmic ThrRS by coupled spectrophotometry ChEMBL. 23362938
MIC (functional) = 64 ug ml-1 Antimicrobial activity against Escherichia coli BW25113 expressing TolC Leu13-Ala480 deletion mutant measured after overnight incubation by alamarBlue assay ChEMBL. 23362938

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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