Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6) | 0.0213 | 0.8388 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0071 | 0.2642 | 0.3501 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.061 | 0.1783 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0032 | 0.1085 | 0.1229 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0042 | 0.1482 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.7097 | 0.8414 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0042 | 0.1482 | 0.5311 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.061 | 0.045 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0029 | 0.0963 | 0.3 |
Brugia malayi | Pre-SET motif family protein | 0.0223 | 0.8762 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.1085 | 0.1034 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0046 | 0.1635 | 0.1492 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0046 | 0.1635 | 1 |
Toxoplasma gondii | Myb family DNA-binding domain-containing protein | 0.0009 | 0.017 | 0.1041 |
Echinococcus multilocularis | geminin | 0.0181 | 0.7097 | 1 |
Echinococcus granulosus | geminin | 0.0181 | 0.7097 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0071 | 0.2642 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.7097 | 0.8414 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.061 | 0.043 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.0963 | 0.0845 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0223 | 0.8762 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1085 | 0.0989 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.1085 | 0.1034 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0009 | 0.017 | 0.0002 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.061 | 0.3728 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.061 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0011 | 0.0243 | 0.1486 |
Leishmania major | cytochrome p450-like protein | 0.0029 | 0.0963 | 0.3 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0071 | 0.2642 | 0.2817 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0071 | 0.2642 | 0.3501 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0071 | 0.2642 | 0.2817 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0151 | 0.5866 | 0.8205 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.1085 | 0.1034 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0046 | 0.1635 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0029 | 0.0963 | 0.0884 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.061 | 0.1528 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.061 | 0.1528 |
Loa Loa (eye worm) | acetyltransferase | 0.0155 | 0.6041 | 0.6806 |
Brugia malayi | Pre-SET motif family protein | 0.0032 | 0.1085 | 0.0989 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.0963 | 0.0845 |
Trichomonas vaginalis | set domain proteins, putative | 0.0253 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0029 | 0.0963 | 0.3 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0071 | 0.2642 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0046 | 0.1635 | 0.1492 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit A | 0.0213 | 0.8388 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.0963 | 0.0845 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.061 | 0.3349 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit A | 0.0213 | 0.8388 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.061 | 0.0535 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0031 | 0.1038 | 0.116 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0046 | 0.1635 | 1 |
Schistosoma mansoni | ATP synthase F0 subunit 6 | 0.0213 | 0.8388 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0032 | 0.1085 | 0.1229 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.061 | 0.0535 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0071 | 0.2642 | 1 |
Trichomonas vaginalis | MYB, putative | 0.0009 | 0.017 | 0.0002 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0041 | 0.1445 | 0.1754 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0029 | 0.0963 | 0.0845 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0032 | 0.1085 | 0.6637 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0009 | 0.017 | 0.0002 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0155 | 0.6041 | 0.7118 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0071 | 0.2642 | 0.2946 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.061 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.052 | 0.0325 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0032 | 0.1085 | 0.1034 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.061 | 0.045 |
Mycobacterium tuberculosis | Probable ATP synthase a chain AtpB (protein 6) | 0.0213 | 0.8388 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0155 | 0.6041 | 0.846 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.061 | 0.045 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0032 | 0.1085 | 0.1229 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0071 | 0.2642 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0071 | 0.2642 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.0963 | 0.0845 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.061 | 0.1528 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.061 | 0.045 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.061 | 0.3728 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0155 | 0.6041 | 0.6806 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.061 | 0.1528 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0029 | 0.0963 | 0.3 |
Plasmodium vivax | SET domain protein, putative | 0.0032 | 0.1085 | 0.6637 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0046 | 0.1635 | 0.2031 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.061 | 0.0449 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0041 | 0.1445 | 0.1754 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.061 | 0.0449 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0042 | 0.1482 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.6 uM | Evaluated for the antioxidant property by measuring the inhibition of microsomal lipid peroxidation | ChEMBL. | 11206462 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.