Detailed view for ATP6

Basic information

TDR Targets ID: 3184
Schistosoma mansoni, ATP synthase F0 subunit 6
Source Database / ID:  GeneDB

pI: 7.6014 | Length (AA): 173 | MW (Da): 20329 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 5

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0016020   membrane  
GO:0005524   ATP binding  
GO:0005388   calcium-transporting ATPase activity  
GO:0003824   catalytic activity  
GO:0008152   metabolic process  
GO:0006816   calcium ion transport  
GO:0006812   cation transport  
GO:0006754   ATP biosynthetic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
623 800 1mo7 (A) 413 595 22.00 0 1 0.38 0.44
668 960 2b8e (A) 416 663 24.00 0 1 -0.03 0.63
4 169 3ne5 (A) 871 1037 10.00 0 0.02 1.00264 0.32
51 131 3mpq (A) 93 190 35.00 0.44 0.02 0.339508 2.45

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite. PlasmoDB
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_128903)

Species Accession Gene Product
Arabidopsis thaliana ArthMp035   ATPase subunit 6
Arabidopsis thaliana AT2G07741   ATPase, F0 complex, subunit A protein
Arabidopsis thaliana ArthMp098   ATPase subunit 6
Arabidopsis thaliana ArthCp010   ATPase IV subunit
Candida albicans CaalfMp06   ATPase subunit 6
Dictyostelium discoideum DidioMp19   ATPase subunit 6
Escherichia coli b3738   F0 sector of membrane-bound ATP synthase, subunit a
Homo sapiens 4508   ATP synthase F0 subunit 6
Mycobacterium leprae ML1139   PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6)
Mus musculus 17705   ATP synthase F0 subunit 6
Mycobacterium tuberculosis Rv1304   Probable ATP synthase a chain AtpB (protein 6)
Mycobacterium ulcerans MUL_3960   F0F1 ATP synthase subunit A
Oryza sativa 9271958   Os10g0355100
Oryza sativa 6450195   ATP synthase F0 subunit 6
Oryza sativa 4349180   Os10g0527100
Oryza sativa 3131393   ATPase IV subunit
Saccharomyces cerevisiae Q0085   F1F0 ATP synthase subunit A
Schistosoma japonicum Sjp_0080510   IPR000568,ATPase, F0 complex, subunit A,domain-containing
Schistosoma japonicum Sjp_0126020   IPR000568,ATPase, F0 complex, subunit A,domain-containing
Schistosoma japonicum Sjp_0126430   IPR000568,ATPase, F0 complex, subunit A,domain-containing
Schistosoma japonicum Sjp_0128800   IPR000568,ATPase, F0 complex, subunit A,domain-containing
Schistosoma mansoni ATP6   ATP synthase F0 subunit 6
Wolbachia endosymbiont of Brugia malayi Wbm0460   ATP synthase F0F1 subunit A

Essentiality

ATP6 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b3738 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium falciparum 268935   585607  
Annotator: saralph@unimelb.edu.au. Comment: 012/Mar/09. References: 12931192 15937493

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.7

Known modulators for this target

Compound Source Reference
Curated by TDRTargets References
Curated by TDRTargets References

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mycobacterium tuberculosis Probable ATP synthase a chain AtpB (protein 6) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0246 0.8564 1
0.0239 0.7006 0.7611
0.0212 0.2554 1
0.0225 1 1
0.0231 0.8361 1
0.0214 0.2559 0.6264
0.0234 0.2534 0.252
0.0213 0.2604 0.3206
0.0223 0.8368 1
0.0204745 0.749299 0.704078
0.022 0.9595 1
0.0234 1 1
0.0213 0.2604 0.3206
0.0229 0.3345 0.3241
0.0253 1 1
0.0226 1 0.5
0.0213 0.2604 0.3206
0.0217 0.4517 0.4449
0.0213 0.2604 0.3206
0.0213 0.8388 1
0.0212 0.2554 1
0.0262 1 1
0.0213 0.2604 0.3206
0.0225 0.2761 0.6649
0.0262 1 1
0.0223 0.2568 0.2568
0.0225 1 1
0.0243 1 1
0.0217 1 1
0.0224 0.9619 1
0.0221 0.4692 0.4676
0.0246 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

7 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier ATP6 (Schistosoma mansoni), ATP synthase F0 subunit 6
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