Detailed information for compound 1385734

Basic information

Technical information
  • TDR Targets ID: 1385734
  • Name: N-[3-[[2-(2-methylphenoxy)acetyl]amino]propyl ]furan-2-carboxamide
  • MW: 316.352 | Formula: C17H20N2O4
  • H donors: 2 H acceptors: 2 LogP: 2.33 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(COc1ccccc1C)NCCCNC(=O)c1ccco1
  • InChi: 1S/C17H20N2O4/c1-13-6-2-3-7-14(13)23-12-16(20)18-9-5-10-19-17(21)15-8-4-11-22-15/h2-4,6-8,11H,5,9-10,12H2,1H3,(H,18,20)(H,19,21)
  • InChiKey: PJBZIRWSJWKHBZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[3-[[2-(2-methylphenoxy)-1-oxoethyl]amino]propyl]-2-furancarboxamide
  • N-[3-[[2-(2-methylphenoxy)acetyl]amino]propyl]-2-furamide
  • N-[3-[2-(2-methylphenoxy)ethanoylamino]propyl]furan-2-carboxamide
  • ASN 11412586
  • Furan-2-carboxylic acid [3-(2-o-tolyloxy-acetylamino)-propyl]-amide
  • AO-365/43264333
  • ZINC05015357

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni transmemberane protein 0.0064 0.0543 0.0526
Schistosoma mansoni ap endonuclease 0.002 0.0035 0.0017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0212 0.0776
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0054 0.0431 0.1669
Loa Loa (eye worm) hypothetical protein 0.0035 0.0212 0.0776
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0035 0.0283
Schistosoma mansoni nuclear hormone receptor 0.0035 0.0212 0.0195
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0059 0.0484 0.3692
Schistosoma mansoni thyroid hormone receptor 0.0035 0.0212 0.0195
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0124 0.125 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0065
Schistosoma mansoni hypothetical protein 0.0158 0.1643 0.1628
Schistosoma mansoni hypothetical protein 0.0037 0.0226 0.0209
Mycobacterium leprae PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6) 0.0234 0.2534 1
Echinococcus granulosus lamin dm0 0.0053 0.0421 0.1632
Loa Loa (eye worm) calcium ATPase 0.002 0.0031 0.0112
Brugia malayi Na,K-ATPase alpha subunit 0.0045 0.033 0.115
Loa Loa (eye worm) steroid hormone receptor 0.0035 0.0212 0.0776
Brugia malayi hypothetical protein 0.0231 0.2491 0.9095
Loa Loa (eye worm) hypothetical protein 0.0045 0.033 0.1208
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0054 0.0431 0.1669
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0064 0.0543 0.2123
Onchocerca volvulus 0.0053 0.0421 0.0828
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0124 0.125 0.1234
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0059 0.0484 0.3692
Brugia malayi steroid hormone receptor 0.0035 0.0212 0.0716
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.006 0.0497 0.1938
Trypanosoma cruzi plasma-membrane proton-efflux P-type ATPase, putative 0.0021 0.004 0.0321
Echinococcus granulosus intermediate filament protein 0.0053 0.0421 0.1632
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0035 0.0212 0.0787
Schistosoma mansoni steroid hormone receptor ad4bp 0.0035 0.0212 0.0195
Trichomonas vaginalis cation-transporting ATPase, putative 0.0044 0.0317 0.2319
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0124 0.125 1
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.0021 0.004 0.0147
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0054 0.0431 0.3254
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0124 0.125 0.4862
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0059 0.0484 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0035 0.0212 0.0195
Echinococcus granulosus ecdysone induced protein 78C 0.0035 0.0212 0.0787
Schistosoma mansoni thyroid hormone receptor 0.0035 0.0212 0.0195
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.004 0.0264 0.0246
Schistosoma mansoni survival motor neuron protein 0.0047 0.0349 0.0332
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0081 0.0747 0.2849
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0036 0.022 0.4187
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0035 0.0212 0.0787
Loa Loa (eye worm) hypothetical protein 0.0053 0.0421 0.154
Schistosoma mansoni hypothetical protein 0.0183 0.1934 0.1919
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0035 0.0071
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0025 0.009 0.0266
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0035 0.0212 0.0195
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.004 0.0264 0.2111
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0035 0.0212 0.0195
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0212 0.0787
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0035 0.0212 0.0776
Leishmania major calcium-translocating P-type ATPase 0.0044 0.0317 0.2319
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0045 0.033 0.1181
Echinococcus granulosus nervana 2 0.0064 0.0543 0.2123
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0035 0.0212 0.0195
Echinococcus multilocularis musashi 0.0053 0.0421 0.1632
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0045 0.033 0.1208
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0035 0.0212 0.0787
Trichomonas vaginalis cation-transporting ATPase, putative 0.0027 0.0117 0.0673
Onchocerca volvulus 0.0047 0.0349 0.054
Brugia malayi hypothetical protein 0.0252 0.2737 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0053 0.042 0.3169
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0065
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0054 0.0431 0.0413
Echinococcus multilocularis ecdysone induced protein 78C 0.0035 0.0212 0.0787
Brugia malayi E1-E2 ATPase family protein 0.0028 0.0131 0.0414
Echinococcus granulosus Na:K ATPase alpha subunit 0.0039 0.0254 0.0953
Brugia malayi Sodium/potassium-transporting ATPase alpha-3 chain, putative 0.0021 0.004 0.0082
Trypanosoma brucei P-type H+-ATPase, putative 0.0027 0.0117 0.0673
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0044 0.0317 0.1127
Schistosoma mansoni hypothetical protein 0.0183 0.1934 0.1919
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0059 0.0484 0.3692
Loa Loa (eye worm) hypothetical protein 0.0035 0.0212 0.0776
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0064 0.0543 0.2123
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0421 0.1484
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0065
Brugia malayi glucose-6-phosphate dehydrogenase 0.0124 0.125 0.4532
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0124 0.125 0.4568
Leishmania major P-type ATPase, putative 0.0054 0.0431 0.3254
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0065
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0059 0.0484 1
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0124 0.125 1
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0029 0.0141 0.0421
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0035 0.0212 0.0787
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0212 0.0787
Schistosoma mansoni ATPase 0.0044 0.0317 0.03
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0035 0.0212 0.0716
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0045 0.033 0.2429
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0424 0.1493
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0349 0.1217
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0039 0.0257 0.4999
Wolbachia endosymbiont of Brugia malayi ATP synthase F0F1 subunit A 0.0234 0.2534 1
Echinococcus multilocularis nervana 2 0.0064 0.0543 0.2123
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0035 0.0212 0.0776
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0035 0.0212 0.0776
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0421 0.154
Schistosoma mansoni ATP synthase F0 subunit 6 0.0234 0.2534 0.252
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.006 0.0494 0.3777
Onchocerca volvulus 0.0064 0.0543 0.1309
Schistosoma mansoni intermediate filament proteins 0.0053 0.0421 0.0404
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0044 0.0317 0.121
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.003 0.0154 0.0501
Toxoplasma gondii P-type ATPase4, putative 0.0045 0.033 0.2429
Mycobacterium ulcerans F0F1 ATP synthase subunit A 0.0234 0.2534 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.0756
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0039 0.0254 0.0236
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0059 0.0484 0.3692
Echinococcus multilocularis lamin 0.0053 0.0421 0.1632
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0054 0.0431 0.1669
Loa Loa (eye worm) hypothetical protein 0.0025 0.0089 0.0324
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0035 0.0129
Echinococcus granulosus nervana 2 0.0064 0.0543 0.2123
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0059 0.0484 0.3692
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0045 0.033 0.0313
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0124 0.125 0.4983
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0035 0.0212 0.0716
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0035 0.0212 0.0716
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.2491 1
Plasmodium vivax calcium-transporting ATPase, putative 0.0045 0.033 0.2429
Echinococcus granulosus nervana 2 0.0064 0.0543 0.2123
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0035 0.0212 0.0716
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0133 0.0423
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0059 0.0484 0.3692
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0029 0.0141 0.0421
Schistosoma mansoni coup transcription factor 0.0035 0.0212 0.0195
Plasmodium falciparum calcium-transporting ATPase 0.0039 0.0254 0.1796
Schistosoma mansoni lamin 0.0053 0.0421 0.0404
Trypanosoma brucei calcium-transporting ATPase, putative 0.0025 0.0088 0.0429
Echinococcus granulosus calcium transporting atpase 0.004 0.0264 0.0995
Leishmania major P-type H -ATPase, putative 0.0027 0.0117 0.0673
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0038 0.024 0.1685
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0059 0.0484 0.387
Brugia malayi nuclear receptor NHR-88 0.0035 0.0212 0.0716
Loa Loa (eye worm) calcium ATPase 0.0039 0.0257 0.094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0035 0.0212 0.0776
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0124 0.125 1
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0064 0.0543 0.2123
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0044 0.0317 0.121
Loa Loa (eye worm) hypothetical protein 0.0052 0.041 0.1498
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0038 0.0244 0.4703
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0059 0.0484 0.3692
Echinococcus multilocularis lamin dm0 0.0053 0.0421 0.1632
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0043 0.0303 0.1071
Loa Loa (eye worm) hypothetical protein 0.0252 0.2737 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.006 0.0497 0.3802
Trypanosoma cruzi P-type H+-ATPase, putative 0.0021 0.004 0.0321
Schistosoma mansoni ap endonuclease 0.002 0.0035 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0035 0.0212 0.0716
Loa Loa (eye worm) E1-E2 ATPase 0.0027 0.0117 0.0428
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0059 0.0484 0.3692
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0212 0.0716
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0035 0.0212 0.0776
Echinococcus multilocularis FTZ F1 alpha 0.0035 0.0212 0.0787
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0064 0.0543 0.2123
Trypanosoma brucei calcium-translocating P-type ATPase 0.004 0.0264 0.1881
Loa Loa (eye worm) hypothetical protein 0.0037 0.0226 0.0827
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0041 0.0281 0.2244
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0018 0.0065
Loa Loa (eye worm) hypothetical protein 0.0026 0.01 0.0365
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0059 0.0484 0.3692
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0124 0.125 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.01 0.0332
Echinococcus granulosus lamin 0.0053 0.0421 0.1632
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0124 0.125 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0035 0.0212 0.0776
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0059 0.0484 0.3692
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0064 0.0543 0.2123
Brugia malayi calcium ATPase 0.0021 0.004 0.0082
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0133 0.0486
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0035 0.0212 0.0716
Loa Loa (eye worm) hypothetical protein 0.0231 0.2491 0.9101
Brugia malayi calcium ATPase 0.0033 0.0191 0.0635
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0421 0.154
Trichomonas vaginalis cation-transporting ATPase, putative 0.0059 0.0484 0.3692
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0035 0.0212 0.0716
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0081 0.0747 0.5859
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.004 0.0264 0.2111
Brugia malayi nuclear hormone receptor 0.0035 0.0212 0.0716
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0024 0.0077 0.0218
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0035 0.0283
Onchocerca volvulus 0.0044 0.0317 0.0414
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0124 0.125 0.5
Onchocerca volvulus Huntingtin homolog 0.0252 0.2737 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0212 0.0776
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.004 0.0264 0.0905
Loa Loa (eye worm) hypothetical protein 0.0053 0.0424 0.1549
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0039 0.0254 0.0953
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0212 0.0787
Loa Loa (eye worm) hypothetical protein 0.0064 0.0543 0.1984
Mycobacterium tuberculosis Probable ATP synthase a chain AtpB (protein 6) 0.0234 0.2534 1
Onchocerca volvulus Huntingtin homolog 0.0252 0.2737 1
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0226 0.0767
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.004 0.0267 0.2133
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0064 0.0543 0.2123
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0124 0.125 1
Schistosoma mansoni retinoic acid receptor RXR 0.0035 0.0212 0.0195
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0035 0.0212 0.0195
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0212 0.0787
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.004 0.0264 0.0246
Echinococcus multilocularis nervana 2 0.0064 0.0543 0.2123
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0124 0.125 1
Echinococcus granulosus geminin 0.0183 0.1934 0.7747
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0035 0.0212 0.0787
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0059 0.0484 0.387
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0059 0.0484 1
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.006 0.0497 0.1938
Trypanosoma brucei calcium motive p-type ATPase, putative 0.004 0.0264 0.1881
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0054 0.0431 0.1669
Plasmodium vivax P-type ATPase4, putative 0.0045 0.033 0.2429
Schistosoma mansoni hypothetical protein 0.0047 0.0349 0.0332
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0044 0.0317 0.2536
Schistosoma mansoni ATPase 0.0044 0.0317 0.03
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0039 0.0254 0.0236
Toxoplasma gondii P-type ATPase PMA1 0.0027 0.0117 0.0673
Loa Loa (eye worm) hypothetical protein 0.0064 0.0543 0.1984
Echinococcus multilocularis calcium transporting atpase 0.004 0.0264 0.0995
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0045 0.033 0.1264
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0035 0.0212 0.0716
Loa Loa (eye worm) hypothetical protein 0.0252 0.2737 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0424 0.1549
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0064 0.0543 0.0526
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0064 0.0543 0.0526
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0035 0.0212 0.0716
Echinococcus multilocularis thyroid hormone receptor alpha 0.0035 0.0212 0.0787
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0124 0.125 0.4983
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0054 0.0431 0.0413
Leishmania major calcium-transporting ATPase, putative 0.004 0.0264 0.1881
Loa Loa (eye worm) hypothetical protein 0.0044 0.0317 0.1158
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0035 0.0106
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0875 1 1
Echinococcus granulosus nervana 2 0.0064 0.0543 0.2123
Brugia malayi photoreceptor-specific nuclear receptor 0.0035 0.0212 0.0716
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0021 0.004 0.0321
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0035 0.0212 0.0716
Trypanosoma cruzi P-type H+-ATPase, putative 0.0027 0.0117 0.0937
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0059 0.0484 0.3692
Echinococcus multilocularis nervana 2 0.0064 0.0543 0.2123
Onchocerca volvulus 0.0053 0.0421 0.0828
Onchocerca volvulus 0.0064 0.0543 0.1309
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0035 0.0212 0.0716
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0035 0.0212 0.0716
Brugia malayi Steroid receptor seven-up type 2 0.0035 0.0212 0.0716
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0124 0.125 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0212 0.0776
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0025 0.0088 0.07
Loa Loa (eye worm) hypothetical protein 0.0025 0.0089 0.0324
Echinococcus multilocularis nervana 2 0.0064 0.0543 0.2123
Brugia malayi intermediate filament protein 0.0053 0.0421 0.1484
Trypanosoma cruzi P-type H+-ATPase, putative 0.0027 0.0117 0.0937
Trichomonas vaginalis cation-transporting ATPase, putative 0.0044 0.0317 0.2319
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0045 0.033 0.1264
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0064 0.0543 0.2123
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0035 0.0212 0.0716
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0035 0.0212 0.0776
Leishmania major P-type H -ATPase, putative 0.0027 0.0117 0.0673
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0124 0.125 1
Schistosoma mansoni RAR-like nuclear receptor 0.0035 0.0212 0.0195
Loa Loa (eye worm) hypothetical protein 0.0035 0.0212 0.0776
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0035 0.0064
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.2491 1
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0025 0.0088 0.032
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0035 0.0212 0.0787
Schistosoma mansoni lamin 0.0053 0.0421 0.0404
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0124 0.125 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0212 0.0776
Loa Loa (eye worm) hypothetical protein 0.0035 0.0212 0.0776
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0035 0.0212 0.0195
Leishmania major calcium motive p-type ATPase, putative 0.004 0.0264 0.1881
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0064 0.0543 0.2123
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0035 0.0212 0.0787
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0035 0.0212 0.0787
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0035 0.0071
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.01 0.0332
Trypanosoma brucei P-type H+-ATPase, putative 0.0027 0.0117 0.0673
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0045 0.033 0.6617
Brugia malayi Membrane calcium atpase protein 3 0.0054 0.0431 0.1518
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0039 0.0254 0.1796
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0424 0.1493
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0045 0.033 0.2429
Toxoplasma gondii E1-E2 ATPase subfamily protein 0.0021 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0065
Echinococcus granulosus FTZ F1 alpha 0.0035 0.0212 0.0787
Loa Loa (eye worm) hypothetical protein 0.0039 0.0254 0.0929
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0035 0.0212 0.0787
Echinococcus multilocularis geminin 0.0183 0.1934 0.7747
Brugia malayi ecdysteroid receptor 0.0035 0.0212 0.0716
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.003 0.0154 0.0563

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.9362 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.