Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit A | 0.0262 | 1 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.428 | 0.5 |
Mycobacterium tuberculosis | Probable ATP synthase a chain AtpB (protein 6) | 0.0262 | 1 | 0.5 |
Schistosoma mansoni | ATP synthase F0 subunit 6 | 0.0262 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.7118 | 0.7118 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.428 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.428 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.7118 | 0.7118 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.428 | 0.5 |
Brugia malayi | hypothetical protein | 0.0148 | 0.428 | 0.5 |
Echinococcus granulosus | geminin | 0.0205 | 0.7118 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.7118 | 0.5 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit A | 0.0262 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.