Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Schistosoma mansoni | ATP synthase F0 subunit 6 | Curated by TDR Targets | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0253829 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0253829 | 1 | 1 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6) | 0.0204745 | 0.749299 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0253829 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0253829 | 1 | 1 |
Mycobacterium tuberculosis | Probable ATP synthase a chain AtpB (protein 6) | 0.0204745 | 0.749299 | 0.704078 |
Trichomonas vaginalis | mercuric reductase, putative | 0.00879592 | 0.152811 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0253829 | 1 | 1 |
Schistosoma mansoni | ATP synthase F0 subunit 6 | 0.0204745 | 0.749299 | 0.704078 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.00879592 | 0.152811 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0253829 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0253829 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0253829 | 1 | 1 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit A | 0.0204745 | 0.749299 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0253829 | 1 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.00879592 | 0.152811 | 0.123389 |
Treponema pallidum | NADH oxidase | 0.00879592 | 0.152811 | 0.5 |
Leishmania major | trypanothione reductase | 0.0253829 | 1 | 1 |
Brugia malayi | glutathione reductase | 0.0253829 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit A | 0.0204745 | 0.749299 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0253829 | 1 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.00879592 | 0.152811 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0253829 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0253829 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0253829 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.00879592 | 0.152811 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.02 uM | Antiparasitic activity against malaria parasite (Plasmodium falciparum D6) | ChEMBL. | 14741254 |
EC50 (functional) | = 0.02 uM | Antiparasitic activity against chloroquine resistant Plasmodium falciparum W2 strain | ChEMBL. | 14741254 |
EC50 (functional) | = 0.02 uM | Antiparasitic activity against malaria parasite (Plasmodium falciparum D6) | ChEMBL. | 14741254 |
EC50 (functional) | = 0.02 uM | Antiparasitic activity against chloroquine resistant Plasmodium falciparum W2 strain | ChEMBL. | 14741254 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 14741254 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Targets |
---|---|---|---|---|---|---|
growth (GO:0040007) | lethal (sensu genetics) (PATO:0000718) | multi-cellular organism (CARO:0000012) | bloodstream stage (PLO:0040) | in vivo inhibition (TDR:00016) | Plasmodium falciparum | 3184 |
Annotator: | saralph@unimelb.edu.au | Comment: | 012/Mar/09 | References: | 12931192 15937493 |
31 literature references were collected for this gene.