Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0.1392 | 0.5 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit A | 0.0246 | 0.8564 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0019 | 0.0381 | 0.0436 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0991 | 0.1133 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0175 | 0.5999 | 0.6857 |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.0381 | 0.0436 |
Echinococcus multilocularis | geminin | 0.0205 | 0.7066 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0019 | 0.0381 | 0.0445 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 1 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0047 | 0.1392 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0991 | 0.1157 |
Schistosoma mansoni | ATP synthase F0 subunit 6 | 0.0246 | 0.8564 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0019 | 0.0381 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.8749 | 1 |
Mycobacterium tuberculosis | Probable ATP synthase a chain AtpB (protein 6) | 0.0246 | 0.8564 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0991 | 0.1157 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0991 | 0.1403 |
Brugia malayi | Pre-SET motif family protein | 0.0036 | 0.0991 | 0.1133 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit A | 0.0246 | 0.8564 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0019 | 0.0381 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.7066 | 0.8251 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0051 | 0.1547 | 0.2189 |
Echinococcus granulosus | geminin | 0.0205 | 0.7066 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0019 | 0.0381 | 0.0436 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0.1547 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0019 | 0.0381 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.7066 | 0.8251 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0.1547 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 0.5999 | 0.849 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.8749 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0019 | 0.0381 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0073 | 0.0084 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 0.5999 | 0.6857 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6) | 0.0246 | 0.8564 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.0381 | 0.0436 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0991 | 0.1157 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0036 | 0.0991 | 0.1403 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.1547 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0036 | 0.0991 | 0.1403 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 0.5999 | 0.7005 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.5822 | 0.824 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0.1392 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0036 | 0.0991 | 0.6407 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0019 | 0.0381 | 0.0436 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0035 | 0.0943 | 0.1335 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0036 | 0.0991 | 0.1157 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.