Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | acetyltransferase, GNAT family protein | 0.0175 | 0.6815 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.008 | 0.2551 | 0.3134 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0046 | 0.1048 | 0.1288 |
Echinococcus multilocularis | geminin | 0.0205 | 0.814 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.008 | 0.2551 | 0.3742 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.2551 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 0.6815 | 0.8373 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0.1287 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit A | 0.0246 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.814 | 0.814 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0047 | 0.1095 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0.1095 | 1 |
Schistosoma mansoni | ATP synthase F0 subunit 6 | 0.0246 | 1 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.008 | 0.2551 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.814 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0046 | 0.1048 | 0.1288 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit A | 0.0246 | 1 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.1287 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0051 | 0.1287 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.008 | 0.2551 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.814 | 0.814 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.6596 | 0.8103 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.008 | 0.2551 | 0.2551 |
Mycobacterium tuberculosis | Probable ATP synthase a chain AtpB (protein 6) | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.008 | 0.2551 | 0.3742 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 0.6815 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 0.6815 | 0.6815 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0.1095 | 0.4293 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0051 | 0.1287 | 0.1581 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.2551 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0051 | 0.1287 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.008 | 0.2551 | 0.3134 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0.1287 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.2551 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.