TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 445.254 | Formula: C19H16IN3O2
H donors: 2 H acceptors: 3 LogP: 4.12 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1cc(cc(c1O)I)C=C(c1[nH]c2c(n1)cc(cc2)C)C#N
InChi: 1S/C19H16IN3O2/c1-3-25-17-9-12(8-14(20)18(17)24)7-13(10-21)19-22-15-5-4-11(2)6-16(15)23-19/h4-9,24H,3H2,1-2H3,(H,22,23)/b13-7+
InChiKey: BXDHYFNWZOMSPI-NTUHNPAUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Chlamydia trachomatis	glucose-6-phosphate 1-dehydrogenase	0.0121	0.1349	0.5
Loa Loa (eye worm)	sodium/potassium-transporting ATPase subunit alpha	0.0008	0.0007	0.0045
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0227	0.1601
Brugia malayi	glucose-6-phosphate dehydrogenase	0.0121	0.1349	0.9552
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0015	0.0096	0.0479
Schistosoma mansoni	hypothetical protein	0.0174	0.1986	0.1985
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0015	0.0096	0.0479
Echinococcus multilocularis	nervana 2	0.0062	0.065	0.3272
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0067	0.0467
Trypanosoma brucei	calcium motive p-type ATPase, putative	0.0013	0.0069	0.0392
Echinococcus multilocularis	Tetracycline resistance leader peptide, TetL	0.0016	0.0109	0.0543
Mycobacterium ulcerans	metal cation-transporting p-type ATPase F, CtpF	0.0012	0.0059	0.0053
Echinococcus granulosus	plasma membrane calcium transporting ATPase 2	0.0016	0.0109	0.0543
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0015	0.0095	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0096	0.0674
Echinococcus granulosus	nervana 2	0.0062	0.065	0.3272
Echinococcus multilocularis	Na+:K+ ATPase alpha subunit	0.0012	0.0059	0.0295
Echinococcus multilocularis	plasma membrane calcium transporting ATPase	0.0017	0.0119	0.0595
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0062	0.065	0.3272
Schistosoma mansoni	lamin	0.0026	0.0227	0.0226
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0015	0.0096	0.0479
Echinococcus multilocularis	calcium transporting atpase	0.0013	0.0069	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0126	0.1412	1
Giardia lamblia	Glucose-6-phosphate 1-dehydrogenase	0.0121	0.1349	1
Plasmodium falciparum	glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0.0121	0.1349	1
Toxoplasma gondii	calcium-translocating P-type ATPase, PMCA-type protein	0.0016	0.0105	0.0359
Schistosoma mansoni	plasma membrane calcium-transporting atpase	0.0017	0.0119	0.0118
Entamoeba histolytica	calcium-transporting P-type ATPase, putative	0.0012	0.0059	0.4923
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0011	0.0072
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0008	0.0011	0.001
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0096	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0011	0.0072
Loa Loa (eye worm)	Na,K-ATPase alpha subunit	0.0012	0.0059	0.0415
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0015	0.0096	0.0095
Echinococcus granulosus	calcium transporting ATPase type 2C member	0.0012	0.0059	0.0295
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0015	0.0096	0.0677
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0066	0.0461
Giardia lamblia	Potassium-transporting ATPase alpha chain 1	0.0012	0.0059	0.0102
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0082	0.0578
Schistosoma mansoni	nuclear hormone receptor	0.0015	0.0096	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0096	0.0674
Schistosoma mansoni	thyroid hormone receptor	0.0015	0.0096	0.0095
Echinococcus granulosus	nervana 2	0.0062	0.065	0.3272
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0015	0.0095	0.0379
Trichomonas vaginalis	cation-transporting ATPase fungi, putative	0.0015	0.0095	0.0379
Brugia malayi	Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type	0.0013	0.0069	0.0491
Trichomonas vaginalis	glucosamine-6-phosphate isomerase, putative	0.0121	0.1349	1
Brugia malayi	Nuclear hormone receptor E75	0.0007	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0096	0.0674
Mycobacterium ulcerans	F0F1 ATP synthase subunit A	0.0223	0.2568	1
Toxoplasma gondii	plasma membrane-type Ca(2+)-ATPase A1 PMCAA1	0.0017	0.0119	0.0462
Onchocerca volvulus	Bile acid receptor homolog	0.0015	0.0096	0.0674
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.0013	0.0069	0.0392
Echinococcus granulosus	FTZ F1 alpha	0.0015	0.0096	0.0479
Brugia malayi	hypothetical protein	0.0007	0.0001	0.0004
Brugia malayi	tailless protein	0.0007	0.0001	0.0004
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0015	0.0095	0.0379
Schistosoma mansoni	lamin	0.0026	0.0227	0.0226
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0015	0.0096	0.0674
Brugia malayi	Sodium/potassium-transporting ATPase alpha chain, putative	0.0008	0.0007	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0096	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0011	0.0072
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0008	0.0011	0.0051
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0008	0.0011	0.0072
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0015	0.0096	0.0677
Schistosoma mansoni	ATPase	0.0011	0.0046	0.0045
Onchocerca volvulus		0.0015	0.0096	0.0674
Plasmodium vivax	glucose-6-phosphate 1-dehydrogenase, putative	0.0121	0.1349	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0015	0.0096	0.0677
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0062	0.065	0.3272
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0066	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0227	0.1601
Echinococcus multilocularis	FTZ F1 alpha	0.0015	0.0096	0.0479
Toxoplasma gondii	glucose-6-phosphate 1-dehydrogenase	0.0121	0.1349	1
Trypanosoma brucei	glucose-6-phosphate 1-dehydrogenase	0.0121	0.1349	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0096	0.0674
Trichomonas vaginalis	6-phosphogluconolactonase, putative	0.0121	0.1349	1
Leishmania major	P-type ATPase, putative	0.0017	0.0119	0.0559
Brugia malayi	orphan nuclear receptor NR2E1	0.0007	0.0001	0.0004
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0015	0.0096	0.0674
Onchocerca volvulus	Huntingtin homolog	0.0126	0.1412	1
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0062	0.065	0.3272
Echinococcus multilocularis	musashi	0.0026	0.0227	0.1138
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0096	0.0674
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0015	0.0096	0.0677
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0096	0.0674
Echinococcus multilocularis	geminin	0.0174	0.1986	1
Brugia malayi	nuclear receptor RXR	0.0008	0.0011	0.0076
Schistosoma mansoni	retinoic acid receptor RXR	0.0015	0.0096	0.0095
Echinococcus granulosus	lamin	0.0026	0.0227	0.1138
Echinococcus granulosus	nervana 2	0.0062	0.065	0.3272
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0015	0.0096	0.0479
Echinococcus multilocularis	lamin	0.0026	0.0227	0.1138
Trypanosoma cruzi	glucose-6-phosphate 1-dehydrogenase, putative	0.0121	0.1349	1
Loa Loa (eye worm)	calcium ATPase	0.001	0.0037	0.0261
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0015	0.0095	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0015	0.0096	0.0677
Brugia malayi	Nuclear hormone receptor-like 1	0.0008	0.0011	0.0076
Schistosoma mansoni	hypothetical protein	0.0174	0.1986	0.1985
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0015	0.0095	0.0379
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0015	0.0095	0.0379
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 1	0.0015	0.0095	0.0586
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0016	0.0109	0.048
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0015	0.0096	0.0674
Brugia malayi	intermediate filament protein	0.0026	0.0227	0.1604
Brugia malayi	Nuclear hormone receptor-like 1	0.0015	0.0096	0.0677
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0015	0.0095	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0015	0.0096	0.0479
Brugia malayi	nuclear hormone receptor family member odr-7	0.0007	0.0001	0.0004
Trypanosoma brucei	vacuolar-type Ca2+-ATPase, putative	0.0015	0.0095	0.0586
Echinococcus granulosus	lamin dm0	0.0026	0.0227	0.1138
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0015	0.0095	0.0586
Treponema pallidum	glucose-6-phosphate 1-dehydrogenase	0.0121	0.1349	0.5
Onchocerca volvulus		0.0062	0.065	0.4601
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0015	0.0096	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0046	0.0321
Echinococcus multilocularis	ecdysone induced protein 78C	0.0015	0.0096	0.0479
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0015	0.0096	0.0479
Echinococcus granulosus	ecdysone induced protein 78C	0.0015	0.0096	0.0479
Loa Loa (eye worm)	steroid hormone receptor	0.0015	0.0096	0.0674
Onchocerca volvulus		0.0026	0.0227	0.1601
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0015	0.0096	0.0479
Echinococcus granulosus	sodium:potassium transporting ATPase subunit	0.0062	0.065	0.3272
Loa Loa (eye worm)	hypothetical protein	0.0126	0.1412	1
Brugia malayi	Na,K-ATPase alpha subunit	0.0012	0.0059	0.0419
Entamoeba histolytica	plasma membrane calcium ion-transporting ATPase, putative	0.0011	0.0049	0.3541
Brugia malayi	ecdysone receptor	0.0007	0.0001	0.0004
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0227	0.1601
Brugia malayi	hypothetical protein	0.0007	0.0001	0.0004
Brugia malayi	Probable calcium-transporting ATPase KIAA0703	0.0008	0.0007	0.0049
Echinococcus granulosus	glucose 6 phosphate 1 dehydrogenase	0.0121	0.1349	0.6793
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0221	0.1561
Brugia malayi	nuclear receptor NHR-88	0.0007	0.0001	0.0004
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0015	0.0096	0.0479
Mycobacterium ulcerans	glucose-6-phosphate 1-dehydrogenase	0.0079	0.0852	0.3196
Echinococcus granulosus	intermediate filament protein	0.0026	0.0227	0.1138
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0066	0.0328
Trypanosoma cruzi	Glucose-6-phosphate dehydrogenase, putative	0.0039	0.0377	0.2701
Brugia malayi	nuclear receptor NHR-67	0.0007	0.0001	0.0004
Schistosoma mansoni	ATPase	0.0011	0.0046	0.0045
Onchocerca volvulus	Protein ultraspiracle homolog	0.0015	0.0096	0.0674
Brugia malayi	Nuclear hormone receptor-like 1	0.0008	0.0011	0.0076
Echinococcus multilocularis	lamin dm0	0.0026	0.0227	0.1138
Onchocerca volvulus	Huntingtin homolog	0.0126	0.1412	1
Onchocerca volvulus		0.0026	0.0227	0.1601
Wolbachia endosymbiont of Brugia malayi	ATP synthase F0F1 subunit A	0.0223	0.2568	0.5
Brugia malayi	ecdysteroid receptor	0.0015	0.0096	0.0677
Echinococcus multilocularis	sarco:endoplasmic reticulum calcium ATPase	0.0011	0.0046	0.0228
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0007	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.0421
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0227	0.1604
Loa Loa (eye worm)	hypothetical protein	0.0062	0.065	0.4601
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.0013	0.0069	0.0392
Schistosoma mansoni	calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)	0.0013	0.0069	0.0069
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0015	0.0096	0.0677
Schistosoma mansoni	RAR-like nuclear receptor	0.0015	0.0096	0.0095
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0015	0.0096	0.0095
Onchocerca volvulus		0.0011	0.0046	0.0321
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0015	0.0096	0.0095
Toxoplasma gondii	glucose-6-phosphate 1-dehydrogenase	0.0079	0.0852	0.6145
Brugia malayi	nuclear hormone receptor	0.0015	0.0096	0.0677
Mycobacterium leprae	PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6)	0.0223	0.2568	0.5
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0015	0.0096	0.0095
Trypanosoma cruzi	Calcium ATPase SERCA-like	0.0011	0.0046	0.0215
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0062	0.065	0.065
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0015	0.0096	0.0677
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0008	0.0011	0.001
Echinococcus multilocularis	glucose 6 phosphate 1 dehydrogenase	0.0121	0.1349	0.6793
Echinococcus multilocularis	calcium transporting ATPase type 2C member	0.0012	0.0059	0.0295
Brugia malayi	steroid hormone receptor	0.0015	0.0096	0.0677
Leishmania major	calcium motive p-type ATPase, putative	0.0013	0.0069	0.018
Schistosoma mansoni	calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)	0.0013	0.0069	0.0069
Trichomonas vaginalis	glucosamine-6-phosphate isomerase, putative	0.0121	0.1349	1
Leishmania major	glucose-6-phosphate 1-dehydrogenase, putative	0.0121	0.1349	1
Trypanosoma cruzi	glucose-6-phosphate 1-dehydrogenase, putative	0.004	0.0391	0.2804
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0227	0.0226
Echinococcus granulosus	Ca2 transporting ATPase plasma membrane	0.0017	0.0119	0.0595
Schistosoma mansoni	plasma membrane calcium-transporting atpase	0.0017	0.0119	0.0118
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0015	0.0095	0.0379
Echinococcus multilocularis	Ca2+ transporting ATPase plasma membrane	0.0017	0.0119	0.0595
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0015	0.0096	0.0677
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0015	0.0096	0.0674
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0062	0.065	0.3272
Brugia malayi	hypothetical protein	0.0008	0.0011	0.0076
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0015	0.0096	0.0479
Echinococcus granulosus	geminin	0.0174	0.1986	1
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 2	0.0015	0.0095	0.0586
Schistosoma mansoni	ATP synthase F0 subunit 6	0.0223	0.2568	0.2568
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0062	0.065	0.3272
Brugia malayi	Steroid receptor seven-up type 2	0.0015	0.0096	0.0677
Loa Loa (eye worm)	hypothetical protein	0.0062	0.065	0.4601
Mycobacterium tuberculosis	Probable ATP synthase a chain AtpB (protein 6)	0.0223	0.2568	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0015	0.0096	0.0479
Schistosoma mansoni	Na+/K+ transporting ATPase subunit alpha	0.0012	0.0059	0.0059
Echinococcus multilocularis	nervana 2	0.0062	0.065	0.3272
Leishmania major	calcium-transporting ATPase, putative	0.0013	0.0069	0.018
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0015	0.0096	0.0677
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0016	0.0109	0.048
Mycobacterium ulcerans	glucose-6-phosphate 1-dehydrogenase	0.0121	0.1349	0.5167
Schistosoma mansoni	sodium / potassium ATPase beta chain	0.0849	1	1
Echinococcus multilocularis	nervana 2	0.0062	0.065	0.3272
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0015	0.0096	0.0095
Echinococcus granulosus	sarco:endoplasmic reticulum calcium ATPase	0.0011	0.0046	0.0228
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0015	0.0096	0.0674
Brugia malayi	photoreceptor-specific nuclear receptor	0.0015	0.0096	0.0677
Brugia malayi	nuclear receptor NHR-88	0.0015	0.0096	0.0677
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0015	0.0096	0.0677
Echinococcus multilocularis	sodium:potassium transporting ATPase subunit	0.0062	0.065	0.3272
Brugia malayi	nuclear receptor RXR	0.0007	0.0001	0.0004
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0015	0.0096	0.0479
Brugia malayi	calcium ATPase	0.0011	0.0048	0.0338
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0015	0.0096	0.0677
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0015	0.0096	0.0479
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0015	0.0096	0.0674
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0015	0.0096	0.0677
Echinococcus multilocularis	nervana 2	0.0062	0.065	0.3272
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0007	0.0001	0.0004
Entamoeba histolytica	plasma membrane calcium ion-transporting ATPase, putative	0.001	0.0037	0.1869
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0062	0.065	0.3272
Echinococcus granulosus	calcium transporting atpase	0.0013	0.0069	0.0346
Loa Loa (eye worm)	calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type	0.0009	0.0017	0.0118
Brugia malayi	Membrane calcium atpase protein 3	0.0017	0.0119	0.0841
Brugia malayi	conserved hypotetical protein	0.0007	0.0001	0.0004
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0015	0.0096	0.0674
Schistosoma mansoni	transmemberane protein	0.0062	0.065	0.065
Echinococcus granulosus	Na:K ATPase alpha subunit	0.0012	0.0059	0.0295
Loa Loa (eye worm)	hypothetical protein	0.001	0.0036	0.0251
Onchocerca volvulus		0.0062	0.065	0.4601
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0082	0.0582
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0062	0.065	0.065
Schistosoma mansoni	calcium-transporting atpase 2 (atpase 2)	0.0012	0.0059	0.0059
Schistosoma mansoni	thyroid hormone receptor	0.0015	0.0096	0.0095
Schistosoma mansoni	coup transcription factor	0.0015	0.0096	0.0095
Schistosoma mansoni	na+/k+ atpase alpha subunit	0.0012	0.0059	0.0059
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0015	0.0096	0.0677
Echinococcus granulosus	nervana 2	0.0062	0.065	0.3272
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0059	0.0415
Brugia malayi	Nuclear hormone receptor E75	0.0007	0.0001	0.0004
Schistosoma mansoni	hypothetical protein	0.0103	0.1144	0.1143
Trypanosoma brucei	calcium-translocating P-type ATPase	0.0013	0.0069	0.0392
Brugia malayi	hypothetical protein	0.0126	0.1412	1
Loa Loa (eye worm)	glucose-6-phosphate dehydrogenase	0.0121	0.1349	0.9552
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0011	0.0072
Giardia lamblia	Plasma membrane calcium-transporting ATPase 2	0.0015	0.0095	0.0379
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0015	0.0096	0.0674
Brugia malayi	hypothetical protein	0.0008	0.0011	0.0076
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0015	0.0096	0.0479
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0015	0.0096	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0012	0.006	0.0421
Schistosoma mansoni	glucose-6-phosphate 1-dehydrogenase	0.0121	0.1349	0.1349
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0008	0.0011	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0011	0.0072
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0015	0.0096	0.0095
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0015	0.0095	0.0379
Brugia malayi	nuclear hormone receptor	0.0007	0.0001	0.0004
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0015	0.0095	0.0586
Echinococcus granulosus	plasma membrane calcium transporting ATPase	0.0017	0.0119	0.0595
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0015	0.0095	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 804883