Detailed information for compound 868087

Basic information

Technical information
  • TDR Targets ID: 868087
  • Name: T5433576
  • MW: 342.349 | Formula: C17H18N4O4
  • H donors: 1 H acceptors: 3 LogP: 0.89 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)CNC(=O)c1cc2c(n1C)nc1n(c2=O)cccc1C
  • InChi: 1S/C17H18N4O4/c1-4-25-13(22)9-18-16(23)12-8-11-15(20(12)3)19-14-10(2)6-5-7-21(14)17(11)24/h5-8H,4,9H2,1-3H3,(H,18,23)
  • InChiKey: LRUJMQNQYWLCLG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • E201-0254
  • NCGC00121117-01
  • ZINC02917289

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans F0F1 ATP synthase subunit A 0.0225 0.2761 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0323
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0102 0.0323
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0102 0.0196
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0102 0.0196
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0182 0.199
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0102 0.0196
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0182 0.0633
Leishmania major cytochrome p450-like protein 0.0016 0.0145 0.1487
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0145 0.0495
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0195 0.0695
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.003 0.0021
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0182 0.0531
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0102 0.0323
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0102 0.0196
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0102 0.0323
Schistosoma mansoni coup transcription factor 0.0012 0.0102 0.0196
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0195 0.0541
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0102 0.0196
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.1688 0.4046
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.1851 0.1834
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0009 0.0067 0.0234
Loa Loa (eye worm) hypothetical protein 0.0006 0.003 0.0035
Brugia malayi ecdysteroid receptor 0.0012 0.0102 0.0323
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0318 0.072
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0102 0.0323
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0102 0.0323
Schistosoma mansoni ATP synthase F0 subunit 6 0.0225 0.2761 0.6649
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.1739 0.6877
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0182 0.199
Loa Loa (eye worm) hypothetical protein 0.0006 0.003 0.0035
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0102 0.0196
Schistosoma mansoni DNA helicase recq1 0.002 0.0195 0.0421
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0009 0.0067 0.0234
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0765 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0.0145 0.0397
Entamoeba histolytica recQ family helicase, putative 0.001 0.007 0.0042
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2518 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0305 0.0687
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0102 0.0323
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0195 0.2176
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0421 0.097
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0145 0.1487
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0102 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0102 0.0323
Wolbachia endosymbiont of Brugia malayi ATP synthase F0F1 subunit A 0.0225 0.2761 1
Trichomonas vaginalis MYB3r3, putative 0.0009 0.0067 0.0234
Brugia malayi Cytochrome P450 family protein 0.0007 0.0037 0.0061
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0182 0.3133
Brugia malayi nuclear receptor RXR 0.0006 0.003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0029 0.0318 0.1187
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0476 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0075 0.052
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0009 0.0067 0.0234
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.1739 0.1721
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0195 0.3504
Schistosoma mansoni thyroid hormone receptor 0.0164 0.2004 0.4812
Brugia malayi hypothetical protein 0.0006 0.003 0.0035
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0102 0.0081
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0009 0.0068 0.0236
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0318 0.072
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0195 0.0695
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0195 0.068
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0145 0.0495
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0765 0.2975
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0765 0.2975
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0432 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0102 0.0323
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0102 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0102 0.0323
Brugia malayi Pre-SET motif family protein 0.0029 0.0318 0.1187
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0145 0.1487
Loa Loa (eye worm) hypothetical protein 0.0006 0.003 0.0035
Onchocerca volvulus 0.0012 0.0102 0.0283
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0318 0.072
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0323
Toxoplasma gondii cytochrome p450 superfamily protein 0.0007 0.0037 0.064
Trichomonas vaginalis MYB72, putative 0.0009 0.0067 0.0234
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.003 0.0035
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.003 0.0035
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0145 0.1487
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.003 0.0035
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0195 0.0541
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0102 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0102 0.0323
Brugia malayi hypothetical protein 0.0006 0.003 0.0035
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0102 0.0081
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0102 0.0323
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0195 0.0421
Brugia malayi nuclear receptor NHR-88 0.0012 0.0102 0.0323
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0102 0.0196
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0102 0.0081
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0182 0.0389
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0102 0.0283
Loa Loa (eye worm) acetyltransferase 0.0143 0.1739 0.6877
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.007 0.1345
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0318 0.072
Echinococcus granulosus geminin 0.0335 0.4141 1
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0102 0.0081
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0102 0.0196
Brugia malayi Cytochrome P450 family protein 0.0007 0.0037 0.0061
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0432 1
Schistosoma mansoni hypothetical protein 0.0335 0.4141 1
Schistosoma mansoni ap endonuclease 0.0019 0.0182 0.0389
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0009 0.0067 0.0234
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0102 0.0323
Onchocerca volvulus 0.0234 0.2873 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0318 0.0297
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0182 0.0641
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0075 0.052
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0182 0.199
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.1851 0.4441
Mycobacterium leprae PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6) 0.0225 0.2761 1
Echinococcus multilocularis geminin 0.0335 0.4141 0.4128
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0102 0.0196
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0318 0.072
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0323
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0102 0.0323
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0476 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0182 0.3728
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0102 0.0196
Plasmodium vivax SET domain protein, putative 0.0029 0.0318 0.6637
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0145 0.0495
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.003 0.0021
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.007 0.1345
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0102 0.0196
Schistosoma mansoni hypothetical protein 0.0152 0.1851 0.4441
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0075 0.1447
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0765 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0075 0.0213
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0009 0.0067 0.0234
Schistosoma mansoni DNA helicase recq5 0.002 0.0195 0.0421
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0195 0.0174
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0195 0.4017
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0195 0.0174
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0102 0.0196
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0102 0.0323
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0182 0.1644
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0102 0.0323
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0102 0.0081
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0009 0.0068 0.1294
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0009 0.0067 0.0234
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0765 0.0744
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0102 0.0323
Entamoeba histolytica recQ family DNA helicase 0.001 0.0075 0.0111
Brugia malayi nuclear hormone receptor 0.0012 0.0102 0.0323
Trichomonas vaginalis C-MYB, putative 0.0009 0.0067 0.0234
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0102 0.0081
Loa Loa (eye worm) cytochrome P450 family protein 0.0007 0.0037 0.0061
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0476 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0182 0.0633
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0102 0.0081
Loa Loa (eye worm) hypothetical protein 0.0009 0.0058 0.0145
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0476 0.1656
Loa Loa (eye worm) hypothetical protein 0.0006 0.003 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0102 0.0323
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0102 0.0196
Schistosoma mansoni hypothetical protein 0.0335 0.4141 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0765 0.1803
Echinococcus granulosus cytochrome P450 2K1 0.0007 0.0037 0.0037
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0765 0.1803
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0182 0.199
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0102 0.0081
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0195 0.068
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0421 0.04
Trichomonas vaginalis pc-MYB2, putative 0.0009 0.0067 0.0234
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0075 0.1447
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0102 0.0323
Brugia malayi Pre-SET motif family protein 0.0205 0.2518 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0102 0.0196
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0102 0.0283
Echinococcus granulosus bloom syndrome protein 0.002 0.0195 0.0421
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2873 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0102 0.0283
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0102 0.0323
Loa Loa (eye worm) cytochrome P450 0.0007 0.0037 0.0061
Schistosoma mansoni cytochrome P450 0.0007 0.0037 0.0037
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0195 0.2176
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0075 0.0129
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0195 0.2176
Loa Loa (eye worm) hypothetical protein 0.001 0.0075 0.0213
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0195 0.0695
Entamoeba histolytica recQ family helicase, putative 0.002 0.0195 0.1838
Brugia malayi cytochrome P450 0.0007 0.0037 0.0061
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0182 0.0641
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0195 0.0695
Schistosoma mansoni thyroid hormone receptor 0.0164 0.2004 0.4812
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0195 0.068
Schistosoma mansoni ap endonuclease 0.0019 0.0182 0.0389
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0765 1
Brugia malayi steroid hormone receptor 0.0012 0.0102 0.0323
Brugia malayi Cytochrome P450 family protein 0.0016 0.0145 0.0495
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0182 0.016
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0318 0.0297
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0476 0.1102
Trichomonas vaginalis C-MYB, putative 0.0009 0.0067 0.0234
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0476 0.1656
Loa Loa (eye worm) hypothetical protein 0.002 0.0195 0.0695
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0195 0.0421
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0182 0.0531
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.007 0.0118
Loa Loa (eye worm) hypothetical protein 0.0006 0.003 0.0035
Trichomonas vaginalis MYB, putative 0.0009 0.0068 0.0236
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0323
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0432 0.5231
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0318 0.6637
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.2004 0.1987
Trichomonas vaginalis pc-MYB2, putative 0.0009 0.0067 0.0234
Schistosoma mansoni hypothetical protein 0.0007 0.0037 0.0037
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0009 0.0068 0.0236
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0102 0.0196
Mycobacterium tuberculosis Probable ATP synthase a chain AtpB (protein 6) 0.0225 0.2761 1
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0102 0.0323
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0765 1
Onchocerca volvulus 0.0029 0.0318 0.104
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0323
Echinococcus multilocularis 0.0007 0.0037 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0102 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0102 0.0323
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0102 0.0196
Echinococcus multilocularis bloom syndrome protein 0.002 0.0195 0.0174
Brugia malayi Cytochrome P450 family protein 0.0016 0.0145 0.0495
Toxoplasma gondii exonuclease III APE 0.0019 0.0182 0.3728
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0182 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0323
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0102 0.0196
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0765 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0195 0.4017
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.003 0.0021
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.1739 0.4168
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0102 0.0196
Loa Loa (eye worm) RecQ helicase 0.002 0.0195 0.0695

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 70.7946 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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