Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.5484 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.0873 | 0.0873 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0873 | 0.1593 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit A | 0.0217 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0873 | 0.1593 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0873 | 0.0873 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.051 | 0.051 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0561 | 0.1023 |
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 0.5484 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0873 | 0.0873 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0873 | 0.0873 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0019 | 0.0561 | 1 |
Echinococcus granulosus | geminin | 0.0169 | 0.7725 | 1 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.2941 | 0.5362 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0873 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0873 | 0.1593 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.2941 | 0.5362 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.2941 | 0.3807 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0008 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.051 | 0.051 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0561 | 0.0561 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.2941 | 0.5362 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.2105 | 0.2105 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0873 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0026 | 0.0873 | 1 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0008 | 0 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0873 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit A | 0.0217 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0122 | 0.5484 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.2941 | 0.2941 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.5484 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.2941 | 0.2941 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.0873 | 0.0873 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.7725 | 0.7725 |
Onchocerca volvulus | 0.0026 | 0.0873 | 0.1593 | |
Mycobacterium tuberculosis | Probable ATP synthase a chain AtpB (protein 6) | 0.0217 | 1 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0873 | 0.0873 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | ATP synthase F0 subunit 6 | 0.0217 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0561 | 0.1023 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.2941 | 0.5362 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.0873 | 0.0873 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.7725 | 0.7725 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.0561 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.051 | 0.051 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.2941 | 0.2941 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0873 | 0.0873 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0873 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0561 | 0.1023 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0873 | 0.1593 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0873 | 0.0873 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.0873 | 0.0873 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0008 | 0 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.0873 | 0.0873 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.2941 | 0.5362 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0561 | 0.1023 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0561 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0561 | 0.1023 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0008 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.051 | 0.051 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0873 | 1 |
Brugia malayi | RNA binding protein | 0.0069 | 0.2941 | 0.5362 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.2941 | 0.2941 |
Toxoplasma gondii | propionate-CoA ligase | 0.0008 | 0 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0873 | 0.1593 |
Echinococcus multilocularis | geminin | 0.0169 | 0.7725 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.2941 | 0.3807 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.2941 | 0.2941 |
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 0.5484 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.0873 | 0.0873 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0019 | 0.0561 | 0.0561 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0873 | 0.1593 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 0.23 ug kg-1 | Inhibitory activity against Bezold-jarisch functional assay, inducing a transient bradicardia upon intravenous administration of 5-hydroxytryptamine(10 ug/kg) in anesthetized rats. | ChEMBL. | 1527780 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.