Detailed information for compound 1105519

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 399.447 | Formula: C19H25N7O3
  • H donors: 4 H acceptors: 5 LogP: -1.38 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCc1ccccc1CN(C[C@H]1OC([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N)C
  • InChi: 1S/C19H25N7O3/c1-25(7-12-5-3-2-4-11(12)6-20)8-13-15(27)16(28)19(29-13)26-10-24-14-17(21)22-9-23-18(14)26/h2-5,9-10,13,15-16,19,27-28H,6-8,20H2,1H3,(H2,21,22,23)/t13-,15-,16-,19?/m1/s1
  • InChiKey: BKCKWSAOAPSKLR-XAUNWSGPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0071 0.0243 0.4155
Onchocerca volvulus 0.0092 0.0333 0.1754
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0082 0.0108
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0077 0.0269 0.0353
Loa Loa (eye worm) hypothetical protein 0.0063 0.0208 0.0208
Schistosoma mansoni hypothetical protein 0.0327 0.1341 0.1764
Trichomonas vaginalis sulfite reductase, putative 0.0074 0.0258 0.0342
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0023 0.0029
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0205 0.0269
Echinococcus multilocularis importin subunit beta 1 0.003 0.0069 0.009
Trypanosoma brucei guanylate kinase, putative 0.002 0.0023 0.001
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.1785 0.7598 1
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0074 0.0258 0.0338
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0145 0.0559 0.0717
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.1785 0.7598 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Schistosoma mansoni alpha-glucosidase 0.0137 0.0526 0.0691
Schistosoma mansoni netrin receptor unc5 0.0028 0.0058 0.0075
Echinococcus granulosus Rac GTPase activating protein 1 0.0073 0.025 0.0328
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.006 0.0195 0.0254
Echinococcus granulosus dna polymerase kappa 0.006 0.0195 0.0256
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.009 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0065 0.0066
Brugia malayi eukaryotic initiation factor 4A 0.005 0.0153 0.0201
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0068 0.0232 0.0286
Schistosoma mansoni integrin alpha-ps 0.0682 0.2865 0.377
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0018 0.0015 0.002
Plasmodium vivax subtilisin-like protease 1 0.1103 0.4672 0.6141
Loa Loa (eye worm) hypothetical protein 0.0332 0.1363 0.1363
Echinococcus multilocularis Rac GTPase activating protein 1 0.0073 0.025 0.0328
Plasmodium vivax aspartyl protease, putative 0.0092 0.0333 0.0419
Schistosoma mansoni integrin beta subunit 0.0181 0.0716 0.0941
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0045 0.0133 0.0174
Echinococcus multilocularis caspase 8 0.0018 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.0079 0.0277 0.0277
Trypanosoma brucei Aminopeptidase M1, putative 0.0145 0.0559 0.0717
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0058 0.0076
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0057 0.0181 0.0219
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0184 0.0184
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1328 0.5637 0.7419
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0205 0.0205
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.005 0.0153 0.2479
Plasmodium falciparum subtilisin-like protease 3 0.0077 0.0269 0.0335
Brugia malayi Guanylate kinase family protein 0.0025 0.0046 0.006
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) 0.0289 0.118 0.1634
Echinococcus granulosus importin subunit beta 1 0.003 0.0069 0.009
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0178 0.0704 0.0926
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0184 0.0241
Echinococcus multilocularis c src tyrosine kinase 0.0017 0.0012 0.0015
Echinococcus granulosus lamin dm0 0.0027 0.0053 0.0069
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.009 0.0105
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.1785 0.7598 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0019 0.0004
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.009 0.0118
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.0068 0.023 0.023
Brugia malayi Tyrosine-protein kinase abl-1 0.0017 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0171 0.0671 0.0671
Plasmodium falciparum M17 leucyl aminopeptidase 0.0068 0.0232 0.0286
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0145 0.0559 0.0717
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.0019 0.0024
Echinococcus granulosus leucine aminopeptidase protein 0.0115 0.0433 0.057
Echinococcus granulosus leukotriene A 4 hydrolase 0.0057 0.0181 0.0238
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0034 0.0086 0.0113
Loa Loa (eye worm) hypothetical protein 0.044 0.1827 0.1827
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0077 0.0269 0.0335
Loa Loa (eye worm) apoptosis regulator protein 0.0055 0.0176 0.0176
Trypanosoma cruzi p450 reductase, putative 0.0074 0.0258 0.0319
Loa Loa (eye worm) peripheral plasma membrane protein CASK 0.0025 0.0046 0.0046
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.009 0.0098
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0023 0.001
Echinococcus multilocularis bloom syndrome protein 0.002 0.0023 0.0029
Entamoeba histolytica Ran family GTPase 0.0022 0.0034 0.0293
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0023 0.0029
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Schistosoma mansoni caspase-3 (C14 family) 0.0018 0.0015 0.0019
Brugia malayi hypothetical protein 0.044 0.1827 0.2405
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0092 0.0333 0.0437
Schistosoma mansoni maguk P55 subfamily member 26 0.002 0.0023 0.0029
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0184 0.0228
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0184 0.0228
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0023 0.001
Echinococcus granulosus disintegrin and metalloproteinase 0.0074 0.0256 0.0336
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0277 0.0277
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0133 0.0174
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.0133 0.0174
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.009 0.1316
Schistosoma mansoni hypothetical protein 0.0055 0.0176 0.0231
Echinococcus granulosus tyrosine protein kinase Lyn 0.0045 0.0133 0.0174
Plasmodium vivax aspartyl protease, putative 0.0092 0.0333 0.0419
Toxoplasma gondii subtilisin SUB1 0.1103 0.4672 0.6143
Brugia malayi hypothetical protein 0.0071 0.0243 0.032
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0053
Brugia malayi Calcitonin receptor-like protein seb-1 0.025 0.1009 0.1329
Chlamydia trachomatis cytosol aminopeptidase 0.0115 0.0433 0.0542
Chlamydia trachomatis sulfite reductase 0.0046 0.0136 0.0149
Schistosoma mansoni cpg binding protein 0.0059 0.019 0.0249
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0269 0.0358
Schistosoma mansoni DNA helicase recq5 0.002 0.0023 0.0029
Loa Loa (eye worm) hypothetical protein 0.0037 0.0096 0.0096
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0023 0.0016
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0019 0.0024
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.022 0.0288
Echinococcus granulosus furin 0.0077 0.0269 0.0353
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.011 0.0125
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0028 0.006 0.0064
Echinococcus multilocularis disks large 1 0.002 0.0023 0.0029
Loa Loa (eye worm) endoprotease bli-4 0.0077 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0015
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0222 0.0291
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0077 0.0269 0.0353
Echinococcus granulosus caspase 8 0.0018 0.0015 0.0019
Plasmodium vivax importin-beta 2, putative 0.003 0.0069 0.0071
Schistosoma mansoni tyrosine kinase 0.0153 0.0596 0.0783
Entamoeba histolytica type A flavoprotein, putative 0.0028 0.006 0.0774
Brugia malayi ADAMTS-like protease 0.0104 0.0386 0.0508
Plasmodium vivax aspartyl proteinase, putative 0.0165 0.0648 0.0834
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0277 0.0364
Schistosoma mansoni hypothetical protein 0.0399 0.1651 0.2173
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.009 0.0105
Toxoplasma gondii subtilisin SUB5 0.0077 0.0269 0.034
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0044 0.0041
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0045 0.0133 0.0174
Brugia malayi Furin-like cysteine rich region family protein 0.0289 0.118 0.1552
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.1785 0.7598 1
Echinococcus granulosus 55 kDa erythrocyte membrane protein 0.0025 0.0046 0.0059
Loa Loa (eye worm) pigment dispersing factor receptor c 0.025 0.1009 0.1009
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0088 0.0316 0.0414
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0088 0.0316 0.0415
Brugia malayi guanylate kinase 0.002 0.0023 0.003
Schistosoma mansoni furin-1 (S08 family) 0.0077 0.0269 0.0353
Plasmodium vivax flavodoxin domain containing protein 0.0066 0.0221 0.0272
Treponema pallidum ATP-dependent RNA helicase 0.005 0.0153 0.0122
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0077 0.0269 0.0348
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0098 0.0359 0.0453
Echinococcus multilocularis kelch ECH associated protein 1 0.0093 0.0339 0.0446
Schistosoma mansoni ran 0.0022 0.0034 0.0044
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0019 0.0024
Plasmodium vivax RNA helicase-1, putative 0.005 0.0153 0.0181
Loa Loa (eye worm) hypothetical protein 0.0025 0.0046 0.0046
Echinococcus granulosus calpain A 0.0066 0.0222 0.0291
Loa Loa (eye worm) hypothetical protein 0.0057 0.0181 0.0181
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0205 0.0269
Trichomonas vaginalis calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase, putative 0.002 0.0023 0.001
Echinococcus multilocularis aminopeptidase N 0.0389 0.1606 0.2113
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0065 0.0066
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0145 0.0559 0.0735
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0068 0.0232 0.0286
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0184 0.0241
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0165 0.0648 0.0893
Leishmania major cytochrome P450 reductase, putative 0.0066 0.0221 0.0272
Loa Loa (eye worm) hypothetical protein 0.0244 0.0985 0.0985
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0205 0.0269
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0145 0.0559 0.0735
Schistosoma mansoni site-1 peptidase (S08 family) 0.0077 0.0269 0.0353
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0195 0.0237
Plasmodium vivax plasmepsin IV, putative 0.0165 0.0648 0.0834
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0001 0.0001
Plasmodium vivax aspartyl proteinase, putative 0.0092 0.0333 0.0419
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0086 0.0113
Plasmodium falciparum plasmepsin X 0.0092 0.0333 0.0419
Schistosoma mansoni calpain C (C02 family) 0.0019 0.0019 0.0024
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.0082 0.0107
Trypanosoma cruzi aminopeptidase, putative 0.0145 0.0559 0.0717
Loa Loa (eye worm) TK protein kinase 0.0031 0.0071 0.0071
Schistosoma mansoni high voltage-activated calcium channel beta subunit 1 0.002 0.0023 0.0029
Chlamydia trachomatis transcriptional repressor NrdR 0.0116 0.0435 0.0544
Trypanosoma brucei subtilisin peptidase 0.0077 0.0269 0.0335
Brugia malayi latrophilin 2 splice variant baaae 0.0171 0.0671 0.0883
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0145 0.0559 0.0735
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0093 0.0338 0.0444
Trypanosoma cruzi aminopeptidase, putative 0.0057 0.0181 0.0219
Schistosoma mansoni lamin 0.0027 0.0053 0.0069
Entamoeba histolytica type A flavoprotein, putative 0.0028 0.006 0.0774
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.022 0.027
Loa Loa (eye worm) proprotein convertase 2 0.0077 0.0269 0.0269
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0145 0.0559 0.0735
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.1785 0.7598 0.7598
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0044 0.0041
Schistosoma mansoni cell polarity protein 0.0031 0.0069 0.009
Echinococcus multilocularis netrin receptor unc 5 0.0028 0.0058 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0195 0.0237
Schistosoma mansoni hypothetical protein 0.0055 0.0176 0.0231
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0115 0.0433 0.058
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0195 0.0237
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0195 0.0237
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0145 0.0559 0.0735
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0322 0.0322
Echinococcus multilocularis 55 kDa erythrocyte membrane protein 0.0025 0.0046 0.0059
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0145 0.0559 0.0735
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0019 0.0004
Echinococcus granulosus calpain 7 C02 family 0.0019 0.0019 0.0024
Echinococcus multilocularis 0.0077 0.0269 0.0353
Toxoplasma gondii subtilisin SUB12 0.0077 0.0269 0.034
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0016 0.002
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0028 0.006 0.0059
Toxoplasma gondii subtilisin SUB9 0.0077 0.0269 0.034
Echinococcus granulosus c src tyrosine kinase 0.0017 0.0012 0.0015
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0165 0.0648 0.0852
Loa Loa (eye worm) calpain family protein 1 0.0044 0.0128 0.0128
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.0621 0.0621
Schistosoma mansoni hypothetical protein 0.0094 0.0341 0.0447
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.005 0.0153 0.0194
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0045 0.0133 0.0174
Toxoplasma gondii subtilisin SUB6 0.0077 0.0269 0.034
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0066 0.0222 0.0291
Giardia lamblia DINP protein human, muc B family 0.004 0.011 0.4394
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0205 0.0269
Brugia malayi calpain family protein 1 0.0063 0.0208 0.0274
Echinococcus multilocularis calpain A 0.0066 0.0222 0.0291
Trichomonas vaginalis sap-102, putative 0.002 0.0023 0.001
Plasmodium falciparum plasmepsin V 0.0092 0.0333 0.0419
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0053 0.0053
Plasmodium vivax aspartyl protease, putative 0.0092 0.0333 0.0419
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0195 0.0237
Echinococcus multilocularis caspase 0.0018 0.0015 0.0019
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0019 0.0019 0.0004
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0694 0.2918 0.384
Brugia malayi Death domain containing protein 0.0028 0.0058 0.0076
Schistosoma mansoni ap endonuclease 0.0057 0.0184 0.0241
Brugia malayi Eukaryotic aspartyl protease family protein 0.0092 0.0333 0.0438
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0028 0.006 0.0064
Loa Loa (eye worm) hypothetical protein 0.115 0.4876 0.4876
Schistosoma mansoni tyrosine kinase 0.0017 0.0012 0.0015
Plasmodium falciparum eukaryotic initiation factor 4A 0.005 0.0153 0.0181
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0077 0.0269 0.0353
Brugia malayi hypothetical protein 0.002 0.0023 0.003
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0074 0.0258 0.0319
Echinococcus granulosus caspase 2 0.0018 0.0015 0.0019
Echinococcus multilocularis integrin alpha ps 0.0682 0.2865 0.377
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0023 0.003
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.022 0.027
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0034 0.0044
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0184 0.0223
Loa Loa (eye worm) hypothetical protein 0.0091 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0074 0.0256 0.0256
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0019 0.0004
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0092 0.0333 0.0437
Echinococcus multilocularis insulin receptor 0.0093 0.0338 0.0444
Schistosoma mansoni hypothetical protein 0.0079 0.0277 0.0364
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0145 0.0559 0.0767
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0057 0.0181 0.0238
Echinococcus granulosus death domain containing protein 0.0028 0.0058 0.0075
Schistosoma mansoni hypothetical protein 0.0364 0.15 0.1974
Plasmodium falciparum plasmepsin IV 0.0165 0.0648 0.0834
Trichomonas vaginalis discs large, putative 0.002 0.0023 0.001
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0057 0.0181 0.0219
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0077 0.0269 0.0348
Loa Loa (eye worm) guanylate kinase 0.0064 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0088 0.0316 0.0316
Trypanosoma brucei guanylate kinase, putative 0.002 0.0023 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Echinococcus multilocularis epidermal growth factor receptor 0.0289 0.118 0.1552
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0289 0.118 0.1535
Echinococcus multilocularis integrin alpha ps 0.0327 0.1341 0.1764
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0015 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0322 0.0423
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0057 0.0181 0.0219
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0133 0.0174
Schistosoma mansoni apoptosis regulator bax 0.0055 0.0176 0.0231
Brugia malayi Integrin beta pat-3 precursor 0.0308 0.1259 0.1656
Echinococcus granulosus calpain 0.0019 0.0019 0.0024
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0018 0.0015 0.0019
Loa Loa (eye worm) TK/INSR protein kinase 0.0093 0.0338 0.0338
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Toxoplasma gondii aminopeptidase N, putative 0.0344 0.1416 0.1851
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0145 0.0559 0.0717
Brugia malayi Disintegrin family protein 0.0074 0.0256 0.0337
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0082 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0065 0.0066
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0077 0.0269 0.0348
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0344 0.1416 0.1847
Leishmania major importin beta-1 subunit, putative 0.0025 0.0044 0.0038
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0019 0.0024
Echinococcus multilocularis 0.0089 0.0321 0.0422
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.005 0.0153 0.0187
Schistosoma mansoni diflavin oxidoreductase 0.0037 0.0097 0.0126
Echinococcus multilocularis kelch ECH associated protein 1 0.0093 0.0339 0.0446
Echinococcus granulosus geminin 0.0364 0.15 0.1974
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0057 0.0181 0.0238
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.009 0.1316
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0017 0.0012 0.0015
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0092 0.0333 0.0437
Brugia malayi Reprolysin 0.0104 0.0387 0.0509
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0322 0.0423
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Schistosoma mansoni cpg binding protein 0.0062 0.0204 0.0268
Trypanosoma brucei kinesin, putative 0.0019 0.0019 0.0004
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0042 0.012 0.0157
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0184 0.3063
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.1651 0.2173
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.005 0.0153 0.02
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0133 0.0174
Schistosoma mansoni tyrosine kinase 0.0289 0.118 0.1552
Echinococcus multilocularis geminin 0.0364 0.15 0.1974
Brugia malayi SRC-1 0.0045 0.0133 0.0175
Schistosoma mansoni caspase-7 (C14 family) 0.0018 0.0015 0.0019
Trypanosoma cruzi kinesin, putative 0.0019 0.0019 0.0004
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.0082 0.0107
Echinococcus granulosus calpain 5 0.0019 0.0019 0.0024
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.1669 0.7102 1
Echinococcus multilocularis Furin 1 0.0077 0.0269 0.0353
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0277 0.0364
Schistosoma mansoni guanylate kinase 0.002 0.0023 0.0029
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0023 0.0029
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0077 0.0269 0.0348
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0019 0.0019 0.0004
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0019 0.0004
Plasmodium falciparum nitric oxide synthase, putative 0.0074 0.0258 0.0319
Echinococcus multilocularis tyrosine protein kinase Abl 0.0017 0.0012 0.0015
Echinococcus multilocularis caspase 2 0.0018 0.0015 0.0019
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0015 0.0001 0.0001
Entamoeba histolytica type A flavoprotein, putative 0.0028 0.006 0.0774
Echinococcus granulosus calpain A 0.0019 0.0019 0.0024
Plasmodium vivax calpain, putative 0.0019 0.0019 0.0004
Echinococcus granulosus guanylate kinase 0.002 0.0023 0.0029
Echinococcus granulosus intermediate filament protein 0.0027 0.0053 0.0069
Toxoplasma gondii ribonucleoside-diphosphate reductase small subunit 0.0289 0.118 0.154
Echinococcus multilocularis guanylate kinase 0.002 0.0023 0.0029
Echinococcus granulosus dna polymerase eta 0.0033 0.0082 0.0107
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0205 0.0269
Echinococcus granulosus lamin 0.0027 0.0053 0.0069
Loa Loa (eye worm) hypothetical protein 0.0055 0.0176 0.0176
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0074 0.0258 0.0319
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0165 0.0648 0.0648
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0184 0.813
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0019 0.0004
Echinococcus multilocularis tyrosine protein kinase Srms 0.0034 0.0086 0.0113
Leishmania major p450 reductase, putative 0.0074 0.0258 0.0319
Leishmania major guanylate kinase, putative 0.002 0.0023 0.001
Plasmodium falciparum plasmepsin VI 0.0165 0.0648 0.0834
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit beta 0.0289 0.118 0.1527
Mycobacterium ulcerans aminopeptidase N PepN 0.0145 0.0559 0.0758
Schistosoma mansoni hypothetical protein 0.0055 0.0176 0.0231
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.1785 0.7598 1
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.005 0.0153 0.0181
Leishmania major eukaryotic initiation factor 4a, putative 0.005 0.0153 0.0181
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0046 0.0136 0.0177
Toxoplasma gondii exonuclease III APE 0.0057 0.0184 0.0228
Loa Loa (eye worm) hypothetical protein 0.0092 0.0333 0.0333
Trypanosoma cruzi guanylate kinase, putative 0.002 0.0023 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0195 0.0237
Echinococcus multilocularis adam 0.0243 0.0983 0.1293
Brugia malayi hypothetical protein 0.0057 0.0181 0.0239
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0178 0.0704 0.0926
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0512 0.2136 0.2797
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0077 0.0269 0.0335
Toxoplasma gondii aminopeptidase N protein 0.0344 0.1416 0.1851
Trypanosoma brucei unspecified product 0.0023 0.0037 0.0029
Schistosoma mansoni calpain (C02 family) 0.0019 0.0019 0.0024
Schistosoma mansoni hypothetical protein 0.0028 0.0058 0.0075
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0074 0.0256 0.0336
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0074 0.0258 0.0338
Echinococcus multilocularis cpg binding protein 0.0062 0.0204 0.0268
Brugia malayi polk-prov protein 0.0037 0.0096 0.0127
Echinococcus granulosus kelch ECH associated protein 1 0.0093 0.0339 0.0446
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0055 0.0176 0.0232
Trichomonas vaginalis ran, putative 0.0022 0.0034 0.0027
Brugia malayi aspartic protease BmAsp-2, identical 0.0092 0.0333 0.0438
Toxoplasma gondii aspartyl protease 0.0092 0.0333 0.0424
Echinococcus multilocularis snurportin 1 0.0325 0.1332 0.1753
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0019 0.0004
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0289 0.118 0.1535
Brugia malayi neuroendocrine convertase 1 precursor 0.0077 0.0269 0.0354
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0077 0.0269 0.0354
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0101 0.0132
Plasmodium falciparum plasmepsin VIII, putative 0.0092 0.0333 0.0419
Echinococcus granulosus neuroendocrine convertase 2 0.0077 0.0269 0.0353
Brugia malayi hypothetical protein 0.0234 0.0941 0.1238
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.011 0.0125
Schistosoma mansoni integrin alpha 0.1521 0.6465 0.8509
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.1669 0.7102 1
Toxoplasma gondii subtilisin SUB7 0.0077 0.0269 0.034
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0019 0.0004
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0694 0.2918 0.384
Echinococcus granulosus eukaryotic initiation factor 4A 0.005 0.0153 0.02
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0074 0.0258 0.0319
Brugia malayi FAD binding domain containing protein 0.0046 0.0136 0.0178
Entamoeba histolytica type A flavoprotein, putative 0.0028 0.006 0.0774
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0034 0.0034
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0082 0.0084
Schistosoma mansoni DNA helicase recq1 0.002 0.0023 0.0029
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0015 0.0006
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.019 0.019
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0101 0.0132
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.005 0.0153 0.0183
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0057 0.0181 0.0234
Echinococcus granulosus tyrosine protein kinase HCK 0.0031 0.0071 0.0092
Schistosoma mansoni hypothetical protein 0.0325 0.1332 0.1753
Toxoplasma gondii flavodoxin domain-containing protein 0.0037 0.0097 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0269 0.0358
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0069 0.0071
Loa Loa (eye worm) hypothetical protein 0.0063 0.0207 0.0207
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0077 0.0269 0.0348
Schistosoma mansoni hypothetical protein 0.0071 0.0243 0.0319
Onchocerca volvulus 0.0036 0.0092 0.0425
Entamoeba histolytica recQ family helicase, putative 0.002 0.0023 0.0078
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.1785 0.7598 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit beta 0.0098 0.0359 0.0475
Schistosoma mansoni hypothetical protein 0.0079 0.0277 0.0364
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0195 0.0237
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0034 0.0044
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.005 0.0153 0.0194
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.009 0.0105
Toxoplasma gondii aminopeptidase n, putative 0.0344 0.1416 0.1851
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0234 0.0941 0.1237
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0028 0.006 0.0059
Echinococcus multilocularis tyrosine protein kinase Blk 0.0034 0.0086 0.0113
Echinococcus multilocularis lamin 0.0027 0.0053 0.0069
Loa Loa (eye worm) hypothetical protein 0.0074 0.0258 0.0258
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0044 0.0041
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0023
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0055 0.0176 0.0231
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.0082 0.0107
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0277 0.0365
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0199 0.0249
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.1785 0.7598 1
Echinococcus granulosus disks large 1 0.002 0.0023 0.0029
Brugia malayi hypothetical protein 0.0145 0.0559 0.0736
Toxoplasma gondii subtilisin SUB2 0.0077 0.0269 0.034
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0145 0.0559 0.0735
Schistosoma mansoni MAGUK homolog 0.0025 0.0046 0.0059
Loa Loa (eye worm) hypothetical protein 0.0057 0.0181 0.0181
Schistosoma mansoni rac gtpase activating protein 0.0073 0.025 0.0328
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.002 0.0023 0.0023
Echinococcus multilocularis eukaryotic initiation factor 4A 0.005 0.0153 0.02
Brugia malayi Importin beta-1 subunit 0.003 0.0069 0.0091
Onchocerca volvulus 0.0077 0.0269 0.14
Mycobacterium tuberculosis Probable transcriptional regulatory protein NrdR 0.0116 0.0435 0.0582
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0096 0.0107
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0019 0.0004
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0077 0.0269 0.0348
Trypanosoma cruzi kinesin, putative 0.0019 0.0019 0.0004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.011 0.0123
Loa Loa (eye worm) hypothetical protein 0.0355 0.1462 0.1462
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0621 0.0816
Echinococcus multilocularis dna polymerase eta 0.0033 0.0082 0.0107
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0289 0.118 0.1535
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0092 0.0333 0.0437
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0289 0.118 0.1535
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.009 0.0098
Brugia malayi Pepsin A precursor 0.0092 0.0333 0.0438
Echinococcus granulosus integrin alpha ps 0.0682 0.2865 0.377
Schistosoma mansoni intermediate filament proteins 0.0027 0.0053 0.0069
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0289 0.118 0.1535
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0199 0.0249
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.022 0.3724
Echinococcus granulosus MAGUK p55 subfamily 0.0025 0.0046 0.0059
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0023 0.0023
Brugia malayi metalloprotease 0.0049 0.015 0.0198
Echinococcus multilocularis dna polymerase kappa 0.006 0.0195 0.0256
Echinococcus multilocularis musashi 0.0027 0.0053 0.0069
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0077 0.0269 0.0353
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0042 0.012 0.0157
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.022 0.0288
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0088 0.0316 0.0415
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0023 0.003
Schistosoma mansoni caspase-7 (C14 family) 0.0018 0.0015 0.0019
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0165 0.0648 0.0852
Loa Loa (eye worm) hypothetical protein 0.044 0.1827 0.1827
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.1785 0.7598 1
Echinococcus multilocularis 0.0025 0.0046 0.0059
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0023
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Onchocerca volvulus 0.0057 0.0181 0.0917
Echinococcus granulosus eukaryotic initiation factor 4A III 0.005 0.0153 0.02
Echinococcus multilocularis disintegrin and metalloproteinase 0.0074 0.0256 0.0336
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0077 0.0269 0.0353
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0053 0.0053
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0077 0.0269 0.0353
Plasmodium falciparum plasmepsin II 0.0165 0.0648 0.0834
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0057 0.0181 0.0238
Echinococcus granulosus disks large 3 0.0073 0.0253 0.0332
Brugia malayi protein-tyrosine kinase 0.0034 0.0086 0.0114
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0057 0.0181 0.0219
Plasmodium vivax ribonucleotide reductase small subunit, putative 0.0098 0.0359 0.0453
Schistosoma mansoni tyrosine kinase 0.0156 0.0607 0.0798
Echinococcus granulosus tar DNA binding protein 0.0062 0.0205 0.0269
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.009 0.0098
Echinococcus granulosus Ankyrin 0.0028 0.0058 0.0075
Trypanosoma cruzi guanylate kinase, putative 0.002 0.0023 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Entamoeba histolytica guanylate kinase, putative 0.002 0.0023 0.0075
Loa Loa (eye worm) hypothetical protein 0.0088 0.0316 0.0316
Echinococcus granulosus epidermal growth factor receptor 0.0289 0.118 0.1552
Leishmania major subtilisin-like serine peptidase 0.0077 0.0269 0.0335
Loa Loa (eye worm) hypothetical protein 0.0044 0.0128 0.0128
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0019 0.0004
Loa Loa (eye worm) angiogenesis inhibito 0.0049 0.015 0.015
Echinococcus multilocularis Ankyrin 0.0028 0.0058 0.0075
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0057 0.0181 0.0238
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0023 0.0011
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.0082 0.0088
Schistosoma mansoni hypothetical protein 0.0171 0.0671 0.0882
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0184 0.0223
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0017 0.0012 0.0015
Loa Loa (eye worm) SRC-1 0.0045 0.0133 0.0133
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0178 0.0704 0.0926
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0015 0.0001 0.0001
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.022 0.027
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.009 0.0117
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.1669 0.7102 1
Brugia malayi Guanylate kinase family protein 0.0084 0.0299 0.0394
Entamoeba histolytica type A flavoprotein, putative 0.0028 0.006 0.0774
Entamoeba histolytica hypothetical protein 0.0071 0.0243 0.4155
Onchocerca volvulus 0.044 0.1827 1
Echinococcus multilocularis MAGUK p55 subfamily 0.0025 0.0046 0.0059
Schistosoma mansoni cytochrome P450 reductase 0.0074 0.0258 0.0338
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.009 0.0105
Toxoplasma gondii subtilisin SUB11 0.0077 0.0269 0.034
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0023
Loa Loa (eye worm) metalloprotease 0.0049 0.015 0.015
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0028 0.0058 0.0058
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.009 0.0104
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0115 0.0433 0.058
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.022 0.0288
Loa Loa (eye worm) runx1 0.0055 0.0175 0.0175
Schistosoma mansoni MAGUK homolog 0.0025 0.0046 0.0059
Entamoeba histolytica hypothetical protein 0.0071 0.0243 0.4155
Mycobacterium ulcerans transcriptional regulator NrdR 0.0116 0.0435 0.0582
Plasmodium falciparum guanylate kinase 0.002 0.0023 0.001
Plasmodium falciparum subtilisin-like protease 2 0.0077 0.0269 0.0335
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0088 0.0316 0.0396
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0184 0.0242
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0045 0.0133 0.0174
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0195 0.0237
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0034 0.0045
Echinococcus multilocularis high voltage activated calcium channel beta 0.002 0.0023 0.0029
Onchocerca volvulus 0.0044 0.0128 0.0621
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0019 0.0004
Loa Loa (eye worm) RecQ helicase 0.002 0.0023 0.0023
Echinococcus granulosus netrin receptor unc 5 0.0028 0.0058 0.0075
Echinococcus granulosus high voltage activated calcium channel beta 0.002 0.0023 0.0029
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0241 0.0974 0.1282
Echinococcus multilocularis calpain 5 0.0019 0.0019 0.0024
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.009 0.0105
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0077 0.0269 0.0335
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0277 0.0365
Echinococcus granulosus kelch ECH associated protein 1 like 0.0093 0.0339 0.0446
Brugia malayi Subtilase family protein 0.0077 0.0269 0.0354
Loa Loa (eye worm) aminopeptidase N 0.0145 0.0559 0.0559
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0044 0.0038
Brugia malayi Cell death protein 3 precursor 0.0018 0.0015 0.002
Echinococcus multilocularis hypothetical protein 0.0019 0.0019 0.0024
Echinococcus multilocularis ribonucleoside diphosphate reductase subunit 0.0289 0.118 0.1552
Onchocerca volvulus 0.0027 0.0053 0.021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0322 0.0423
Brugia malayi RNA, U transporter 1 0.0087 0.031 0.0408
Echinococcus multilocularis integrin alpha ps 0.0682 0.2865 0.377
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Entamoeba histolytica protein kinase, putative 0.0031 0.0071 0.0965
Schistosoma mansoni site-1 peptidase (S08 family) 0.0077 0.0269 0.0353
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0145 0.0559 0.0767
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0066 0.0222 0.0291
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.1785 0.7598 1
Loa Loa (eye worm) guanylate kinase 0.0025 0.0046 0.0046
Loa Loa (eye worm) flavodoxin family protein 0.0028 0.006 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0195 0.0237
Loa Loa (eye worm) hypothetical protein 0.003 0.0069 0.0069
Toxoplasma gondii aspartyl protease ASP3 0.0092 0.0333 0.0424
Echinococcus granulosus snurportin 1 0.0325 0.1332 0.1753
Brugia malayi abnormal cell lineage protein 2 0.002 0.0023 0.003
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.06 0.2514 0.3519
Brugia malayi Peripheral plasma membrane protein CASK 0.0036 0.0092 0.0122
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.009 0.0105
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0018 0.0015 0.0019
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain, putative 0.0289 0.118 0.1535
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0028 0.0058 0.0075
Echinococcus multilocularis Kelch repeat type 1 0.0094 0.0341 0.0447
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0028 0.006 0.0059
Brugia malayi Peptidase family M1 containing protein 0.0145 0.0559 0.0736
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0028 0.006 0.0059
Schistosoma mansoni tyrosine kinase 0.0153 0.0596 0.0783
Loa Loa (eye worm) peptidase family M1 containing protein 0.0301 0.1228 0.1228
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0023 0.0016
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0017 0.0012 0.0015
Onchocerca volvulus 0.0145 0.0559 0.3001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0058 0.0058
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.022 0.0289
Schistosoma mansoni hypothetical protein 0.0079 0.0277 0.0364
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0322 0.0423
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0023 0.001
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0145 0.0559 0.0735
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0092 0.0333 0.0333
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Schistosoma mansoni tyrosine kinase 0.0093 0.0338 0.0444
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0199 0.0261
Brugia malayi hypothetical protein 0.0092 0.0333 0.0438
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0016 0.0016
Echinococcus granulosus adam 17 protease 0.0074 0.0256 0.0336
Loa Loa (eye worm) guanylate kinase 0.002 0.0023 0.0023
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0133 0.0174
Echinococcus granulosus tyrosine protein kinase Src42A 0.0032 0.0075 0.0098
Brugia malayi CXXC zinc finger family protein 0.0059 0.019 0.025
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) 0.0289 0.118 0.1634
Trypanosoma brucei glucosidase, putative 0.0035 0.009 0.0098
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0243 0.0319
Entamoeba histolytica hypothetical protein 0.0071 0.0243 0.4155
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0222 0.0291
Schistosoma mansoni dihydroceramide desaturase 0.0074 0.0256 0.0336
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0547 0.2288 0.3011
Schistosoma mansoni maguk P55 subfamily member 35 0.0025 0.0046 0.0059
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0145 0.0559 0.0735
Brugia malayi Peptidase family M1 containing protein 0.0057 0.0181 0.0239
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.1669 0.7102 1
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0074 0.0258 0.0319
Schistosoma mansoni alpha glucosidase 0.0035 0.009 0.0117
Brugia malayi proprotein convertase 2 0.0077 0.0269 0.0354
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.005 0.0153 0.02
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0032 0.0075 0.0098
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0184 0.0164
Echinococcus granulosus tyrosine kinase 0.0034 0.0086 0.0113
Brugia malayi TATA binding protein associated factor 0.0057 0.0181 0.0239
Loa Loa (eye worm) hypothetical protein 0.0137 0.0528 0.0528
Loa Loa (eye worm) integrin beta-2 0.0308 0.1259 0.1259
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0019 0.0004
Leishmania major GTP-binding protein, putative 0.0022 0.0034 0.0025
Loa Loa (eye worm) calpain family protein 1 0.0063 0.0208 0.0208
Echinococcus multilocularis peripheral plasma membrane protein CASK 0.0025 0.0046 0.0059
Loa Loa (eye worm) subtilase 0.0077 0.0269 0.0269
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.0082 0.0082
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0195 0.0237
Echinococcus granulosus integrin beta 2 0.0228 0.0916 0.1205
Schistosoma mansoni tyrosine kinase 0.0093 0.0338 0.0444
Schistosoma mansoni hypothetical protein 0.0079 0.0277 0.0364
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit beta 0.0289 0.118 0.1634
Echinococcus multilocularis calpain 0.0019 0.0019 0.0024
Giardia lamblia Nitric oxide synthase, inducible 0.0066 0.0221 1
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0028 0.006 0.0059
Echinococcus granulosus MAGUK p55 subfamily 0.0025 0.0046 0.0059
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0205 0.0269
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0134 0.0514 0.0676
Schistosoma mansoni integrin alpha-ps 0.0355 0.1462 0.1923
Leishmania major hypothetical protein, conserved 0.0028 0.006 0.0059
Loa Loa (eye worm) hypothetical protein 0.0057 0.0181 0.0181
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0289 0.118 0.1535
Brugia malayi intermediate filament protein 0.0027 0.0053 0.007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0322 0.0423
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0019 0.0004
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0028 0.006 0.0064
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0195 0.0237
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.022 0.027
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0068 0.0232 0.0286
Plasmodium vivax subtilisin-like protease 2, putative 0.0077 0.0269 0.0335
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0621 0.0816
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0047 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.005 0.0153 0.0153
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0028 0.006 0.0059
Plasmodium vivax hypothetical protein, conserved 0.0028 0.006 0.0059
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.1785 0.7598 1
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0028 0.0058 0.0075
Brugia malayi calpain 5 0.0019 0.0019 0.0025
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.08 0.3373 0.4439
Brugia malayi calpain 7 0.0019 0.0019 0.0025
Mycobacterium ulcerans aminopeptidase N PepN 0.0057 0.0181 0.0224
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0322 0.0423
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Onchocerca volvulus 0.0092 0.0333 0.1754
Echinococcus granulosus tyrosine protein kinase Src64B 0.0045 0.0133 0.0174
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0077 0.0269 0.0269
Brugia malayi endoprotease bli-4 precursor 0.0077 0.0269 0.0354
Echinococcus granulosus high voltage activated calcium channel beta 0.002 0.0023 0.0029
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0082 0.0088
Echinococcus granulosus insulin receptor 0.0093 0.0338 0.0444
Brugia malayi FAD binding domain containing protein 0.0074 0.0258 0.0339
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0115 0.0433 0.0551
Echinococcus granulosus MAGUK p55 subfamily 0.0025 0.0046 0.0059
Brugia malayi Uncoordinated protein 44 0.0028 0.0058 0.0076
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0145 0.0559 0.0735
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0184 0.0223
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0074 0.0258 0.0338
Schistosoma mansoni memapsin-2 (A01 family) 0.1747 0.7437 0.9788
Loa Loa (eye worm) RNA binding protein 0.0062 0.0205 0.0205
Brugia malayi hypothetical protein 0.0092 0.0333 0.0438
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0096 0.0107
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0199 0.0249
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0015 0.002
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0133 0.0174
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0289 0.118 0.1535
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0034 0.0025
Trypanosoma brucei Aminopeptidase M1, putative 0.0145 0.0559 0.0717
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0074 0.0258 0.0319
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0184 0.0238
Brugia malayi calpain family protein 1 0.0063 0.0208 0.0274
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0077 0.0269 0.0335
Echinococcus granulosus integrin alpha 3 0.1166 0.4942 0.6504
Plasmodium falciparum plasmepsin I 0.0165 0.0648 0.0834
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0165 0.0648 0.0852
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0034 0.0025
Echinococcus multilocularis tyrosine protein kinase HCK 0.0031 0.0071 0.0092
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0015 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0269 0.0358
Brugia malayi ribonucleotide reductase 2 0.0289 0.118 0.1552
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0195 0.0237
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0322 0.0424
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Loa Loa (eye worm) hypothetical protein 0.0178 0.0704 0.0704
Schistosoma mansoni ribonucleoside-diphosphate reductase small chain 0.0289 0.118 0.1552
Brugia malayi Protein kinase domain containing protein 0.0093 0.0338 0.0445
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0034 0.0025
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0145 0.0559 0.0735
Schistosoma mansoni tyrosine kinase 0.0017 0.0012 0.0015
Entamoeba histolytica aminopeptidase, putative 0.0145 0.0559 1
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0066 0.0221 0.0291
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0074 0.0258 0.0319
Echinococcus granulosus kelch ECH associated protein 1 like 0.0093 0.0339 0.0446
Loa Loa (eye worm) hypothetical protein 0.0165 0.0648 0.0648
Loa Loa (eye worm) ribonucleotide reductase M2 B 0.0289 0.118 0.118
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0145 0.0559 0.0717
Toxoplasma gondii subtilisin SUB4 0.0077 0.0269 0.034
Schistosoma mansoni cathepsin D (A01 family) 0.0352 0.1451 0.1909
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0472 0.062
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0077 0.0269 0.0348
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.022 0.022
Brugia malayi ADAM-TS Spacer 1 family protein 0.0104 0.0386 0.0508
Echinococcus granulosus integrin alpha ps 0.0327 0.1341 0.1764
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.009 0.0105
Echinococcus multilocularis methionine synthase reductase 0.0046 0.0136 0.0177
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0289 0.118 0.1535
Schistosoma mansoni alpha-glucosidase 0.0137 0.0526 0.0691
Trypanosoma cruzi Aminopeptidase M1, putative 0.0145 0.0559 0.0717
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0077 0.0269 0.0348
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0377 0.1556 0.2047
Echinococcus granulosus GPCR family 2 0.0079 0.0277 0.0364
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0199 0.0242
Schistosoma mansoni ankyrin 23/unc44 0.0028 0.0058 0.0075
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0023 0.001
Brugia malayi hypothetical protein 0.0047 0.0139 0.0183
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0068 0.0232 0.0286
Loa Loa (eye worm) TATA binding protein associated factor 0.0057 0.0181 0.0181
Echinococcus multilocularis integrin alpha 3 0.1166 0.4942 0.6504
Loa Loa (eye worm) reprolysin 0.0178 0.0704 0.0704
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0063 0.0208 0.0273
Brugia malayi RNA binding protein 0.0062 0.0205 0.0269
Schistosoma mansoni ran 0.0022 0.0034 0.0044
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.005 0.0153 0.0194
Toxoplasma gondii aspartyl protease ASP1 0.0165 0.0648 0.0839
Schistosoma mansoni cpg binding protein 0.0062 0.0204 0.0268
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0199 0.0248
Echinococcus granulosus caspase 0.0018 0.0015 0.0019
Giardia lamblia Hypothetical protein 0.0066 0.0221 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0377 0.1556 0.2047
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0001 0.0001
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0092 0.0333 0.0437
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Plasmodium falciparum plasmepsin VII 0.0092 0.0333 0.0419
Trypanosoma brucei aminopeptidase, putative 0.0057 0.0181 0.0219
Echinococcus multilocularis MAGUK p55 subfamily 0.0025 0.0046 0.0059
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.009 0.0117
Brugia malayi Protein kinase domain containing protein 0.0028 0.0058 0.0076
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0077 0.0269 0.0348
Giardia lamblia Translation initiation factor eIF-4A, putative 0.005 0.0153 0.654
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN) 0.0098 0.0359 0.0475
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0034 0.0025
Echinococcus multilocularis calpain family protein 1, d 0.0044 0.0128 0.0167
Giardia lamblia Rho GAP, putative 0.0063 0.0207 0.929
Onchocerca volvulus 0.0059 0.019 0.0963
Leishmania major kinesin, putative 0.0019 0.0019 0.0004
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.002 0.0023 0.003
Schistosoma mansoni hypothetical protein 0.0364 0.15 0.1974
Loa Loa (eye worm) hypothetical protein 0.0055 0.0175 0.0175
Schistosoma mansoni tyrosine kinase 0.0153 0.0596 0.0783
Echinococcus multilocularis integrin beta 2 0.0228 0.0916 0.1205
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0092 0.0333 0.0437
Echinococcus multilocularis membrane bound transcription factor site 1 0.0077 0.0269 0.0353
Loa Loa (eye worm) aspartyl protease 6 0.0092 0.0333 0.0333
Schistosoma mansoni NADPH flavin oxidoreductase 0.0037 0.0099 0.013
Loa Loa (eye worm) hypothetical protein 0.0839 0.3539 0.3539
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0028 0.006 0.0064
Schistosoma mansoni cathepsin D (A01 family) 0.0352 0.1451 0.1909
Schistosoma mansoni lozenge 0.0055 0.0175 0.023
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Loa Loa (eye worm) hypothetical protein 0.0063 0.0208 0.0208
Loa Loa (eye worm) FAD binding domain-containing protein 0.0074 0.0258 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0269 0.0358
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0133 0.0174
Brugia malayi ZU5 domain containing protein 0.002 0.0023 0.003
Echinococcus granulosus bloom syndrome protein 0.002 0.0023 0.0029
Loa Loa (eye worm) hypothetical protein 0.0047 0.0139 0.0139
Brugia malayi Guanylate kinase family protein 0.002 0.0023 0.003
Toxoplasma gondii subtilisin SUB8 0.0077 0.0269 0.034
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0057 0.0181 0.0219
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0042 0.012 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0269 0.0358
Echinococcus multilocularis disks large 3 0.0073 0.0253 0.0332
Echinococcus multilocularis neuroendocrine convertase 2 0.0077 0.0269 0.0353
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0034 0.0025
Plasmodium falciparum importin beta, putative 0.003 0.0069 0.0071
Loa Loa (eye worm) hypothetical protein 0.0104 0.0386 0.0386
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0092 0.0333 0.0437
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.0082 0.0107
Schistosoma mansoni tumor necrosis factor receptor related 0.0042 0.012 0.0157
Plasmodium vivax subtilisin-like serine protease, putative 0.0077 0.0269 0.0335
Brugia malayi TAR-binding protein 0.0062 0.0205 0.0269
Loa Loa (eye worm) hypothetical protein 0.0125 0.0476 0.0476
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.002 0.0023 0.0029
Schistosoma mansoni aminopeptidase A (M01 family) 0.0057 0.0181 0.0238
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0034 0.0031
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0178 0.0704 0.0926
Schistosoma mansoni tyrosine kinase 0.0045 0.0133 0.0174
Loa Loa (eye worm) hypothetical protein 0.0028 0.0058 0.0058
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.005 0.0153 0.0181
Plasmodium falciparum plasmepsin III 0.0092 0.0333 0.0419
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0028 0.0058 0.0075
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0184 0.0238
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.005 0.0153 0.0757
Toxoplasma gondii guanylate kinase family protein 0.002 0.0023 0.0015
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0074 0.0258 0.0338
Loa Loa (eye worm) hypothetical protein 0.0327 0.1341 0.1341
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0184 0.0223
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0115 0.0433 0.058
Echinococcus multilocularis Protein lozenge 0.0055 0.0175 0.023
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0023 0.0009
Schistosoma mansoni cell polarity protein 0.0073 0.0253 0.0332
Trypanosoma brucei unspecified product 0.0023 0.0037 0.0029
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0093 0.0338 0.0444
Treponema pallidum ribonucleotide-diphosphate reductase subunit beta 0.0289 0.118 0.1485
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.0082 0.1169
Mycobacterium ulcerans leucyl aminopeptidase 0.0115 0.0433 0.058
Brugia malayi Integrin alpha cytoplasmic region family protein 0.115 0.4876 0.6417
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Schistosoma mansoni DNA polymerase eta 0.0033 0.0082 0.0107
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.0415 0.0532
Echinococcus multilocularis MAGUK p55 subfamily 0.0025 0.0046 0.0059
Loa Loa (eye worm) FAD binding domain-containing protein 0.0046 0.0136 0.0136
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0057 0.0181 0.0219
Onchocerca volvulus Netrin receptor homolog 0.0028 0.0058 0.0233
Trichomonas vaginalis guanylate kinase, putative 0.002 0.0023 0.001
Echinococcus granulosus ribonucleoside diphosphate reductase subunit 0.0289 0.118 0.1552
Echinococcus granulosus epidermal growth factor receptor 0.0156 0.0607 0.0798
Trypanosoma brucei unspecified product 0.0053 0.0167 0.02
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Brugia malayi flavodoxin family protein 0.0074 0.0258 0.0339
Schistosoma mansoni lamin 0.0027 0.0053 0.0069
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0057 0.0181 0.0219
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0074 0.0258 0.0319
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0243 0.0319
Loa Loa (eye worm) hypothetical protein 0.0073 0.025 0.025
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0199 0.0261
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0077 0.0269 0.0354
Echinococcus granulosus methionine synthase reductase 0.0046 0.0136 0.0177
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0053 0.007
Echinococcus granulosus tyrosine protein kinase Blk 0.0034 0.0086 0.0113
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0055 0.0176 0.0231
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0195 0.0237
Echinococcus granulosus dnaJ subfamily B 0.0399 0.1651 0.2173
Leishmania major DNA polymerase kappa, putative 0.004 0.011 0.0125
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Brugia malayi RhoGAP domain containing protein 0.0073 0.025 0.0329
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0195 0.0244
Loa Loa (eye worm) hypothetical protein 0.0104 0.0386 0.0386
Onchocerca volvulus 0.0027 0.0053 0.021
Entamoeba histolytica hypothetical protein 0.0025 0.0044 0.0474
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0195 0.0237
Echinococcus granulosus Furin 1 0.0077 0.0269 0.0353
Loa Loa (eye worm) hypothetical protein 0.0044 0.0128 0.0128
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.1785 0.7598 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0205 0.0205
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0074 0.0258 0.0319
Plasmodium vivax guanylate kinase, putative 0.002 0.0023 0.001
Leishmania major guanylate kinase-like protein 0.002 0.0023 0.001
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0074 0.0256 0.0336
Trypanosoma brucei DNA polymerase IV, putative 0.0053 0.0167 0.02
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.0133 0.0174
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0019 0.0004
Schistosoma mansoni ATP-dependent RNA Helicase 0.0025 0.0046 0.0059
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0045 0.0133 0.0174
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0077 0.0269 0.0353
Mycobacterium leprae Possible secreted protease 0.0077 0.0269 0.0348
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0055 0.0176 0.0231
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0205 0.0269
Trypanosoma cruzi subtilisin peptidase 0.0077 0.0269 0.0335
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0092 0.0333 0.0424
Echinococcus granulosus peripheral plasma membrane protein CASK 0.0025 0.0046 0.0059
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0184 0.0223
Echinococcus multilocularis leucine aminopeptidase protein 0.0115 0.0433 0.057
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0199 0.0249
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.1669 0.7102 1
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0243 0.0319
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0184 0.0228
Onchocerca volvulus 0.0092 0.0333 0.1753
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.1785 0.7598 1
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0057 0.0181 0.0219
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0025 0.0046 0.0059
Loa Loa (eye worm) calpain 0.0019 0.0019 0.0019
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0069 0.0071
Loa Loa (eye worm) hypothetical protein 0.1194 0.5063 0.5063
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0156 0.0607 0.0798
Echinococcus multilocularis guanylate kinase 0.002 0.0023 0.0029
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0195 0.0244
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0322 0.0423
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0023 0.003
Loa Loa (eye worm) calpain 5 0.0019 0.0019 0.0019
Echinococcus multilocularis epidermal growth factor receptor 0.0156 0.0607 0.0798
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0145 0.0559 0.0735
Echinococcus granulosus cpg binding protein 0.0062 0.0204 0.0268
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0199 0.0261
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0092 0.0333 0.0437
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.009 0.0105
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0018 0.0015 0.0019
Schistosoma mansoni importin beta-1 0.003 0.0069 0.009
Brugia malayi celfurPC protein 0.0077 0.0269 0.0354
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0051
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0034 0.0592
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0184 0.0223
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0045 0.0133 0.0174
Loa Loa (eye worm) TK protein kinase 0.0034 0.0086 0.0086
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0165 0.0648 0.0839
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0016 0.002
Toxoplasma gondii flavodoxin domain-containing protein 0.0037 0.0097 0.0113
Brugia malayi flavodoxin family protein 0.0028 0.006 0.008
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0025 0.0046 0.0059
Leishmania major DNA polymerase eta, putative 0.0033 0.0082 0.0088
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0019 0.0004
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0344 0.1416 0.1847
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0199 0.0261
Plasmodium vivax ribonucleoside-diphosphate reductase small chain, putative 0.0289 0.118 0.1535
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0077 0.0269 0.0353
Loa Loa (eye worm) hypothetical protein 0.0547 0.2288 0.2288
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.0621 0.0817
Brugia malayi RhoGAP domain containing protein 0.0063 0.0207 0.0273
Leishmania major eukaryotic initiation factor 4a, putative 0.005 0.0153 0.0181
Echinococcus granulosus aminopeptidase N 0.0389 0.1606 0.2113
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0074 0.0258 0.0332
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Echinococcus granulosus membrane bound transcription factor site 1 0.0077 0.0269 0.0353
Brugia malayi angiogenesis inhibito 0.0104 0.0386 0.0508
Onchocerca volvulus 0.0389 0.1606 0.8778
Schistosoma mansoni ap endonuclease 0.0057 0.0184 0.0241
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0049 0.015 0.0197
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0195 0.0237
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0098 0.0359 0.0453
Toxoplasma gondii leucyl aminopeptidase LAP 0.0115 0.0433 0.0557
Plasmodium falciparum plasmepsin IX 0.0092 0.0333 0.0419
Schistosoma mansoni maguk P55 subfamily member 26 0.0025 0.0046 0.0059
Schistosoma mansoni tyrosine kinase 0.0156 0.0607 0.0798
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0325 0.1332 0.1332
Mycobacterium leprae conserved hypothetical protein 0.0116 0.0435 0.0582
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0042 0.012 0.0157
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.009 0.0105
Loa Loa (eye worm) TK/EGFR protein kinase 0.0289 0.118 0.118
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0019 0.0004
Schistosoma mansoni mannosidase endo-alpha 0.002 0.0023 0.0029
Trypanosoma brucei antigen, putative 0.0019 0.0019 0.0004
Plasmodium vivax plasmepsin V, putative 0.0092 0.0333 0.0419
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0023 0.001
Loa Loa (eye worm) hypothetical protein 0.0049 0.015 0.015
Brugia malayi Kelch motif family protein 0.0047 0.0139 0.0183
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.0621 0.0816
Loa Loa (eye worm) hypothetical protein 0.0033 0.0082 0.0082
Toxoplasma gondii subtilisin SUB10 0.0077 0.0269 0.034
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0019 0.0004
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0023 0.0011
Brugia malayi aspartic protease BmAsp-1, identical 0.0092 0.0333 0.0438
Plasmodium falciparum subtilisin-like protease 1 0.1103 0.4672 0.6141
Loa Loa (eye worm) hypothetical protein 0.0092 0.0333 0.0333
Brugia malayi Sex muscle abnormal protein 5 0.0015 0.0001 0.0001
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0057 0.0181 0.0238
Echinococcus granulosus adam 0.0243 0.0983 0.1293
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0077 0.0269 0.0269
Brugia malayi Peptidase family M1 containing protein 0.0389 0.1606 0.2114
Echinococcus multilocularis GPCR, family 2 0.0079 0.0277 0.0364
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Echinococcus multilocularis lamin dm0 0.0027 0.0053 0.0069
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.005 0.0153 0.0181
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0019 0.0004
Trichomonas vaginalis DNA polymerase eta, putative 0.006 0.0195 0.0254
Schistosoma mansoni tyrosine kinase 0.0045 0.0133 0.0174
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0023 0.0029
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0045 0.0133 0.0174
Brugia malayi Integrin alpha pat-2 precursor 0.1521 0.6465 0.8509
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0057 0.0181 0.0181
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0074 0.0258 0.0319
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0269 0.0358
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.005 0.0153 0.02
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0069 0.0076
Echinococcus multilocularis high voltage activated calcium channel beta 0.002 0.0023 0.0029
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0023 0.0011
Echinococcus granulosus guanylate kinase 0.002 0.0023 0.0029

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 14 uM In vitro anti trypanosomal activity of the compound against Trypanosomal 110 (EATRO)strain ChEMBL. 12408722
IC50 (functional) > 600 uM In vitro Anti Neoplastic Activity of the compound against L1210 murine leukemia Cell lines ChEMBL. 12408722
Inhibition (functional) = 41 % In Vitro inhibition of L1210 Murine Leukemia Cells by the compound at a dose of 100 uM ChEMBL. 12408722
Inhibition (functional) = 42 % In Vitro inhibition of Trypanosomal 243 (KETRI)strain by the compound at a dose of 100 uM ChEMBL. 12408722

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma brucei gambiense 12408722

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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