TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 439.336 | Formula: C20H24Cl2N4O3
H donors: 2 H acceptors: 3 LogP: 2.24 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C1NC(=O)C2(N1)CCN([C@@H](C2)CN1CCCC1)C(=O)Cc1ccc(c(c1)Cl)Cl
InChi: 1S/C20H24Cl2N4O3/c21-15-4-3-13(9-16(15)22)10-17(27)26-8-5-20(18(28)23-19(29)24-20)11-14(26)12-25-6-1-2-7-25/h3-4,9,14H,1-2,5-8,10-12H2,(H2,23,24,28,29)/t14-,20?/m0/s1
InChiKey: GNJLINZLUYVCPA-PVCZSOGJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.0419	0.0619
Echinococcus multilocularis	cpg binding protein	0.003	0.0184	0.0267
Brugia malayi	PXA domain containing protein	0.0019	0.0097	0.008
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0097	0.0079
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0097	0.0138
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0056	0.0385	0.0512
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.0385	0.0512
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.0417	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0385	0.0368
Loa Loa (eye worm)	hypothetical protein	0.1231	0.9565	0.9564
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0141	0.1053	0.1414
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0019	0.0097	0.0138
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0056	0.0385	0.0568
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0141	0.1053	0.1515
Brugia malayi	regulator of G-protein signaling egl-10	0.0019	0.0097	0.008
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0056	0.0385	0.0568
Trichomonas vaginalis	rho5 protein, putative	0.0012	0.0044	0.0066
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0097	0.0138
Echinococcus granulosus	ras C3 botulinum toxin substrate 2	0.0012	0.0044	0.0059
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0056	0.0385	0.4153
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0097	0.0138
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.0385	0.0399
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0056	0.0385	0.2822
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0141	0.1053	0.1565
Brugia malayi	hypothetical protein	0.0019	0.0097	0.008
Echinococcus multilocularis	ras C3 botulinum toxin substrate 2	0.0012	0.0044	0.0059
Brugia malayi	Ras-related protein Rac1	0.0012	0.0044	0.0027
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0095	0.0689	0.0968
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0103	0.0755	0.1067
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0056	0.0385	0.4153
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-2	0.0103	0.0755	0.0961
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0103	0.0755	0.1126
Entamoeba histolytica	hypothetical protein	0.0103	0.0755	0.1067
Chlamydia trachomatis	two component regulatory system response regulator/ATPase	0.0015	0.0063	0.5
Brugia malayi	hypothetical protein	0.0233	0.1771	0.1757
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0056	0.0385	0.0575
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0864	0.6702	1
Echinococcus granulosus	Regulator of G protein signaling 20	0.0019	0.0097	0.0138
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.0103	0.0755	0.1126
Echinococcus granulosus	ras gtpase	0.0137	0.1023	0.1521
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.0385	0.0399
Giardia lamblia	hypothetical protein	0.0056	0.0385	0.48
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-4	0.0103	0.0755	0.1067
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0097	0.0138
Echinococcus granulosus	uridine 5' monophosphate synthase	0.0022	0.0123	0.0176
Trichomonas vaginalis	hypothetical protein	0.0103	0.0755	0.1126
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0056	0.0385	0.0568
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-1	0.0864	0.6702	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Brugia malayi	translation initiation factor 4E	0.0864	0.6702	0.6696
Entamoeba histolytica	hypothetical protein	0.0103	0.0755	0.1067
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0056	0.0385	0.0575
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0097	0.0138
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0056	0.0385	0.0568
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0056	0.0385	0.0512
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0056	0.0385	0.0368
Giardia lamblia	Hypothetical protein	0.0103	0.0755	1
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0097	0.0138
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0095	0.0689	0.1021
Leishmania major	eukaryotic translation initiation factor 4e, putative	0.0103	0.0755	0.0961
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Trichomonas vaginalis	ribose-phosphate pyrophosphokinase, putative	0.0022	0.0123	0.0183
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0095	0.0689	0.086
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0072	0.0511	0.9884
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.0103	0.0755	0.1126
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0056	0.0385	0.0575
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0385	0.0575
Loa Loa (eye worm)	PDE1B protein	0.0141	0.1053	0.1037
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0056	0.0385	0.0575
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0019	0.0097	0.008
Brugia malayi	A-kinase anchor protein 10, precursor	0.0019	0.0097	0.008
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0056	0.0385	0.0568
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0141	0.1053	0.1414
Mycobacterium ulcerans	amidophosphoribosyltransferase	0.0022	0.0123	0.095
Mycobacterium leprae	Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho	0.0072	0.0516	1
Schistosoma mansoni	z-protein (S1r protein)	0.0019	0.0097	0.0138
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0097	0.008
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0056	0.0385	0.0575
Schistosoma mansoni	eukaryotic translation initiation factor 4e	0.0864	0.6702	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.0385	0.0399
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0097	0.0138
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.0385	0.0399
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0103	0.0755	0.1126
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.0385	0.0512
Schistosoma mansoni	rac gtpase	0.0012	0.0044	0.0059
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0141	0.1053	0.1565
Plasmodium falciparum	eukaryotic translation initiation factor 4E, putative	0.0103	0.0755	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.0385	0.0399
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0097	0.0138
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0022	0.0123	0.0176
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0103	0.0755	0.1067
Echinococcus multilocularis	survival motor neuron protein 1	0.0233	0.1771	0.2637
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0056	0.0385	0.0399
Onchocerca volvulus	Putative eukaryotic translation initiation factor 4e	0.0103	0.0755	1
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-3	0.0103	0.0755	0.1067
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.0385	0.0399
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0864	0.6702	1
Treponema pallidum	adenine phosphoribosyltransferase	0.0022	0.0123	1
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0097	0.0138
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0056	0.0385	0.0568
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0056	0.0385	0.4153
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0321	0.0304
Toxoplasma gondii	eukaryotic initiation factor-4E, putative	0.0103	0.0755	0.0961
Trichomonas vaginalis	receptor histidine kinase, putative	0.0015	0.0063	0.0095
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0097	0.0145
Leishmania major	hypothetical protein, conserved	0.0103	0.0755	0.0961
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0056	0.0385	0.0575
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0056	0.0385	0.0568
Plasmodium vivax	hypothetical protein, conserved	0.0103	0.0755	0.6794
Loa Loa (eye worm)	PXA domain-containing protein	0.0019	0.0097	0.0079
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0056	0.0385	0.4153
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0097	0.0079
Onchocerca volvulus		0.0048	0.0321	0.3899
Schistosoma mansoni	cpg binding protein	0.0028	0.0171	0.0248
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.0385	0.0512
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0022	0.0123	0.0118
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.0103	0.0755	0.1126
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0864	0.6702	1
Echinococcus granulosus	adenine phosphoribosyltransferase	0.0022	0.0123	0.0176
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0417	0.0616
Mycobacterium ulcerans	orotate phosphoribosyltransferase	0.0022	0.0123	0.095
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.0417	0.7826
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0056	0.0385	0.0575
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0056	0.0385	0.48
Trichomonas vaginalis	sensory transduction histidine kinase, putative	0.0015	0.0063	0.0095
Loa Loa (eye worm)	GTP-binding protein	0.0137	0.1023	0.1007
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0385	0.0368
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Schistosoma mansoni	Adenine phosphoribosyltransferase	0.0022	0.0123	0.0176
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Entamoeba histolytica	hypothetical protein	0.0019	0.0097	0.008
Trichomonas vaginalis	GTPase_rho, putative	0.0012	0.0044	0.0066
Schistosoma mansoni	uracil phosphoribosyltransferase	0.0022	0.0123	0.0176
Brugia malayi	GTP-binding protein, identical	0.0137	0.1023	0.1008
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0056	0.0385	0.0568
Mycobacterium leprae	AMIDOPHOSPHORIBOSYLTRANSFERASE PURF (GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE) (ATASE) (GPATASE)	0.0022	0.0123	0.1313
Loa Loa (eye worm)	translation initiation factor 4E	0.0864	0.6702	0.6696
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0019	0.0097	0.0138
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0171	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0385	0.0368
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0056	0.0385	0.0399
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0141	0.1053	0.1414
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0097	0.0145
Echinococcus granulosus	expressed protein	0.0368	0.2824	0.421
Loa Loa (eye worm)	eukaryotic translation initiation factor 4E type 3	0.0103	0.0755	0.0738
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0056	0.0385	0.0368
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0056	0.0385	0.4153
Trichomonas vaginalis	Ribose-phosphate pyrophosphokinase, putative	0.0022	0.0123	0.0183
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.0369	0.0374
Mycobacterium leprae	conserved hypothetical protein	0.0072	0.0511	0.9884
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.0385	0.0399
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Toxoplasma gondii	eukaryotic initiation factor-4E, putative	0.0864	0.6702	1
Entamoeba histolytica	hypothetical protein	0.0019	0.0097	0.008
Schistosoma mansoni	orotidine 5'-phosphate decarboxylase	0.0022	0.0123	0.0176
Echinococcus multilocularis	Ras C3 botulinum toxin substrate 1	0.0012	0.0044	0.0059
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0056	0.0385	0.0575
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0056	0.0385	0.0568
Brugia malayi	small GTPase	0.0012	0.0044	0.0027
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0097	0.0138
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.0385	0.0399
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0056	0.0385	0.0568
Mycobacterium ulcerans	hypothetical protein	0.0022	0.0123	0.095
Onchocerca volvulus		0.0028	0.0171	0.1786
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0056	0.0385	0.0575
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0097	0.0138
Brugia malayi	PXA domain containing protein	0.0019	0.0097	0.008
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0056	0.0385	0.0368
Leishmania major	hypothetical protein, conserved	0.0103	0.0755	0.0961
Echinococcus multilocularis	regulator of G protein signaling	0.0019	0.0097	0.0138
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0056	0.0385	0.0568
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0097	0.0138
Entamoeba histolytica	eukaryotic initiation factor 4E, putative	0.0103	0.0755	0.1067
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0095	0.0689	0.0968
Leishmania major	hypothetical protein, conserved	0.0056	0.0385	0.0399
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0097	0.0138
Brugia malayi	Adenine phosphoribosyltransferase	0.0022	0.0123	0.0106
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Echinococcus multilocularis	ras gtpase	0.0137	0.1023	0.1521
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0141	0.1053	0.1565
Leishmania major	eukaryotic translation initiation factor-like	0.0864	0.6702	1
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0103	0.0755	0.1126
Schistosoma mansoni	gtpase_rho	0.0012	0.0044	0.0059
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0385	0.0575
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0056	0.0385	0.0512
Loa Loa (eye worm)	hypothetical protein	0.1287	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0103	0.0755	0.1126
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0417	0.5661
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0019	0.0097	0.0145
Mycobacterium tuberculosis	Adenine phosphoribosyltransferase Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase)	0.0022	0.0123	0.1313
Echinococcus granulosus	eukaryotic translation initiation factor 4E type	0.0103	0.0755	0.112
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0056	0.0385	0.0568
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0269	0.2048	0.2926
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0056	0.0385	0.0568
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.0417	0.0616
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.007	0.0499	0.0744
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase	0.0095	0.0689	0.086
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0022	0.0123	0.0118
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0056	0.0385	0.0399
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	0.0095	0.0689	0.1021
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0097	0.0138
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0022	0.0123	0.0118
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0103	0.0755	0.1126
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0056	0.0385	0.0568
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0019	0.0097	0.0079
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0056	0.0385	0.0575
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.0385	0.0512
Brugia malayi	eukaryotic translation initiation factor 4E-1	0.0103	0.0755	0.0739
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0018	0.002
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	0.0095	0.0689	0.1021
Mycobacterium tuberculosis	Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor	0.0072	0.0516	1
Leishmania major	hypothetical protein, conserved	0.0056	0.0385	0.0399
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	0.0095	0.0689	0.1021
Toxoplasma gondii	hypothetical protein	0.0103	0.0755	0.0961
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0056	0.0385	0.0568
Schistosoma mansoni	Adenine phosphoribosyltransferase	0.0022	0.0123	0.0176
Trichomonas vaginalis	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0095	0.0689	0.1028
Treponema pallidum	hypothetical protein	0.0022	0.0123	1
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0141	0.1053	0.1565
Entamoeba histolytica	translation initiation factor 4e, putative	0.0103	0.0755	0.1067
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0056	0.0385	0.0568
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0019	0.0097	0.0138
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0056	0.0385	0.0512
Trichomonas vaginalis	receptor histidine kinase, putative	0.0015	0.0063	0.0095
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0141	0.1053	0.1414
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.0385	0.0512
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0097	0.0138
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Brugia malayi	hypothetical protein	0.0019	0.0097	0.008
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0056	0.0385	0.0568
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0056	0.0385	0.0568
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0019	0.0097	0.0138
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0103	0.0755	0.1126
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-4	0.0103	0.0755	0.0961
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0141	0.1053	0.1037
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0019	0.0097	0.0138
Trichomonas vaginalis	conserved hypothetical protein	0.0103	0.0755	0.1126
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0097	0.0079
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0321	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0233	0.1771	0.1756
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.0385	0.0399
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.0385	0.0399
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0019	0.0097	0.0138
Treponema pallidum	phosphoribosylpyrophosphate synthetase	0.0022	0.0123	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0056	0.0385	0.0368
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0103	0.0755	0.1067
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0417	0.5661
Wolbachia endosymbiont of Brugia malayi	orotate phosphoribosyltransferase	0.0022	0.0123	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.0385	0.0399
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0056	0.0385	0.0575
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0056	0.0385	0.2822
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0022	0.0123	0.0118
Plasmodium falciparum	phosphodiesterase delta, putative	0.0056	0.0385	0.4153
Schistosoma mansoni	cpg binding protein	0.003	0.0184	0.0267
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0417	0.0616
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0097	0.0138
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0019	0.0097	0.0079
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0056	0.0385	0.0575
Loa Loa (eye worm)	small GTPase	0.0012	0.0044	0.0026
Mycobacterium tuberculosis	Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase)	0.0022	0.0123	0.1313
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0056	0.0385	0.0575
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0056	0.0385	0.0575
Giardia lamblia	Hypothetical protein	0.0103	0.0755	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0141	0.1053	0.1565
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0018	0.002
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase	0.0095	0.0689	0.086
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0417	0.5661
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0097	0.0145
Echinococcus granulosus	eukaryotic translation initiation factor 4E	0.0864	0.6702	1
Echinococcus multilocularis	eukaryotic translation initiation factor 4E	0.0864	0.6702	1
Echinococcus multilocularis	adenine phosphoribosyltransferase	0.0022	0.0123	0.0176
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0141	0.1053	0.1515
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.0385	0.0399
Plasmodium vivax	translation initiation factor 4E, putative	0.0103	0.0755	0.6794
Mycobacterium tuberculosis	Probable pyrimidine operon regulatory protein PyrR	0.0022	0.0123	0.1313
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E type 5, putative	0.0103	0.0755	0.1067
Trypanosoma cruzi	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0022	0.0123	0.0118
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0864	0.6702	1
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Loa Loa (eye worm)	RGS-3 protein	0.0019	0.0097	0.0079
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0097	0.0138
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Schistosoma mansoni	sensor histidine kinase/response regulator	0.0015	0.0063	0.0088
Brugia malayi	Eukaryotic translation initiation factor 4E type 3, putative	0.0103	0.0755	0.0739
Echinococcus granulosus	cpg binding protein	0.003	0.0184	0.0267
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0097	0.0138
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0385	0.0575
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0171	0.0153
Trypanosoma cruzi	eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative	0.0103	0.0755	0.1067
Echinococcus multilocularis	uridine 5' monophosphate synthase	0.0022	0.0123	0.0176
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0097	0.008
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0097	0.0079
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0141	0.1053	1
Leishmania major	eukaryotic translation initiation factor, putative	0.0103	0.0755	0.0961
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0095	0.0689	0.1021
Brugia malayi	GTP-binding protein	0.0137	0.1023	0.1008
Plasmodium falciparum	eukaryotic translation initiation factor 4E	0.0103	0.0755	1
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0095	0.0689	0.0968
Schistosoma mansoni	hypothetical protein	0.0048	0.0321	0.0473
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0103	0.0755	0.1126
Mycobacterium tuberculosis	Conserved protein	0.0022	0.0123	0.1313
Mycobacterium leprae	PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE (OPRT) (OPRTASE)	0.0022	0.0123	0.1313
Trichomonas vaginalis	rho4, putative	0.0012	0.0044	0.0066
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0056	0.0385	0.0575
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0097	0.0138
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0095	0.0689	0.0968
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0097	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0097	0.0079
Leishmania major	eukaryotic translation initiation factor eIF-4E, putative	0.0864	0.6702	1
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0097	0.0138
Loa Loa (eye worm)	orotate phosphoribosyltransferase	0.0022	0.0123	0.0105
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0015	0.0063	0.0095
Trypanosoma cruzi	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0022	0.0123	0.0118
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0864	0.6702	1
Plasmodium vivax	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0095	0.0689	0.6084
Trichomonas vaginalis	sensor histidine kinase, putative	0.0015	0.0063	0.0095
Loa Loa (eye worm)	eukaryotic translation initiation factor 4E-1	0.0103	0.0755	0.0738
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0103	0.0755	0.1126
Toxoplasma gondii	hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT	0.0095	0.0689	0.086
Brugia malayi	regulator of G-protein signaling rgs-7	0.0019	0.0097	0.008
Trichomonas vaginalis	two component sensor and regulator histidine kinase bacteria, putative	0.0015	0.0063	0.0095
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0056	0.0385	0.0368
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.0103	0.0755	0.1126
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0097	0.0138
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	0.0864	0.6702	1
Entamoeba histolytica	hypothetical protein	0.0019	0.0097	0.008
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0056	0.0385	0.0568
Leishmania major	xanthine phosphoribosyltransferase	0.0095	0.0689	0.086
Schistosoma mansoni	cell polarity protein	0.0137	0.1023	0.1521
Mycobacterium tuberculosis	Amidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase)	0.0022	0.0123	0.1313
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0056	0.0385	0.0399
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0056	0.0385	0.0568
Mycobacterium ulcerans	adenine phosphoribosyltransferase	0.0022	0.0123	0.095
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0269	0.2048	0.301
Mycobacterium ulcerans	hypoxanthine-guanine phosphoribosyltransferase Hpt	0.0095	0.0689	1
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0103	0.0755	0.1126
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0022	0.0123	0.1313
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.0385	0.0399
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0015	0.0063	0.0095
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0072	0.0511	0.9884
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0097	0.0145
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-4	0.0103	0.0755	0.1067
Giardia lamblia	hypothetical protein	0.0103	0.0755	1
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	0.0095	0.0689	0.1021
Trichomonas vaginalis	rho4, putative	0.0012	0.0044	0.0066
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.0103	0.0755	0.1126
Giardia lamblia	Hypothetical protein	0.0056	0.0385	0.48
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0864	0.6702	1
Mycobacterium ulcerans	bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase	0.0022	0.0123	0.095
Plasmodium falciparum	hypoxanthine-guanine phosphoribosyltransferase	0.0095	0.0689	0.8955
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-3	0.0103	0.0755	0.0961
Onchocerca volvulus	Adenine phosphoribosyltransferase homolog	0.0022	0.0123	0.1107
Giardia lamblia	Translation elongation factor	0.0103	0.0755	1
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	0.0864	0.6702	1
Leishmania major	hypoxanthine-guanine phosphoribosyltransferase	0.0095	0.0689	0.086
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0056	0.0385	0.0568
Trypanosoma brucei	hypothetical protein, conserved	0.0056	0.0385	0.0399
Trichomonas vaginalis	sensor histidine kinase, putative	0.0015	0.0063	0.0095
Schistosoma mansoni	cpg binding protein	0.003	0.0184	0.0267
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0056	0.0385	0.0575
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0056	0.0385	0.0568
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0097	0.0138
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Trichomonas vaginalis	conserved hypothetical protein	0.0103	0.0755	0.1126
Brugia malayi	Phosphoribosyl transferase domain containing protein	0.0095	0.0689	0.0673
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.0385	0.0399
Mycobacterium leprae	conserved hypothetical protein	0.0072	0.0511	0.9884
Giardia lamblia	Guanine phosphoribosyltransferase	0.0095	0.0689	0.9071
Plasmodium vivax	phosphodiesterase gamma, putative	0.0056	0.0385	0.2822
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.0385	0.0399
Wolbachia endosymbiont of Brugia malayi	amidophosphoribosyltransferase	0.0022	0.0123	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0056	0.0385	0.0399
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0097	0.0138
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0097	0.0145
Mycobacterium tuberculosis	Conserved protein	0.0022	0.0123	0.1313
Onchocerca volvulus		0.0095	0.0689	0.9071
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0056	0.0385	0.0512
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0022	0.0123	0.0176
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.0417	0.0616
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0097	0.0145
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0019	0.0097	0.0079
Brugia malayi	orotate phosphoribosyltransferase family protein	0.0022	0.0123	0.0106
Echinococcus granulosus	survival motor neuron protein 1	0.0233	0.1771	0.2637
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0269	0.2048	0.2926
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E type 5, putative	0.0103	0.0755	0.1067
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0056	0.0385	0.0575
Schistosoma mansoni	cell polarity protein	0.0137	0.1023	0.1521
Entamoeba histolytica	eukaryotic initiation factor 4E, putative	0.0103	0.0755	0.1067
Leishmania major	eukaryotic translation initiation factor-like protein	0.0864	0.6702	1
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.0417	0.0448
Trypanosoma cruzi	hypothetical protein, conserved	0.0056	0.0385	0.0512
Loa Loa (eye worm)	rac GTPase	0.0012	0.0044	0.0026
Trypanosoma brucei	Eukaryotic translation initiation factor 4E type 5	0.0103	0.0755	0.0961
Echinococcus multilocularis	expressed protein	0.0368	0.2824	0.421
Loa Loa (eye worm)	adenine phosphoribosyltransferase	0.0022	0.0123	0.0105
Giardia lamblia	Adenine phosphoribosyltransferase	0.0022	0.0123	0.1107
Trypanosoma cruzi	eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative	0.0103	0.0755	0.1067
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0097	0.0079

Activities

Activity type	Activity value	Assay description	Source	Reference
Permeability (ADMET)	0	BBB penetration classification	ChEMBL.	10841799

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 114816