Detailed information for compound 1171240

Basic information

Technical information
  • TDR Targets ID: 1171240
  • Name: ethyl 6,7-bis(cyclopropylmethoxy)-4-oxo-1H-qu inoline-3-carboxylate
  • MW: 357.4 | Formula: C20H23NO5
  • H donors: 1 H acceptors: 3 LogP: 4.04 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1cnc2c(c1O)cc(c(c2)OCC1CC1)OCC1CC1
  • InChi: 1S/C20H23NO5/c1-2-24-20(23)15-9-21-16-8-18(26-11-13-5-6-13)17(7-14(16)19(15)22)25-10-12-3-4-12/h7-9,12-13H,2-6,10-11H2,1H3,(H,21,22)
  • InChiKey: JBCLGHRMQCEPFM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6,7-bis(cyclopropylmethoxy)-4-oxo-1H-quinoline-3-carboxylic acid ethyl ester
  • 6,7-bis(cyclopropylmethoxy)-4-keto-1H-quinoline-3-carboxylic acid ethyl ester
  • 19485-08-6
  • 3-Quinolinecarboxylic acid, 6,7-bis(cyclopropylmethoxy)-4-hydroxy-, ethyl ester
  • BRN 0495900
  • CIBA 18137 SU
  • CYPROQUINATE
  • Ciproquinate
  • Ciproquinato [INN-Spanish]
  • Ciproquinatum [INN-Latin]
  • Coxytrol
  • Cyproquinate [USAN]
  • Cyproquinidate
  • Cyproxyquine
  • Ethyl 6,7-bis(cyclopropylmethoxy)-4-hydroxy-3-quinolinecarboxylate
  • NSC 142840
  • SU-18317
  • Su 18137
  • 3-Quinolinecarboxylic acid, 6, 7-bis(cyclopropylmethoxy)-4-hydroxy-, ethyl ester
  • AIDS-127094
  • AIDS127094
  • Ethyl 6, 7-bis(cyclopropylmethoxy)-4-hydroxy-3-quinolinecarboxylate
  • NSC142840
  • Su-18137
  • Cyproquinate (USAN)
  • D03633

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0034 0.0513
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0011 0.0162
Mycobacterium leprae Probable dihydroorotase PyrC (DHOase) 0.0038 0.0103 0.5
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0034 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0011 0.0162
Echinococcus granulosus GPCR family 2 0.0016 0.0024 0.0358
Entamoeba histolytica D-hydantoinase, putative 0.0038 0.0103 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0011 0.0162
Trypanosoma brucei guanine deaminase, putative 0.0038 0.0103 1
Loa Loa (eye worm) hydrolase 0.0492 0.1696 1
Trichomonas vaginalis protein ssnA, putative 0.0038 0.0103 0.5
Mycobacterium tuberculosis Urease gamma subunit UreA (urea amidohydrolase) 0.136 0.4741 0.4723
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.0315 0.186
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0024 0.0358
Echinococcus granulosus dihydropyrimidinase 2 0.0038 0.0103 0.1545
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0011 0.013
Schistosoma mansoni dihydropyrimidinase related protein-1 (M38 family) 0.0038 0.0103 0.1545
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0011 0.0162
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0034 0.0513
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0103 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0011 0.013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0011 0.013
Trichomonas vaginalis aminohydrolase, putative 0.0038 0.0103 0.5
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0178 0.0594 0.3502
Schistosoma mansoni hypothetical protein 0.0016 0.0024 0.0358
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0011 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0011 0.013
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0034 0.0513
Brugia malayi isocitrate dehydrogenase 0.0018 0.0034 0.0413
Loa Loa (eye worm) amidohydrolase 0.0038 0.0103 0.0606
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0011 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0011 0.0064
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0064
Loa Loa (eye worm) hypothetical protein 0.0178 0.0594 0.3502
Loa Loa (eye worm) hypothetical protein 0.0149 0.0492 0.2902
Onchocerca volvulus 0.0012 0.0011 0.0064
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0064
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0011 0.013
Mycobacterium tuberculosis Urease beta subunit UreB (urea amidohydrolase) 0.136 0.4741 0.4723
Schistosoma mansoni coup transcription factor 0.0012 0.0011 0.0162
Echinococcus granulosus imidazolonepropionase 0.0038 0.0103 0.1545
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0011 0.013
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0011 0.0162
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0024 0.0358
Leishmania major dihydroorotase, putative 0.0038 0.0103 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0011 0.013
Schistosoma mansoni hypothetical protein 0.0038 0.0103 0.1545
Trypanosoma cruzi imidazolonepropionase, putative 0.0038 0.0103 1
Echinococcus multilocularis dihydropyrimidinase 0.0038 0.0103 0.1545
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0011 0.0162
Brugia malayi N-terminal motif family protein 0.0178 0.0594 0.7187
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0034 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0024 0.0358
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0315 0.4741
Trichomonas vaginalis guanine deaminase, putative 0.0038 0.0103 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0011 0.0064
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0024 0.0358
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0011 0.013
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0034 0.0413
Trypanosoma cruzi guanine deaminase, putative 0.0038 0.0103 1
Wolbachia endosymbiont of Brugia malayi dihydroorotase, PyrC 0.0038 0.0103 0.5
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0011 0.0162
Schistosoma mansoni hypothetical protein 0.0034 0.0087 0.131
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0011 0.0064
Trypanosoma cruzi imidazolonepropienase, putative 0.0038 0.0103 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0011 0.0162
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0011 0.0162
Brugia malayi nuclear receptor NHR-88 0.0012 0.0011 0.013
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0034 0.0201
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0011 0.0162
Trypanosoma cruzi dihydroorotase, putative 0.0038 0.0103 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0011 0.013
Brugia malayi hydrolase, alpha/beta fold family protein 0.0244 0.0826 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0064
Echinococcus granulosus dihydropyrimidinase 0.0038 0.0103 0.1545
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0142 0.0836
Echinococcus multilocularis dihydropyrimidinase 2 0.0038 0.0103 0.1545
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0024 0.0288
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0011 0.013
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0011 0.0064
Onchocerca volvulus Epoxide hydrolase 1 homolog 0.0492 0.1696 1
Schistosoma mansoni hypothetical protein 0.0198 0.0665 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0011 0.0064
Trichomonas vaginalis hypothetical protein 0.0038 0.0103 0.5
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0011 0.0064
Trypanosoma cruzi dihydroorotase, putative 0.0038 0.0103 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0011 0.0162
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0011 0.013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0315 0.4741
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0011 0.013
Entamoeba histolytica guanine deaminase, putative 0.0038 0.0103 0.5
Loa Loa (eye worm) hypothetical protein 0.0049 0.0142 0.0836
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0064
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0064
Schistosoma mansoni hypothetical protein 0.0016 0.0024 0.0358
Echinococcus multilocularis geminin 0.0198 0.0665 1
Leishmania major N-acetylglucosamine-6-phosphate deacetylase-like protein 0.0038 0.0103 1
Mycobacterium ulcerans urease subunit beta UreB 0.136 0.4741 0.4687
Onchocerca volvulus 0.0149 0.0492 0.2902
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0011 0.0162
Brugia malayi steroid hormone receptor 0.0012 0.0011 0.013
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0011 0.0162
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0011 0.0162
Plasmodium vivax dihydroorotase, putative 0.0038 0.0103 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0034 0.0513
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0064
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0034 0.0513
Echinococcus granulosus geminin 0.0198 0.0665 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0142 0.1715
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0064
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0011 0.0162
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0011 0.0162
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0024 0.0358
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.0315 0.3817
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0011 0.0162
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0024 0.0288
Schistosoma mansoni dihydropyrimidinase (M38 family) 0.0038 0.0103 0.1545
Brugia malayi Amidohydrolase family protein 0.0038 0.0103 0.1244
Echinococcus granulosus dihydropyrimidinase protein 4 0.0038 0.0103 0.1545
Brugia malayi hypothetical protein 0.0149 0.0492 0.5955
Schistosoma mansoni hypothetical protein 0.0198 0.0665 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0011 0.0162
Brugia malayi ecdysteroid receptor 0.0012 0.0011 0.013
Schistosoma mansoni hypothetical protein 0.0016 0.0024 0.0358
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0011 0.0064
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0011 0.0064
Trypanosoma cruzi imidazolonepropionase, putative 0.0038 0.0103 1
Schistosoma mansoni aspartate carbamoyltransferase 0.0038 0.0103 0.1545
Trypanosoma brucei guanine deaminase, putative 0.0038 0.0103 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0011 0.013
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0011 0.0162
Trypanosoma cruzi guanine deaminase, putative 0.0038 0.0103 1
Trichomonas vaginalis protein ssnA, putative 0.0038 0.0103 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0024 0.0141
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0034 0.0513
Mycobacterium ulcerans urease subunit gamma 0.136 0.4741 0.4687
Loa Loa (eye worm) hypothetical protein 0.0034 0.0087 0.0514
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0034 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0315 0.4741
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0315 0.4741
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0011 0.013
Echinococcus multilocularis dihydropyrimidinase protein 4 0.0038 0.0103 0.1545
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0011 0.0162
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0315 0.4741
Brugia malayi nuclear hormone receptor 0.0012 0.0011 0.013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0011 0.0162
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0034 0.0513
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0064
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0087 0.1055
Echinococcus multilocularis imidazolonepropionase 0.0038 0.0103 0.1545
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0315 0.4741
Leishmania major guanine deaminase, putative 0.0038 0.0103 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0011 0.0162
Trypanosoma cruzi dihydroorotase, putative 0.0038 0.0103 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0315 0.4741
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0011 0.013
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0011 0.013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0142 0.1715
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0011 0.0162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0011 0.0064
Schistosoma mansoni hypothetical protein 0.0016 0.0024 0.0358
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0011 0.0162
Schistosoma mansoni hypothetical protein 0.0038 0.0103 0.1545
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0011 0.0162
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0011 0.0064
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0011 0.0162
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0011 0.0162
Schistosoma mansoni dihydropyrimidinase related protein-2 (M38 family) 0.0038 0.0103 0.1545
Mycobacterium tuberculosis Conserved protein 0.0038 0.0103 0.0069
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0141
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0011 0.0162
Mycobacterium ulcerans urease subunit alpha 0.2858 1 1
Schistosoma mansoni dihydropyrimidinase (M38 family) 0.0038 0.0103 0.1545
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0011 0.0162
Trypanosoma brucei dihydroorotase, putative 0.0038 0.0103 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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