Detailed view for Rv1849

Basic information

TDR Targets ID: 10015
Mycobacterium tuberculosis, Urease beta subunit UreB (urea amidohydrolase)
Source Database / ID:  Tuberculist 

pI: 10.0678 | Length (AA): 104 | MW (Da): 11190 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00699   Urease beta subunit

Gene Ontology

Mouse over links to read term descriptions.
GO:0016151   nickel ion binding  
GO:0009039   urease activity  
GO:0006807   nitrogen compound metabolic process  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 103 1e9y (A) 106 207 44.00 0 1 1.44918 0.44
1 104 5ol4 (B) 7 109 48.00 0 0.98 1.5199 0.21
1 102 4ep8 (B) 2001 2101 50.00 0 1 1.51047 0.33
3 103 3qga (A) 107 207 41.00 0 0.81 1.42175 -0.07

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Dormant phase. hasan
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Dormant phase. murphy
Show/Hide expression data references
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.

Orthologs

Ortholog group members (OG5_145075)

Species Accession Gene Product
Mycobacterium tuberculosis Rv1849   Urease beta subunit UreB (urea amidohydrolase)
Mycobacterium ulcerans MUL_3030   urease subunit beta UreB

Essentiality

Rv1849 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu1879 this record Mycobacterium tuberculosis non-essential nmpdr
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.4845 0.4746 0.4746
0.1116 0.4237 0.243
0.0544 0.4687 0.4687
0.0149 0.4471 0.4471
0.0837 0.3144 0.4687
0.0549 0.4679 0.4664
0.1097 0.4567 0.4717
0.1104 0.4719 0.4687
0.1433 0.4728 0.4724
0.1153 0.2759 0.4714
0.0271 0.3722 0.4631
0.0265 0.4664 0
0.3004 0.4739 0.4738
0.2757 0.3415 0.3415
0.4052 0.2751 0.474
0.3004 0.4739 0.4738
0.171 0.4727 0.4727
0.028 0.2775 0.456
0.1126 0.4702 0.4687
0.059 0.3591 0.4689
0.0329 0.3154 0
0.1185 0.4303 0.4717
0.1472 0.473 0.4725
0.0795 0.4697 0.4687
0.0568 0.2669 0.4636
0.0274 0.3201 0.4622
0.0277 0.2748 0.4633
0.0826 0.4687 0.4687
0.1126 0.3165 0.4715
0.0877 0.4742 0.472
0.2583 0.4741 0.4739
0.4559 0.475 0.475
0.1085 0.2666 0.4722
0.0798 0.4719 0.4719
0.0855 0.4714 0.4696
0.1672 0.4625 0.4522
0.1151 0.4242 0.4705
0.1453 0.4731 0.4731
0.1104 0.4719 0.4687
0.2536 0.4586 0.3332
0.2198 0.4738 0.4738
0.2952 0.4734 0.4687
0.0267 0.4656 0.4451
0.0855 0.4714 0.4696
0.0301 0.472 0.4687
0.084 0.4673 0.4668
0.0267 0.4294 0.4687
0.0264 0.46 0.46
0.2853 0.4702 0.4687
0.0555 0.4728 0.4707
0.0329 0.3212 0.4579
0.0277 0.3584 0.4423
0.0283 0.3321 0.4018
0.0807 0.334 0.4539
0.1085 0.2666 0.4722
0.0851 0.3432 0.4687
0.1084 0.4746 0.4727
0.2515 0.4744 0.4739
0.0942 0.3835 0.3597
0.0842 0.2732 0.4677
0.1382 0.4733 0.4733
0.4235 0.4747 0.4746
0.1415 0.4712 0.471
0.057 0.339 0.4687
0.027 0.4719 0.4719
0.0297 0.317 0.4687
0.087 0.3309 0.4688
0.0443 0.2511 0.25
0.0596 0.4719 0.4687
0.4647 0.4751 0.475
0.0549 0.3303 0.4687
0.0265 0.3098 0.459
0.0567 0.4668 0.4154
0.0807 0.334 0.4539
0.196 0.2636 0.4697
0.0274 0.3732 0.4687
0.0833 0.319 0.4699
0.231 0.4546 0.4103
0.0329 0.4699 0.4687
0.434 0.4614 0.3975
0.3261 0.3502 0.4729
0.0593 0.4705 0.4701
0.1479 0.4431 0
0.0817 0.4731 0.4687
0.1117 0.4712 0.4712
0.196 0.2636 0.4697
0.056 0.3495 0.4675
0.0269 0.2969 0.4587
0.4647 0.4751 0.475
0.0274 0.3201 0.4622
0.1147 0.4743 0.4743
0.3703 0.4748 0.4731
0.1147 0.4742 0.4739
0.0329 0.3413 0
0.196 0.2636 0.4697
0.0546 0.4676 0.4134
0.5207 0.3398 0.4743
0.0526 0.4138 0.4573
0.0572 0.469 0.4687
0.1444 0.3246 0.4687
0.1444 0.416 0.4157
0.0276 0.3028 0.4687
0.0264 0.2632 0.4687
0.4647 0.4752 0.475
0.1116 0.4237 0.243
0.0277 0.2514 0
0.0873 0.4548 0
0.2023 0.4746 0.4746
0.622 0.475 0.4748
0.4039 0.4738 0.473
0.143 0.41 0.4725
0.0269 0.3182 0.4531
0.1382 0.4733 0.4733
0.0277 0.2748 0.4633
0.0869 0.4687 0.4687
0.0533 0.4667 0.4667
0.0264 0.2645 0.4687
0.4231 0.4748 0.4744
0.0292 0.3198 0
0.1139 0.4598 0
0.2609 0.4744 0.4744
0.0829 0.3146 0
0.1381 0.4732 0.4727
0.0279 0.4664 0.4664
0.0487 0.251 0.2506
0.028 0.4459 0.444
0.0263 0.4084 0.4084
0.0329 0.2615 0
0.0543 0.4328 0
0.0605 0.4611 0
0.0271 0.467 0.4578
0.0264 0.2794 0.264
0.0811 0.3227 0.4684
0.0329 0.4673 0
0.0895 0.4742 0.4718
0.1387 0.4708 0.4706
0.0529 0.32 0.4724
0.1442 0.4711 0.4708
0.0274 0.4598 0.4374
0.4321 0.4751 0.4749
0.0277 0.2861 0.4672
0.0821 0.4626 0.4624
0.056 0.4705 0.4687
0.0478 0.251 0.2507
0.0265 0.3298 0.4687
0.1085 0.2666 0.4722
0.1465 0.47 0.4687
0.0264 0.4677 0
0.0537 0.4714 0.4689
0.1116 0.4237 0.243
0.3546 0.475 0.4748
0.0578 0.3224 0.3013
0.138 0.4687 0.4687
0.0445 0.251 0.2506
0.0891 0.4058 0.4446
0.0636 0.4533 0
0.0533 0.4704 0.4687
0.0542 0.4687 0.4687
0.0799 0.4677 0.4677
0.027 0.4533 0.4533
0.0888 0.4687 0.4687
0.0838 0.4725 0.4702
0.0636 0.4688 0.4687
0.0438 0.2506 0.25
0.0277 0.2514 0
0.0608 0.4703 0.4691
0.0277 0.2748 0.4633
0.1127 0.4687 0.4687
0.0283 0.3137 0.4427
0.0267 0.2716 0.2595
0.1126 0.4702 0.4687
0.1156 0.3386 0.4689
0.0559 0.3182 0.4687
0.0291 0.3468 0.4567
0.1124 0.4712 0.471
0.136 0.4741 0.4723
0.1416 0.3422 0.4729
0.1428 0.4747 0.4732
0.0264 0.2614 0.4539
0.0277 0.2748 0.4633
0.0294 0.2929 0.4687
0.0271 0.3768 0.4631
0.2505 0.4748 0.4744
0.0282 0.2996 0
0.196 0.2636 0.4697
0.0851 0.3432 0.4687
0.1382 0.4733 0.4733
0.2419 0.4748 0.4741
0.2515 0.4744 0.4739
0.1366 0.471 0.4698
0.0807 0.334 0.4539
0.3377 0.4469 0.4742
0.0265 0.3144 0.4563
0.0843 0.3241 0.4698
0.0329 0.3384 0
0.1085 0.2666 0.4722
0.0583 0.3484 0.4719
0.0291 0.2897 0.4367
0.0538 0.3528 0.467
0.2868 0.4747 0.4746
0.0299 0.3717 0.4687
0.1486 0.4726 0.4724
0.7178 0.4751 0.4751
0.0609 0.4667 0.4666
0.0533 0.328 0.4687
0.0269 0.4391 0.4687
0.0282 0.3863 0.4428
0.0288 0.3475 0.4549
0.1996 0.4749 0.4741
0.0855 0.4714 0.4696
0.0294 0.4598 0.4438
0.5156 0.4755 0.4748
0.1109 0.264 0.4687
0.0266 0.4662 0.4428
0.2763 0.4745 0.4745
0.1133 0.4722 0.4715
0.0274 0.3732 0.4687
0.0275 0.4644 0.4578
0.0272 0.2947 0
0.1448 0.4737 0.4729
0.4681 0.3753 0.4749
0.0329 0.4388 0
0.1085 0.2666 0.4722
0.0802 0.4694 0.4687
0.0296 0.3342 0.4638
0.0313 0.4663 0
0.0807 0.4452 0
0.027 0.2595 0.4199
0.0263 0.3247 0.4687
0.0559 0.4718 0.4687
0.1163 0.4687 0.4687
0.0265 0.4477 0.4477
0.1391 0.4712 0.471
0.0866 0.434 0
0.1373 0.4312 0.1336
0.1663 0.4707 0.4702
0.0559 0.2748 0.4727
0.0492 0.2761 0.472
0.0551 0.452 0
0.1085 0.2666 0.4722
0.0294 0.2929 0.4687
0.1387 0.47 0.4698
0.1085 0.2666 0.4722
0.0493 0.251 0.2506
0.0303 0.3455 0.4618
0.0549 0.4679 0.4664
0.0277 0.2748 0.4633
0.1957 0.343 0.4731
0.0329 0.2615 0
0.0272 0.4687 0.4687
0.0826 0.4687 0.4687
0.0889 0.4113 0
0.547 0.475 0.475
0.0277 0.2748 0.4633
0.0293 0.4536 0.3242
0.0543 0.4328 0
0.2778 0.4744 0.4743
0.0842 0.2732 0.4677
0.0267 0.3818 0.4687
0.0306 0.3873 0
0.0895 0.3431 0.471
0.0263 0.3056 0.4607
0.0844 0.4721 0.4697
0.1465 0.47 0.4687
0.1444 0.3246 0.4687
0.118 0.4609 0
0.054 0.3214 0.4687
0.0591 0.3636 0.4687
0.1366 0.471 0.4698
0.1132 0.4647 0
0.3617 0.4746 0.4746
0.0583 0.3484 0.4719
0.2829 0.4681 0.4673
0.5438 0.4748 0.4745
0.028 0.3805 0.4428
0.0277 0.4293 0.4564
0.0286 0.3428 0.4688
0.0559 0.2748 0.4727
0.168 0.4732 0.4732
0.0277 0.2748 0.4633
0.3167 0.4688 0.4687
0.053 0.3016 0.4724
0.0296 0.3123 0.4438
0.0565 0.4739 0.4737
0.1409 0.4726 0.4713
0.0835 0.3195 0.4699
0.0299 0.3717 0.4687
0.3003 0.4743 0.4743
0.0869 0.2596 0.4696
0.196 0.2636 0.4697
0.434 0.4614 0.3975
0.0821 0.4626 0.4624
0.4349 0.475 0.475
0.1085 0.2666 0.4722
0.0537 0.4628 0.4434
0.082 0.467 0.465
0.1085 0.2666 0.4722
0.0283 0.4662 0.4634
0.0264 0.3302 0.4687
0.0266 0.4374 0.3717
0.0277 0.2748 0.4633
0.0264 0.458 0.4312
0.0863 0.4675 0.4705
0.0565 0.3391 0.4687
0.4912 0.475 0.475
0.3004 0.4739 0.4738
0.0285 0.4611 0.4611
0.0599 0.4662 0.4548
0.1085 0.2666 0.4722
0.0267 0.2941 0.4622
0.027 0.4626 0.4626
0.5227 0.4749 0.4746
0.0834 0.4738 0.4732
0.1131 0.4418 0.4687
0.1091 0.469 0.4687
0.0269 0.4659 0.4135
0.0272 0.3405 0.4687
0.027 0.3307 0.4612
0.1124 0.2653 0.4683
0.0282 0.3396 0.4695
0.0559 0.4558 0.3089
0.2023 0.4746 0.4746
0.0533 0.4704 0.4687
0.1365 0.4733 0.4728
0.7178 0.4751 0.4751
0.2197 0.4739 0.4687
0.0264 0.3012 0.4559
0.0888 0.4112 0
0.6879 0.4751 0.4751
0.0277 0.2748 0.4633
0.056 0.4687 0.4687
0.0329 0.2612 0.2807
0.027 0.3353 0.4606
0.1079 0.3263 0.4718
0.0269 0.3304 0.4687
0.0269 0.4684 0.4549
0.0556 0.3474 0.4687
0.0272 0.4695 0.4687
0.027 0.4647 0.4589
0.3229 0.4741 0.4741
0.028 0.2795 0.4574
0.082 0.4709 0.4708
0.0329 0.452 0
0.196 0.2636 0.4697
0.0636 0.4547 0
0.1085 0.2666 0.4722
0.4411 0.4748 0.4687
0.0271 0.3713 0
0.0273 0.2836 0.4606
0.0329 0.4182 0
0.0844 0.4721 0.4697
0.029 0.4687 0.4687
0.1703 0.4734 0.4733
0.0285 0.3011 0.4683
0.0277 0.2748 0.4633
0.0556 0.4617 0
0.0535 0.465 0.4469
0.0294 0.2929 0.4687
0.1645 0.4732 0.4729
0.0513 0.2512 0.2512
0.0575 0.3565 0.4657
0.3004 0.4739 0.4738
0.0329 0.3248 0.4462
0.1086 0.3866 0.4723
0.045 0.2511 0.2506
0.0451 0.251 0.25
0.0288 0.3447 0
0.0837 0.3156 0.47
0.0856 0.4708 0.4708
0.0272 0.4447 0
0.0296 0.3757 0.4438
0.1403 0.4613 0
0.0844 0.4721 0.4697
0.0441 0.2512 0.2507
0.0854 0.3666 0.4693
0.0289 0.3245 0
0.1994 0.453 0.3976
0.1079 0.3261 0.4719
0.0807 0.334 0.4539
0.1104 0.4375 0.4715
0.0537 0.3225 0.4687
0.0329 0.3292 0.4687
0.0269 0.3193 0.4404
0.1366 0.471 0.4698
0.0329 0.4662 0.4662
0.054 0.3214 0.4687
0.0329 0.2612 0.2807
0.2023 0.4746 0.4746
0.0824 0.4718 0.4704
0.0444 0.251 0.25
0.0636 0.4533 0
0.0866 0.2595 0.4691
0.7178 0.475 0.474
0.1996 0.4749 0.4741
0.1086 0.3866 0.4723
0.0881 0.3066 0.4718
0.0329 0.3305 0.4612
0.1457 0.4717 0.4713
0.0609 0.4117 0
0.0807 0.334 0.4539
0.0283 0.3321 0.4018
0.0266 0.3107 0.4608
0.5438 0.4748 0.4745
0.3654 0.4744 0.474
0.0292 0.3198 0
0.5207 0.3398 0.4743
0.0548 0.4603 0.4568
0.1424 0.4152 0.4725
0.0572 0.47 0.4687
0.1116 0.4237 0.243
0.0273 0.2836 0.4606
0.1097 0.3106 0.4705
0.0548 0.3319 0.467
0.12 0.4732 0.4687
0.2751 0.4741 0.4741
0.028 0.4522 0.4396
0.4052 0.2751 0.474
0.0903 0.4687 0.4687
0.0559 0.3141 0.4581
0.1085 0.2666 0.4722
0.0277 0.2748 0.4633
0.03 0.3626 0.4574
0.028 0.2793 0.0348
0.0299 0.4078 0.4524
0.0266 0.4224 0
0.0267 0.4507 0.4486
0.029 0.3339 0
0.1171 0.4737 0.4732
0.3703 0.4748 0.4731
0.0278 0.3616 0.4608
0.0312 0.3658 0.4632
0.0292 0.3198 0
0.0448 0.251 0.2503
0.0268 0.4644 0.4629
0.5207 0.3398 0.4743
0.0942 0.3835 0.3597
0.3891 0.4751 0.4749
0.0891 0.4058 0.4446
0.0574 0.3387 0.4687
0.0855 0.4714 0.4696
0.2734 0.4735 0.4735
0.1116 0.4237 0.243
0.1444 0.3246 0.4687
0.0839 0.3067 0.4715
0.0826 0.4683 0.4683
0.0478 0.251 0.2509
0.0487 0.251 0.2506
0.0274 0.3201 0.4622
0.1156 0.3386 0.4689
0.0817 0.4718 0.4687
0.0264 0.4677 0
0.0846 0.4742 0.4733
0.4024 0.4752 0.475
0.1403 0.3398 0.4734
0.0278 0.296 0.4723
0.4286 0.4751 0.4749
0.1138 0.4701 0.4687
0.0329 0.4508 0
0.5451 0.4752 0.4751
0.0576 0.3419 0.4616
0.6931 0.4751 0.4751
0.044 0.2503 0.25
0.0844 0.4609 0
0.0554 0.4709 0.4688
0.0892 0.4687 0.4687
0.0842 0.2732 0.4677
0.0264 0.458 0.4312
0.2757 0.3415 0.3415
0.0309 0.4684 0.4445
0.0865 0.4545 0
0.3688 0.4664 0.3835
0.0559 0.4718 0.4687
0.2568 0.4728 0.4727
0.0802 0.4708 0.47
0.0537 0.4628 0.4434
0.1382 0.4733 0.4733
0.1454 0.4286 0.4727
0.0273 0.4593 0
0.0636 0.4533 0
0.1122 0.447 0.4703
0.0546 0.4707 0.4687
0.1085 0.2666 0.4722
0.0318 0.4574 0.4539
0.0843 0.3241 0.4698
0.1142 0.4687 0.4687
0.196 0.2636 0.4697
0.0287 0.3519 0.4611
0.3324 0.4748 0.4748
0.0291 0.4287 0
0.03 0.4317 0.156
0.6636 0.475 0.4748
0.0559 0.4671 0
0.0535 0.4461 0
0.0572 0.47 0.4687
0.0801 0.4719 0.4716
0.0263 0.4084 0.4084
0.1115 0.4734 0.4717
0.0881 0.3066 0.4718
0.196 0.2636 0.4697
0.0329 0.2767 0.2743
0.0583 0.3484 0.4719
0.0546 0.4687 0.4687
0.1085 0.2666 0.4722
0.1085 0.2666 0.4722
0.1404 0.4739 0.4739
0.0889 0.4729 0.4723
0.0812 0.3245 0.4687
0.0817 0.4718 0.4687
0.0532 0.4697 0.4694
0.0564 0.474 0.47
0.2023 0.4746 0.4746
0.0291 0.3306 0.4601
0.1085 0.2666 0.4722
0.0552 0.4006 0.4128
0.134 0.4693 0.4687
0.1967 0.4739 0.4735
0.0833 0.4732 0.4721
0.0559 0.4718 0.4687
0.0329 0.4645 0
0.2447 0.4747 0.4743
0.0877 0.4701 0.4701
0.0263 0.2835 0.4485
0.0884 0.2601 0.4707
0.054 0.4712 0.469
0.045 0.251 0.2509
0.1116 0.4237 0.243
0.1416 0.4735 0.473
0.0829 0.3962 0.4707
0.1444 0.3246 0.4687
0.217 0.4698 0.4687
0.0444 0.2512 0.2509
0.136 0.4728 0.4697
0.0277 0.2765 0.4135
0.0863 0.3066 0.4705
0.053 0.3016 0.4724
0.0895 0.4742 0.4718
0.0264 0.2794 0.264
0.0632 0.4652 0.4593
0.0582 0.4717 0.4717
0.2451 0.4741 0.4741
0.0329 0.279 0.4647
0.1139 0.4723 0.4719
0.0864 0.4662 0.4662
0.1085 0.2666 0.4722
0.0263 0.3518 0.4281
0.028 0.3162 0.3101
0.056 0.4705 0.4687
0.6625 0.4751 0.4751
0.1406 0.4741 0.4725
0.0807 0.334 0.4539
0.028 0.3382 0.461
0.0267 0.2716 0.2595
0.0291 0.4287 0
0.0276 0.3028 0.4687
0.029 0.3755 0.4428
0.196 0.2636 0.4697
0.0827 0.3203 0.4687
0.0264 0.2614 0.4539
0.1421 0.4718 0.4699
0.2195 0.4326 0.4727
0.0329 0.3383 0.4593
0.0544 0.4724 0.4687
0.0535 0.3454 0.4529
0.5207 0.3398 0.4743
0.0329 0.4637 0
0.2778 0.4744 0.4743
0.0842 0.3286 0.4687
0.0529 0.3274 0.4646
0.3004 0.4739 0.4738
0.196 0.2636 0.4697
0.0265 0.4716 0.4687
0.1085 0.2666 0.4722
0.5438 0.4748 0.4745
0.0269 0.4684 0.4549
0.0329 0.4266 0
0.0548 0.4603 0.4568
0.0278 0.3086 0.4581
0.1692 0.4721 0.4721
0.0544 0.2562 0.4687
0.0529 0.253 0.4687
0.0284 0.3158 0.4135
0.2505 0.4735 0.4733
0.0636 0.4533 0
0.0329 0.452 0
0.2821 0.4746 0.4746
0.1151 0.4242 0.4705
0.109 0.4733 0.4722
0.0448 0.2511 0.2507
0.0879 0.4722 0.4709
0.0288 0.2881 0.468
0.4021 0.475 0.4749
0.0895 0.3431 0.471
0.1444 0.3246 0.4687
0.3003 0.4743 0.4743
0.3261 0.3502 0.4729
0.0816 0.4656 0.4635
0.1453 0.4731 0.4731
0.0855 0.4714 0.4696
0.196 0.2636 0.4697
0.6579 0.475 0.475

Assayability

Assay information

  • Assay for Urease (3.5.1.5 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.
  • BRENDA Assay
  • An enzyme with this EC number or name or sequence has been assayed in Mycobacterium tuberculosis ( 1 )

Reagent availability

  • Reagent:
  • Target Type Source Notes
    Rv1849 cloned gene BRENDA A gene with this EC number or name or sequence has been cloned from Mycobacterium tuberculosis ( 1 )

Bibliographic References

42 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Rv1849 (Mycobacterium tuberculosis), Urease beta subunit UreB (urea amidohydrolase)
Title for this comment
Comment