TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 516.263 | Formula: C16H15BrN5O6PS
H donors: 3 H acceptors: 6 LogP: 0.54 Rotable bonds: 3
Rule of 5 violations (Lipinski): 2
SMILES: OC1C2OP(=O)(O)OCC2OC1n1c(Sc2ccc(cc2)Br)nc2c1ncnc2N
InChi: 1S/C16H15BrN5O6PS/c17-7-1-3-8(4-2-7)30-16-21-10-13(18)19-6-20-14(10)22(16)15-11(23)12-9(27-15)5-26-29(24,25)28-12/h1-4,6,9,11-12,15,23H,5H2,(H,24,25)(H2,18,19,20)
InChiKey: CVTVCFNZSLYAGI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Schistosoma mansoni	protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0189	0.2568	0.7756
Loa Loa (eye worm)	TK/FER protein kinase	0.0226	0.3311	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0226	0.3311	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0226	0.3311	1
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0119	0.1137	0.3435
Loa Loa (eye worm)	TK/RYK protein kinase	0.0226	0.3311	1
Loa Loa (eye worm)	TK protein kinase	0.0226	0.3311	1
Entamoeba histolytica	tyrosine kinase, putative	0.0226	0.3311	0.5
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Plasmodium falciparum	protein kinase, putative	0.0226	0.3311	0.5
Trypanosoma brucei	protein kinase, putative	0.0226	0.3311	0.5
Echinococcus multilocularis	activin receptor type	0.0226	0.3311	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0226	0.3311	0.5
Schistosoma mansoni	hypothetical protein	0.0226	0.3311	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0226	0.3311	0.5
Onchocerca volvulus		0.0226	0.3311	1
Entamoeba histolytica	tyrosine kinase, putative	0.0226	0.3311	0.5
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0226	0.3311	1
Mycobacterium ulcerans	urease subunit beta UreB	0.0263	0.4084	0.4084
Brugia malayi	hypothetical protein	0.0226	0.3311	1
Schistosoma mansoni	ephrin receptor	0.0226	0.3311	1
Entamoeba histolytica	protein kinase domain containing protein	0.0226	0.3311	0.5
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0226	0.3311	0.5
Loa Loa (eye worm)	hypothetical protein	0.0226	0.3311	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0226	0.3311	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0226	0.3311	1
Entamoeba histolytica	protein kinase domain containing protein	0.0226	0.3311	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0226	0.3311	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Entamoeba histolytica	hypothetical protein, conserved	0.0226	0.3311	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0226	0.3311	0.5
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Entamoeba histolytica	tyrosine kinase, putative	0.0226	0.3311	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0226	0.3311	1
Entamoeba histolytica	protein kinase domain containing protein	0.0226	0.3311	0.5
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Entamoeba histolytica	protein kinase, putative	0.0226	0.3311	0.5
Schistosoma mansoni	serine/threonine RGC	0.0226	0.3311	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0226	0.3311	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Entamoeba histolytica	protein kinase, putative	0.0226	0.3311	0.5
Loa Loa (eye worm)	hypothetical protein	0.0226	0.3311	1
Loa Loa (eye worm)	hypothetical protein	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0226	0.3311	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0226	0.3311	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0226	0.3311	0.5
Entamoeba histolytica	hypothetical protein	0.0226	0.3311	0.5
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Entamoeba histolytica	protein kinase, putative	0.0226	0.3311	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0226	0.3311	0.5
Giardia lamblia	Kinase, NEK	0.0226	0.3311	0.5
Schistosoma mansoni	protein kinase	0.0226	0.3311	1
Echinococcus granulosus	tyrosine kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Mycobacterium ulcerans	urease subunit gamma	0.0263	0.4084	0.4084
Loa Loa (eye worm)	TK/FER protein kinase	0.0226	0.3311	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0226	0.3311	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0226	0.3311	1
Entamoeba histolytica	tyrosin kinase, putative	0.0226	0.3311	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0226	0.3311	0.5
Entamoeba histolytica	cysteine surface protein, putative	0.0226	0.3311	0.5
Entamoeba histolytica	hypothetical protein	0.0226	0.3311	0.5
Loa Loa (eye worm)	serine/threonine protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Entamoeba histolytica	tyrosine kinase, putative	0.0226	0.3311	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0226	0.3311	0.5
Brugia malayi	Receptor family ligand binding region containing protein	0.0226	0.3311	1
Loa Loa (eye worm)	SRC-1	0.0226	0.3311	1
Trichomonas vaginalis	conserved hypothetical protein	0.0226	0.3311	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.0226	0.3311	1
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Entamoeba histolytica	protein kinase domain containing protein	0.0226	0.3311	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0226	0.3311	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0226	0.3311	1
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0079	0.033	0.0997
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Leishmania major	protein kinase, putative	0.0226	0.3311	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0226	0.3311	1
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0119	0.1137	0.3435
Loa Loa (eye worm)	TK protein kinase	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0226	0.3311	1
Echinococcus granulosus	protein tyrosine kinase	0.0226	0.3311	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0226	0.3311	1
Trypanosoma brucei	Pseudokinase, putative	0.0226	0.3311	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0226	0.3311	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0226	0.3311	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0226	0.3311	0.5
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0226	0.3311	1
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0226	0.3311	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0226	0.3311	1
Entamoeba histolytica	protein kinase domain containing protein	0.0226	0.3311	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0226	0.3311	1
Entamoeba histolytica	hypothetical protein	0.0226	0.3311	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0226	0.3311	0.5
Echinococcus granulosus	integrin linked protein kinase	0.0226	0.3311	1
Loa Loa (eye worm)	TK protein kinase	0.0226	0.3311	1
Entamoeba histolytica	hypothetical protein	0.0226	0.3311	0.5
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0189	0.2568	0.7507
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0226	0.3311	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0189	0.2568	0.7756
Loa Loa (eye worm)	hypothetical protein	0.0226	0.3311	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Loa Loa (eye worm)	hypothetical protein	0.0226	0.3311	1
Leishmania major	hypothetical protein, conserved	0.0226	0.3311	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0226	0.3311	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0226	0.3311	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0226	0.3311	1
Leishmania major	protein kinase, putative	0.0226	0.3311	1
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Entamoeba histolytica	protein kinase, putative	0.0226	0.3311	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0226	0.3311	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0226	0.3311	0.5
Entamoeba histolytica	protein kinase, putative	0.0226	0.3311	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0226	0.3311	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0226	0.3311	1
Giardia lamblia	Protein 21.1	0.0226	0.3311	0.5
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Entamoeba histolytica	receptor protein kinase, putative	0.0226	0.3311	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0226	0.3311	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0226	0.3311	1
Loa Loa (eye worm)	hypothetical protein	0.0226	0.3311	1
Entamoeba histolytica	protein kinase domain containing protein	0.0226	0.3311	0.5
Entamoeba histolytica	protein kinase, putative	0.0226	0.3311	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Schistosoma mansoni	protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Echinococcus multilocularis	integrin linked protein kinase	0.0226	0.3311	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0226	0.3311	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0226	0.3311	1
Schistosoma mansoni	protein kinase	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0226	0.3311	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0226	0.3311	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0226	0.3311	1
Loa Loa (eye worm)	hypothetical protein	0.0226	0.3311	1
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0226	0.3311	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0226	0.3311	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0226	0.3311	1
Entamoeba histolytica	protein kinase domain containing protein	0.0226	0.3311	0.5
Loa Loa (eye worm)	TK/CSK protein kinase	0.0226	0.3311	1
Schistosoma mansoni	serine/threonine protein kinase	0.0226	0.3311	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0226	0.3311	0.5
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0119	0.1137	0.3435
Entamoeba histolytica	tyrosine kinase, putative	0.0226	0.3311	0.5
Plasmodium falciparum	protein kinase, putative	0.0226	0.3311	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0226	0.3311	0.5
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Entamoeba histolytica	protein kinase domain containing protein	0.0226	0.3311	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0226	0.3311	0.5
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0226	0.3311	1
Loa Loa (eye worm)	TK protein kinase	0.0226	0.3311	1
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0119	0.1137	0.3435
Echinococcus multilocularis	tyrosine protein kinase csk	0.0226	0.3311	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0226	0.3311	1
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0226	0.3311	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0226	0.3311	1
Entamoeba histolytica	tyrosine kinase, putative	0.0226	0.3311	0.5
Brugia malayi	Tyrosine-protein kinase PR2	0.0226	0.3311	1
Onchocerca volvulus		0.0226	0.3311	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0226	0.3311	0.5
Echinococcus multilocularis	FL cytokine receptor	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0226	0.3311	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0226	0.3311	1
Echinococcus granulosus	epidermal growth factor receptor	0.0226	0.3311	1
Schistosoma mansoni	serine/threonine protein kinase	0.0226	0.3311	1
Brugia malayi	protein-tyrosine kinase	0.0226	0.3311	1
Entamoeba histolytica	tyrosine kinase, putative	0.0226	0.3311	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	STE family protein kinase	0.0226	0.3311	1
Entamoeba histolytica	protein kinase domain containing protein	0.0226	0.3311	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0226	0.3311	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0226	0.3311	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Entamoeba histolytica	tyrosine kinase, putative	0.0226	0.3311	0.5
Echinococcus granulosus	tyrosine protein kinase HCK	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0226	0.3311	0.5
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0226	0.3311	1
Toxoplasma gondii	STE kinase	0.0226	0.3311	1
Loa Loa (eye worm)	TK protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Echinococcus multilocularis	c src tyrosine kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0226	0.3311	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0226	0.3311	1
Schistosoma mansoni	alpha-glucosidase	0.0163	0.2032	0.6135
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Entamoeba histolytica	tyrosine kinase, putative	0.0226	0.3311	0.5
Schistosoma mansoni	ephrin receptor	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0226	0.3311	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0226	0.3311	1
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0119	0.1137	0.3435
Loa Loa (eye worm)	TK/FER protein kinase	0.0226	0.3311	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0226	0.3311	0.5
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0226	0.3311	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0226	0.3311	1
Loa Loa (eye worm)	TK protein kinase	0.0226	0.3311	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0226	0.3311	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0226	0.3311	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0226	0.3311	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0226	0.3311	1
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0226	0.3311	1
Toxoplasma gondii	melibiase subfamily protein	0.0119	0.1137	0.3435
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0226	0.3311	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Entamoeba histolytica	hypothetical protein	0.0226	0.3311	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0226	0.3311	1
Entamoeba histolytica	protein kinase domain containing protein	0.0226	0.3311	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0226	0.3311	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Trichomonas vaginalis	AGC family protein kinase	0.0226	0.3311	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0226	0.3311	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0226	0.3311	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0226	0.3311	1
Onchocerca volvulus		0.0226	0.3311	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0226	0.3311	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0226	0.3311	1
Entamoeba histolytica	protein kinase, putative	0.0226	0.3311	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0226	0.3311	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0226	0.3311	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0226	0.3311	1
Giardia lamblia	Kinase	0.0226	0.3311	0.5
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0226	0.3311	1
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0079	0.033	0.0997
Entamoeba histolytica	serine/threonine kinase, putative	0.0226	0.3311	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Schistosoma mansoni	protein kinase	0.0226	0.3311	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.0226	0.3311	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0226	0.3311	1
Onchocerca volvulus		0.0226	0.3311	1
Brugia malayi	Raf kinase	0.0226	0.3311	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0226	0.3311	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.0226	0.3311	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0226	0.3311	0.5
Brugia malayi	SH2 domain containing protein	0.0226	0.3311	1
Entamoeba histolytica	hypothetical protein	0.0226	0.3311	0.5
Onchocerca volvulus		0.0226	0.3311	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Schistosoma mansoni	tyrosine protein kinase	0.0226	0.3311	1
Entamoeba histolytica	hypothetical protein	0.0226	0.3311	0.5
Echinococcus granulosus	tyrosine kinase	0.0226	0.3311	1
Brugia malayi	SH2 domain containing protein	0.0226	0.3311	1
Entamoeba histolytica	protein kinase, putative	0.0226	0.3311	0.5
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0119	0.1137	0.3435
Echinococcus granulosus	activated cdc42 kinase 1	0.0226	0.3311	1
Loa Loa (eye worm)	TK protein kinase	0.0226	0.3311	1
Echinococcus granulosus	activin receptor type	0.0226	0.3311	1
Entamoeba histolytica	ankyrin repeat protein	0.0226	0.3311	0.5
Entamoeba histolytica	receptor protein kinase, putative	0.0226	0.3311	0.5
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0119	0.1137	0.3435
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0226	0.3311	1
Entamoeba histolytica	tyrosine kinase, putative	0.0226	0.3311	0.5
Loa Loa (eye worm)	TK protein kinase	0.0226	0.3311	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0226	0.3311	1
Schistosoma mansoni	serine/threonine protein kinase	0.0226	0.3311	1
Entamoeba histolytica	tyrosin kinase, putative	0.0226	0.3311	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0226	0.3311	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0226	0.3311	1
Onchocerca volvulus		0.0226	0.3311	1
Schistosoma mansoni	protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0226	0.3311	1
Schistosoma mansoni	protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0226	0.3311	0.5
Echinococcus granulosus	tyrosine protein kinase	0.0226	0.3311	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0226	0.3311	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0226	0.3311	1
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0226	0.3311	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0226	0.3311	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0226	0.3311	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0226	0.3311	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0226	0.3311	1
Schistosoma mansoni	protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Entamoeba histolytica	protein kinase domain containing protein	0.0226	0.3311	0.5
Echinococcus multilocularis	insulin receptor	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Onchocerca volvulus		0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0226	0.3311	1
Entamoeba histolytica	protein kinase, putative	0.0226	0.3311	0.5
Schistosoma mansoni	protein kinase	0.0226	0.3311	1
Entamoeba histolytica	tyrosine kinase, putative	0.0226	0.3311	0.5
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0226	0.3311	1
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0226	0.3311	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.0226	0.3311	1
Entamoeba histolytica	tyrosine kinase, putative	0.0226	0.3311	0.5
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0226	0.3311	1
Onchocerca volvulus		0.0226	0.3311	1
Schistosoma mansoni	protein tyrosine kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Entamoeba histolytica	protein kinase, putative	0.0226	0.3311	0.5
Brugia malayi	Furin-like cysteine rich region family protein	0.0226	0.3311	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0226	0.3311	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0226	0.3311	1
Entamoeba histolytica	hypothetical protein	0.0226	0.3311	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0226	0.3311	0.5
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0226	0.3311	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0189	0.2568	0.7507
Loa Loa (eye worm)	TK protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Trichomonas vaginalis	conserved hypothetical protein	0.0226	0.3311	1
Echinococcus granulosus	insulin receptor	0.0226	0.3311	1
Schistosoma mansoni	serine/threonine protein kinase	0.0226	0.3311	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0226	0.3311	0.5
Loa Loa (eye worm)	hypothetical protein	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Entamoeba histolytica	tyrosine kinase, putative	0.0226	0.3311	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0226	0.3311	0.5
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0226	0.3311	1
Onchocerca volvulus		0.0226	0.3311	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0226	0.3311	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0226	0.3311	1
Toxoplasma gondii	protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Entamoeba histolytica	protein kinase, putative	0.0226	0.3311	0.5
Mycobacterium tuberculosis	Urease beta subunit UreB (urea amidohydrolase)	0.0263	0.4084	0.4084
Loa Loa (eye worm)	hypothetical protein	0.0226	0.3311	1
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0226	0.3311	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0226	0.3311	1
Schistosoma mansoni	protein kinase	0.0226	0.3311	1
Entamoeba histolytica	protein kinase domain containing protein	0.0226	0.3311	0.5
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0226	0.3311	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0226	0.3311	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0226	0.3311	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0226	0.3311	1
Loa Loa (eye worm)	TK protein kinase	0.0226	0.3311	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0226	0.3311	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0226	0.3311	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0226	0.3311	1
Entamoeba histolytica	protein kinase, putative	0.0226	0.3311	0.5
Loa Loa (eye worm)	TK/EPH protein kinase	0.0226	0.3311	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0226	0.3311	1
Brugia malayi	C-terminal src kinase protein 1	0.0226	0.3311	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0226	0.3311	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.0226	0.3311	1
Brugia malayi	ephrin receptor 1 precursor	0.0226	0.3311	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0226	0.3311	1
Echinococcus multilocularis	transfer RNA-Thr	0.0226	0.3311	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0226	0.3311	1
Entamoeba histolytica	protein kinase, putative	0.0226	0.3311	0.5
Onchocerca volvulus		0.0226	0.3311	1
Giardia lamblia	Kinase, NEK	0.0226	0.3311	0.5
Plasmodium falciparum	protein kinase, putative	0.0226	0.3311	0.5
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Echinococcus multilocularis	tyrosine kinase	0.0226	0.3311	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0226	0.3311	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0226	0.3311	1
Echinococcus granulosus	c src tyrosine kinase	0.0226	0.3311	1
Onchocerca volvulus		0.0226	0.3311	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0226	0.3311	0.5
Echinococcus multilocularis	protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0226	0.3311	1
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0226	0.3311	1
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Echinococcus multilocularis	protein kinase	0.0226	0.3311	1
Plasmodium vivax	protein kinase, putative	0.0226	0.3311	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0226	0.3311	1
Brugia malayi	integrin-linked kinase	0.0226	0.3311	1
Entamoeba histolytica	protein kinase domain containing protein	0.0226	0.3311	0.5
Trichomonas vaginalis	TK family protein kinase	0.0226	0.3311	1
Entamoeba histolytica	protein kinase, putative	0.0226	0.3311	0.5
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0226	0.3311	1
Entamoeba histolytica	hypothetical protein	0.0226	0.3311	0.5
Entamoeba histolytica	protein kinase, putative	0.0226	0.3311	0.5
Echinococcus granulosus	tyrosine protein kinase pr2	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0226	0.3311	1
Brugia malayi	hypothetical protein	0.0226	0.3311	1
Entamoeba histolytica	protein kinase, putative	0.0226	0.3311	0.5
Brugia malayi	Guanylyl cyclase protein 23	0.0226	0.3311	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0226	0.3311	0.5
Entamoeba histolytica	protein kinase, putative	0.0226	0.3311	0.5
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0226	0.3311	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0226	0.3311	1
Schistosoma mansoni	protein kinase	0.0226	0.3311	1
Entamoeba histolytica	protein kinase domain containing protein	0.0226	0.3311	0.5
Entamoeba histolytica	hypothetical protein	0.0226	0.3311	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0226	0.3311	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Trypanosoma cruzi	protein kinase, putative	0.0226	0.3311	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0226	0.3311	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0226	0.3311	1
Echinococcus granulosus	ephrin type A receptor 4 A	0.0226	0.3311	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	conserved hypothetical protein	0.0226	0.3311	1
Entamoeba histolytica	protein kinase, putative	0.0226	0.3311	0.5
Echinococcus multilocularis	heat shock protein 70	0.0226	0.3311	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0226	0.3311	1
Entamoeba histolytica	tyrosine kinase, putative	0.0226	0.3311	0.5
Onchocerca volvulus		0.0226	0.3311	1
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Onchocerca volvulus		0.0226	0.3311	1
Mycobacterium ulcerans	urease subunit alpha	0.0554	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0226	0.3311	1
Onchocerca volvulus		0.0226	0.3311	1
Entamoeba histolytica	protein kinase, putative	0.0226	0.3311	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0226	0.3311	1
Entamoeba histolytica	protein kinase domain containing protein	0.0226	0.3311	0.5
Echinococcus granulosus	lysosomal alpha glucosidase	0.0189	0.2568	0.7756
Schistosoma mansoni	alpha-glucosidase	0.0163	0.2032	0.6135
Loa Loa (eye worm)	hypothetical protein	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Loa Loa (eye worm)	hypothetical protein	0.0226	0.3311	1
Brugia malayi	SRC-1	0.0226	0.3311	1
Echinococcus granulosus	tyrosine kinase	0.0226	0.3311	1
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0226	0.3311	0.5
Echinococcus multilocularis	tyrosine kinase	0.0226	0.3311	1
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0226	0.3311	1
Echinococcus multilocularis	tyrosine protein kinase	0.0226	0.3311	1
Schistosoma mansoni	tyrosine kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Onchocerca volvulus		0.0226	0.3311	1
Brugia malayi	hypothetical protein	0.0226	0.3311	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0226	0.3311	0.5
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Entamoeba histolytica	hypothetical protein	0.0226	0.3311	0.5
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Trypanosoma cruzi	protein kinase, putative	0.0226	0.3311	0.5
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0226	0.3311	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0226	0.3311	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0226	0.3311	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0226	0.3311	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Loa Loa (eye worm)	hypothetical protein	0.0226	0.3311	1
Echinococcus granulosus	protein kinase	0.0226	0.3311	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0226	0.3311	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Mycobacterium tuberculosis	Urease gamma subunit UreA (urea amidohydrolase)	0.0263	0.4084	0.4084
Echinococcus granulosus	tyrosine protein kinase Blk	0.0226	0.3311	1
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1
Echinococcus multilocularis	protein tyrosine kinase	0.0226	0.3311	1
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0226	0.3311	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0226	0.3311	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0226	0.3311	1
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0226	0.3311	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0226	0.3311	1
Loa Loa (eye worm)	hypothetical protein	0.0226	0.3311	1
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0226	0.3311	1
Entamoeba histolytica	protein kinase domain containing protein	0.0226	0.3311	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0226	0.3311	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0226	0.3311	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0226	0.3311	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0226	0.3311	1
Trichomonas vaginalis	conserved hypothetical protein	0.0226	0.3311	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0226	0.3311	1
Brugia malayi	Protein kinase domain containing protein	0.0226	0.3311	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Hydrolysis (functional)	< 0.05	Susceptibility to be hydrolysed by a partially purified cAMP phosphodiesterase from rabbit kidney	ChEMBL.	6245211
I50 (binding)	= 60 uM	Inhibition of cAMP phosphodiesterase preparation from bovine heart at a substrate concentration of 0.14 microM	ChEMBL.	6245211
I50 (binding)	= 240 uM	Inhibition of cAMP phosphodiesterase preparation from rabbit lung at a substrate concentration of 0.14 microM	ChEMBL.	6245211
Ka' (binding)	= 1.6	Activate a partially purified type II cAMP-dependent protein kinase from bovine brain	ChEMBL.	6245211

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 234932

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 138321