pI: 6.6113 |
Length (AA): 584 |
MW (Da): 66849 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 11 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 242 | 3eqc (A) | 46 | 267 | 21.00 | 0 | 0.68 | 0.515259 | 0.33 |
6 | 255 | 4oh4 (A) | 869 | 1103 | 26.00 | 0 | 1 | 0.615382 | 0.22 |
7 | 230 | 5k75 (A) | 167 | 379 | 28.00 | 0 | 0.94 | 0.527862 | 0.09 |
20 | 309 | 1byg (A) | 188 | 448 | 28.00 | 0.000000000034 | 1 | 0.621975 | 0.2 |
60 | 305 | 4c02 (A) | 232 | 499 | 29.00 | 0.000000015 | 1 | 0.709633 | -0.43 |
325 | 361 | 3hls (A) | 372 | 408 | 43.00 | 0 | 0.3 | 0.572756 | -0.64 |
330 | 556 | 5o5l (A) | 206 | 427 | 41.00 | 0 | 1 | 0.943099 | -0.91 |
364 | 550 | 3et6 (A) | 467 | 651 | 52.00 | 0 | 1 | 0.956605 | -0.81 |
364 | 552 | 4p2f (A) | 241 | 424 | 44.00 | 0 | 1 | 0.90303 | -0.84 |
365 | 545 | 4ni2 (A) | 472 | 649 | 42.00 | 0 | 1 | 0.888332 | -0.9 |
367 | 552 | 6ao9 (A) | 445 | 625 | 43.00 | 0 | 1 | 0.828893 | -1.05 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_156265)
Species | Accession | Gene Product |
---|---|---|
Echinococcus granulosus | EgrG_000928050 | atrial natriuretic peptide receptor 1 |
Echinococcus granulosus | EgrG_000131200 | Adenylyl cyclase class 3 4 guanylyl cyclase |
Echinococcus multilocularis | EmuJ_000131200 | |
Echinococcus multilocularis | EmuJ_000605900 | natriuretic peptide receptor 1 |
Echinococcus multilocularis | EmuJ_000928050 | atrial natriuretic peptide receptor 1 |
Schistosoma japonicum | Sjp_0082080 | ko:K01769 guanylate cyclase [EC4.6.1.2], putative |
Schistosoma japonicum | Sjp_0119590 | Retinal guanylyl cyclase 2 precursor, putative |
Schistosoma mansoni | Smp_085680 | serine/threonine RGC |
Schmidtea mediterranea | mk4.008216.00 | Heat-stable enterotoxin receptor |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Patiria pectinifera | Cdc2 | 300 aa | 22.4% | 241 aa | Compounds | References |
Rattus norvegicus | Jak1 protein | 210 aa | 24.9% | 201 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 23.3% | 258 aa | Compounds | References |
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 25.0% | 160 aa | Compounds | References |