Detailed information for compound 1177806

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 275.387 | Formula: C20H21N
  • H donors: 0 H acceptors: 0 LogP: 3.97 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CN2CCC1/C(=C/c1ccc(cc1)c1ccccc1)/C2
  • InChi: 1S/C20H21N/c1-2-4-17(5-3-1)18-8-6-16(7-9-18)14-20-15-21-12-10-19(20)11-13-21/h1-9,14,19H,10-13,15H2/b20-14+
  • InChiKey: RTFHBXLCOFNPOR-XSFVSMFZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Leishmania major squalene synthase, putative Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Trypanosoma congolense squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Trypanosoma congolense squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Trypanosoma cruzi squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Trypanosoma congolense squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Leishmania braziliensis squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Leishmania mexicana farnesyltransferase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Candida albicans squalene synthase similar to S. cerevisiae ERG9 (YHR190W) involved in ergosterol biosynthesis Get druggable targets OG5_129470 All targets in OG5_129470
Trypanosoma cruzi squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Leishmania infantum squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Trypanosoma brucei gambiense farnesyltransferase, putative,squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Candida albicans squalene synthase similar to S. cerevisiae ERG9 (YHR190W) involved in ergosterol biosynthesis Get druggable targets OG5_129470 All targets in OG5_129470
Leishmania donovani farnesyltransferase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Leishmania major squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Protein ultraspiracle homolog 0.0072 0.0203 0.2357
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0166 0.135
Entamoeba histolytica hypothetical protein 0.0184 0.0548 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0034 0.0085 0.0691
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0072 0.0203 0.1647
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0078 0.0634
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0043 0.0111 0.1547
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0043 0.0111 0.1447
Leishmania major 4-coumarate:coa ligase-like protein 0.0145 0.0428 0.1507
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0203 0.2028
Brugia malayi beta-lactamase family protein 0.0072 0.0203 0.282
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0462 0.1405 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.029 0.3403
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0203 0.5973
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0034 0.0085 0.0691
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0037 0.5
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0043 0.0111 0.0904
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0078 0.1086
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0103 0.0296 0.1892
Loa Loa (eye worm) nuclear receptor NHR-67 0.0034 0.0085 0.0997
Onchocerca volvulus 0.0026 0.0061 0.0692
Schistosoma mansoni hypothetical protein 0.0186 0.0555 0.4502
Leishmania major squalene synthase, putative 0.0908 0.2783 1
Onchocerca volvulus Bile acid receptor homolog 0.0072 0.0203 0.2357
Plasmodium falciparum acyl-CoA synthetase 0.0108 0.0315 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0315 0.3685
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0043 0.0111 0.0906
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.0997
Entamoeba histolytica hypothetical protein 0.0184 0.0548 1
Schistosoma mansoni hypothetical protein 0.0283 0.0854 0.6926
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.0997
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0043 0.0111 0.0541
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0718
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0111 0.0366
Loa Loa (eye worm) hypothetical protein 0.0072 0.0203 0.2378
Schistosoma mansoni nuclear receptor nhr-48 0.0034 0.0085 0.0691
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0085 0.0691
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0037 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0072 0.0203 0.1647
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0111 0.0906
Loa Loa (eye worm) hypothetical protein 0.0032 0.0078 0.0915
Brugia malayi MH2 domain containing protein 0.0016 0.003 0.042
Brugia malayi hypothetical protein 0.0034 0.0085 0.1183
Loa Loa (eye worm) hypothetical protein 0.0072 0.0203 0.2379
Brugia malayi hypothetical protein 0.0038 0.0098 0.1358
Loa Loa (eye worm) MH1 domain-containing protein 0.0007 0.0002 0.0028
Echinococcus granulosus lamin 0.0026 0.0061 0.0497
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0203 0.282
Schistosoma mansoni hypothetical protein 0.0032 0.0078 0.0634
Loa Loa (eye worm) nuclear factor I 0.0009 0.0008 0.009
Schistosoma mansoni smad 0.0007 0.0002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0101 0.029 0.3403
Brugia malayi intermediate filament protein 0.0026 0.0061 0.0852
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0203 0.121
Brugia malayi mothers against decapentaplegic homolog 3 0.0007 0.0002 0.0033
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0283 0.0854 0.5967
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0416 0.0416
Schistosoma mansoni retinoic acid receptor RXR 0.0072 0.0203 0.1647
Brugia malayi AMP-binding enzyme family protein 0.0145 0.0428 0.5945
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0416 0.3373
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0034 0.0085 0.0085
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0192 0.2671
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0145 0.0428 0.4783
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0203 0.121
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0037 0.5
Schistosoma mansoni ap endonuclease 0.0019 0.0037 0.0304
Schistosoma mansoni coup transcription factor 0.0072 0.0203 0.1647
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0043 0.0111 0.0906
Mycobacterium ulcerans acyl-CoA synthetase 0.0145 0.0428 0.4783
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0203 0.2894
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0111 0.0906
Loa Loa (eye worm) hypothetical protein 0.0072 0.0203 0.2379
Brugia malayi Smad1 0.0016 0.003 0.042
Brugia malayi MH2 domain containing protein 0.0007 0.0002 0.0033
Schistosoma mansoni lamin 0.0026 0.0061 0.0497
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0145 0.0428 1
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0085 0.1183
Brugia malayi Steroid receptor seven-up type 2 0.0072 0.0203 0.2821
Leishmania major hypothetical protein, conserved 0.0072 0.0203 0.0697
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0182 0.1476
Brugia malayi TAR-binding protein 0.0065 0.0182 0.2527
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0085 0.0691
Echinococcus multilocularis thyroid hormone receptor alpha 0.0072 0.0203 0.0203
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.029 0.4036
Loa Loa (eye worm) hypothetical protein 0.0072 0.0203 0.2378
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0416 0.3373
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0203 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0043 0.0111 0.0366
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0416 0.3373
Loa Loa (eye worm) hypothetical protein 0.0108 0.0315 0.3685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0103 0.0296 0.1892
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0111 0.1547
Mycobacterium ulcerans hypothetical protein 0.0072 0.0203 0.2028
Loa Loa (eye worm) hypothetical protein 0.0007 0.0002 0.0028
Brugia malayi STAT protein, DNA binding domain containing protein 0.0154 0.0456 0.6343
Brugia malayi steroid hormone receptor 0.0072 0.0203 0.2821
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0145 0.0428 0.2854
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0002 0.0014
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.003 0.0245
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0002 0.0014
Echinococcus granulosus GPCR family 2 0.0032 0.0078 0.0634
Brugia malayi hypothetical protein 0.0033 0.0082 0.1133
Mycobacterium leprae Probable lipase LipE 0.0072 0.0203 0.2894
Brugia malayi MH1 domain containing protein 0.0016 0.003 0.042
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0137 0.3607
Loa Loa (eye worm) hypothetical protein 0.0108 0.0315 0.3685
Brugia malayi hypothetical protein 0.0051 0.0137 0.1909
Brugia malayi MH1 domain containing protein 0.0009 0.0008 0.0107
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0002 0.0002
Onchocerca volvulus 0.0026 0.0061 0.0692
Schistosoma mansoni hypothetical protein 0.0406 0.1232 1
Echinococcus multilocularis lamin dm0 0.0026 0.0061 0.0061
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0203 0.2378
Leishmania major hypothetical protein, conserved 0.0051 0.0137 0.046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0224
Echinococcus granulosus mothers against decapentaplegic 6 0.0007 0.0002 0.0019
Loa Loa (eye worm) MH2 domain-containing protein 0.0007 0.0002 0.0028
Brugia malayi hypothetical protein 0.0184 0.0548 0.7621
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0043 0.0111 0.0541
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0072 0.0203 0.2821
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0203 1
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0283 0.0854 1
Echinococcus granulosus dnaJ subfamily B 0.0406 0.1232 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0085 0.0085
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0002 0.0014
Brugia malayi MH2 domain containing protein 0.024 0.072 1
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0182 0.213
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0078 0.1086
Leishmania major acetyl-CoA synthetase, putative 0.0043 0.0111 0.0366
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0108 0.0315 0.2026
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.005 0.005
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0085 0.0972
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0203 1
Schistosoma mansoni zinc finger protein 0.0034 0.0085 0.0691
Loa Loa (eye worm) hypothetical protein 0.0043 0.0111 0.1305
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0145 0.0428 1
Mycobacterium tuberculosis Conserved protein 0.0072 0.0203 0.121
Loa Loa (eye worm) hypothetical protein 0.0072 0.0203 0.2379
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0145 0.0428 0.4783
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0085 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0072 0.0203 0.2821
Entamoeba histolytica acyl-CoA synthetase, putative 0.0145 0.0428 0.7639
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0072 0.0203 0.2379
Echinococcus granulosus Smad4 0.0016 0.003 0.0245
Brugia malayi photoreceptor-specific nuclear receptor 0.0072 0.0203 0.2821
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0072 0.0203 0.1647
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0072 0.0203 0.2821
Onchocerca volvulus 0.0072 0.0203 0.2356
Echinococcus granulosus cpg binding protein 0.003 0.0073 0.0591
Onchocerca volvulus 0.0072 0.0203 0.2356
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0085 0.1183
Echinococcus granulosus lamin dm0 0.0026 0.0061 0.0497
Plasmodium vivax acetyl-CoA synthetase, putative 0.0043 0.0111 0.2668
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0043 0.0111 0.0541
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0038 0.0098 0.0793
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0111 0.1547
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0043 0.0111 0.0541
Echinococcus multilocularis smad 0.0016 0.003 0.003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0037 0.01
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0007 0.0083
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0078 0.0915
Plasmodium vivax acyl-CoA synthetase, putative 0.0108 0.0315 1
Trypanosoma cruzi squalene synthase, putative 0.0908 0.2783 1
Schistosoma mansoni smad 0.0016 0.003 0.0245
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0182 0.1476
Echinococcus granulosus mothers against decapentaplegic 2 0.0007 0.0002 0.0019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0072 0.0203 0.2821
Onchocerca volvulus 0.0034 0.0085 0.0972
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0043 0.0111 0.0541
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0072 0.0203 0.2379
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0137 0.3607
Loa Loa (eye worm) hypothetical protein 0.0072 0.0203 0.2378
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0111 0.0906
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0072 0.0203 0.2379
Loa Loa (eye worm) hypothetical protein 0.0072 0.0203 0.2379
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0061 0.0852
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.003 0.0245
Echinococcus granulosus smad 0.0016 0.003 0.0245
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0072 0.0203 0.2379
Loa Loa (eye worm) hypothetical protein 0.0072 0.0203 0.2379
Brugia malayi tailless protein 0.0034 0.0085 0.1183
Entamoeba histolytica acyl-coA synthetase, putative 0.0145 0.0428 0.7639
Brugia malayi MH2 domain containing protein 0.0016 0.003 0.042
Schistosoma mansoni smad1 5 8 and 0.0016 0.003 0.0245
Echinococcus granulosus intermediate filament protein 0.0026 0.0061 0.0497
Trypanosoma cruzi squalene synthase, putative 0.0908 0.2783 1
Mycobacterium ulcerans phytoene synthase, CrtB 0.0283 0.0854 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0111 0.0906
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0043 0.0111 0.0366
Brugia malayi nuclear receptor RXR 0.0034 0.0085 0.1183
Brugia malayi nuclear receptor NHR-88 0.0034 0.0085 0.1183
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0111 0.1547
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0085 0.0691
Brugia malayi beta-lactamase 0.0072 0.0203 0.282
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0111 0.0906
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.0416 0.5777
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0111 0.0541
Schistosoma mansoni hypothetical protein 0.0186 0.0555 0.4502
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.003 0.0354
Echinococcus granulosus nuclear receptor nhr 48 0.0034 0.0085 0.0691
Schistosoma mansoni thyroid hormone receptor 0.0072 0.0203 0.1647
Echinococcus multilocularis mothers against decapentaplegic 2 0.0007 0.0002 0.0002
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0061 0.0718
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0037 0.0304
Schistosoma mansoni smad1 5 8 and 0.0016 0.003 0.0245
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0037 0.0093 0.0407
Brugia malayi orphan nuclear receptor NR2E1 0.0034 0.0085 0.1183
Echinococcus multilocularis musashi 0.0026 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0072 0.0203 0.2378
Onchocerca volvulus 0.0072 0.0203 0.2356
Loa Loa (eye worm) hypothetical protein 0.0038 0.0098 0.1145
Loa Loa (eye worm) hypothetical protein 0.0072 0.0203 0.2379
Echinococcus granulosus geminin 0.0186 0.0555 0.4502
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0078 0.0634
Echinococcus multilocularis geminin 0.0186 0.0555 0.0555
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0072 0.0203 0.0203
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0072 0.0203 0.2821
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.0997
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0182 0.1476
Brugia malayi conserved hypotetical protein 0.0034 0.0085 0.1183
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0043 0.0111 0.0906
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0072 0.0203 0.1647
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.0997
Mycobacterium ulcerans beta-lactamase 0.0072 0.0203 0.2028
Loa Loa (eye worm) hypothetical protein 0.0283 0.0854 1
Trichomonas vaginalis esterase, putative 0.0072 0.0203 1
Echinococcus granulosus FTZ F1 alpha 0.0072 0.0203 0.1647
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0146 0.6587
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0085 0.0691
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0137 0.6039
Schistosoma mansoni nuclear receptor 0.0034 0.0085 0.0691
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.0997
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0072 0.0203 0.2821
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0111 0.0906
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0416 0.0416
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0184 0.0548 0.445
Schistosoma mansoni acetyl-CoA synthetase 0.0043 0.0111 0.0904
Schistosoma mansoni Smad4 0.0016 0.003 0.0245
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0072 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0072 0.0203 0.2379
Schistosoma mansoni steroid hormone receptor ad4bp 0.0072 0.0203 0.1647
Schistosoma mansoni hypothetical protein 0.0023 0.005 0.041
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0137 0.0364
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0072 0.0203 0.2821
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0007 0.0057
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0072 0.0203 0.0203
Brugia malayi ecdysteroid receptor 0.0072 0.0203 0.2821
Mycobacterium ulcerans acyl-CoA synthetase 0.0145 0.0428 0.4783
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0023 0.0326
Schistosoma mansoni hypothetical protein 0.0032 0.0078 0.0634
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0111 0.0906
Loa Loa (eye worm) hypothetical protein 0.0072 0.0203 0.2378
Brugia malayi nuclear hormone receptor 0.0034 0.0085 0.1183
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0203 0.1647
Schistosoma mansoni hypothetical protein 0.0032 0.0078 0.0634
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.0997
Loa Loa (eye worm) hypothetical protein 0.0145 0.0428 0.5012
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0137 0.3607
Toxoplasma gondii propionate-CoA ligase 0.0043 0.0111 0.4467
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.0997
Loa Loa (eye worm) hypothetical protein 0.0108 0.0315 0.3685
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0203 1
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0043 0.0111 0.0906
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0182 0.1476
Brugia malayi nuclear receptor RXR 0.0038 0.0098 0.1358
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0111 0.0269
Schistosoma mansoni lamin 0.0026 0.0061 0.0497
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0034 0.0085 0.0997
Schistosoma mansoni ap endonuclease 0.0019 0.0037 0.0304
Brugia malayi nuclear hormone receptor family member odr-7 0.0034 0.0085 0.1183
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0072 0.0203 0.2379
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0043 0.0111 0.0269
Echinococcus multilocularis cpg binding protein 0.003 0.0073 0.0073
Schistosoma mansoni nuclear hormone receptor 0.0072 0.0203 0.1647
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.0416 0.487
Loa Loa (eye worm) MH2 domain-containing protein 0.024 0.072 0.8431
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.005 0.041
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0111 0.0366
Brugia malayi CXXC zinc finger family protein 0.0028 0.0068 0.0942
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0203 0.121
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0043 0.0111 0.0366
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0203 0.121
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.003 0.003
Leishmania major acetyl-CoA synthetase, putative 0.0043 0.0111 0.0366
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0043 0.0111 0.1305
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0072 0.0203 0.1647
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0043 0.0111 0.0906
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.0997
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0072 0.0203 0.1647
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0061 0.0718
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0072 0.0203 0.2821
Mycobacterium tuberculosis Conserved protein 0.0072 0.0203 0.121
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0103 0.0296 0.1892
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0207
Loa Loa (eye worm) hypothetical protein 0.0145 0.0428 0.5012
Brugia malayi AMP-binding enzyme family protein 0.0043 0.0111 0.1547
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.003 0.0354
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0037 0.01
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0072 0.0203 0.1647
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0068 0.0794
Schistosoma mansoni Smad4 0.0007 0.0002 0.0019
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0182 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0072 0.0203 0.2821
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0072 0.0203 0.1647
Leishmania major 4-coumarate:coa ligase-like protein 0.0145 0.0428 0.1507
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0145 0.0428 0.2854
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0203 0.121
Loa Loa (eye worm) hypothetical protein 0.0051 0.0137 0.161
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0203 0.2028
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0072 0.0203 0.2821
Onchocerca volvulus 0.0034 0.0085 0.0972
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0037 0.01
Brugia malayi beta-lactamase family protein 0.0072 0.0203 0.282
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0043 0.0111 0.4467
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.0997
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0203 0.1647
Schistosoma mansoni hypothetical protein 0.0032 0.0078 0.0634
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0182 0.2527
Loa Loa (eye worm) hypothetical protein 0.0108 0.0315 0.3685
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0145 0.0428 0.4783
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0037 0.052
Echinococcus multilocularis FTZ F1 alpha 0.0072 0.0203 0.0203
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0038 0.0098 0.0098
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0019 0.0155
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0043 0.0111 0.1305
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0416 0.3373
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0043 0.0111 0.1547
Mycobacterium ulcerans lipase LipD 0.0072 0.0203 0.2028
Echinococcus granulosus Squalene phytoene synthase 0.0283 0.0854 0.6926
Loa Loa (eye worm) transcription factor SMAD2 0.024 0.072 0.8431
Brugia malayi hypothetical protein 0.0034 0.0085 0.1183
Loa Loa (eye worm) oxidoreductase 0.0043 0.0111 0.1305
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0072 0.0203 0.1647
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0108 0.0315 0.5
Onchocerca volvulus 0.0028 0.0068 0.0769
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0098 0.1358
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0203 0.1647
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0182 0.213
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0078 0.0078
Trypanosoma cruzi phytoene synthase, putative 0.0283 0.0854 0.3043
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.1232 0.1232
Mycobacterium ulcerans acyl-CoA synthetase 0.0145 0.0428 0.4783
Brugia malayi RNA binding protein 0.0065 0.0182 0.2527
Brugia malayi nuclear hormone receptor 0.0072 0.0203 0.2821
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.003 0.0245
Echinococcus multilocularis Squalene phytoene synthase 0.0283 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.0997
Schistosoma mansoni hypothetical protein 0.0184 0.0548 0.445
Brugia malayi AMP-binding enzyme family protein 0.0145 0.0428 0.5945
Toxoplasma gondii ABC1 family protein 0.0072 0.0203 1
Mycobacterium ulcerans acetyl-CoA synthetase 0.0043 0.0111 0.0906
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0203 0.0603
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0072 0.0203 0.1647
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0007 0.0093
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0043 0.0111 0.4467
Schistosoma mansoni smad1 5 8 and 0.0016 0.003 0.0245
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0072 0.0203 0.2821
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0007 0.0007
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0203 1
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0043 0.0111 0.0906
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0184 0.0548 0.0548
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0111 0.0541
Brugia malayi MH1 domain containing protein 0.0009 0.0008 0.0107
Echinococcus granulosus tar DNA binding protein 0.0065 0.0182 0.1476
Mycobacterium tuberculosis Conserved protein 0.0072 0.0203 0.121
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0078 0.0078
Schistosoma mansoni cpg binding protein 0.003 0.0073 0.0591
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0043 0.0111 0.0541
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0137 0.046
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0203 0.0697
Loa Loa (eye worm) Smad1 0.0016 0.003 0.0354
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.003 0.003
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0072 0.0203 0.1647
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0072 0.0203 0.2357
Brugia malayi nuclear receptor NHR-88 0.0072 0.0203 0.2821
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0043 0.0111 0.2668
Trichomonas vaginalis antibiotic synthetase, putative 0.0043 0.0111 0.4467
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0072 0.0203 0.1647
Loa Loa (eye worm) hypothetical protein 0.0038 0.0098 0.1145
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0072 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.009
Loa Loa (eye worm) hypothetical protein 0.0145 0.0428 0.5012
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0043 0.0111 0.0541
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0207
Schistosoma mansoni thyroid hormone receptor 0.0072 0.0203 0.1647
Brugia malayi MH1 domain containing protein 0.0016 0.003 0.042
Loa Loa (eye worm) hypothetical protein 0.0043 0.0111 0.1305
Onchocerca volvulus 0.0043 0.0111 0.1281
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0416 0.3373
Mycobacterium ulcerans acyl-CoA synthetase 0.0043 0.0111 0.0906
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0072 0.0203 0.2821
Schistosoma mansoni RAR-like nuclear receptor 0.0072 0.0203 0.1647
Mycobacterium ulcerans hypothetical protein 0.0145 0.0428 0.4783
Schistosoma mansoni cpg binding protein 0.0028 0.0068 0.055
Echinococcus multilocularis mothers against decapentaplegic 6 0.0007 0.0002 0.0002
Schistosoma mansoni Smad4 0.0007 0.0002 0.0019
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0085 0.0972
Onchocerca volvulus 0.0145 0.0428 0.4998
Loa Loa (eye worm) hypothetical protein 0.0026 0.006 0.07
Schistosoma mansoni hypothetical protein 0.0069 0.0192 0.1559
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0043 0.0111 0.0906
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0072 0.0203 0.2379
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0103 0.0296 0.1892
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0072 0.0203 0.2378
Loa Loa (eye worm) DR-78 0.0034 0.0085 0.0997
Schistosoma mansoni cpg binding protein 0.003 0.0073 0.0591
Schistosoma mansoni nuclear receptor 0.0034 0.0085 0.0691
Brugia malayi ecdysone receptor 0.0034 0.0085 0.1183
Loa Loa (eye worm) hypothetical protein 0.0038 0.0098 0.1145
Trichomonas vaginalis antibiotic synthetase, putative 0.0043 0.0111 0.4467
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0111 0.0541
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0203 0.0697
Echinococcus multilocularis nuclear receptor nhr 48 0.0034 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0069 0.0192 0.2252
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0203 0.121
Onchocerca volvulus 0.0072 0.0203 0.2357
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0043 0.0111 0.0541
Echinococcus multilocularis GPCR, family 2 0.0032 0.0078 0.0078
Entamoeba histolytica hypothetical protein 0.0184 0.0548 1
Onchocerca volvulus 0.0043 0.0111 0.1281
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0182 0.1476
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0072 0.0203 0.0203
Trypanosoma brucei squalene synthase, putative 0.0908 0.2783 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0072 0.0203 0.2821
Echinococcus multilocularis Smad4 0.0016 0.003 0.003
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0072 0.0203 0.0203
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0034 0.0085 0.1183
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0203 0.121
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0034 0.0085 0.0691
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0145 0.0428 0.4783
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0034 0.0085 0.0085
Loa Loa (eye worm) STAT protein 0.0154 0.0456 0.5348
Loa Loa (eye worm) beta-lactamase 0.0072 0.0203 0.2378
Loa Loa (eye worm) hypothetical protein 0.0072 0.0203 0.2379
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.0997
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0037 0.0438
Brugia malayi nuclear hormone receptor family member nhr-6 0.0034 0.0085 0.1183
Entamoeba histolytica hypothetical protein 0.0184 0.0548 1
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0098 0.1358
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0037 0.0037
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0023 0.0275
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0043 0.0111 0.0906
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.0997
Loa Loa (eye worm) hypothetical protein 0.0038 0.0098 0.1145
Echinococcus granulosus ecdysone induced protein 78C 0.0072 0.0203 0.1647
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0019 0.0019
Loa Loa (eye worm) RNA binding protein 0.0065 0.0182 0.213
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.029 0.4036
Loa Loa (eye worm) steroid hormone receptor 0.0072 0.0203 0.2379
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0137 0.046
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0038 0.0098 0.0793
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0108 0.0315 0.3396
Onchocerca volvulus 0.0043 0.0111 0.1281
Entamoeba histolytica acyl-CoA synthetase, putative 0.0145 0.0428 0.7639
Brugia malayi hypothetical protein 0.0038 0.0098 0.1358
Loa Loa (eye worm) nuclear hormone receptor 0.0034 0.0085 0.0997
Leishmania major hypothetical protein, conserved 0.0283 0.0854 0.3043
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0043 0.0111 0.0111
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0098 0.0793
Echinococcus multilocularis ecdysone induced protein 78C 0.0072 0.0203 0.0203
Onchocerca volvulus 0.0043 0.0111 0.1281
Brugia malayi Nuclear hormone receptor-like 1 0.0072 0.0203 0.2821
Brugia malayi AMP-binding enzyme family protein 0.0145 0.0428 0.5945
Schistosoma mansoni transcription factor LCR-F1 0.0184 0.0548 0.445
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0203 0.0203
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0072 0.0203 0.1647
Echinococcus multilocularis lamin 0.0026 0.0061 0.0061
Brugia malayi nuclear receptor NHR-67 0.0034 0.0085 0.1183
Leishmania major 4-coumarate:coa ligase-like protein 0.0145 0.0428 0.1507
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0085 0.0691
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0038 0.0098 0.1145
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.0997
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0072 0.0203 0.2379
Loa Loa (eye worm) hypothetical protein 0.0038 0.0098 0.1145
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0034 0.0085 0.0691
Schistosoma mansoni intermediate filament proteins 0.0026 0.0061 0.0497

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) Inhibition of human recombinant squalene synthase expressed in Escherichia coli BL21(DE3 pLysS) up to 1 uM by liquid scintillation counter ChEMBL. 17709461
IC50 (functional) = 0.7 uM Trypanocidal activity against Trypanosoma brucei rhodesiense STIB 900 bloodstream form after 72 hrs by resazurin assay ChEMBL. 17709461
IC50 (binding) > 1 uM Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter ChEMBL. 17709461
IC50 (functional) = 1.8 uM Antitrypanosomal activity against trypomastigotes of Trypanosoma cruzi Tulahuen C2C4 containing lacZ gene in rat L6 cells after 4 days by chlorophenol red-beta-D-galactopyranoside/Nonidet assay ChEMBL. 17709461
IC50 (functional) = 3.1 uM Antiplasmodial activity after 48 hrs against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 in human erythrocytes by [3H]hypoxanthine uptake ChEMBL. 17709461
IC50 (functional) = 41.3 uM Antileishmanial activity against Leishmania donovani MHOM/ET/67/L82 axenic amastigotes after 72 hrs by resazurin assay ChEMBL. 17709461

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma brucei gambiense 17709461
Plasmodium falciparum 17709461
Trypanosoma cruzi ChEMBL23 17709461

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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