Detailed view for LmjF.31.2940

Basic information

TDR Targets ID: 23949
Leishmania major, squalene synthase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.7212 | Length (AA): 414 | MW (Da): 47121 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00494   Squalene/phytoene synthase

Gene Ontology

Mouse over links to read term descriptions.
GO:0051996   GO:squalene synthase activity  

GO:0016765   transferase activity, transferring alkyl or aryl (other than methyl) groups  
GO:0016021   integral to membrane  
GO:0004310   farnesyl-diphosphate farnesyltransferase activity  
GO:0016740   transferase activity  
GO:0009058   biosynthetic process  
GO:0008610   lipid biosynthetic process  
GO:0006696   ergosterol biosynthetic process  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
29 363 1ezf (A) 38 367 47.00 0 1 1.43 -2.25
28 369 3wca (A) 28 368 61.00 0 1 1.72619 -1.95

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_129470)

Species Accession Gene Product
Arabidopsis thaliana AT4G34640   Squalene synthase 1
Arabidopsis thaliana AT4G34650   squalene synthase 2
Candida albicans CaO19.11099   squalene synthase similar to S. cerevisiae ERG9 (YHR190W) involved in ergosterol biosynthesis
Candida albicans CaO19.3616   squalene synthase similar to S. cerevisiae ERG9 (YHR190W) involved in ergosterol biosynthesis
Dictyostelium discoideum DDB_G0292072   farnesyl-diphosphate farnesyltransferase
Homo sapiens ENSG00000079459   farnesyl-diphosphate farnesyltransferase 1
Leishmania braziliensis LbrM.31.3310   squalene synthase, putative
Leishmania donovani LdBPK_313050.1   farnesyltransferase, putative
Leishmania infantum LinJ.31.3050   squalene synthase, putative
Leishmania major LmjF.31.2940   squalene synthase, putative
Leishmania mexicana LmxM.30.2940   farnesyltransferase, putative
Mus musculus ENSMUSG00000021273   farnesyl diphosphate farnesyl transferase 1
Oryza sativa 4342663   Os07g0200700
Oryza sativa 4334492   Os03g0805100
Saccharomyces cerevisiae YHR190W   bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase
Trypanosoma brucei gambiense Tbg972.8.7370   farnesyltransferase, putative,squalene synthase, putative
Trypanosoma brucei Tb927.8.7120   squalene synthase, putative
Trypanosoma congolense TcIL3000_0_37460   squalene synthase, putative
Trypanosoma congolense TcIL3000_8_7210   squalene synthase, putative
Trypanosoma congolense TcIL3000_0_23140   squalene synthase, putative
Trypanosoma cruzi TcCLB.507897.20   squalene synthase, putative
Trypanosoma cruzi TcCLB.508369.20   squalene synthase, putative

Essentiality

LmjF.31.2940 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.7120 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.7120 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.7120 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.7120 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
YHR190W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis No drug identifiers listed for this gene.
Annotator: aaronjr@u.washington.edu. Comment: Drug: (BPQ-OH) 136562-09-9 . chemical inhibition with squalene synthase (2.5.1.21) inhibitors leads to slow growth and membrane disruption of Leishmania sp. in cell assay; biphenylquinuclidine inhibitors. References: 16198340
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) inferred from bioassay (ECO:0000094) Leishmania amazonensis No drug identifiers listed for this gene.
Annotator: aaronjr@u.washington.edu. Comment: Drug: (BPQ-OH) 136562-09-9 . chemical inhibition with squalene synthase (2.5.1.21) inhibitors leads to slow growth and membrane disruption of Leishmania sp. in cell assay; biphenylquinuclidine inhibitors. References: 16198340
plasma membrane (GO:0005886) disrupted (PATO:0001507) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from visible phenotype (ECO:0000176) Leishmania amazonensis No drug identifiers listed for this gene.
Annotator: aaronjr@u.washington.edu. Comment: Drug: (BPQ-OH) 136562-09-9 . chemical inhibition with squalene synthase (2.5.1.21) inhibitors leads to slow growth and membrane disruption of Leishmania sp. in cell assay; biphenylquinuclidine inhibitors. References: 16198340
plasma membrane (GO:0005886) disrupted (PATO:0001507) single cell organism (CARO:0000064) amastigote (BTO:0000062) inferred from visible phenotype (ECO:0000176) Leishmania amazonensis No drug identifiers listed for this gene.
Annotator: aaronjr@u.washington.edu. Comment: Drug: (BPQ-OH) 136562-09-9 . chemical inhibition with squalene synthase (2.5.1.21) inhibitors leads to slow growth and membrane disruption of Leishmania sp. in cell assay; biphenylquinuclidine inhibitors. References: 16198340
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania mexicana No drug identifiers listed for this gene.
Annotator: aaronjr@u.washington.edu. Comment: Drug: (BPQ-OH) 136562-09-9 . chemical inhibition with squalene synthase (2.5.1.21) inhibitors leads to slow growth and membrane disruption of Leishmania sp. in cell assay; biphenylquinuclidine inhibitors. References: 12467972 15848765
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania mexicana No drug identifiers listed for this gene.
Annotator: aaronjr@u.washington.edu. Comment: Drug: (BPQ-OH) 136562-09-9 . chemical inhibition with squalene synthase (2.5.1.21) inhibitors leads to reduced enzyme activity in vitro; biphenylquinuclidine inhibitors. References: 12467972
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) inferred from bioassay (ECO:0000094) Leishmania donovani No drug identifiers listed for this gene.
Annotator: aaronjr@u.washington.edu. Comment: Drug: (BPQ-OH) 136562-09-9 . chemical inhibition with squalene synthase (2.5.1.21) inhibitors leads to slow growth and membrane disruption of Leishmania sp. in cell assay; biphenylquinuclidine inhibitors. References: 15848765
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania major No drug identifiers listed for this gene.
Annotator: aaronjr@u.washington.edu. Comment: Drug: (BPQ-OH) 136562-09-9 . chemical inhibition with squalene synthase (2.5.1.21) inhibitors leads to reduced enzyme activity in vitro; biphenylquinuclidine inhibitors. References: 15848765
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania amazonensis 149351  
Annotator: aaronjr@u.washington.edu. Comment: Drug: 212519-41-0; Drug: 212519-47-6. chemical inhibition with PFT inhibitors leads to slow growth of Leishmania sp. in cell assay; . References: 9719512

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

  • Validation: inhibited in cell-free system
  • annotated by: aaronjr@u.washington.edu.
  • References: 12467972 15848765

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.8

Known modulators for this target

51 chemical compounds are associated with this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Trypanosoma cruzi squalene synthase, putative Compounds References
Homo sapiens farnesyl-diphosphate farnesyltransferase 1 Compounds References
Saccharomyces cerevisiae bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase Compounds References
Rattus norvegicus Squalene synthetase Compounds References
Bos taurus Squalene synthetase Compounds References
Trypanosoma cruzi squalene synthase, putative Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Staphylococcus aureus Dehydrosqualene synthase 287 aa 20.9% 320 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1888 0.65 1
0.059 0.2532 0.7618
0.0542 0.3171 1
1.7416 0.327 1
0.8726 0.3573 1
0.1043 0.2963 0.7001
0.0259 0.3019 1
0.053 0.4021 0.5007
0.0271 0.3098 1
0.2529 0.5236 0.5232
0.0498 0.7256 1
0.1 0.3361 0.3356
0.0303 0.3284 1
0.0252 0.284 0.3097
0.0303 0.3721 1
0.0303 0.3554 1
1.3242 0.5087 1
0.1126 0.3426 1
0.0312 0.3331 1
0.7982 0.3946 0.5617
0.0605 0.7332 1
0.0518 0.4765 1
1.5457 0.2789 1
0.021 0.9803 0.9755
0.0353 0.649 1
0.1362 0.5025 1
0.7994 0.2866 1
0.0251 0.348 1
0.0385 0.4268 1
0.0303 0.3164 0.4828
0.0522 0.4591 1
0.073 0.9978 1
0.3129 0.9599 1
0.0262 0.3105 0.8795
0.0261 0.9111 1
0.0303 0.6472 1
0.0523 0.5516 1
0.0272 0.9105 1
1.049 0.6252 1
0.0258 0.4775 0.4615
0.6228 0.3284 0.5616
0.0507 0.4027 0.5007
0.0283 0.2657 0.33
0.0267 0.3012 1
0.7693 0.4142 1
0.0268 0.3572 1
0.1001 0.2823 1
0.3759 0.254 1
0.0257 0.8575 1
1.5442 0.3476 1
0.0243 0.3654 1
0.8009 0.7011 1
0.056 0.3899 0.6059
0.3873 0.6748 1
0.0439 0.4204 0.4426
0.0303 0.3151 0.9986
0.7807 0.7808 1
0.0247 0.3054 1
0.0267 0.4234 1
0.0243 0.3654 1
1.2029 0.3322 0.3322
0.1004 0.4049 1
0.0259 0.3294 1
0.0245 0.4065 1
0.0158 0.2618 0.3282
0.0351 0.4065 0.4063
0.0065 0.295 1
0.4673 0.9006 1
0.0242 0.257 0.2534
0.0262 0.9102 1
0.0506 0.437 1
1.049 0.6252 1
0.2083 0.2817 0.2962
1.1746 0.3032 1
0.0261 0.9111 1
0.0522 0.4591 1
0.0303 0.9545 1
0.0255 0.4346 1
0.0793 0.281 0.2301
0.0317 0.721 1
0.0534 0.307 1
1.1627 0.6584 1
0.9183 0.6517 0.6913
0.1211 0.4141 0.6105
0.0561 0.37 1
0.071 0.2957 0.7929
0.2796 0.3285 0.8399
0.0492 0.2786 1
0.5727 0.3233 1
0.8922 0.4183 1
0.025 0.9592 1
0.1043 0.3553 0.7001
0.0303 0.5068 1
0.9113 0.3845 0.5483
1.4141 0.3231 0.4322
0.0243 0.2974 0.8141
0.0277 0.422 1
0.0262 0.9105 1
0.0303 0.3902 1
0.0262 0.3105 0.8795
0.0252 0.501 0.5905
0.3815 0.6803 1
1.8497 0.9449 1
0.0303 0.9277 1
0.2083 0.2817 0.2962
0.0791 0.4787 1
0.1534 0.2997 1
0.0262 0.2533 1
0.0257 0.4298 1
0.0605 0.8802 1
0.3873 0.6748 1
0.0757 0.271 0.7425
0.1484 0.4647 0.4761
0.0522 0.4021 0.5007
1.4131 0.326 1
2.1838 0.9651 1
0.0495 0.2924 1
0.0303 0.3069 1
0.0789 0.2821 0.6244
0.0258 0.3152 1
0.0278 0.4438 0.6728
0.0291 0.2657 0.33
0.0262 0.2789 0.3408
0.08 0.3586 0.5035
0.0171 0.4615 1
0.0303 0.4317 1
0.8959 0.5359 1
0.0246 0.3044 1
0.0246 0.3044 1
0.1001 0.2823 1
0.0284 0.2656 0.33
1.049 0.6252 1
0.0303 0.2913 1
1.5218 0.3628 1
0.0791 0.4787 1
1.8704 0.315 1
0.0303 0.3213 0.9558
0.0813 0.5033 1
0.0506 0.7057 1
0.314 0.3367 1
0.0516 0.5052 1
0.0303 0.7574 1
0.0246 0.9094 1
0.0592 0.8176 0.8176
0.0247 0.9191 1
0.0813 0.5033 1
0.0767 0.3299 1
0.0246 0.5945 1
0.0303 0.405 1
0.0303 0.8736 0.9548
0.0262 0.9094 1
0.0272 0.2793 0.9986
0.1586 0.831 0.831
0.1921 0.265 1
0.0591204 0.737492 1
0.1686 0.2509 0.2509
1.4141 0.3231 0.4322
1.7833 0.3375 1
0.0303 0.9161 1
0.0312 0.3331 1
1.3242 0.5087 1
0.0497 0.301 0.3008
0.0252 0.2701 1
0.2619 0.5196 1
0.0283 0.2508 0.254
0.0247 0.4769 0.5687
0.0242 0.3219 1
0.1087 0.4573 1
0.1374 0.6655 1
0.279 0.3466 1
0.0374 0.3693 1
0.0293 0.3088 0.3715
0.0287 0.5694 0.8003
1.8742 0.3426 1
0.1617 0.7334 1
0.1043 0.2782 0.5573
0.1248 0.8802 1
0.3398 0.5972 1
0.0252 0.2701 1
0.0251 0.588 1
0.3129 0.9599 1
0.0595 0.2778 1
0.079 0.2514 0.4161
0.0272 0.2793 0.9986
0.2231 0.3163 1
0.0426 0.4351 0.4351
0.0303 0.7287 0.8281
0.0251 0.3004 0.8368
0.0273 0.6948 1
0.0274 0.2721 0.6632
0.0303 0.3303 1
0.053 0.3093 1
0.031 0.5883 1
0.0254 0.3107 1
0.0242 0.8011 0.7956
0.0381 0.4021 0.5007
0.0254 0.2548 0.6767
0.0253 0.3208 1
0.0303 0.6018 1
0.0244 0.263 1
0.0295602 0.433852 1
1.3345 0.3829 0.3961
0.0303 0.5068 1
0.0444 0.9266 1
0.1982 0.3113 0.7982
0.0514 0.5649 1
0.0538 0.4014 0.4834
1.049 0.6252 1
0.0564 0.3133 0.685
0.0243 0.5852 1
0.0255 0.3095 1
0.0243 0.2552 0.3282
1.9937 0.6821 1
0.0242 0.2864 1
0.3875 0.2705 1
2.1312 0.4535 1
0.0303 0.329 1
0.0544 0.4021 0.5007
0.025 0.2875 1
0.0791 0.4787 1
0.0605 0.9797 1
0.3258 0.3205 1
0.228 0.4359 1
0.0508 0.6345 1
0.5727 0.3233 1
1.3242 0.5087 1
1.049 0.6252 1
1.049 0.6252 1
0.1982 0.3113 0.7982
0.0242 0.3413 1
0.711 0.2712 1
0.2295 0.861 1
0.1921 0.265 1
0.0518 0.4765 1
0.0257 0.3448 1
0.5727 0.3233 1
1.049 0.6252 1
0.0303 0.3541 1
0.1211 0.4141 0.6105
1.1956 0.3623 1
0.0524 0.7816 1
0.0244 0.5938 1
0.1484 0.4647 0.4761
0.581 0.2819 0.9805
0.3398 0.5972 1
0.0882 0.6976 1
1.9616 0.3999 0.4351
0.0938 0.7283 1
1.4131 0.326 1
0.0245 0.3155 1
0.0591204 0.5 0.5
0.0557 0.4021 0.5007
0.0272 0.2793 0.9986
0.0366 0.726 1
0.1087 0.4573 1
0.0262 0.9107 1
0.023 0.2665 0.3282
1.3906 0.5324 0.7848
0.0539 0.3371 0.7851
0.0253 0.2979 1
0.0462 0.2974 0.5007
0.0513 0.4153 0.4152
0.8313 0.3933 1
0.0504 0.3512 1
0.2879 0.4597 0.4597
0.0244 0.2696 0.3305
0.07 0.2622 1
0.0244 0.6544 1
0.0699 0.2888 1
0.0247 0.5657 1
0.0262 0.9079 1
0.0303 0.6472 1
0.0266 0.2747 0.7958
0.0244 0.5943 1
0.0784 0.9652 1
1.1841 0.4454 1
0.0303 0.3679 1
0.0249 0.4388 1
0.0242 0.2987 1
0.0535 0.5972 1
0.0272 0.2793 0.9986
0.0246 0.2879 1
0.0492 0.9826 1
0.0554 0.3664 0.3664
0.025 0.2754 1
0.2532 0.5688 1
0.0256 0.4382 1
0.0251 0.2903 1
0.0303 0.3018 0.8367
0.1087 0.4573 1
1.2233 0.2886 1
0.0474 0.2766 0.4562
0.0301 0.2638 0.3266
0.1686 0.2509 0.2509
0.0303 0.4361 0.6353
0.0392 0.4696 1
0.0303 0.3789 1
0.3211 0.3276 0.5616
1.3268 0.3536 1
0.0242 0.5375 1
0.1686 0.2509 0.2509
1.049 0.6252 1
0.0516 0.5052 1
0.2519 0.5383 1
1.6472 0.2696 1
0.0576 0.6989 1
0.2247 0.2752 1
0.1001 0.2823 1
0.0982 0.3751 0.3751
1.7988 0.385 1
0.0259 0.3187 0.8098
0.0252 0.2889 1
0.1686 0.2509 0.2509
2.1838 0.9651 1
0.104 0.3144 0.3527
0.0257 0.4298 1
0.0303 0.3786 1
0.1484 0.4647 0.4761
0.0249 0.989 1
1.3196 0.2954 1
0.9925 0.4658 1
0.0247 0.2673 1
0.1691 0.4511 1
0.0535 0.9904 1
0.9183 0.6517 0.6913
0.0735 0.347 0.8077
1.2899 0.8792 1
0.7891 0.4562 1
0.0303 0.3979 1
0.0252 0.5361 1
1.6384 0.39 1
0.0263 0.5194 0.5194
0.0309 0.6324 1
0.0269 0.2991 1
0.0249 0.3078 1
0.331 0.3276 0.5616
0.5459 0.6148 1
1.6472 0.2696 1
2.1838 0.9651 1
0.1565 0.9779 1
0.0303 0.5662 1
1.0989 0.4519 0.8675
0.0303 0.8663 1
0.0295602 0.5 0.5
1.3242 0.5087 1
0.0242 0.4278 1
1.3414 0.3789 1
0.0247 0.2717 1
0.0552 0.6262 1
0.0262 0.4132 0.5678
0.3759 0.254 1
0.0535 0.5972 1
0.0504 0.4021 0.5007
0.0244 0.2821 1
1.4779 0.4991 1
0.0338 0.7019 1
0.0504 0.3512 1
1.4141 0.3231 0.4322
0.8959 0.5359 1
0.0249 0.4388 1
0.0982 0.3048 0.4358
1.3242 0.5087 1
0.0295602 0.301722 0.301722
0.0303 0.5954 0.5
0.0767 0.3299 1
0.0247 0.347 1
0.0303 0.3217 1
0.0303 0.4282 1
0.0272 0.2793 0.9986
0.3815 0.5182 1
1.3784 0.3725 1
0.0287 0.8125 0.8125
0.0461 0.2707 1
0.0257 0.3057 1
0.0397 0.7206 1
1.5308 0.6754 1
0.2247 0.2752 1
0.6507 0.2549 1
0.0994 0.3964 0.8958
0.0245 0.2584 1
1.049 0.6252 1
0.0979 0.4631 1
0.3873 0.6748 1
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0.0468 0.4191 0.4414
0.0262 0.315 1
0.0736 0.2909 0.5065
0.1596 0.7608 1
1.3345 0.3829 0.3961
0.0231 0.3788 1
0.0303 0.5766 1
1.3345 0.3829 0.3961
1.5442 0.3476 1
2.1057 0.415 1
0.0303 0.6041 1
0.027 0.2987 1
0.0246 0.4372 1
0.2231 0.3163 1
0.0605 0.7818 1
0.0249 0.4388 1
0.1016 0.3734 0.9107
1.3627 0.3074 1
0.9113 0.3845 0.5483
0.3395 0.2802 1
0.0374 0.6976 1
0.1004 0.2999 0.3848
0.0251 0.3411 1
0.0295602 0.5 0.5
0.0746 0.4084 1
2.2259 0.8922 1
0.0303 0.3786 1
0.2796 0.3285 0.8399
0.0495 0.2924 1
0.2558 0.6171 1
0.7913 0.9823 1
0.0272 0.2793 0.9986
0.0495 0.2924 1
0.104 0.3144 0.3527
0.0257 0.3547 0.7046
0.0276 0.2687 0.3305
0.0247 0.2717 1
1.3142 0.3723 0.3723
0.02 0.3701 1
0.0252 0.5361 1
0.0138 0.2631 0.3282
0.0243 0.8282 1
1.6497 0.3599 0.4671
0.0328 0.3833 1
0.0254 0.5196 0.7794
0.0437 0.251 0.8657
0.0567 0.5811 1
1.4113 0.2765 1
0.0728 0.4082 0.5979
0.0252 0.2701 1
0.1517 0.5016 0.5016
0.0582 0.7242 1
0.0138 0.2631 0.3282
0.049 0.3006 1
0.3512 0.6988 1
0.1131 0.8605 1
0.0295602 0.5 0.5
0.1691 0.4511 1
2.2259 0.8922 1
0.1484 0.4647 0.4761
0.0261 0.6152 1
0.0295602 1 1
0.0261 0.9111 1
0.1686 0.2509 0.2509
1.3242 0.5087 1
0.0281 0.2516 1
0.0299 0.2663 0.3274
0.0222 0.3325 1
0.0584 0.2707 1
0.0397 0.5883 1
0.0758 0.2809 0.6897
0.0303 0.3236 1
0.1353 0.8039 1
0.0261 0.2915 1
1.3194 0.9566 1
0.0751 0.3617 0.8785
0.0214 0.8164 1
1.3414 0.3789 1
0.0272 0.4475 0.7103
0.0561 0.7782 1
0.248 0.3208 1
0.0303 0.3786 1
0.8922 0.4183 1
0.5727 0.3233 1
0.0552 0.6878 1
0.0246 0.2879 1
1.3242 0.5213 1
0.0249 0.9122 1
0.0986 0.286 0.2973
0.0605 0.8802 1
0.2083 0.2817 0.2962
0.0254 0.5884 1
0.0767 0.3299 1
1.9815 0.3635 1
0.0303 0.405 1
0.025 0.5119 1
0.0551 0.4021 0.5007
0.3512 0.6988 1
0.3815 0.5182 1
0.2247 0.2752 1
0.1686 0.2509 0.2509
0.0303 0.7287 0.8281
0.0506 0.437 1
0.0251 0.3007 0.5528
0.0504 0.3512 1
0.0507 0.6299 1
0.3563 0.6446 1
0.1323 0.5893 0.5877
0.0974 0.8309 1
0.0529 0.5674 1
0.0504 0.3512 1
0.0262 0.7725 1
0.4238 0.2868 0.4071

Assayability

Assay information

  • ChEMBL
  • Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter

Reagent availability

No reagent availability information for this target.

Bibliographic References

7 literature references were collected for this gene.

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Gene identifier LmjF.31.2940 (Leishmania major), squalene synthase, putative
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