Detailed information for compound 1244915

Basic information

Technical information
  • TDR Targets ID: 1244915
  • Name: 3-(4-fluorophenyl)-5-morpholin-4-yl-7-(phenyl amino)-1,4-thiazepine-6-carbonitrile
  • MW: 406.476 | Formula: C22H19FN4OS
  • H donors: 1 H acceptors: 1 LogP: 3.92 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(SC=C(N=C1N1CCOCC1)c1ccc(cc1)F)Nc1ccccc1
  • InChi: 1S/C22H19FN4OS/c23-17-8-6-16(7-9-17)20-15-29-22(25-18-4-2-1-3-5-18)19(14-24)21(26-20)27-10-12-28-13-11-27/h1-9,15,25H,10-13H2
  • InChiKey: KNAUULRAWSDHEW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-fluorophenyl)-5-morpholino-7-(phenylamino)-1,4-thiazepine-6-carbonitrile
  • ZINC01382840
  • 7-anilino-3-(4-fluorophenyl)-5-morpholino-1,4-thiazepine-6-carbonitrile
  • MLS000540614
  • SMR000125872
  • 2M-932

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine receptor 0.008 0.0387 0.043
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.0855 0.2
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0354 0.1099
Echinococcus granulosus RUN 0.0061 0.0274 0.0305
Schistosoma mansoni zinc finger protein 0.0045 0.0179 0.0199
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0006 0.0007
Schistosoma mansoni lipoxygenase 0.0255 0.1442 0.1603
Echinococcus multilocularis GPCR, family 2 0.0132 0.0702 0.0702
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0247 0.1396 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.015 0.0811 0.0901
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0116 0.0576
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0227 0.1275 0.1275
Toxoplasma gondii melibiase subfamily protein 0.021 0.1171 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.008 0.0387 0.0387
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0158 0.0158
Schistosoma mansoni biogenic amine (dopamine) receptor 0.008 0.0387 0.043
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0387 0.0387
Echinococcus granulosus neuropeptide receptor A26 0.008 0.0387 0.043
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0492 0.1146
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0743 0.0743
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0149 0.0166
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0098 0.0132
Schistosoma mansoni hypothetical protein 0.0031 0.0094 0.0105
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Schistosoma mansoni bromodomain containing protein 0.0134 0.0714 0.0793
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0149 0.0452
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0034 0.011 0.0819
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0354 0.072
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0209 0.0388
Loa Loa (eye worm) acetyltransferase 0.0159 0.0866 0.2026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0387 0.043
Brugia malayi hypothetical protein 0.008 0.0387 0.09
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0162 0.018
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.026 0.0816
Leishmania major squalene synthase, putative 0.0542 0.3171 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0056 0.0127
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0387 0.043
Echinococcus multilocularis allatostatin A receptor 0.008 0.0387 0.0387
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.008 0.0387 0.043
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.011 0.0329
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0149 0.1302
Mycobacterium tuberculosis Conserved protein 0.0074 0.0354 0.116
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Brugia malayi follicle stimulating hormone receptor 0.0547 0.32 0.7489
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0149 0.0452
Onchocerca volvulus 0.008 0.0387 0.0795
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.0347 0.0347
Plasmodium falciparum thioredoxin reductase 0.0034 0.011 0.2137
Brugia malayi G protein-coupled receptor 0.008 0.0387 0.09
Schistosoma mansoni hypothetical protein 0.004 0.0149 0.0165
Echinococcus multilocularis neuropeptide Y receptor 0.008 0.0387 0.0387
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0354 0.3566
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0149 0.0452
Schistosoma mansoni biogenic amine (5HT) receptor 0.008 0.0387 0.043
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0365 0.2103 0.2338
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0098 0.0132
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.014 0.108
Onchocerca volvulus 0.0074 0.0354 0.072
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0354 0.0354
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0039 0.0043
Echinococcus granulosus 7TM GPCR rhodopsin 0.008 0.0387 0.043
Echinococcus granulosus intermediate filament protein 0.0057 0.025 0.0278
Loa Loa (eye worm) hypothetical protein 0.0074 0.0354 0.0829
Echinococcus granulosus neuropeptide FF receptor 2 0.008 0.0387 0.043
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0038 0.01
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0476 0.053
Onchocerca volvulus 0.008 0.0387 0.0795
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0149 0.0149
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0222 0.1246 0.4434
Schistosoma mansoni hypothetical protein 0.0395 0.2286 0.2541
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0116 0.0129
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Loa Loa (eye worm) hypothetical protein 0.0074 0.0354 0.0829
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.1695 0.3796
Loa Loa (eye worm) hypothetical protein 0.0061 0.0274 0.0642
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0038 0.01
Schistosoma mansoni smad 0.0049 0.0204 0.0227
Schistosoma mansoni hypothetical protein 0.008 0.0387 0.043
Schistosoma mansoni smdr2 0.0032 0.0098 0.0109
Echinococcus granulosus neuropeptide s receptor 0.008 0.0387 0.043
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0297 0.1695 0.3965
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.0855 0.0855
Brugia malayi G-protein coupled receptor 0.008 0.0387 0.09
Leishmania major DNA polymerase kappa, putative 0.004 0.0149 0.0452
Echinococcus granulosus peptide allatostatin:somatostatin 0.008 0.0387 0.043
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0279 0.031
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0039 0.014 0.0328
Echinococcus granulosus thioredoxin glutathione reductase 0.0098 0.0494 0.0549
Toxoplasma gondii Alpha-galactosidase 0.003 0.0086 0.0685
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0006 0.0014
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.008 0.0387 0.043
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0074 0.0215
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0229
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0149 0.0452
Echinococcus multilocularis neuropeptides capa receptor 0.008 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0501 0.0557
Schistosoma mansoni biogenic amine (dopamine) receptor 0.008 0.0387 0.043
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0038 0.01
Echinococcus granulosus neuropeptide Y receptor 0.008 0.0387 0.043
Mycobacterium tuberculosis Probable reductase 0.0222 0.1246 0.4434
Schistosoma mansoni intermediate filament proteins 0.0057 0.025 0.0278
Echinococcus granulosus phd:f box containing protein 0.0016 0.0006 0.0007
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0149 0.0452
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0032 0.0098 0.0132
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Echinococcus granulosus Smad4 0.0049 0.0204 0.0227
Brugia malayi putative neuropeptide receptor 0.008 0.0387 0.09
Entamoeba histolytica hypothetical protein 0.0041 0.0156 0.1476
Echinococcus multilocularis dna polymerase eta 0.004 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0132 0.0702 0.1642
Trichomonas vaginalis ABC transporter, putative 0.0032 0.0098 0.0132
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0324 0.0754
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0387 0.043
Echinococcus multilocularis ATP binding cassette sub family B 0.0031 0.0096 0.0096
Schistosoma mansoni amine GPCR 0.008 0.0387 0.043
Echinococcus granulosus g protein coupled receptor 0.008 0.0387 0.043
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0098 0.0132
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0324 0.0759
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.008 0.0387 0.0387
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.108 0.2385
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0158 0.037
Onchocerca volvulus 0.008 0.0387 0.0795
Leishmania major hypothetical protein, conserved 0.0031 0.0094 0.0278
Mycobacterium tuberculosis Probable oxidoreductase 0.0247 0.1396 0.4982
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.008 0.0387 0.0387
Echinococcus multilocularis lamin dm0 0.0057 0.025 0.025
Loa Loa (eye worm) cytochrome P450 0.0022 0.0038 0.0089
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0149 0.0166
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0202 0.0202
Echinococcus granulosus transcription factor btf3 0.004 0.0149 0.0166
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.008 0.0387 0.0387
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0049 0.0202 0.0225
Loa Loa (eye worm) hypothetical protein 0.0146 0.0788 0.1843
Echinococcus granulosus G protein coupled receptor 139 0.008 0.0387 0.043
Schistosoma mansoni inositol monophosphatase 0.0039 0.014 0.0156
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Loa Loa (eye worm) hypothetical protein 0.0338 0.1942 0.4546
Brugia malayi hypothetical protein 0.008 0.0387 0.09
Mycobacterium ulcerans beta-lactamase 0.0074 0.0354 0.3566
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0117 0.0177
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0117 0.0177
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.026 0.0289
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.1695 0.3796
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.008 0.0387 0.09
Onchocerca volvulus 0.008 0.0387 0.0795
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0117 0.0177
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0209 0.1744
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0032 0.0098 0.029
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0006 0.0014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0282 0.0314
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Echinococcus granulosus biogenic amine 5HT receptor 0.033 0.1896 0.2107
Brugia malayi hypothetical protein 0.013 0.0688 0.1606
Echinococcus granulosus histone lysine methyltransferase setb 0.0129 0.0685 0.0761
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0032 0.0098 0.0109
Brugia malayi jmjC domain containing protein 0.0016 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0074 0.0354 0.0829
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0354 0.0829
Trypanosoma brucei DNA polymerase eta, putative 0.004 0.0149 0.0452
Onchocerca volvulus 0.008 0.0387 0.0795
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0006 0.0007
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.0855 0.095
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.1275 0.1418
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.026 0.0289
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0098 0.0132
Trypanosoma brucei trypanothione reductase 0.0098 0.0494 0.1542
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.108 0.2385
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0365 0.2103 0.2103
Loa Loa (eye worm) hypothetical protein 0.0169 0.0924 0.2164
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0132 0.0702 0.1638
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0116 0.0287
Echinococcus multilocularis sex peptide receptor 0.008 0.0387 0.0387
Schistosoma mansoni amine GPCR 0.008 0.0387 0.043
Brugia malayi neuropeptide F receptor 0.008 0.0387 0.09
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0149 0.0452
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0132 0.0702 0.0702
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0072 0.0343 0.0798
Brugia malayi hypothetical protein 0.008 0.0387 0.09
Brugia malayi hypothetical protein 0.008 0.0387 0.09
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0202 0.0619
Leishmania major p-glycoprotein 0.0032 0.0098 0.029
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0279 0.0279
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0227 0.1275 0.2985
Brugia malayi RE15519p 0.008 0.0387 0.09
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0149 0.0249
Echinococcus multilocularis protein patched 0.0042 0.0158 0.0158
Onchocerca volvulus 0.008 0.0387 0.0795
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0049 0.0202 0.0225
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0354 0.072
Schistosoma mansoni DNA polymerase eta 0.004 0.0149 0.0166
Onchocerca volvulus 0.008 0.0387 0.0795
Schistosoma mansoni transcription factor btf3 0.004 0.0149 0.0166
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0354 0.116
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Leishmania major hypothetical protein, conserved 0.0169 0.0924 0.2901
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.026 0.2507
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0324 0.0324
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0156 0.0174
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.1695 0.3796
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0116 0.0129
Brugia malayi mothers against decapentaplegic homolog 3 0.0022 0.004 0.0088
Brugia malayi Cytochrome P450 family protein 0.0022 0.0038 0.0083
Schistosoma mansoni hypothetical protein 0.0285 0.1624 0.1805
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.011 0.0329
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0387 0.043
Echinococcus multilocularis expressed conserved protein 0.0091 0.0456 0.0456
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0227 0.1275 0.1418
Echinococcus granulosus fmrfamide receptor 0.008 0.0387 0.043
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0169 0.0924 0.2028
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0117 0.0177
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0324 0.1005
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0354 0.713
Loa Loa (eye worm) isocitrate dehydrogenase 0.0049 0.0202 0.0473
Brugia malayi jmjC domain containing protein 0.0062 0.0279 0.0648
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0117 0.0117
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0072 0.0343 0.0381
Loa Loa (eye worm) glutathione reductase 0.0098 0.0494 0.1156
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0038 0.01
Echinococcus granulosus multidrug resistance protein 1 0.0032 0.0098 0.0109
Schistosoma mansoni biogenic amine receptor 0.008 0.0387 0.043
Brugia malayi hypothetical protein 0.008 0.0387 0.09
Echinococcus granulosus tachykinin peptides receptor 99D 0.008 0.0387 0.043
Trichomonas vaginalis abcb9, putative 0.0032 0.0098 0.0132
Schistosoma mansoni smad1 5 8 and 0.0049 0.0204 0.0227
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0072 0.0343 0.1064
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0072 0.0343 0.0381
Brugia malayi Serotonin receptor 0.008 0.0387 0.09
Echinococcus granulosus tm gpcr rhodopsin 0.008 0.0387 0.043
Schistosoma mansoni neuropeptide F-like receptor 0.008 0.0387 0.043
Schistosoma mansoni smad1 5 8 and 0.0049 0.0204 0.0227
Brugia malayi Dopamine receptor protein 1 0.008 0.0387 0.09
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.011 0.0253
Leishmania major cytochrome p450-like protein 0.0022 0.0038 0.01
Plasmodium vivax SET domain protein, putative 0.0095 0.0476 0.9637
Loa Loa (eye worm) multidrug resistance protein 3 0.0032 0.0098 0.0229
Echinococcus multilocularis g protein coupled receptor 0.008 0.0387 0.0387
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0006 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0074 0.0215
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0034 0.011 0.0819
Echinococcus multilocularis mothers against decapentaplegic 6 0.0022 0.004 0.004
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0032 0.0098 0.0788
Schistosoma mansoni hypothetical protein 0.0061 0.0274 0.0305
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.011 0.0329
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0324 0.1005
Echinococcus multilocularis muscleblind protein 0.0146 0.0788 0.0788
Brugia malayi Dopamine receptor 0.008 0.0387 0.09
Schistosoma mansoni hypothetical protein 0.004 0.0149 0.0165
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0014
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0222 0.1246 0.4434
Schistosoma mansoni inositol monophosphatase 0.0039 0.014 0.0156
Echinococcus granulosus expressed conserved protein 0.0091 0.0456 0.0507
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0297 0.1695 0.3968
Loa Loa (eye worm) ICD-1 protein 0.004 0.0149 0.0349
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0132 0.0702 0.078
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.014 0.023
Entamoeba histolytica transcription factor BTF3, putative 0.004 0.0149 0.1298
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0324 0.036
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0152 0.0355
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.008 0.0387 0.0387
Schistosoma mansoni adenoreceptor 0.008 0.0387 0.043
Echinococcus multilocularis Squalene phytoene synthase 0.0169 0.0924 0.0924
Onchocerca volvulus 0.0061 0.0274 0.0537
Brugia malayi Cytochrome P450 family protein 0.0041 0.0152 0.035
Brugia malayi GnHR receptor homolog 0.008 0.0387 0.09
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0354 0.116
Schistosoma mansoni amine GPCR 0.008 0.0387 0.043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.1275 0.1418
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0125 0.0194
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.011 0.0329
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.011 0.011
Echinococcus multilocularis muscleblind protein 1 0.0146 0.0788 0.0788
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0156 0.0174
Onchocerca volvulus Glucosylceramidase homolog 0.0195 0.108 0.2386
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0387 0.043
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.014 0.0424
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.011 0.0329
Schistosoma mansoni rab6-interacting 0.0061 0.0274 0.0305
Trypanosoma brucei transcription factor BTF3, putative 0.004 0.0149 0.0452
Echinococcus granulosus neuropeptide Y receptor 0.008 0.0387 0.043
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0222 0.1246 0.8899
Plasmodium falciparum thioredoxin reductase 0.0098 0.0494 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0038 0.0272
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0222 0.1246 0.4434
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.026 0.026
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.004 0.0045
Echinococcus granulosus transcription factor Dp 1 0.004 0.0149 0.0165
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.011 0.0895
Entamoeba histolytica hypothetical protein 0.0041 0.0156 0.1476
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0354 0.116
Schistosoma mansoni alpha glucosidase 0.0035 0.0117 0.013
Echinococcus granulosus lamin dm0 0.0057 0.025 0.0278
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0354 0.3566
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0098 0.0132
Brugia malayi beta-lactamase family protein 0.0074 0.0354 0.0824
Brugia malayi MH1 domain containing protein 0.0049 0.0204 0.0474
Loa Loa (eye worm) hypothetical protein 0.033 0.1896 0.4437
Toxoplasma gondii ABC1 family protein 0.0074 0.0354 0.2986
Echinococcus multilocularis alpha 1A adrenergic receptor 0.008 0.0387 0.0387
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0209 0.1744
Onchocerca volvulus 0.0091 0.0455 0.0952
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0387 0.0387
Echinococcus granulosus biogenic amine 5HT receptor 0.008 0.0387 0.043
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0039 0.014 0.0323
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0038 0.01
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.011 0.0123
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.008 0.0387 0.043
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.017
Onchocerca volvulus 0.0074 0.0354 0.072
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0072 0.0343 0.0343
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0038 0.0042
Echinococcus multilocularis RUN 0.0061 0.0274 0.0274
Loa Loa (eye worm) latrophilin receptor protein 2 0.0132 0.0702 0.1642
Echinococcus multilocularis multidrug resistance protein 1 0.0032 0.0098 0.0098
Brugia malayi cytochrome P450 0.0022 0.0038 0.0083
Loa Loa (eye worm) hypothetical protein 0.0417 0.2418 0.566
Brugia malayi hypothetical protein 0.008 0.0387 0.09
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0117 0.0954
Trypanosoma brucei glucosidase, putative 0.0035 0.0117 0.0351
Schistosoma mansoni alpha-glucosidase 0.0135 0.0723 0.0803
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.108 0.2385
Onchocerca volvulus 0.0746 0.4401 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0073 0.0081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0227 0.1275 0.1418
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.011 0.0329
Loa Loa (eye worm) hypothetical protein 0.0034 0.0109 0.0256
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0229
Schistosoma mansoni hypothetical protein 0.008 0.0387 0.043
Brugia malayi Tachykinin-like peptides receptor 99D 0.008 0.0387 0.09
Onchocerca volvulus 0.0028 0.0074 0.0078
Brugia malayi Calcitonin receptor-like protein seb-1 0.0417 0.2418 0.5658
Trichomonas vaginalis abcb9, putative 0.0032 0.0098 0.0132
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0074 0.0173
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.008 0.0387 0.0387
Loa Loa (eye worm) G-protein coupled receptor 0.008 0.0387 0.0905
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0031 0.0096 0.0107
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0072 0.0343 0.0694
Schistosoma mansoni rab6-interacting 0.0061 0.0274 0.0305
Echinococcus granulosus microtubule associated protein 2 0.151 0.8997 1
Leishmania major cytochrome p450-like protein 0.0022 0.0038 0.01
Brugia malayi jmjC domain containing protein 0.0016 0.0006 0.0009
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.021 0.1171 0.1302
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0049 0.0202 0.0619
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0387 0.043
Onchocerca volvulus 0.008 0.0387 0.0795
Loa Loa (eye worm) thioredoxin reductase 0.0098 0.0494 0.1156
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0038 0.0089
Brugia malayi Dopamine receptor protein 2 0.008 0.0387 0.09
Echinococcus multilocularis biogenic amine (5HT) receptor 0.008 0.0387 0.0387
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.004 0.0045
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0159 0.0866 0.0866
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0038 0.0089
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0387 0.043
Loa Loa (eye worm) MH2 domain-containing protein 0.0049 0.0204 0.0478
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0312 0.0346
Brugia malayi MH1 domain containing protein 0.0027 0.0071 0.0162
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0354 0.0824
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0354 0.0394
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0149 0.0452
Brugia malayi jmjC domain containing protein 0.0016 0.0006 0.0009
Echinococcus multilocularis mothers against decapentaplegic 5 0.0049 0.0204 0.0204
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0354 0.1099
Entamoeba histolytica hypothetical protein 0.004 0.0149 0.1298
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.011 0.2137
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.008 0.0387 0.043
Brugia malayi multidrug resistance protein 3 0.0032 0.0098 0.0224
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0056 0.0127
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0202 0.0619
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.0192 0.0214
Loa Loa (eye worm) hypothetical protein 0.0285 0.1624 0.38
Schistosoma mansoni patched 1 0.0042 0.0158 0.0176
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0098 0.0132
Echinococcus granulosus mothers against decapentaplegic 2 0.0022 0.004 0.0044
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0032 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0022 0.004 0.0093
Brugia malayi ABC transporter family protein 0.0032 0.0098 0.0224
Trichomonas vaginalis set domain proteins, putative 0.0746 0.44 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0072 0.0343 0.0343
Onchocerca volvulus 0.008 0.0387 0.0795
Echinococcus granulosus orexin receptor type 2 0.008 0.0387 0.043
Trypanosoma brucei squalene synthase, putative 0.0542 0.3171 1
Onchocerca volvulus 0.0095 0.0476 0.1001
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0149 0.0452
Brugia malayi CXXC zinc finger family protein 0.0028 0.0074 0.0168
Brugia malayi jmjC domain containing protein 0.0067 0.0312 0.0725
Echinococcus granulosus g-protein coupled receptor 0.008 0.0387 0.043
Schistosoma mansoni multidrug resistance protein 0.0032 0.0098 0.0109
Schistosoma mansoni polycystin 1-related 0.0061 0.0274 0.0305
Brugia malayi acetyltransferase, GNAT family protein 0.0159 0.0866 0.2022
Echinococcus multilocularis musashi 0.0057 0.025 0.025
Schistosoma mansoni biogenic amine (dopamine) receptor 0.008 0.0387 0.043
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0417 0.2418 0.5658
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.008 0.0387 0.0387
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0354 0.072
Giardia lamblia DINP protein human, muc B family 0.004 0.0149 0.1669
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Brugia malayi hypothetical protein 0.008 0.0387 0.09
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0032 0.0098 0.0109
Onchocerca volvulus 0.0061 0.0274 0.0537
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.011 0.0329
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0417 0.2418 0.566
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0158 0.0176
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0132 0.0702 0.0702
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0156 0.0156
Schistosoma mansoni zinc finger protein 0.0031 0.0094 0.0105
Brugia malayi larval opioid receptor 0.008 0.0387 0.09
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0209 0.0233
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0032 0.0098 0.0098
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0034 0.011 0.0819
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0474 0.2763 1
Treponema pallidum NADH oxidase 0.0034 0.011 0.5
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.0855 0.0855
Brugia malayi MH2 domain containing protein 0.0049 0.0204 0.0474
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.008 0.0387 0.043
Brugia malayi MH2 domain containing protein 0.0022 0.004 0.0088
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0209 0.4165
Loa Loa (eye worm) hypothetical protein 0.004 0.0149 0.0349
Echinococcus multilocularis lipoxygenase domain containing protein 0.0061 0.0274 0.0274
Schistosoma mansoni peptide (allatostatin)-like receptor 0.008 0.0387 0.043
Brugia malayi hypothetical protein 0.008 0.0387 0.09
Echinococcus granulosus muscleblind protein 0.0146 0.0788 0.0875
Schistosoma mansoni hypothetical protein 0.008 0.0387 0.043
Brugia malayi MH1 domain containing protein 0.0049 0.0204 0.0474
Brugia malayi hypothetical protein 0.0061 0.0274 0.0637
Onchocerca volvulus Neuropeptide F receptor homolog 0.008 0.0387 0.0795
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1143 0.253
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0117 0.013
Echinococcus multilocularis mothers against decapentaplegic 2 0.0022 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0051 0.0216 0.024
Echinococcus multilocularis serotonin receptor 0.033 0.1896 0.1896
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0149 0.0349
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.014 0.1158
Echinococcus multilocularis thioredoxin glutathione reductase 0.0098 0.0494 0.0494
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0492 0.0492
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0038 0.01
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0072 0.0343 0.0694
Brugia malayi hypothetical protein 0.008 0.0387 0.09
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0049 0.0202 0.4016
Echinococcus multilocularis multidrug resistance protein 1 0.0022 0.004 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0149 0.0452
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0006 0.0006
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0032 0.0098 0.0098
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0279 0.0279
Brugia malayi Thioredoxin reductase 0.0098 0.0494 0.1152
Loa Loa (eye worm) hypothetical protein 0.033 0.1896 0.4437
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.0347 0.0385
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0038 0.0089
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0098 0.0132
Schistosoma mansoni hypothetical protein 0.0132 0.0702 0.078
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Echinococcus granulosus GPCR family 2 0.0132 0.0702 0.078
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0095 0.0476 0.4036
Trypanosoma cruzi phytoene synthase, putative 0.0169 0.0924 0.2901
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0149 0.0344
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.011 0.2137
Echinococcus multilocularis smad 0.0049 0.0204 0.0204
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0098 0.0132
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.008 0.0387 0.0905
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0117 0.0177
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0032 0.0098 0.0221
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0034 0.011 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.008 0.0387 0.0795
Echinococcus multilocularis g protein coupled receptor 0.008 0.0387 0.0387
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0032 0.0098 0.0132
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0149 0.0452
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.008 0.0387 0.043
Mycobacterium tuberculosis Conserved protein 0.0074 0.0354 0.116
Echinococcus multilocularis neuropeptide FF receptor 2 0.008 0.0387 0.0387
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0149 0.0452
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.021 0.1171 0.1302
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.025 0.0586
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.011 0.0329
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Echinococcus granulosus dna polymerase eta 0.004 0.0149 0.0166
Schistosoma mansoni microtubule-associated protein tau 0.151 0.8997 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0061 0.0274 0.5493
Onchocerca volvulus 0.008 0.0387 0.0795
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Echinococcus granulosus dro:myosuppressin receptor 0.008 0.0387 0.043
Brugia malayi Melatonin receptor type 1A 0.008 0.0387 0.09
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0032 0.0098 0.0132
Schistosoma mansoni cpg binding protein 0.0033 0.0107 0.0119
Schistosoma mansoni neuropeptide receptor 0.008 0.0387 0.043
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0743 0.0825
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.014 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0095 0.0476 0.0476
Echinococcus multilocularis neuropeptide receptor A26 0.008 0.0387 0.0387
Schistosoma mansoni opsin-like receptor 0.008 0.0387 0.043
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0039 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0149 0.0452
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0117 0.0269
Echinococcus multilocularis tachykinin peptides receptor 99D 0.008 0.0387 0.0387
Schistosoma mansoni alpha-1 adrenergic receptor 0.008 0.0387 0.043
Echinococcus granulosus smad 0.0049 0.0204 0.0227
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0098 0.0132
Schistosoma mansoni hypothetical protein 0.0708 0.417 0.4635
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.008 0.0387 0.043
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0098 0.0132
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.008 0.0387 0.043
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0149 0.0409
Brugia malayi Cytochrome P450 family protein 0.0022 0.0038 0.0083
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0072 0.0343 0.0381
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0227 0.1275 0.1418
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0156
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.008 0.0387 0.043
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0072 0.0343 0.1064
Brugia malayi Bromodomain containing protein 0.0158 0.0857 0.2002
Schistosoma mansoni biogenic amine receptor 0.008 0.0387 0.043
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.021 0.1171 0.1171
Schistosoma mansoni Smad4 0.0049 0.0204 0.0227
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0098 0.0132
Trichomonas vaginalis ABC transporter, putative 0.0032 0.0098 0.0132
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.1695 0.3796
Schistosoma mansoni hypothetical protein 0.0708 0.417 0.4635
Loa Loa (eye worm) intermediate filament protein 0.0057 0.025 0.0586
Echinococcus multilocularis lipoxygenase domain containing protein 0.0061 0.0274 0.0274
Loa Loa (eye worm) transcription factor SMAD2 0.0725 0.4272 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0492 1
Loa Loa (eye worm) inositol-1 0.0039 0.014 0.0329
Loa Loa (eye worm) hypothetical protein 0.0087 0.0428 0.1002
Echinococcus granulosus somatostatin receptor 0.008 0.0387 0.043
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0038 0.01
Mycobacterium tuberculosis Conserved protein 0.0074 0.0354 0.116
Brugia malayi Muscleblind-like protein 0.0146 0.0788 0.1839
Echinococcus granulosus dnaJ subfamily B 0.0395 0.2286 0.2541
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0247 0.1396 0.4982
Echinococcus multilocularis 0.0022 0.0038 0.0038
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0032 0.0098 0.0132
Schistosoma mansoni opsin-like receptor 0.008 0.0387 0.043
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0387 0.0387
Plasmodium vivax thioredoxin reductase, putative 0.0098 0.0494 1
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0387 0.043
Loa Loa (eye worm) doublecortin family protein 0.0061 0.0274 0.0642
Schistosoma mansoni neuropeptide receptor 0.008 0.0387 0.043
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0354 0.072
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0073 0.0073
Echinococcus granulosus alpha 1A adrenergic receptor 0.008 0.0387 0.043
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0006 0.0006
Brugia malayi Cytochrome P450 family protein 0.0022 0.0038 0.0083
Echinococcus granulosus lipoxygenase domain containing protein 0.0061 0.0274 0.0305
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.008 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.011 0.0161
Loa Loa (eye worm) hypothetical protein 0.0144 0.0772 0.1808
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.011 0.0329
Trichomonas vaginalis esterase, putative 0.0074 0.0354 0.072
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0343 0.0694
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.014 0.075 0.0834
Echinococcus multilocularis orexin receptor type 2 0.008 0.0387 0.0387
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0387 0.0387
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0149 0.0249
Loa Loa (eye worm) hypothetical protein 0.0072 0.0343 0.0803
Toxoplasma gondii thioredoxin reductase 0.0098 0.0494 0.4188
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0032 0.0098 0.0109
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0006 0.0007
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.014 0.023
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.008 0.0387 0.0905
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Mycobacterium tuberculosis Probable dehydrogenase 0.0222 0.1246 0.4434
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.008 0.0387 0.0387
Echinococcus granulosus g protein coupled receptor 0.008 0.0387 0.043
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0117 0.0177
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0034 0.011 0.0266
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0014
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Schistosoma mansoni neuropeptide receptor 0.008 0.0387 0.043
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0324 0.1005
Echinococcus granulosus mothers against decapentaplegic 5 0.0049 0.0204 0.0227
Echinococcus multilocularis zinc finger protein 0.0045 0.0179 0.0179
Brugia malayi PHD-finger family protein 0.0056 0.0244 0.0566
Plasmodium falciparum basic transcription factor 3b, putative 0.004 0.0149 0.2929
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0387 0.043
Trypanosoma cruzi squalene synthase, putative 0.0542 0.3171 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0387 0.0387
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0116 0.0129
Echinococcus granulosus TGF beta signal transducer SmadC 0.0049 0.0204 0.0227
Plasmodium falciparum glutathione reductase 0.0098 0.0494 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0376 0.0881
Loa Loa (eye worm) hypothetical protein 0.0057 0.025 0.0586
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0032 0.0098 0.0098
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0091 0.0208
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0098 0.0132
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0095 0.0476 0.053
Schistosoma mansoni growth hormone secretagogue receptor 0.008 0.0387 0.043
Schistosoma mansoni hypothetical protein 0.008 0.0387 0.043
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0324 0.1005
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0032 0.0098 0.0109
Echinococcus multilocularis neuropeptide Y receptor 0.008 0.0387 0.0387
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0049 0.0202 0.0619
Echinococcus multilocularis neuropeptide s receptor 0.008 0.0387 0.0387
Echinococcus granulosus 7tm_1 domain containing protein 0.008 0.0387 0.043
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0149 0.0409
Schistosoma mansoni hypothetical protein 0.0169 0.0924 0.1028
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.108 0.2385
Loa Loa (eye worm) hypothetical protein 0.0074 0.0354 0.0829
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.008 0.0387 0.0905
Loa Loa (eye worm) G-protein coupled receptor 0.008 0.0387 0.0905
Plasmodium falciparum multidrug resistance protein 1 0.0032 0.0098 0.1882
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0158 0.1515
Onchocerca volvulus 0.008 0.0387 0.0795
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0014
Plasmodium vivax multidrug resistance protein 1, putative 0.0032 0.0098 0.1882
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0117 0.0274
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0116 0.0116
Onchocerca volvulus 0.008 0.0387 0.0795
Brugia malayi Isocitrate dehydrogenase 0.0049 0.0202 0.0468
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0159 0.0373
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0072 0.0343 1
Trypanosoma brucei ISWI complex protein 0.0031 0.0094 0.0278
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.014 0.075 0.1628
Loa Loa (eye worm) hypothetical protein 0.0097 0.0492 0.1151
Echinococcus multilocularis G protein coupled receptor 139 0.008 0.0387 0.0387
Entamoeba histolytica hypothetical protein 0.0041 0.0156 0.1476
Echinococcus multilocularis microtubule associated protein 2 0.151 0.8997 0.8997
Trichomonas vaginalis ABC transporter, putative 0.0032 0.0098 0.0132
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0162 0.018
Schistosoma mansoni biogenic amine (5HT) receptor 0.033 0.1896 0.2107
Echinococcus multilocularis neuropeptide receptor 0.008 0.0387 0.0387
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.008 0.0387 0.0387
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0149 0.0452
Loa Loa (eye worm) MH1 domain-containing protein 0.0022 0.004 0.0093
Brugia malayi beta-NAC-like protein 0.004 0.0149 0.0344
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Echinococcus granulosus thyrotropin releasing hormone receptor 0.008 0.0387 0.043
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0149 0.025
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.008 0.0387 0.043
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0209 0.0388
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0032 0.0098 0.0788
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0049 0.0204 0.0227
Schistosoma mansoni smad 0.0022 0.004 0.0044
Brugia malayi jmjC domain containing protein 0.0016 0.0006 0.0009
Schistosoma mansoni cytochrome P450 0.0022 0.0038 0.0042
Schistosoma mansoni hypothetical protein 0.0022 0.0038 0.0042
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.008 0.0387 0.043
Brugia malayi Pre-SET motif family protein 0.0656 0.3855 0.9022
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0006 0.0014
Schistosoma mansoni amine GPCR 0.008 0.0387 0.043
Echinococcus granulosus neuropeptides capa receptor 0.008 0.0387 0.043
Schistosoma mansoni hypothetical protein 0.004 0.0149 0.0165
Brugia malayi Smad1 0.0049 0.0204 0.0474
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0279 0.031
Echinococcus multilocularis Glycoside hydrolase, family 27 0.021 0.1171 0.1171
Brugia malayi MH1 domain containing protein 0.0027 0.0071 0.0162
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.014 0.014
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0149 0.0452
Onchocerca volvulus 0.008 0.0387 0.0795
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0149 0.0452
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0227 0.1275 0.2982
Schistosoma mansoni Smad4 0.0022 0.004 0.0044
Schistosoma mansoni opsin-like receptor 0.008 0.0387 0.043
Loa Loa (eye worm) hypothetical protein 0.014 0.075 0.1756
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0324 0.5749
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Loa Loa (eye worm) TYRA-2 protein 0.008 0.0387 0.0905
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0149 0.0452
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0387 0.043
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Echinococcus granulosus Squalene phytoene synthase 0.0169 0.0924 0.1028
Schistosoma mansoni myosin xvIII 0.008 0.0387 0.043
Schistosoma mansoni histamine h1 receptor 0.008 0.0387 0.043
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0132 0.0702 0.078
Brugia malayi MH2 domain containing protein 0.0049 0.0204 0.0474
Echinococcus multilocularis neuropeptides capa receptor 0.008 0.0387 0.0387
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.011 0.0329
Trypanosoma cruzi ISWI complex protein 0.0031 0.0094 0.0278
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0169 0.0924 0.3253
Schistosoma mansoni alpha-glucosidase 0.0135 0.0723 0.0803
Onchocerca volvulus 0.0074 0.0354 0.072
Echinococcus granulosus tm gpcr rhodopsin 0.008 0.0387 0.043
Schistosoma mansoni Smad4 0.0022 0.004 0.0044
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0098 0.0132
Echinococcus granulosus g protein coupled receptor 0.008 0.0387 0.043
Echinococcus multilocularis Polycystic kidney disease protein 0.0061 0.0274 0.0274
Echinococcus granulosus cpg binding protein 0.0033 0.0107 0.0119
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.026 0.2507
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0117 0.0177
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0006 0.0006
Schistosoma mansoni cpg binding protein 0.0033 0.0107 0.0119
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0354 0.2329
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.003 0.0086 0.0096
Trypanosoma cruzi trypanothione reductase, putative 0.0098 0.0494 0.1542
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.108 0.2385
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0324 0.036
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Brugia malayi latrophilin 2 splice variant baaae 0.0285 0.1624 0.3797
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0387 0.043
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.026 0.0289
Schistosoma mansoni neuropeptide f receptor 76f 0.008 0.0387 0.043
Echinococcus multilocularis lamin 0.0057 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0061 0.0274 0.0642
Brugia malayi neuropeptide F receptor 0.008 0.0387 0.09
Echinococcus multilocularis somatostatin receptor 0.008 0.0387 0.0387
Trypanosoma brucei unspecified product 0.0028 0.0074 0.0215
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.011 0.0329
Schistosoma mansoni neuropeptide F-like receptor 0.008 0.0387 0.043
Brugia malayi Latrophilin receptor protein 2 0.0132 0.0702 0.1638
Toxoplasma gondii NAC domain-containing protein 0.004 0.0149 0.1227
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0387 0.0387
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.1695 0.3796
Brugia malayi Bromodomain containing protein 0.0082 0.0398 0.0928
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0247 0.1396 0.4982
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0222 0.1246 0.4434
Echinococcus granulosus neuropeptide receptor 0.008 0.0387 0.043
Brugia malayi hypothetical protein 0.0041 0.0156 0.036
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.014 0.0156
Schistosoma mansoni hypothetical protein 0.0041 0.0156 0.0174
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.011 0.0329
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0078 0.0379 0.0379
Echinococcus multilocularis dna polymerase kappa 0.004 0.0149 0.0149
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0158 0.0176
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.014 0.0424
Plasmodium falciparum glutathione reductase 0.0034 0.011 0.2137
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0149 0.0452
Trichomonas vaginalis taga, putative 0.0032 0.0098 0.0132
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0049 0.0202 0.4016
Loa Loa (eye worm) hypothetical protein 0.0026 0.0066 0.0156
Schistosoma mansoni jumonji/arid domain-containing protein 0.0067 0.0312 0.0346
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.026 0.2507
Plasmodium vivax glutathione reductase, putative 0.0098 0.0494 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.026 0.0802
Loa Loa (eye worm) hypothetical protein 0.0092 0.0461 0.1079
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0072 0.0343 0.1064
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0006 0.0007
Echinococcus multilocularis neuropeptide receptor 0.008 0.0387 0.0387
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.008 0.0387 0.043
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.008 0.0387 0.09
Trypanosoma brucei unspecified product 0.004 0.0149 0.0452
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0074 0.0215
Brugia malayi Melibiase family protein 0.014 0.075 0.1751
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1143 0.253
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.021 0.1171 0.1302
Echinococcus granulosus mothers against decapentaplegic 6 0.0022 0.004 0.0044
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.011 0.2137
Brugia malayi gonadotropin-releasing hormone receptor 2 0.008 0.0387 0.09
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0354 0.0394
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.011 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0158 0.027
Plasmodium falciparum LCCL domain-containing protein 0.0061 0.0274 0.5493
Leishmania major basic transcription factor 3a, putative 0.004 0.0149 0.0452
Toxoplasma gondii isocitrate dehydrogenase 0.0049 0.0202 0.1682
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0492 0.0547
Echinococcus multilocularis serotonin receptor 0.033 0.1896 0.1896
Mycobacterium leprae Probable lipase LipE 0.0074 0.0354 0.2329
Echinococcus granulosus zinc finger protein 0.0045 0.0179 0.0199
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0387 0.043
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0354 0.116
Onchocerca volvulus 0.0057 0.025 0.0483
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.021 0.1171 0.1302
Echinococcus multilocularis Smad4 0.0049 0.0204 0.0204
Brugia malayi MH2 domain containing protein 0.0725 0.4272 1
Brugia malayi Doublecortin family protein 0.0061 0.0274 0.0637
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.008 0.0387 0.0387
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0091 0.0452 0.0502
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.0855 0.1996
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0032 0.0098 0.0132
Echinococcus granulosus multidrug resistance protein 1 0.0032 0.0098 0.0109
Schistosoma mansoni lamin 0.0057 0.025 0.0278
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0387 0.043
Brugia malayi Inositol-1 0.0039 0.014 0.0324
Onchocerca volvulus 0.0057 0.025 0.0483
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0072 0.0343 0.1064
Onchocerca volvulus 0.008 0.0387 0.0795
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.011 0.0329
Echinococcus multilocularis cpg binding protein 0.0033 0.0107 0.0107
Echinococcus granulosus allatostatin A receptor 0.008 0.0387 0.043
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0098 0.0132
Echinococcus granulosus serotonin receptor 0.008 0.0387 0.043
Schistosoma mansoni cpg binding protein 0.0028 0.0074 0.0082
Echinococcus granulosus hypothetical protein 0.008 0.0387 0.043
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0149 0.0452
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.011 0.0161
Loa Loa (eye worm) hypothetical protein 0.0027 0.0071 0.0167
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0006 0.0006
Echinococcus granulosus ubiquitin specific protease 41 0.0072 0.0343 0.0381
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0072 0.0343 0.0381
Echinococcus granulosus multidrug resistance protein 1 0.0032 0.0098 0.0109
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0149 0.025
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.108 0.2385
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0117 0.0177
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.014 0.0156
Schistosoma mansoni multidrug resistance protein 0.0032 0.0098 0.0109
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0006 0.0007
Schistosoma mansoni lipoxygenase 0.0365 0.2103 0.2338
Echinococcus granulosus geminin 0.0708 0.417 0.4635
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0032 0.0098 0.0132
Onchocerca volvulus 0.008 0.0387 0.0795
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.0192 0.0214
Brugia malayi AKH receptor 0.008 0.0387 0.09
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0149 0.1257
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.021 0.1171 0.1302
Trypanosoma cruzi ISWI complex protein 0.0031 0.0094 0.0278
Loa Loa (eye worm) hypothetical protein 0.0146 0.0788 0.1843
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0149 0.0452
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0158 0.3105
Brugia malayi G protein-coupled receptor F59B2.13 0.008 0.0387 0.09
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Brugia malayi G-protein coupled receptor 0.008 0.0387 0.09
Brugia malayi ORL1-like opioid receptor 0.008 0.0387 0.09
Brugia malayi CHE-14 protein 0.0042 0.0158 0.0365
Echinococcus multilocularis protein dispatched 1 0.0048 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0074 0.0354 0.0829
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0685 0.0761
Echinococcus granulosus Polycystic kidney disease protein 0.0061 0.0274 0.0305
Schistosoma mansoni smad1 5 8 and 0.0049 0.0204 0.0227
Schistosoma mansoni hypothetical protein 0.0132 0.0702 0.078
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0354 0.116
Schistosoma mansoni hypothetical protein 0.0042 0.0159 0.0177
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.108 0.2385
Echinococcus multilocularis geminin 0.0708 0.417 0.417
Schistosoma mansoni neuropeptide receptor 0.008 0.0387 0.043
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0049 0.0202 0.0202
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0049 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Plasmodium vivax basic transcription factor 3b, putative 0.004 0.0149 0.2929
Brugia malayi Pre-SET motif family protein 0.0095 0.0476 0.111
Echinococcus granulosus lysine specific demethylase 5A 0.0067 0.0312 0.0346
Loa Loa (eye worm) hypothetical protein 0.0074 0.0354 0.0829
Schistosoma mansoni rhodopsin-like orphan GPCR 0.008 0.0387 0.043
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0117 0.0351
Mycobacterium ulcerans hypothetical protein 0.0074 0.0354 0.3566
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0354 0.116
Brugia malayi Serotonin/octopamine receptor family protein 7 0.008 0.0387 0.09
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0685 0.0761
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0129 0.0685 0.0685
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.026 0.218
Echinococcus multilocularis dro:myosuppressin receptor 0.008 0.0387 0.0387
Trichomonas vaginalis abcb9, putative 0.0032 0.0098 0.0132
Echinococcus multilocularis isocitrate dehydrogenase 0.0049 0.0202 0.0202
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0032 0.0098 0.0229
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0149 0.0452
Onchocerca volvulus 0.0032 0.0098 0.0133
Echinococcus granulosus neuropeptide receptor 0.008 0.0387 0.043
Loa Loa (eye worm) bromodomain containing protein 0.004 0.0146 0.0342
Schistosoma mansoni lamin 0.0057 0.025 0.0278
Echinococcus multilocularis multidrug resistance protein 1 0.0032 0.0098 0.0098
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0312 0.073
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0387 0.0387
Echinococcus multilocularis fmrfamide receptor 0.008 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.0042 0.0158 0.037
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0149 0.0452
Echinococcus multilocularis rhodopsin orphan GPCR 0.008 0.0387 0.0387
Brugia malayi beta-lactamase 0.0074 0.0354 0.0824
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0072 0.0343 0.0343
Brugia malayi Serotonin receptor 0.008 0.0387 0.09
Loa Loa (eye worm) MH2 domain-containing protein 0.0022 0.004 0.0093
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.011 0.2137
Leishmania major DNA polymerase eta, putative 0.004 0.0149 0.0452
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0117 0.049
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0227 0.1275 0.1275
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0032 0.0098 0.0098
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0149 0.0166
Trichomonas vaginalis ABC transporter, putative 0.0032 0.0098 0.0132
Loa Loa (eye worm) MH1 domain-containing protein 0.0049 0.0204 0.0478
Echinococcus granulosus lipoxygenase domain containing protein 0.0061 0.0274 0.0305
Echinococcus multilocularis fmrfamide receptor 0.008 0.0387 0.0387
Brugia malayi glutathione reductase 0.0098 0.0494 0.1152
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.014 0.014
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0049 0.0202 0.0603
Leishmania major trypanothione reductase 0.0098 0.0494 0.1542
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.0192 0.0192
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0117 0.0177
Mycobacterium ulcerans lipase LipD 0.0074 0.0354 0.3566
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0032 0.0098 0.0132
Loa Loa (eye worm) nuclear factor I 0.0027 0.0071 0.0167
Loa Loa (eye worm) melatonin receptor type 1A 0.008 0.0387 0.0905
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0354 0.0394
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.025 0.0581
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0127 0.067 0.067
Echinococcus granulosus lamin 0.0057 0.025 0.0278
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.011 0.0329
Brugia malayi sulfakinin receptor protein 0.008 0.0387 0.09
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0127 0.067 0.0744
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0547 0.32 0.749
Loa Loa (eye worm) hypothetical protein 0.0051 0.0214 0.0502
Echinococcus granulosus neuropeptides capa receptor 0.008 0.0387 0.043
Loa Loa (eye worm) neuropeptide F receptor 0.008 0.0387 0.0905
Mycobacterium ulcerans phytoene synthase, CrtB 0.0169 0.0924 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.014 0.075 0.0834
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0149 0.0344
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.008 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.0031 0.0096 0.0224
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0117 0.049
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.0038 0.01
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0149 0.0249
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0072 0.0343 0.6224
Brugia malayi hypothetical protein 0.0061 0.0274 0.0637
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0149 0.1257
Schistosoma mansoni amine GPCR 0.008 0.0387 0.043
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.008 0.0387 0.09
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0117 0.0351
Trypanosoma brucei unspecified product 0.0028 0.0074 0.0215
Schistosoma mansoni hypothetical protein 0.004 0.0149 0.0165
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0656 0.3855 0.9023
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.014 0.023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.011 0.0329
Loa Loa (eye worm) MH2 domain-containing protein 0.0725 0.4272 1
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0354 0.1099
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0202 0.0202
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.2286 0.2286
Leishmania major hypothetical protein, conserved 0.0074 0.0354 0.1099
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0006 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0387 0.043
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.011 0.0329
Loa Loa (eye worm) Smad1 0.0049 0.0204 0.0478
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0296 0.2488
Brugia malayi beta-lactamase family protein 0.0074 0.0354 0.0824
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.008 0.0387 0.043
Echinococcus multilocularis g protein coupled receptor 0.008 0.0387 0.0387
Onchocerca volvulus 0.008 0.0387 0.0795
Trypanosoma cruzi squalene synthase, putative 0.0542 0.3171 1
Schistosoma mansoni hypothetical protein 0.0132 0.0702 0.078
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.011 0.0329
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.1695 0.3796
Toxoplasma gondii isocitrate dehydrogenase 0.0049 0.0202 0.1682
Brugia malayi hypothetical protein 0.008 0.0387 0.09
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.011 0.0895
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0117 0.0351
Echinococcus granulosus tm gpcr rhodopsin 0.008 0.0387 0.043
Brugia malayi isocitrate dehydrogenase 0.0049 0.0202 0.0468
Schistosoma mansoni loxhd1 0.0061 0.0274 0.0305
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0098 0.0132
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0354 0.072
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.008 0.0387 0.0905
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0091 0.0213
Echinococcus multilocularis g-protein coupled receptor 0.008 0.0387 0.0387
Leishmania major cytochrome p450-like protein 0.0022 0.0038 0.01
Brugia malayi putative neuropeptide receptor NPR1 0.008 0.0387 0.09
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0149 0.0149
Echinococcus granulosus dna polymerase kappa 0.004 0.0149 0.0166
Loa Loa (eye worm) neuropeptide F receptor 0.008 0.0387 0.0905
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.008 0.0387 0.0905
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0202 0.0619
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.014 0.0424
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.014 0.1153
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0354 0.116
Entamoeba histolytica hypothetical protein 0.0041 0.0156 0.1476
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.008 0.0387 0.043
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0125 0.0194
Echinococcus granulosus sex peptide receptor 0.008 0.0387 0.043
Loa Loa (eye worm) beta-lactamase 0.0074 0.0354 0.0829
Echinococcus granulosus nuclear factor of activated T cells 5 0.0078 0.0379 0.0422
Onchocerca volvulus 0.008 0.0387 0.0795
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0158 0.2029
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.014 0.0424
Schistosoma mansoni hypothetical protein 0.0132 0.0702 0.078
Brugia malayi intermediate filament protein 0.0057 0.025 0.0581
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0098 0.0494 0.1674
Loa Loa (eye worm) hypothetical protein 0.0056 0.0244 0.0572
Loa Loa (eye worm) hypothetical protein 0.0129 0.0685 0.1603
Echinococcus granulosus rhodopsin orphan GPCR 0.008 0.0387 0.043
Echinococcus multilocularis transcription factor btf3 0.004 0.0149 0.0149
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0159 0.0866 0.0962
Schistosoma mansoni multidrug resistance protein 0.0032 0.0098 0.0109

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0828 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.0928 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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