Detailed information for compound 958063

Basic information

Technical information
  • TDR Targets ID: 958063
  • Name: [(3S,7S,8R,9S,10R,12R,13R,14S,17R)-3,7-dihydr oxy-10,13-dimethyl-17-[(1R)-1-[(1R,2R)-2-meth yl-2-[(2R)-3-methylbutan-2-yl]cyclopropyl]eth yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro -1H-cyclopenta[a]phenanthren-12-yl] acetate
  • MW: 500.753 | Formula: C32H52O4
  • H donors: 2 H acceptors: 3 LogP: 7.06 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@H]1CC[C@]2(C(=C[C@H]([C@@H]3[C@@H]2C[C@@H](OC(=O)C)[C@]2([C@H]3CC[C@@H]2[C@@H]([C@H]2C[C@]2(C)[C@@H](C(C)C)C)C)C)O)C1)C
  • InChi: 1S/C32H52O4/c1-17(2)19(4)31(7)16-26(31)18(3)23-9-10-24-29-25(15-28(32(23,24)8)36-20(5)33)30(6)12-11-22(34)13-21(30)14-27(29)35/h14,17-19,22-29,34-35H,9-13,15-16H2,1-8H3/t18-,19+,22-,23+,24-,25-,26+,27+,28+,29-,30-,31+,32+/m0/s1
  • InChiKey: CUYULTOZWPGDFW-OZYXUASZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [(3S,7S,8R,9S,10R,12R,13R,14S,17R)-17-[(1R)-1-[(1R,2R)-2-[(1R)-1,2-dimethylpropyl]-2-methyl-cyclopropyl]ethyl]-3,7-dihydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-12-yl] acetate
  • acetic acid [(3S,7S,8R,9S,10R,12R,13R,14S,17R)-17-[(1R)-1-[(1R,2R)-2-[(1R)-1,2-dimethylpropyl]-2-methylcyclopropyl]ethyl]-3,7-dihydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-12-yl] ester
  • acetic acid [(3S,7S,8R,9S,10R,12R,13R,14S,17R)-17-[(1R)-1-[(1R,2R)-2-[(1R)-1,2-dimethylpropyl]-2-methyl-cyclopropyl]ethyl]-3,7-dihydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-12-yl] ester
  • [(3S,7S,8R,9S,10R,12R,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-17-[(1R)-1-[(1R,2R)-2-methyl-2-[(2R)-3-methylbutan-2-yl]cyclopropyl]ethyl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-12-yl] ethanoate
  • (3beta,7alpha,12beta)-3,7-dihydroxygorgost-5-en-12-yl acetate
  • 12beta-Acetoxy-7alpha-hydroxygorgosterol
  • Acetic acid 17-{1-[2-(1,2-dimethyl-propyl)-2-methyl-cyclopropyl]-ethyl}-3,7-dihydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-12-yl ester
  • InChI=1/C32H52O4/c1-17(2)19(4)31(7)16-26(31)18(3)23-9-10-24-29-25(15-28(32(23,24)8)36-20(5)33)30(6)12-11-22(34)13-21(30)14-27(29)35/h14,17-19,22-29,34-35H,9-13,15-16H2,1-8H3/t18-,19+,22-,23+,24-,25-,26+,27+,28+,29-,30-,31+,32+/m0/s

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0009 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0253 0.0274
Brugia malayi fructose-bisphosphate aldolase 2 0.0089 0.3058 0.306
Echinococcus multilocularis survival motor neuron protein 1 0.0269 0.9973 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0009 0.0009
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.1103 1
Onchocerca volvulus 0.0065 0.2118 0.2111
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0933 0.0936
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.504 0.5054
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0423 0.0279
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.036 0.0774
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0089 0.3058 0.3067
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0089 0.3058 0.3067
Loa Loa (eye worm) hypothetical protein 0.0052 0.1618 0.1623
Trichomonas vaginalis set domain proteins, putative 0.0269 0.9991 1
Schistosoma mansoni DNA polymerase eta 0.0014 0.0174 0.0175
Echinococcus multilocularis dna polymerase kappa 0.004 0.1178 0.1181
Brugia malayi Pre-SET motif family protein 0.0034 0.0933 0.0928
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0089 0.3058 0.3234
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0009 0.0009
Brugia malayi polk-prov protein 0.003 0.0801 0.0795
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.1118 0.1113
Echinococcus granulosus dna polymerase kappa 0.004 0.1178 0.1181
Schistosoma mansoni hypothetical protein 0.0041 0.1194 0.12
Loa Loa (eye worm) hypothetical protein 0.002 0.0402 0.0403
Echinococcus multilocularis dna polymerase eta 0.0014 0.0174 0.0174
Echinococcus multilocularis fructose bisphosphate aldolase class I 0.0089 0.3058 0.3067
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1178 0.1292
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.1178 0.1126
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.1237 0.3954
Plasmodium falciparum fructose-bisphosphate aldolase 0.0089 0.3058 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0009 0.0009
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0009 0.0009
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0089 0.3058 0.3067
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0665 0.0275
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.036 0.0774
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0317 0.0318
Loa Loa (eye worm) hypothetical protein 0.0014 0.0174 0.0174
Loa Loa (eye worm) fructose-bisphosphate aldolase 1 0.0089 0.3058 0.3067
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0089 0.3058 0.3073
Schistosoma mansoni patched 1 0.0042 0.1253 0.1259
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0077 0.2578 0.2585
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.0174 0.0174
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0089 0.3058 0.3067
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0933 0.0938
Echinococcus granulosus GPCR family 2 0.0018 0.0317 0.0318
Loa Loa (eye worm) hypothetical protein 0.0027 0.0665 0.0666
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0665 0.055
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.504 0.5054
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0174 0.0166
Schistosoma mansoni hypothetical protein 0.0055 0.1737 0.1746
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0009 0.0009
Trypanosoma cruzi squalene synthase, putative 0.0246 0.9094 1
Echinococcus granulosus FTZ F1 alpha 0.001 0.0009 0.0009
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0665 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0317 0.0318
Echinococcus granulosus expressed conserved protein 0.0092 0.3185 0.3194
Schistosoma mansoni thyroid hormone receptor 0.001 0.0009 0.0009
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0009 0.0009
Brugia malayi Pre-SET motif family protein 0.0237 0.8733 0.8755
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0402 0.095
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0665 0.0275
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0801 0.0877
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1178 0.1292
Echinococcus multilocularis protein patched 0.0042 0.1253 0.1256
Brugia malayi hypothetical protein 0.0065 0.2118 0.2117
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0801 0.0877
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0009 0.0009
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.1178 0.1292
Schistosoma mansoni nuclear hormone receptor 0.001 0.0009 0.0009
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0009 0.0009
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0665 0.0275
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0009 0.0009
Schistosoma mansoni transcription factor LCR-F1 0.0082 0.279 0.2803
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.1253 0.1256
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0665 0.0658
Schistosoma mansoni hypothetical protein 0.0041 0.1194 0.12
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1178 0.1292
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.3415 0.3424
Loa Loa (eye worm) hypothetical protein 0.003 0.0801 0.0803
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0089 0.3058 0.3234
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0665 0.0275
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.0174 0.0174
Echinococcus multilocularis Squalene phytoene synthase 0.0077 0.2578 0.2585
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0665 0.0658
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0009 0.0009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0009 0.0009
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.1237 0.124
Plasmodium vivax SET domain protein, putative 0.0034 0.0933 0.1999
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0665 0.0658
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.0174 0.0175
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0082 0.279 0.2797
Schistosoma mansoni thyroid hormone receptor 0.001 0.0009 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0009 0.0009
Echinococcus multilocularis GPCR, family 2 0.0018 0.0317 0.0318
Brugia malayi fructose-bisphosphate aldolase 1 0.0089 0.3058 0.306
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.1178 0.1126
Leishmania major squalene synthase, putative 0.0246 0.9094 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.036 0.0774
Brugia malayi bZIP transcription factor family protein 0.0082 0.2799 0.28
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.005 0.1551 0.1558
Trypanosoma cruzi squalene synthase, putative 0.0246 0.9094 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0009 0.0009
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0317 0.0318
Echinococcus granulosus transient receptor potential cation channel 0.001 0.0009 0.0009
Echinococcus multilocularis jun protein 0.0082 0.2799 0.2807
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0077 0.2578 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0665 0.1514
Echinococcus multilocularis expressed conserved protein 0.0092 0.3185 0.3194
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.1253 0.1256
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0009 0.0009
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.3415 0.3418
Loa Loa (eye worm) hypothetical protein 0.008 0.2712 0.2719
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0009 0.0009
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0009 0.0009
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0665 0.055
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0933 0.0936
Trypanosoma brucei unspecified product 0.0034 0.0929 0.1017
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0089 0.3058 0.3073
Loa Loa (eye worm) hypothetical protein 0.002 0.0402 0.0403
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0665 0.1514
Schistosoma mansoni hypothetical protein 0.0018 0.0317 0.0319
Echinococcus granulosus jun protein 0.0082 0.2799 0.2807
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0009 0.0009
Echinococcus multilocularis short transient receptor potential channel 6 0.001 0.0009 0.0009
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0317 0.0318
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0082 0.2799 0.2807
Echinococcus granulosus survival motor neuron protein 1 0.0269 0.9973 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0933 0.0938
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0933 0.0936
Brugia malayi hypothetical protein 0.0269 0.9973 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0665 0.0275
Toxoplasma gondii fructose-bisphosphate aldolase, putative 0.0089 0.3058 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.1118 0.1121
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0009 0.0009
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0009 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0253 0.0274
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0933 0.0938
Plasmodium vivax fructose 1,6-bisphosphate aldolase, putative 0.0089 0.3058 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0317 0.0309
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1178 0.1292
Schistosoma mansoni hypothetical protein 0.0067 0.2205 0.2215
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0933 0.2945
Entamoeba histolytica hypothetical protein 0.0082 0.279 0.8071
Echinococcus granulosus Squalene phytoene synthase 0.0077 0.2578 0.2585
Mycobacterium ulcerans phytoene synthase, CrtB 0.0077 0.2578 0.2278
Loa Loa (eye worm) transcription factor SMAD2 0.0136 0.4851 0.4864
Loa Loa (eye worm) hypothetical protein 0.002 0.0402 0.0403
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.5102 0.5126
Loa Loa (eye worm) fructose-bisphosphate aldolase 2 0.0089 0.3058 0.3067
Loa Loa (eye worm) hypothetical protein 0.0034 0.0933 0.0936
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0423 0.0461
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0009 0.0009
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0317 0.0309
Loa Loa (eye worm) hypothetical protein 0.0098 0.3415 0.3424
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0089 0.3058 0.3067
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0933 0.0938
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0665 0.2041
Loa Loa (eye worm) hypothetical protein 0.0269 0.9973 1
Mycobacterium ulcerans glutaminase 0.0268 0.9952 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0009 0.0009
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0089 0.3058 0.3234
Loa Loa (eye worm) hypothetical protein 0.0027 0.0665 0.0666
Schistosoma mansoni survival motor neuron protein 0.0055 0.1737 0.1746
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0027 0.0665 0.0666
Schistosoma mansoni transient receptor potential channel 0.001 0.0009 0.0009
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0665 0.1514
Schistosoma mansoni jun-related protein 0.0067 0.2205 0.2215
Echinococcus granulosus Protein patched homolog 1 0.0042 0.1253 0.1256
Schistosoma mansoni hypothetical protein 0.0041 0.1194 0.12
Loa Loa (eye worm) glutaminase 2 0.0268 0.9952 0.9979
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0009 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1178 0.1292
Brugia malayi CHE-14 protein 0.0042 0.1253 0.1248
Echinococcus granulosus dna polymerase eta 0.0014 0.0174 0.0174
Entamoeba histolytica hypothetical protein 0.0082 0.279 0.8071
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1178 0.1292
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0253 0.0274
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.1178 0.1292
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.1103 0.2638
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0009 0.0009
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0174 0.0174
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0077 0.2578 0.259
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.5102 0.5111
Onchocerca volvulus 0.0055 0.1737 0.173
Loa Loa (eye worm) MH2 domain-containing protein 0.0136 0.4851 0.4864
Brugia malayi MH2 domain containing protein 0.0136 0.4851 0.4859
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.1253 0.1256
Leishmania major fructose-1,6-bisphosphate aldolase 0.0089 0.3058 0.3234
Loa Loa (eye worm) hypothetical protein 0.002 0.0402 0.0403
Trypanosoma cruzi phytoene synthase, putative 0.0077 0.2578 0.2695
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0237 0.8733 0.8756
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.1103 0.2867
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0089 0.3058 1
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0082 0.2799 0.2807
Brugia malayi glutaminase DH11.1 0.0268 0.9952 0.9979
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.1237 0.3143
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0009 0.0009
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0665 0.0275
Entamoeba histolytica hypothetical protein 0.0082 0.279 0.8071
Schistosoma mansoni glutaminase 0.0268 0.9952 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0885 0.0888
Schistosoma mansoni hypothetical protein 0.0041 0.1194 0.12
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.1237 0.0067
Trypanosoma brucei DNA polymerase eta, putative 0.0014 0.0174 0.0187
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.4948 0.4961
Mycobacterium ulcerans DNA polymerase IV 0.004 0.1178 0.0813
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0082 0.279 0.2797
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0089 0.3058 0.3067
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0009 0.0009
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0009 0.0009
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.1237 0.3954
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.1808 0.1806
Brugia malayi hypothetical protein 0.0082 0.279 0.2791
Onchocerca volvulus 0.0027 0.0665 0.0656
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0665 0.055
Loa Loa (eye worm) glutaminase 0.0268 0.9952 0.9979
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1178 0.1292
Schistosoma mansoni coup transcription factor 0.001 0.0009 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1178 0.1292
Loa Loa (eye worm) hypothetical protein 0.0042 0.1253 0.1256
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.1737 0.1735
Mycobacterium ulcerans hypothetical protein 0.0027 0.0665 0.0275
Trichomonas vaginalis glutaminase, putative 0.0268 0.9952 0.9956
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.5102 0.5115
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.3415 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0014 0.0174 0.0175
Schistosoma mansoni hypothetical protein 0.0082 0.279 0.2803
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0317 0.0318
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0665 0.5
Loa Loa (eye worm) hypothetical protein 0.0057 0.1808 0.1813
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0402 0.5
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0089 0.3058 0.3234
Echinococcus multilocularis transient receptor potential cation channel 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Entamoeba histolytica hypothetical protein 0.0082 0.279 0.8071
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.036 0.0774
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0089 0.3058 1
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0077 0.2578 0.2571
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.1237 0.0067
Trypanosoma brucei fructose-bisphosphate aldolase, glycosomal, putative 0.0089 0.3058 0.336
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.1808 0.1813
Mycobacterium ulcerans DNA polymerase IV 0.004 0.1178 0.0813
Trypanosoma brucei squalene synthase, putative 0.0246 0.9094 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0423 0.1037
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.1178 0.1126
Echinococcus granulosus short transient receptor potential channel 6 0.001 0.0009 0.0009
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0174 0.0166
Schistosoma mansoni hypothetical protein 0.0018 0.0317 0.0319
Leishmania major hypothetical protein, conserved 0.0077 0.2578 0.2695
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.3415 0.3424
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.1808 0.1806
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.3474 0.349
Schistosoma mansoni hypothetical protein 0.0039 0.1118 0.1124
Schistosoma mansoni hypothetical protein 0.0018 0.0317 0.0319
Echinococcus multilocularis transient receptor potential cation channel 0.001 0.0009 0.0009
Echinococcus multilocularis protein dispatched 1 0.0048 0.1482 0.1486
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.1178 0.1292
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0665 0.2041
Loa Loa (eye worm) hypothetical protein 0.002 0.0402 0.0403
Loa Loa (eye worm) hypothetical protein 0.0018 0.0317 0.0318
Onchocerca volvulus 0.0034 0.0933 0.0925
Schistosoma mansoni hypothetical protein 0.0018 0.0317 0.0319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0009 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0009 0.0009
Loa Loa (eye worm) acetyltransferase 0.0142 0.5102 0.5115
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.1253 0.0084
Leishmania major DNA polymerase kappa, putative 0.0021 0.0423 0.0279
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0665 0.0275
Echinococcus granulosus fructose bisphosphate aldolase class I 0.0089 0.3058 0.3067
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0929 0.1017
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.1178 0.1126

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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