TDR Targets

Basic information

Technical information

TDR Targets ID: 875939
Name: ethyl 5-methyl-4-oxo-3-(2-oxo-2-pyrrolidin-1- ylethyl)thieno[5,4-d]pyrimidine-6-carboxylate
MW: 349.405 | Formula: C16H19N3O4S
H donors: 0 H acceptors: 3 LogP: 1.84 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1sc2c(c1C)c(=O)n(cn2)CC(=O)N1CCCC1
InChi: 1S/C16H19N3O4S/c1-3-23-16(22)13-10(2)12-14(24-13)17-9-19(15(12)21)8-11(20)18-6-4-5-7-18/h9H,3-8H2,1-2H3
InChiKey: GCVJBBHCKMWAIV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 5-methyl-4-oxo-3-(2-oxo-2-pyrrolidin-1-yl-ethyl)thieno[5,4-d]pyrimidine-6-carboxylate
5-methyl-4-oxo-3-(2-oxo-2-1-pyrrolidinylethyl)-6-thieno[5,4-d]pyrimidinecarboxylic acid ethyl ester
4-keto-3-(2-keto-2-pyrrolidin-1-yl-ethyl)-5-methyl-thieno[5,4-d]pyrimidine-6-carboxylic acid ethyl ester
ST061788
ZINC00109698
BAS 08753436
Oprea1_623792

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	heat shock protein 83-1	0.0051	0.0065	0.0045
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0012	0.0001	0.0003
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0024	0.0021	0.005
Trypanosoma cruzi	phytoene synthase, putative	0.2557	0.4155	0.4173
Echinococcus multilocularis	geminin	0.019	0.0292	0.0703
Schistosoma mansoni	importin beta-1	0.0033	0.0035	0.0085
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0075	0.0104	0.025
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0075	0.0104	0.3427
Schistosoma mansoni	hypothetical protein	0.0052	0.0066	0.0158
Leishmania major	squalene synthase, putative	0.6096	0.9933	1
Onchocerca volvulus	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog	0.2557	0.4155	1
Trypanosoma cruzi	heat shock protein 90, putative	0.0051	0.0065	0.0049
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0075	0.0104	0.0088
Schistosoma mansoni	heat shock protein	0.0051	0.0065	0.0157
Leishmania major	heat shock protein 83-1	0.0051	0.0065	0.0045
Onchocerca volvulus		0.0032	0.0033	0.008
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0075	0.0104	0.3427
Onchocerca volvulus		0.0075	0.0104	0.025
Trypanosoma cruzi	squalene synthase, putative	0.6096	0.9933	1
Trypanosoma brucei	heat shock protein, putative	0.0051	0.0065	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0066	0.0158
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0075	0.0104	0.025
Echinococcus multilocularis	importin subunit beta 1	0.0033	0.0035	0.0085
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0035	0.0014
Trypanosoma cruzi	aminopeptidase, putative	0.0075	0.0104	0.0088
Echinococcus granulosus	snurportin 1	0.0355	0.056	0.1348
Echinococcus granulosus	heat shock protein	0.0051	0.0065	0.0157
Echinococcus multilocularis	cpg binding protein	0.0034	0.0036	0.0088
Echinococcus multilocularis	snurportin 1	0.0355	0.056	0.1348
Loa Loa (eye worm)	aminopeptidase N	0.0075	0.0104	0.025
Plasmodium vivax	endoplasmin, putative	0.0051	0.0065	0.213
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0164	0.0248	0.0597
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0065	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0248	0.0597
Echinococcus multilocularis	GPCR, family 2	0.0052	0.0066	0.0158
Echinococcus granulosus	peregrin	0.0033	0.0034	0.0082
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0075	0.0104	1
Entamoeba histolytica	aminopeptidase, putative	0.0075	0.0104	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0104	0.025
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0075	0.0104	0.025
Leishmania major	heat shock protein 83-1	0.0051	0.0065	0.0045
Leishmania major	heat shock protein, putative	0.0034	0.0037	0.0016
Trypanosoma brucei	heat shock protein, putative	0.0051	0.0065	0.0045
Loa Loa (eye worm)	hypothetical protein	0.2557	0.4155	1
Entamoeba histolytica	90 kDa heat shock protein, putative	0.0034	0.0037	0.1923
Echinococcus granulosus	aminopeptidase N	0.0075	0.0104	0.025
Echinococcus multilocularis	peregrin	0.0033	0.0034	0.0082
Toxoplasma gondii	heat shock protein 90, putative	0.0051	0.0065	0.1584
Leishmania major	heat shock protein 83-1	0.0051	0.0065	0.0045
Toxoplasma gondii	heat shock protein HSP90	0.0051	0.0065	0.1584
Brugia malayi	jmjC domain containing protein	0.0107	0.0155	0.1489
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0024	0.0021	0.0649
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0075	0.0104	0.0084
Trypanosoma brucei	heat shock protein, putative	0.0051	0.0065	0.0045
Brugia malayi	hypothetical protein	0.0075	0.0104	0.0994
Brugia malayi	jmjC domain containing protein	0.0041	0.0048	0.0464
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0075	0.0104	0.025
Toxoplasma gondii	aminopeptidase n, putative	0.0075	0.0104	0.2971
Onchocerca volvulus		0.0075	0.0104	0.025
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0061	0.008	0.2132
Leishmania major	heat shock protein 83-1	0.0051	0.0065	0.0045
Trypanosoma brucei	aminopeptidase, putative	0.0075	0.0104	0.0084
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0052	0.0066	0.0158
Trichomonas vaginalis	heat shock protein, putative	0.0037	0.0042	0.2547
Echinococcus granulosus	lysine specific demethylase 5A	0.0041	0.0048	0.0117
Schistosoma mansoni	endoplasmin	0.0051	0.0065	0.0157
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0048	0.006	0.5
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0075	0.0104	1
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0024	0.0021	0.005
Plasmodium vivax	importin-beta 2, putative	0.0033	0.0035	0.1129
Schistosoma mansoni	ran	0.0024	0.0021	0.005
Plasmodium falciparum	heat shock protein 90, putative	0.003	0.003	0.0949
Entamoeba histolytica	heat shock protein 90, putative	0.0051	0.0065	0.5331
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0065	0.0156
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0065	0.0156
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0075	0.0104	0.0084
Leishmania major	heat shock protein 83-1	0.0051	0.0065	0.0045
Echinococcus granulosus	PHD finger protein rhinoceros	0.0033	0.0034	0.0082
Leishmania major	heat shock protein 83-1	0.0051	0.0065	0.0045
Trypanosoma brucei	Aminopeptidase M1, putative	0.0075	0.0104	0.0084
Leishmania major	heat shock protein 83-1	0.0051	0.0065	0.0045
Brugia malayi	F/Y-rich N-terminus family protein	0.002	0.0014	0.0138
Plasmodium falciparum	importin beta, putative	0.0033	0.0035	0.1129
Echinococcus multilocularis	heat shock protein 90	0.0044	0.0053	0.0127
Plasmodium vivax	heat shock protein 90, putative	0.0034	0.0037	0.1183
Trypanosoma cruzi	squalene synthase, putative	0.6096	0.9933	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0075	0.0104	0.025
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0075	0.0104	1
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0034	0.0037	0.0089
Echinococcus granulosus	neuropeptide receptor A26	0.052	0.0829	0.1996
Echinococcus multilocularis	Squalene phytoene synthase	0.2557	0.4155	1
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.1415	0.2291	0.5514
Schistosoma mansoni	hypothetical protein	0.0052	0.0066	0.0158
Echinococcus granulosus	endoplasmin	0.0048	0.006	0.0144
Schistosoma mansoni	ran	0.0024	0.0021	0.005
Plasmodium falciparum	heat shock protein 90, putative	0.0195	0.03	1
Treponema pallidum	heat shock protein 90	0.0048	0.006	0.5
Trypanosoma brucei	heat shock protein 90, putative	0.0051	0.0065	0.0045
Brugia malayi	latrophilin 2 splice variant baaae	0.0112	0.0164	0.1569
Trichomonas vaginalis	heat shock protein, putative	0.0044	0.0053	0.3864
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0075	0.0104	0.025
Leishmania major	heat shock protein 83-1	0.0051	0.0065	0.0045
Schistosoma mansoni	hypothetical protein	0.0112	0.0164	0.0394
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0065	0.0156
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0033	0.0034	0.0082
Trypanosoma brucei	heat shock protein, putative	0.0051	0.0065	0.0045
Trypanosoma cruzi	Heat shock protein 83, putative	0.0051	0.0065	0.0049
Plasmodium vivax	heat shock protein 86, putative	0.0051	0.0065	0.213
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0355	0.056	0.1348
Echinococcus multilocularis	neuropeptide receptor A26	0.052	0.0829	0.1996
Leishmania major	heat shock protein 83-1	0.0051	0.0065	0.0045
Leishmania major	heat shock protein 83-1	0.0051	0.0065	0.0045
Leishmania major	heat shock protein 83-1	0.0051	0.0065	0.0045
Brugia malayi	Hsp90 protein	0.0034	0.0037	0.0353
Trypanosoma cruzi	heat shock protein, putative	0.0034	0.0037	0.0021
Echinococcus multilocularis	heat shock protein	0.0051	0.0065	0.0157
Brugia malayi	hypothetical protein	0.0075	0.0104	0.0994
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0075	0.0104	0.3427
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0052	0.0066	0.0158
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.1415	0.2291	0.5514
Schistosoma mansoni	heat shock protein	0.0034	0.0037	0.0089
Brugia malayi	hypothetical protein	0.0651	0.1043	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0034	0.0082
Trypanosoma brucei	squalene synthase, putative	0.6096	0.9933	1
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0075	0.0104	0.025
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0065	0.0156
Echinococcus multilocularis	heat shock protein 90	0.0051	0.0065	0.0157
Brugia malayi	Peptidase family M1 containing protein	0.0075	0.0104	0.0994
Schistosoma mansoni	hypothetical protein	0.0355	0.056	0.1348
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0024	0.0021	0.0201
Echinococcus multilocularis	aminopeptidase N	0.0075	0.0104	0.025
Loa Loa (eye worm)	PHD-finger family protein	0.0033	0.0034	0.0082
Schistosoma mansoni	heat shock protein	0.0051	0.0065	0.0157
Toxoplasma gondii	HEAT repeat-containing protein	0.0033	0.0035	0.0514
Trypanosoma cruzi	heat shock protein 85, putative	0.0051	0.0065	0.0049
Brugia malayi	Endoplasmin precursor	0.0051	0.0065	0.0624
Echinococcus granulosus	neuropeptide s receptor	0.052	0.0829	0.1996
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0075	0.0104	0.025
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0041	0.0048	0.0117
Leishmania major	importin beta-1 subunit, putative	0.0027	0.0025	0.0004
Loa Loa (eye worm)	heat shock protein 90	0.0051	0.0065	0.0157
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0019	0.0011	0.0027
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0075	0.0104	0.025
Loa Loa (eye worm)	TATA binding protein associated factor	0.0075	0.0104	0.025
Echinococcus granulosus	jumonji domain containing protein	0.0045	0.0055	0.0133
Echinococcus multilocularis	jumonji domain containing protein	0.0045	0.0055	0.0133
Toxoplasma gondii	PHD-finger domain-containing protein	0.0033	0.0034	0.0477
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0075	0.0104	0.0088
Brugia malayi	Peptidase family M1 containing protein	0.0075	0.0104	0.0994
Toxoplasma gondii	PHD-finger domain-containing protein	0.0033	0.0034	0.0477
Trypanosoma cruzi	heat shock protein 90, putative	0.0044	0.0053	0.0037
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0107	0.0155	0.0374
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0052	0.0066	0.0158
Trypanosoma brucei	heat shock protein 84, putative	0.0034	0.0037	0.0016
Echinococcus granulosus	heat shock protein 90	0.0044	0.0053	0.0127
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0048	0.006	0.5
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0065	0.0156
Schistosoma mansoni	hypothetical protein	0.0052	0.0066	0.0158
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0012	0.0001	0.0003
Toxoplasma gondii	Hsp90 domain-containing protein	0.0195	0.03	1
Onchocerca volvulus		0.0075	0.0104	0.025
Plasmodium falciparum	phd finger protein, putative	0.0033	0.0034	0.1095
Trypanosoma cruzi	heat shock protein 85, putative	0.0051	0.0065	0.0049
Trichomonas vaginalis	importin beta-1, putative	0.0027	0.0025	0.0491
Trypanosoma brucei	Heat shock protein 83, putative	0.0051	0.0065	0.0045
Trichomonas vaginalis	endoplasmin, putative	0.0037	0.0042	0.2547
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0104	0.025
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0025	0.0491
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0033	0.0034	0.0082
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0107	0.0155	0.0374
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0068	0.0092	0.0222
Leishmania major	heat shock protein 83-1	0.0051	0.0065	0.0045
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0033	0.008
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0025	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0072	0.0174
Trypanosoma brucei	heat shock protein, putative	0.0051	0.0065	0.0045
Brugia malayi	Importin beta-1 subunit	0.0033	0.0035	0.0338
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0065	0.0622
Toxoplasma gondii	aminopeptidase N, putative	0.0075	0.0104	0.2971
Plasmodium vivax	heat shock protein, putative	0.0195	0.03	1
Schistosoma mansoni	hypothetical protein	0.2557	0.4155	1
Giardia lamblia	Grp94/Hsp90	0.0048	0.006	0.883
Schistosoma mansoni	jumonji domain containing protein	0.0085	0.0119	0.0288
Toxoplasma gondii	heat shock protein 75, putative	0.0034	0.0037	0.0571
Leishmania major	hypothetical protein, conserved	0.2557	0.4155	0.417
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.1415	0.2291	0.5514
Trichomonas vaginalis	heat shock protein, putative	0.0048	0.006	0.4708
Onchocerca volvulus	Alhambra homolog	0.0033	0.0034	0.0082
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0024	0.0021	0.0005
Trypanosoma brucei	heat shock protein, putative	0.0051	0.0065	0.0045
Echinococcus multilocularis	lysine specific demethylase 5A	0.0039	0.0045	0.0109
Schistosoma mansoni	hypothetical protein	0.019	0.0292	0.0703
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0024	0.0021	0.005
Schistosoma mansoni	cpg binding protein	0.0032	0.0033	0.008
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0065	0.0156
Brugia malayi	heat shock protein 90	0.0051	0.0065	0.0624
Mycobacterium ulcerans	aminopeptidase N PepN	0.0075	0.0104	0.0044
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0075	0.0104	0.025
Echinococcus granulosus	cpg binding protein	0.0034	0.0036	0.0088
Trypanosoma brucei	heat shock protein, putative	0.0051	0.0065	0.0045
Entamoeba histolytica	hypothetical protein	0.0027	0.0025	0.0491
Trypanosoma cruzi	heat shock protein 85, putative	0.0044	0.0053	0.0037
Schistosoma mansoni	endoplasmin	0.0051	0.0065	0.0157
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0052	0.0066	0.0158
Toxoplasma gondii	aminopeptidase N protein	0.0075	0.0104	0.2971
Trypanosoma cruzi	heat shock protein 85, putative	0.0051	0.0065	0.0049
Schistosoma mansoni	cpg binding protein	0.0034	0.0036	0.0088
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0075	0.0104	0.3427
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0075	0.0104	0.0088
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0044	0.0053	0.7249
Plasmodium falciparum	endoplasmin, putative	0.0037	0.0042	0.1356
Loa Loa (eye worm)	jmjC domain-containing protein	0.0067	0.0091	0.0219
Loa Loa (eye worm)	heat shock protein 75	0.0034	0.0037	0.0089
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0075	0.0104	0.0084
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0075	0.0104	0.025
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0075	0.0104	0.0088
Brugia malayi	PHD-finger family protein	0.0033	0.0034	0.0328
Echinococcus multilocularis	neuropeptide s receptor	0.052	0.0829	0.1996
Echinococcus granulosus	Squalene phytoene synthase	0.2557	0.4155	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0052	0.0066	0.0628
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0035	0.0014
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0075	0.0104	0.025
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0035	0.0085
Entamoeba histolytica	heat shock protein 90, putative	0.0051	0.0065	0.5331
Leishmania major	heat shock protein 83-1	0.0051	0.0065	0.0045
Loa Loa (eye worm)	endoplasmin	0.0051	0.0065	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0104	0.025
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0034	0.0082
Loa Loa (eye worm)	jmjC domain-containing protein	0.0041	0.0048	0.0117
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0075	0.0104	0.025
Trypanosoma brucei	heat shock protein, putative	0.0051	0.0065	0.0045
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0041	0.0048	0.0117
Plasmodium falciparum	heat shock protein 90	0.0051	0.0065	0.213
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0044	0.0053	0.0127
Trichomonas vaginalis	heat shock protein, putative	0.003	0.003	0.108
Giardia lamblia	PHD finger protein 15	0.0033	0.0034	0.3013
Trypanosoma cruzi	aminopeptidase, putative	0.0075	0.0104	0.0088
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0027	0.0025	0.0009
Schistosoma mansoni	hypothetical protein	0.0052	0.0066	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0164	0.0394
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0075	0.0104	0.0088
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0048	0.006	0.0039
Plasmodium vivax	hypothetical protein, conserved	0.0033	0.0034	0.1095
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0075	0.0104	0.0084
Leishmania major	heat shock protein 83-1	0.0051	0.0065	0.0045
Brugia malayi	Peptidase family M1 containing protein	0.0075	0.0104	0.0994
Brugia malayi	TATA binding protein associated factor	0.0075	0.0104	0.0994
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0065	0.0156
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0075	0.0104	0.025
Echinococcus granulosus	importin subunit beta 1	0.0033	0.0035	0.0085
Brugia malayi	Bromodomain containing protein	0.0033	0.0034	0.0328
Echinococcus granulosus	leukotriene A 4 hydrolase	0.1415	0.2291	0.5514
Mycobacterium ulcerans	aminopeptidase N PepN	0.0075	0.0104	0.0044
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0033	0.032
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0075	0.0104	0.025
Trichomonas vaginalis	heat shock protein, putative	0.0051	0.0065	0.5331
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.0034	0.0037	0.0089
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0075	0.0104	0.0088
Schistosoma mansoni	cpg binding protein	0.0034	0.0036	0.0088
Trypanosoma brucei	Aminopeptidase M1, putative	0.0075	0.0104	0.0084
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0051	0.0065	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0075	0.0104	0.025
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0075	0.0104	0.0084
Echinococcus granulosus	heat shock protein 90	0.0051	0.0065	0.0157
Schistosoma mansoni	hypothetical protein	0.019	0.0292	0.0703
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0075	0.0104	0.025
Trichomonas vaginalis	heat shock protein, putative	0.0048	0.006	0.4708
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0024	0.0021	0.0005
Brugia malayi	Latrophilin receptor protein 2	0.0052	0.0066	0.0628
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0001	0.0003
Brugia malayi	RNA, U transporter 1	0.0095	0.0135	0.1297
Trypanosoma brucei	heat shock protein 90, putative	0.0051	0.0065	0.0045
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0052	0.0066	0.0158
Mycobacterium ulcerans	phytoene synthase, CrtB	0.6137	1	1
Echinococcus multilocularis	endoplasmin	0.0048	0.006	0.0144
Echinococcus granulosus	GPCR family 2	0.0052	0.0066	0.0158
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0034	0.0037	0.0089
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0024	0.0021	0.0649
Echinococcus granulosus	geminin	0.019	0.0292	0.0703
Brugia malayi	PHD-finger family protein	0.0012	0.0001	0.0013
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0164	0.0248	0.2379
Leishmania major	heat shock protein 83-1	0.0051	0.0065	0.0045
Leishmania major	heat shock protein 83-1	0.0051	0.0065	0.0045
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0164	0.0248	0.2379

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

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Detailed information for compound 875939