Detailed information for compound 79595

Basic information

Technical information
  • TDR Targets ID: 79595
  • Name: 73323-34-9
  • MW: 347.457 | Formula: C21H25N5
  • H donors: 2 H acceptors: 2 LogP: 3.94 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCCNc1nccc2c1c(C)c1c(c2C)[nH]c2c1cncc2)C
  • InChi: 1S/C21H25N5/c1-13-15-6-10-24-21(23-8-5-11-26(3)4)19(15)14(2)18-16-12-22-9-7-17(16)25-20(13)18/h6-7,9-10,12,25H,5,8,11H2,1-4H3,(H,23,24)
  • InChiKey: WZKJBRQGAGGPNN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,3-Propanediamine, N'-(6,11-dimethyl-5H-pyrido(3',4':4,5)pyrrolo(2,3-g)isoquinolin-10-yl)-N,N-dimethyl-
  • 1-(gamma-Dimethylaminopropylamino)-5,11-dimethyl-6H-dipyrido(4,3-b)(3,4-f)indole [French]
  • BRN 4559197

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0135 0.0157
Brugia malayi CXXC zinc finger family protein 0.0028 0.0171 0.0216
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.0562 0.6123 1
Echinococcus multilocularis cpg binding protein 0.0029 0.0189 0.0245
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0081 0.0068
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0095 0.0925 1
Loa Loa (eye worm) hypothetical protein 0.0562 0.6123 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0081 0.0068
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0058 0.0507 0.0768
Echinococcus multilocularis glutamate receptor 2 0.002 0.0081 0.0068
Loa Loa (eye worm) hypothetical protein 0.0095 0.0925 0.1456
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0472 0.4632
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0135 0.0157
Schistosoma mansoni hypothetical protein 0.0338 0.3627 0.5898
Echinococcus granulosus glutamate receptor 2 0.002 0.0081 0.0068
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0135 0.0157
Loa Loa (eye worm) norepinephrine transporter 0.0562 0.6123 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0315 0.0436
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0257 0.0358
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0135 0.0157
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0911 1 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0315 0.0236
Echinococcus granulosus fmrfamide receptor 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.008 0.0752 0.1171
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Echinococcus granulosus serotonin transporter 0.0562 0.6123 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0024 0.0135 0.0157
Echinococcus multilocularis glutamate receptor 2 0.0038 0.0288 0.0409
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0095 0.0925 0.1456
Loa Loa (eye worm) hypothetical protein 0.0095 0.0925 0.1456
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0095 0.0925 0.1456
Loa Loa (eye worm) hypothetical protein 0.008 0.0752 0.1171
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0024 0.0135 0.0157
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0095 0.0925 0.1456
Schistosoma mansoni glutamate receptor kainate 0.0038 0.0288 0.0409
Schistosoma mansoni ATP-binding cassette transporter 0.0038 0.0288 0.0409
Schistosoma mansoni cpg binding protein 0.0029 0.0189 0.0245
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0024 0.0135 0.0157
Echinococcus granulosus receptor type guanylyl cyclase 0.002 0.0081 0.0068
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0911 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0024 0.0135 0.0157
Trypanosoma cruzi phytoene synthase, putative 0.0156 0.1603 0.2837
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0058 0.0507 0.0768
Schistosoma mansoni adenoreceptor 0.0024 0.0135 0.0157
Onchocerca volvulus 0.0024 0.0135 0.009
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0368 0.054
Brugia malayi neuropeptide F receptor 0.0024 0.0135 0.0157
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.032 0.0461
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0081 0.0068
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.008 0.0752 0.1171
Onchocerca volvulus 0.0095 0.0925 0.1397
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Echinococcus multilocularis nmda type glutamate receptor 0.0136 0.138 0.2204
Echinococcus multilocularis somatostatin receptor 0.0024 0.0135 0.0157
Brugia malayi Serotonin receptor 0.0024 0.0135 0.0157
Echinococcus granulosus nmda type glutamate receptor 0.002 0.0081 0.0068
Schistosoma mansoni histamine h1 receptor 0.0024 0.0135 0.0157
Mycobacterium tuberculosis Probable lipase LipE 0.008 0.0752 0.1228
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0752 0.1171
Schistosoma mansoni ap endonuclease 0.002 0.0081 0.0068
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0416 0.4493 0.7321
Schistosoma mansoni neuropeptide receptor 0.0024 0.0135 0.0157
Brugia malayi Pre-SET motif family protein 0.0416 0.4493 0.7321
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.008 0.0752 0.1228
Schistosoma mansoni alpha-1 adrenergic receptor 0.0024 0.0135 0.0157
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.0192 0.1997 0.3218
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0914 0.1437
Schistosoma mansoni vesicular acetylcholine transporter 0.0225 0.237 0.3831
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.032 0.0461
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0445 0.4815 1
Schistosoma mansoni tyrosine kinase 0.002 0.0081 0.0068
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0135 0.0157
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0135 0.0157
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0423 0.063
Brugia malayi hypothetical protein 0.0024 0.0135 0.0157
Mycobacterium leprae conserved hypothetical protein 0.008 0.0752 0.1066
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0081 0.0068
Echinococcus multilocularis G-protein coupled receptor, putative 0.0024 0.0135 0.0157
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0135 0.0157
Echinococcus multilocularis g-protein coupled receptor 0.0024 0.0135 0.0157
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0135 0.0157
Echinococcus granulosus allatostatin A receptor 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.0056 0.0485 0.0733
Echinococcus multilocularis vesicular acetylcholine transporter 0.0225 0.237 0.3831
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0024 0.0135 0.0157
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0095 0.0925 0.1456
Echinococcus granulosus tachykinin peptides receptor 99D 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.0095 0.0925 0.1456
Schistosoma mansoni glutamate receptor AMPA 0.0038 0.0288 0.0409
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0135 0.0157
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0024 0.0135 0.0157
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0095 0.0925 0.1456
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0375 0.4039 0.6575
Brugia malayi beta-lactamase 0.008 0.0752 0.1171
Schistosoma mansoni sphingoid long chain base kinase 0.0299 0.3189 0.5177
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0024 0.0135 0.0157
Schistosoma mansoni biogenic amine receptor 0.0024 0.0135 0.0157
Echinococcus multilocularis serotonin receptor 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0752 0.1171
Brugia malayi jmjC domain containing protein 0.0107 0.1053 0.1665
Schistosoma mansoni sodium/chloride dependent transporter 0.0095 0.0925 0.1456
Leishmania major hypothetical protein, conserved 0.0156 0.1603 0.2837
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0911 1 1
Schistosoma mansoni hypothetical protein 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0135 0.0157
Mycobacterium ulcerans hypothetical protein 0.008 0.0752 0.1418
Brugia malayi Glutamate receptor 2 precursor 0.0038 0.0288 0.0409
Schistosoma mansoni tyrosine kinase 0.002 0.0081 0.0068
Entamoeba histolytica hypothetical protein 0.0035 0.0257 0.0178
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0024 0.0135 0.0157
Brugia malayi hypothetical protein 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.002 0.0081 0.0068
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0038 0.0288 0.0409
Plasmodium vivax hypothetical protein, conserved 0.0095 0.0925 1
Plasmodium falciparum phd finger protein, putative 0.0033 0.0226 0.2441
Echinococcus granulosus orexin receptor type 2 0.0024 0.0135 0.0157
Echinococcus granulosus tyrosine kinase 0.002 0.0081 0.0068
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0135 0.0157
Schistosoma mansoni biogenic amine receptor 0.0024 0.0135 0.0157
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0135 0.0157
Brugia malayi Melatonin receptor type 1A 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.0522 0.5678 0.9269
Echinococcus multilocularis sodium and chloride dependent glycine 0.0095 0.0925 0.1456
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Echinococcus granulosus sphingosine kinase 1 0.0299 0.3189 0.5177
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0911 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.127 0.2023
Plasmodium falciparum amino acid transporter, putative 0.0095 0.0925 1
Brugia malayi hypothetical protein 0.0024 0.0135 0.0157
Toxoplasma gondii ABC1 family protein 0.008 0.0752 0.795
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0135 0.0157
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.0562 0.6123 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0095 0.0925 0.1456
Echinococcus granulosus glutamate receptor 2 0.0058 0.0507 0.0768
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0135 0.0157
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0107 0.1053 0.1665
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0752 0.0677
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0024 0.0135 0.0157
Entamoeba histolytica hypothetical protein, conserved 0.0299 0.3189 0.3134
Echinococcus granulosus cpg binding protein 0.0029 0.0189 0.0245
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0752 0.0677
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0038 0.0288 0.0409
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0095 0.0925 0.1456
Loa Loa (eye worm) hypothetical protein 0.0095 0.0925 0.1456
Trypanosoma brucei squalene synthase, putative 0.0501 0.5445 1
Brugia malayi Dopamine receptor protein 1 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Schistosoma mansoni sphingosine kinase A B 0.0299 0.3189 0.5177
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.002 0.0081 0.0068
Brugia malayi sulfakinin receptor protein 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Plasmodium falciparum transporter, putative 0.0095 0.0925 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0024 0.0135 0.0157
Onchocerca volvulus 0.0473 0.5132 0.836
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0024 0.0135 0.0157
Loa Loa (eye worm) glutamate receptor 1 0.0038 0.0288 0.0409
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0095 0.0925 0.1456
Echinococcus multilocularis nmda type glutamate receptor 0.002 0.0081 0.0068
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0058 0.0507 0.0768
Schistosoma mansoni protein kinase 0.002 0.0081 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0752 0.1251
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0375 0.4039 0.7379
Loa Loa (eye worm) TYRA-2 protein 0.0024 0.0135 0.0157
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0024 0.0135 0.0157
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0095 0.0925 0.1456
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0095 0.0925 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0445 0.4815 0.8661
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Onchocerca volvulus 0.0024 0.0135 0.009
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0135 0.0157
Echinococcus granulosus somatostatin receptor 0.0024 0.0135 0.0157
Schistosoma mansoni amine GPCR 0.0024 0.0135 0.0157
Echinococcus multilocularis receptor type guanylyl cyclase 0.002 0.0081 0.0068
Schistosoma mansoni opsin-like receptor 0.0024 0.0135 0.0157
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0135 0.0157
Echinococcus granulosus serotonin receptor 0.0024 0.0135 0.0157
Schistosoma mansoni ap endonuclease 0.002 0.0081 0.0068
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0315 0.0436
Onchocerca volvulus 0.0028 0.0171 0.015
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0532 0.081
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0752 0.0677
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0135 0.0157
Brugia malayi hypothetical protein 0.0024 0.0135 0.0157
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0024 0.0135 0.0157
Schistosoma mansoni inositol monophosphatase 0.0041 0.0315 0.0452
Brugia malayi PHD-finger family protein 0.0033 0.0226 0.0306
Echinococcus granulosus neuropeptide s receptor 0.0024 0.0135 0.0157
Echinococcus multilocularis allatostatin A receptor 0.0024 0.0135 0.0157
Echinococcus multilocularis beta LACTamase domain containing family member 0.008 0.0752 0.1171
Brugia malayi Receptor family ligand binding region containing protein 0.002 0.0081 0.0068
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0302 0.0432
Brugia malayi Bromodomain containing protein 0.0033 0.0226 0.0306
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.0375 0.4039 0.6575
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0024 0.0135 0.0157
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0098 0.0954 0.1598
Onchocerca volvulus 0.0024 0.0135 0.009
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0135 0.0157
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0038 0.0288 0.0409
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0135 0.0157
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0098 0.0954 0.0881
Mycobacterium tuberculosis Conserved protein 0.0299 0.3189 0.5687
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0315 0.0436
Loa Loa (eye worm) hypothetical protein 0.008 0.0752 0.1171
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0135 0.0157
Echinococcus granulosus geminin 0.0338 0.3627 0.5898
Echinococcus multilocularis neuropeptide s receptor 0.0024 0.0135 0.0157
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0562 0.6123 1
Trichomonas vaginalis esterase, putative 0.008 0.0752 0.0677
Echinococcus multilocularis dro:myosuppressin receptor 0.0024 0.0135 0.0157
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0058 0.0507 0.0768
Brugia malayi neuropeptide F receptor 0.0024 0.0135 0.0157
Echinococcus granulosus g protein coupled receptor 0.0024 0.0135 0.0157
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0315 0.0494
Onchocerca volvulus 0.0024 0.0135 0.009
Echinococcus granulosus dro:myosuppressin receptor 0.0024 0.0135 0.0157
Trypanosoma cruzi squalene synthase, putative 0.0501 0.5445 1
Schistosoma mansoni glutamate receptor AMPA 0.0038 0.0288 0.0409
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0135 0.0157
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0532 0.081
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0368 0.054
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0095 0.0925 0.1456
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0095 0.0925 1
Brugia malayi hypothetical protein 0.032 0.3426 0.5567
Echinococcus multilocularis geminin 0.0338 0.3627 0.5898
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Echinococcus granulosus G protein coupled receptor 139 0.0024 0.0135 0.0157
Echinococcus granulosus sodium and chloride dependent glycine 0.0095 0.0925 0.1456
Loa Loa (eye worm) hypothetical protein 0.006 0.0532 0.081
Schistosoma mansoni glutamate receptor NMDA 0.0038 0.0288 0.0409
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Mycobacterium tuberculosis Probable conserved lipoprotein 0.008 0.0752 0.1228
Echinococcus multilocularis neuropeptide FF receptor 2 0.0024 0.0135 0.0157
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0024 0.0135 0.009
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0156 0.1603 0.2519
Loa Loa (eye worm) hypothetical protein 0.0299 0.3189 0.5177
Loa Loa (eye worm) glutamate receptor 0.002 0.0081 0.0068
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0135 0.0157
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0095 0.0925 0.1456
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0226 0.1716
Onchocerca volvulus 0.0095 0.0925 0.1397
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0315 0.0452
Schistosoma mansoni sodium/chloride dependent transporter 0.0562 0.6123 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0024 0.0135 0.0157
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0226 0.0306
Plasmodium vivax amine transporter, putative 0.0095 0.0925 1
Onchocerca volvulus 0.0024 0.0135 0.009
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Brugia malayi Metabotropic glutamate receptor precursor. 0.002 0.0081 0.0068
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0024 0.0135 0.0157
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0225 0.237 0.3831
Schistosoma mansoni glutamate receptor kainate 0.0038 0.0288 0.0409
Echinococcus granulosus peregrin 0.0033 0.0226 0.0306
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0024 0.0135 0.0157
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0226 0.0306
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0135 0.0157
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0095 0.0925 0.1456
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0098 0.0954 1
Schistosoma mansoni inositol monophosphatase 0.0041 0.0315 0.0452
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0135 0.0157
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.002 0.0081 0.0068
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.008 0.0752 0.1418
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0267 0.0341
Echinococcus multilocularis sphingosine kinase 1 0.0299 0.3189 0.5177
Brugia malayi hypothetical protein 0.0522 0.5678 0.9269
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0225 0.237 0.3789
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Brugia malayi Dopamine receptor protein 2 0.0024 0.0135 0.0157
Brugia malayi beta-lactamase family protein 0.008 0.0752 0.1171
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.032 0.0461
Entamoeba histolytica hypothetical protein 0.0035 0.0257 0.0178
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Onchocerca volvulus 0.008 0.0752 0.1111
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0081 0.0068
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0135 0.0157
Trypanosoma brucei C-8 sterol isomerase, putative 0.0375 0.4039 0.7379
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0542 0.0826
Brugia malayi follicle stimulating hormone receptor 0.0024 0.0135 0.0157
Echinococcus granulosus neuropeptide FF receptor 2 0.0024 0.0135 0.0157
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0024 0.0135 0.0157
Onchocerca volvulus 0.008 0.0752 0.1111
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0038 0.0288 0.0409
Onchocerca volvulus 0.0024 0.0135 0.009
Schistosoma mansoni sodium-dependent amino acid transporter 0.0095 0.0925 0.1456
Leishmania major C-8 sterol isomerase-like protein 0.0375 0.4039 0.7379
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.032 0.0461
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0257 0.0358
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0914 0.1437
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0226 0.0306
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0171 0.0216
Schistosoma mansoni glutamate receptor kainate 0.0038 0.0288 0.0409
Echinococcus granulosus neuropeptide receptor 0.0024 0.0135 0.0157
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.008 0.0752 0.1228
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0081 0.0875
Mycobacterium leprae Probable lipase LipE 0.008 0.0752 0.1066
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Schistosoma mansoni opsin-like receptor 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0914 0.1437
Mycobacterium ulcerans lipase LipD 0.008 0.0752 0.1418
Schistosoma mansoni biogenic amine receptor 0.0024 0.0135 0.0157
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0135 0.0157
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0135 0.0157
Onchocerca volvulus Neuropeptide F receptor homolog 0.0024 0.0135 0.009
Echinococcus granulosus sodium and chloride dependent glycine 0.0095 0.0925 0.1456
Brugia malayi metabotropic GABA-B receptor subtype 2 0.002 0.0081 0.0068
Brugia malayi hypothetical protein 0.0035 0.0257 0.0358
Chlamydia trachomatis glutamine binding protein 0.0098 0.0954 1
Brugia malayi hypothetical protein 0.0024 0.0135 0.0157
Loa Loa (eye worm) solute carrier family 6 member 4 0.0562 0.6123 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0914 0.1437
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0135 0.0157
Schistosoma mansoni glutamate receptor NMDA 0.0058 0.0507 0.0768
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Echinococcus granulosus sex peptide receptor 0.0024 0.0135 0.0157
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0914 0.1437
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0914 0.1437
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Brugia malayi GnHR receptor homolog 0.0024 0.0135 0.0157
Onchocerca volvulus 0.0024 0.0135 0.009
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0135 0.0157
Echinococcus granulosus g protein coupled receptor 0.0024 0.0135 0.0157
Onchocerca volvulus 0.0024 0.0135 0.009
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0135 0.0157
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.002 0.0081 0.0068
Brugia malayi larval opioid receptor 0.0024 0.0135 0.0157
Onchocerca volvulus 0.0024 0.0135 0.009
Onchocerca volvulus 0.0024 0.0135 0.009
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0135 0.0157
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0024 0.0135 0.0157
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0315 0.0436
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.0081 0.0068
Mycobacterium ulcerans hydrolase/amidase 0.0274 0.2909 0.5974
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0135 0.0157
Schistosoma mansoni amine GPCR 0.0024 0.0135 0.0157
Onchocerca volvulus 0.0024 0.0135 0.009
Schistosoma mansoni hypothetical protein 0.0024 0.0135 0.0157
Echinococcus granulosus metabotropic glutamate receptor 2 0.002 0.0081 0.0068
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.0081 0.0068
Onchocerca volvulus 0.0024 0.0135 0.009
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0315 0.0236
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0135 0.0157
Echinococcus granulosus glutamate NMDA receptor subunit 0.0038 0.0288 0.0409
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0024 0.0135 0.0157
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0532 0.5348
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.0095 0.0925 0.1456
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0038 0.0288 0.0409
Loa Loa (eye worm) hypothetical protein 0.002 0.0081 0.0068
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0914 0.1437
Trypanosoma brucei hypothetical protein, conserved 0.008 0.0752 0.1251
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.01 0.0099
Schistosoma mansoni sodium/chloride dependent transporter 0.0095 0.0925 0.1456
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0038 0.0288 0.0409
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0135 0.0157
Echinococcus multilocularis tyrosine kinase 0.002 0.0081 0.0068
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0511 0.5546 1
Schistosoma mansoni neuropeptide receptor 0.0024 0.0135 0.0157
Giardia lamblia Fructose-bisphosphate aldolase 0.0911 1 1
Onchocerca volvulus 0.0562 0.6123 1
Loa Loa (eye worm) serotonin transporter b 0.0562 0.6123 1
Brugia malayi putative neuropeptide receptor 0.0024 0.0135 0.0157
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0058 0.0507 0.0768
Schistosoma mansoni hypothetical protein 0.0034 0.0245 0.0338
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0024 0.0135 0.0157
Echinococcus granulosus neuropeptide receptor 0.0024 0.0135 0.0157
Echinococcus multilocularis metabotropic glutamate receptor 2 0.002 0.0081 0.0068
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.002 0.0081 0.0068
Brugia malayi jmjC domain containing protein 0.0041 0.032 0.0461
Onchocerca volvulus 0.0024 0.0135 0.009
Schistosoma mansoni metabotropic glutamate receptor 0.002 0.0081 0.0068
Loa Loa (eye worm) hypothetical protein 0.0352 0.3783 0.6154
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0095 0.0925 0.1456
Brugia malayi hypothetical protein 0.0024 0.0135 0.0157
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0613 0.0942
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0752 0.1251
Echinococcus granulosus g protein coupled receptor 0.0024 0.0135 0.0157
Giardia lamblia PHD finger protein 15 0.0033 0.0226 0.0146
Echinococcus multilocularis Squalene phytoene synthase 0.0156 0.1603 0.2569
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0095 0.0925 0.1456
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0136 0.138 0.2204
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0752 0.0677
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0445 0.4815 1
Brugia malayi metabotropic glutamate receptor type 2 0.002 0.0081 0.0068
Schistosoma mansoni neuropeptide receptor 0.0024 0.0135 0.0157
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0135 0.0157
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.0081 0.0068
Schistosoma mansoni hypothetical protein 0.0156 0.1603 0.2569
Schistosoma mansoni amine GPCR 0.0024 0.0135 0.0157
Echinococcus granulosus hypothetical protein 0.0024 0.0135 0.0157
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0501 0.0759
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0024 0.0135 0.0157
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0135 0.0157
Brugia malayi beta-lactamase family protein 0.008 0.0752 0.1171
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0911 1 1
Echinococcus granulosus vesicular acetylcholine transporter 0.0225 0.237 0.3831
Loa Loa (eye worm) hypothetical protein 0.032 0.3426 0.5567
Brugia malayi hypothetical protein 0.0024 0.0135 0.0157
Mycobacterium tuberculosis Probable lipase LipD 0.008 0.0752 0.1228
Onchocerca volvulus Alkaline ceramidase homolog 0.0352 0.3783 0.6128
Plasmodium vivax SET domain protein, putative 0.006 0.0532 0.5755
Brugia malayi G protein-coupled receptor F59B2.13 0.0024 0.0135 0.0157
Schistosoma mansoni hypothetical protein 0.0035 0.0257 0.0358
Loa Loa (eye worm) hypothetical protein 0.002 0.0081 0.0068
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0135 0.0157
Echinococcus multilocularis glutamate receptor 2 0.0058 0.0507 0.0768
Onchocerca volvulus 0.006 0.0532 0.0747
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0135 0.0157
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0135 0.0157
Mycobacterium tuberculosis Probable hydrolase 0.008 0.0752 0.1228
Schistosoma mansoni growth hormone secretagogue receptor 0.0024 0.0135 0.0157
Echinococcus granulosus beta LACTamase domain containing family member 0.008 0.0752 0.1171
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0095 0.0925 0.1456
Mycobacterium ulcerans phytoene synthase, CrtB 0.0156 0.1603 0.3214
Loa Loa (eye worm) inositol-1 0.0041 0.0315 0.0452
Brugia malayi Tachykinin-like peptides receptor 99D 0.0024 0.0135 0.0157
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0911 1 1
Trypanosoma cruzi squalene synthase, putative 0.0501 0.5445 1
Brugia malayi AKH receptor 0.0024 0.0135 0.0157
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.002 0.0081 0.0068
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0914 0.1437
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0135 0.0157
Brugia malayi hypothetical protein 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.008 0.0752 0.1171
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0135 0.0157
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0082 0.007
Echinococcus granulosus metabotropic glutamate receptor 5 0.002 0.0081 0.0068
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0135 0.0157
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0911 1 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0107 0.1053 0.1665
Echinococcus granulosus alpha 1A adrenergic receptor 0.0024 0.0135 0.0157
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0024 0.0135 0.0157
Onchocerca volvulus 0.0095 0.0925 0.1397
Schistosoma mansoni hypothetical protein 0.0024 0.0135 0.0157
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0058 0.0507 0.0768
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Brugia malayi RE15519p 0.0024 0.0135 0.0157
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0095 0.0925 0.1456
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0315 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0315 0.0236
Loa Loa (eye worm) hypothetical protein 0.008 0.0752 0.1171
Schistosoma mansoni hypothetical protein 0.0024 0.0135 0.0157
Onchocerca volvulus 0.0024 0.0135 0.009
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0226 0.0306
Echinococcus multilocularis serotonin receptor 0.0024 0.0135 0.0157
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.127 0.2023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0135 0.0157
Echinococcus granulosus peptide allatostatin:somatostatin 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.002 0.0081 0.0068
Schistosoma mansoni hypothetical protein 0.0033 0.0226 0.0306
Echinococcus granulosus Squalene phytoene synthase 0.0156 0.1603 0.2569
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.002 0.0081 0.0068
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0423 0.063
Loa Loa (eye worm) hypothetical protein 0.0033 0.0226 0.0306
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0562 0.6123 1
Echinococcus multilocularis NMDA receptor 0.0038 0.0288 0.0409
Toxoplasma gondii hypothetical protein 0.0095 0.0925 1
Entamoeba histolytica hypothetical protein 0.0035 0.0257 0.0178
Mycobacterium ulcerans hypothetical protein 0.0299 0.3189 0.6566
Onchocerca volvulus 0.0024 0.0135 0.009
Echinococcus multilocularis sex peptide receptor 0.0024 0.0135 0.0157
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0226 0.1716
Schistosoma mansoni cpg binding protein 0.0029 0.0189 0.0245
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0135 0.0157
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0135 0.0157
Echinococcus multilocularis metabotropic glutamate receptor 5 0.002 0.0081 0.0068
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0226 0.2441
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0911 1 1
Brugia malayi putative neuropeptide receptor NPR1 0.0024 0.0135 0.0157
Leishmania major hypothetical protein, conserved 0.008 0.0752 0.1251
Loa Loa (eye worm) hypothetical protein 0.0095 0.0925 0.1456
Onchocerca volvulus Alhambra homolog 0.0033 0.0226 0.024
Trichomonas vaginalis set domain proteins, putative 0.0473 0.5132 0.5093
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.002 0.0081 0.0068
Brugia malayi G-protein coupled receptor 0.0024 0.0135 0.0157
Entamoeba histolytica hypothetical protein 0.0035 0.0257 0.0178
Schistosoma mansoni cpg binding protein 0.0028 0.0171 0.0216
Echinococcus multilocularis peregrin 0.0033 0.0226 0.0306
Schistosoma mansoni neuropeptide receptor 0.0024 0.0135 0.0157
Schistosoma mansoni hypothetical protein 0.0338 0.3627 0.5898
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0135 0.0157
Brugia malayi Dopamine receptor 0.0024 0.0135 0.0157
Brugia malayi MH2 domain containing protein 0.0126 0.127 0.2023
Mycobacterium tuberculosis Conserved protein 0.008 0.0752 0.1228
Schistosoma mansoni amine GPCR 0.0024 0.0135 0.0157
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0024 0.0135 0.0157
Onchocerca volvulus 0.0024 0.0135 0.009
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0532 0.081
Brugia malayi Glutamate receptor 1 precursor 0.0038 0.0288 0.0409
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0532 0.081
Brugia malayi hypothetical protein 0.0095 0.0925 0.1456
Onchocerca volvulus 0.0024 0.0135 0.009
Echinococcus multilocularis atrial natriuretic peptide receptor 0.002 0.0081 0.0068
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0095 0.0925 0.1456
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0098 0.0954 0.1845
Loa Loa (eye worm) hypothetical protein 0.0034 0.0245 0.0338
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0752 0.0677
Echinococcus granulosus neuropeptide receptor A26 0.0024 0.0135 0.0157
Echinococcus multilocularis sodium and chloride dependent glycine 0.0095 0.0925 0.1456
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0095 0.0925 0.1456
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0315 0.0452
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0245 0.0338
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0135 0.0157
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0911 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Loa Loa (eye worm) melatonin receptor type 1A 0.0024 0.0135 0.0157
Treponema pallidum fructose-bisphosphate aldolase 0.0911 1 1
Brugia malayi cancer related gene-liver 1 0.0352 0.3783 0.6154
Onchocerca volvulus 0.032 0.3426 0.5537
Leishmania major squalene synthase, putative 0.0501 0.5445 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0095 0.0925 0.1456
Schistosoma mansoni myosin xvIII 0.0024 0.0135 0.0157
Echinococcus granulosus glutamate receptor subunit protein glur 0.0038 0.0288 0.0409
Plasmodium vivax hypothetical protein, conserved 0.008 0.0752 0.8129
Mycobacterium tuberculosis Conserved protein 0.008 0.0752 0.1228
Loa Loa (eye worm) glutamate receptor 2 0.0038 0.0288 0.0409
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0914 0.1437
Loa Loa (eye worm) hypothetical protein 0.008 0.0752 0.1171
Loa Loa (eye worm) beta-lactamase 0.008 0.0752 0.1171
Brugia malayi hypothetical protein 0.0024 0.0135 0.0157
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0024 0.0135 0.0157
Schistosoma mansoni opsin-like receptor 0.0024 0.0135 0.0157
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0038 0.0288 0.0409
Mycobacterium ulcerans esterase/lipase LipP 0.008 0.0752 0.1418
Schistosoma mansoni neuropeptide f receptor 76f 0.0024 0.0135 0.0157
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0135 0.0157
Echinococcus multilocularis orexin receptor type 2 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.005 0.0423 0.063
Toxoplasma gondii hypothetical protein 0.0095 0.0925 1
Brugia malayi Serotonin receptor 0.0024 0.0135 0.0157
Mycobacterium tuberculosis Conserved protein 0.008 0.0752 0.1228
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0532 0.081
Brugia malayi Guanylyl cyclase protein 23 0.002 0.0081 0.0068
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.008 0.0752 0.1171
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0058 0.0507 0.0768
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0315 0.2768
Brugia malayi vesicular acetylcholine transporter unc-17 0.0225 0.237 0.3831
Schistosoma mansoni amine GPCR 0.0024 0.0135 0.0157
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0135 0.0157
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0315 0.0236
Treponema pallidum sodium- and chloride- dependent transporter 0.0562 0.6123 0.6091
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0081 0.0875
Loa Loa (eye worm) hypothetical protein 0.0156 0.1603 0.2569
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0058 0.0507 0.0768
Loa Loa (eye worm) hypothetical protein 0.0095 0.0925 0.1456
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0135 0.0157
Mycobacterium ulcerans beta-lactamase 0.008 0.0752 0.1418
Brugia malayi hypothetical protein 0.002 0.0081 0.0068
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0135 0.0157
Brugia malayi Pre-SET motif family protein 0.006 0.0532 0.081
Echinococcus multilocularis serotonin transporter 0.0562 0.6123 1
Brugia malayi hypothetical protein 0.0024 0.0135 0.0157
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0257 0.0358
Mycobacterium tuberculosis Probable esterase LipL 0.008 0.0752 0.1228
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Brugia malayi ORL1-like opioid receptor 0.0024 0.0135 0.0157
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0098 0.0954 0.0881
Brugia malayi Inositol-1 0.0041 0.0315 0.0452
Brugia malayi Receptor family ligand binding region containing protein 0.002 0.0081 0.0068
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0135 0.0157
Onchocerca volvulus 0.008 0.0752 0.1111
Brugia malayi G-protein coupled receptor 0.0024 0.0135 0.0157
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0024 0.0135 0.0157
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0024 0.0135 0.0157
Echinococcus granulosus nmda type glutamate receptor 0.0136 0.138 0.2204
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0095 0.0925 0.1456
Schistosoma mansoni jumonji domain containing protein 0.0085 0.0808 0.1263
Echinococcus granulosus 7tm_1 domain containing protein 0.0024 0.0135 0.0157
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0532 0.081
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0423 0.063
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0095 0.0925 0.1456
Echinococcus granulosus g-protein coupled receptor 0.0024 0.0135 0.0157
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0024 0.0135 0.0157
Schistosoma mansoni hypothetical protein 0.0038 0.0288 0.0409
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0156 0.1603 0.2784
Brugia malayi G protein-coupled receptor 0.0024 0.0135 0.0157
Echinococcus multilocularis G protein coupled receptor 139 0.0024 0.0135 0.0157
Loa Loa (eye worm) hypothetical protein 0.0024 0.0135 0.0157
Schistosoma mansoni metabotropic glutamate receptor 0.002 0.0081 0.0068
Echinococcus granulosus atrial natriuretic peptide receptor 0.002 0.0081 0.0068
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0135 0.0157
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0532 0.081
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0135 0.0157

Activities

Activity type Activity value Assay description Source Reference
ID50 (functional) = 0.008 uM In vitro cytotoxicity against L1210 cell line as concentration of the compound required for 50% inhibition of cell growth ChEMBL. 6827534
ID50 (functional) = 0.008 uM In vitro cytotoxicity against L1210 cell line as concentration of the compound required for 50% inhibition of cell growth ChEMBL. 6827534
ILS (functional) = 89 % Antitumor activity against L1210 leukemia cells measured as percent increase in life span (% ILS) at 10 mg/kg ChEMBL. 6827534
ILS (functional) = 89 % Antitumor activity against L1210 leukemia cells measured as percent increase in life span (% ILS) at 10 mg/kg ChEMBL. 6827534
K (functional) = 125 uM-1 Cytotoxicity against L1210 tumor cell line, activity is expressed as K (inverse value of drug concentration) ChEMBL. 6827534
K (functional) = 125 uM-1 Cytotoxicity against L1210 tumor cell line, activity is expressed as K (inverse value of drug concentration) ChEMBL. 6827534
LD0 (ADMET) = 15 mg kg-1 Acute toxicity in mice (LD0) after i.p. administration (highest nontoxic dose) ChEMBL. 6827534
LD0 (ADMET) = 15 mg kg-1 Acute toxicity in mice (LD0) after i.p. administration (highest nontoxic dose) ChEMBL. 6827534
LD100 (ADMET) = 20 mg kg-1 Acute toxicity in mice (LD100) after i.p. administration ChEMBL. 6827534
LD100 (ADMET) = 20 mg kg-1 Acute toxicity in mice (LD100) after i.p. administration ChEMBL. 6827534
MST (functional) = 25.2 day Antitumor activity against L1210 leukemia cells measured as Median survival time at 15 mg/kg ChEMBL. 6827534
MST (functional) = 25.2 day Antitumor activity against L1210 leukemia cells measured as Median survival time at 15 mg/kg ChEMBL. 6827534
Range of death (functional) = 44 day Antitumor activity against L1210 leukemia cells measured as range of death at 20 mg/kg ; value may range from 7 to 44 ChEMBL. 6827534
Range of death (functional) = 44 day Antitumor activity against L1210 leukemia cells measured as range of death at 20 mg/kg ; value may range from 7 to 44 ChEMBL. 6827534

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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