Detailed information for compound 1660164

Basic information

Technical information
  • TDR Targets ID: 1660164
  • Name: (3S,5R,8R,9S,10S,13R,14S,17R)-17-[(E)-4-amino butoxyiminomethyl]-10,13-dimethyl-1,2,3,4,5,6 ,7,8,9,11,12,15,16,17-tetradecahydrocyclopent a[a]phenanthrene-3,14-diol
  • MW: 406.602 | Formula: C24H42N2O3
  • H donors: 3 H acceptors: 2 LogP: 3.39 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCCCO/N=C/[C@@H]1CC[C@]2([C@]1(C)CC[C@H]1[C@H]2CC[C@H]2[C@]1(C)CC[C@@H](C2)O)O
  • InChi: 1S/C24H42N2O3/c1-22-10-8-19(27)15-17(22)5-6-21-20(22)9-11-23(2)18(7-12-24(21,23)28)16-26-29-14-4-3-13-25/h16-21,27-28H,3-15,25H2,1-2H3/b26-16+/t17-,18+,19+,20+,21-,22+,23-,24+/m1/s1
  • InChiKey: WUBIBGYWUZUNNR-AOVIQZMHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase, Na+/K+ transporting, beta 1 polypeptide Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K01540 Na+/K+-exchanging ATPase beta subunit [EC3.6.3.9B], putative Get druggable targets OG5_131864 All targets in OG5_131864
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Get druggable targets OG5_131864 All targets in OG5_131864
Onchocerca volvulus Get druggable targets OG5_131864 All targets in OG5_131864
Schistosoma japonicum ko:K01540 Na+/K+-exchanging ATPase beta subunit [EC3.6.3.9B], putative Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus multilocularis nervana 2 Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus granulosus nervana 2 Get druggable targets OG5_131864 All targets in OG5_131864
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus multilocularis nervana 2 Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus granulosus sodium:potassium transporting ATPase subunit Get druggable targets OG5_131864 All targets in OG5_131864
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Get druggable targets OG5_131864 All targets in OG5_131864
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131864 All targets in OG5_131864
Schistosoma mansoni transmemberane protein Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus granulosus nervana 2 Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus multilocularis sodium:potassium transporting ATPase subunit Get druggable targets OG5_131864 All targets in OG5_131864
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131864 All targets in OG5_131864
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0023 0.0167 0.0167
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0298 0.0596
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Echinococcus multilocularis musashi 0.003 0.0246 0.0246
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.3121 0.9413
Brugia malayi RNA, U transporter 1 0.0092 0.0931 0.2767
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0004
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0669 0.1338
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0167 0.0335
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0202 0.0451
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0331 0.0848
Schistosoma mansoni growth hormone secretagogue receptor 0.0023 0.0167 0.0335
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0167 0.0167
Onchocerca volvulus 0.0023 0.0167 0.0667
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0167 0.0167
Onchocerca volvulus Glucosylceramidase homolog 0.019 0.2017 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0077 0.0762 0.1524
Brugia malayi TAR-binding protein 0.0065 0.0632 0.1858
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0031 0.0249 0.0611
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0602 0.7327
Brugia malayi G-protein coupled receptor 0.0023 0.0167 0.0446
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0156 0.0156
Onchocerca volvulus 0.0022 0.0156 0.0611
Loa Loa (eye worm) hypothetical protein 0.0038 0.0335 0.0843
Schistosoma mansoni cpg binding protein 0.0032 0.0269 0.0537
Schistosoma mansoni hypothetical protein 0.019 0.2017 0.4034
Schistosoma mansoni histamine h1 receptor 0.0023 0.0167 0.0335
Brugia malayi Receptor family ligand binding region containing protein 0.0031 0.0249 0.0694
Onchocerca volvulus Huntingtin homolog 0.0126 0.1305 0.6407
Schistosoma mansoni lipoxygenase 0.0022 0.0156 0.0313
Echinococcus granulosus tachykinin peptides receptor 99D 0.0023 0.0167 0.0335
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0167 0.0167
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0023 0.0167 0.0335
Trypanosoma cruzi extracellular receptor, putative 0.0011 0.0035 0.0044
Loa Loa (eye worm) hypothetical protein 0.0125 0.1295 0.3424
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0167 0.0335
Echinococcus multilocularis lamin 0.003 0.0246 0.0246
Schistosoma mansoni lamin 0.003 0.0246 0.0493
Schistosoma mansoni amine GPCR 0.0023 0.0167 0.0335
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0023 0.0047
Schistosoma mansoni ran 0.0024 0.0175 0.0351
Schistosoma mansoni lipoxygenase 0.0062 0.0597 0.1195
Echinococcus granulosus cpg binding protein 0.0034 0.0289 0.0578
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0022 0.0022
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0391 0.6111
Echinococcus multilocularis g-protein coupled receptor 0.0023 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Schistosoma mansoni hypothetical protein 0.0038 0.0335 0.067
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.1498 0.2996
Schistosoma mansoni metabotropic glutamate receptor 0.01 0.1015 0.203
Echinococcus multilocularis snurportin 1 0.0346 0.3741 0.3741
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0131 0.0263
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0131 0.0263
Onchocerca volvulus 0.0125 0.1295 0.6358
Loa Loa (eye worm) RNA binding protein 0.0065 0.0632 0.1641
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0167 0.0335
Loa Loa (eye worm) hypothetical protein 0.003 0.0246 0.0604
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0125 0.1295 0.2591
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0077 0.0762 0.1524
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0107 0.0265
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0023 0.0167 0.0167
Onchocerca volvulus 0.0032 0.0269 0.1178
Schistosoma mansoni amine GPCR 0.0023 0.0167 0.0335
Onchocerca volvulus 0.0023 0.0167 0.0667
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Onchocerca volvulus 0.0023 0.0167 0.0667
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0125 0.1295 0.2591
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0035 0.0036
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0167 0.0167
Echinococcus multilocularis serotonin receptor 0.0023 0.0167 0.0167
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0628 1
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0011 0.0035 0.0045
Schistosoma mansoni inositol monophosphatase 0.0038 0.0331 0.0663
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Echinococcus granulosus 7TM GPCR rhodopsin 0.0023 0.0167 0.0335
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0419 0.1068
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.3121 0.9413
Echinococcus granulosus alpha 1A adrenergic receptor 0.0023 0.0167 0.0335
Plasmodium vivax importin-beta 2, putative 0.0032 0.027 0.5097
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0112 1
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0511 0.1724
Brugia malayi hypothetical protein 0.0023 0.0167 0.0446
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0023 0.0167 0.0335
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0531 0.1553
Echinococcus granulosus fmrfamide receptor 0.0023 0.0167 0.0335
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.029 0.3121 0.9419
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0419 0.0838
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0298 0.4577
Leishmania major squalene synthase, putative 0.0252 0.2701 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0077 0.0762 0.0762
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.2017 0.6024
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0035 0.007
Loa Loa (eye worm) hypothetical protein 0.0125 0.1295 0.3424
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0023 0.0167 0.0335
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0156 0.0313
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.027 0.4119
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Echinococcus granulosus neuropeptide FF receptor 2 0.0023 0.0167 0.0335
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0112 0.0175
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0091 0.0186
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.027 0.0812
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0298 0.0745
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0073 0.0073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0167 0.0167
Echinococcus multilocularis orexin receptor type 2 0.0023 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Schistosoma mansoni loxhd1 0.0022 0.0156 0.0313
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0167 0.0335
Echinococcus multilocularis dro:myosuppressin receptor 0.0023 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Mycobacterium ulcerans glutaminase 0.0308 0.3312 1
Schistosoma mansoni opsin-like receptor 0.0023 0.0167 0.0335
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0023 0.0167 0.0667
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0351 1
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0011 0.0035 0.0035
Brugia malayi hypothetical protein 0.0023 0.0167 0.0446
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0023 0.0167 0.0335
Echinococcus granulosus nmda type glutamate receptor 0.0011 0.0035 0.007
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0062 0.0597 0.1195
Schistosoma mansoni amine GPCR 0.0023 0.0167 0.0335
Trichomonas vaginalis ran, putative 0.0024 0.0175 0.0368
Loa Loa (eye worm) acetyltransferase 0.0148 0.1544 0.4092
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0112 0.0244
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0167 0.0335
Schistosoma mansoni adenoreceptor 0.0023 0.0167 0.0335
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0023 0.0167 0.0391
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Echinococcus granulosus nervana 2 0.0125 0.1295 0.2591
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0019 0.0125 0.0454
Schistosoma mansoni glutaminase 0.0308 0.3312 0.6624
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0531 0.137
Echinococcus multilocularis nervana 2 0.0077 0.0762 0.0762
Schistosoma mansoni opsin-like receptor 0.0023 0.0167 0.0335
Entamoeba histolytica recQ family DNA helicase 0.001 0.0023 0.0129
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.1544 0.3088
Schistosoma mansoni metabotropic glutamate receptor 0.0058 0.0553 0.1107
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0023 0.0167 0.0167
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0131 0.0337
Echinococcus granulosus receptor type guanylyl cyclase 0.0011 0.0035 0.007
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.2017 0.6024
Brugia malayi hypothetical protein 0.0022 0.0156 0.0413
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.1544 0.4628
Brugia malayi Melatonin receptor type 1A 0.0023 0.0167 0.0446
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0167 0.0335
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0167 0.0167
Echinococcus granulosus lamin 0.003 0.0246 0.0493
Echinococcus granulosus nervana 2 0.0077 0.0762 0.1524
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0167 0.0167
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0125 0.1295 0.1295
Brugia malayi neuropeptide F receptor 0.0023 0.0167 0.0446
Loa Loa (eye worm) hypothetical protein 0.0015 0.0073 0.0138
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0167 0.0335
Schistosoma mansoni hypothetical protein 0.0023 0.0167 0.0335
Loa Loa (eye worm) glutaminase 2 0.0308 0.3312 0.8847
Echinococcus granulosus G protein coupled receptor 139 0.0023 0.0167 0.0335
Schistosoma mansoni hypothetical protein 0.0024 0.018 0.0361
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0023 0.0167 0.0335
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0167 0.0335
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0167 0.0335
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0167 0.0335
Schistosoma mansoni myosin xvIII 0.0023 0.0167 0.0335
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0023 0.0167 0.0167
Echinococcus multilocularis neuropeptide FF receptor 2 0.0023 0.0167 0.0167
Echinococcus granulosus importin subunit beta 1 0.0032 0.027 0.054
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0167 0.0391
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0131 0.0361
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0175 0.0454
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.018 0.0361
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0298 0.0986
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0023 0.0087
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0121
Echinococcus granulosus peptide allatostatin:somatostatin 0.0023 0.0167 0.0335
Trichomonas vaginalis glucosylceramidase, putative 0.0201 0.2131 0.6372
Brugia malayi Tachykinin-like peptides receptor 99D 0.0023 0.0167 0.0446
Brugia malayi Guanylyl cyclase protein 23 0.0011 0.0035 0.0045
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0632 0.1641
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0156 0.0156
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0131 0.0233
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0131 0.0403
Brugia malayi follicle stimulating hormone receptor 0.0282 0.3026 0.9131
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0331 0.1044
Schistosoma mansoni inositol monophosphatase 0.0038 0.0331 0.0663
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.018 0.018
Brugia malayi larval opioid receptor 0.0023 0.0167 0.0446
Echinococcus granulosus sex peptide receptor 0.0023 0.0167 0.0335
Loa Loa (eye worm) melatonin receptor type 1A 0.0023 0.0167 0.0391
Schistosoma mansoni cpg binding protein 0.0034 0.0289 0.0578
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0112 0.028
Echinococcus granulosus allatostatin A receptor 0.0023 0.0167 0.0335
Echinococcus granulosus neuropeptide receptor 0.0023 0.0167 0.0335
Echinococcus multilocularis neuropeptide receptor A26 0.0023 0.0167 0.0167
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0156 0.0156
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.3121 0.9413
Schistosoma mansoni tyrosine kinase 0.0011 0.0035 0.007
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.2017 0.6024
Loa Loa (eye worm) hypothetical protein 0.0011 0.0035 0.0036
Echinococcus granulosus 7tm_1 domain containing protein 0.0023 0.0167 0.0335
Onchocerca volvulus 0.003 0.0246 0.1066
Echinococcus granulosus dro:myosuppressin receptor 0.0023 0.0167 0.0335
Loa Loa (eye worm) hypothetical protein 0.0011 0.0035 0.0036
Schistosoma mansoni hypothetical protein 0.046 0.5 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0298 0.0745
Onchocerca volvulus 0.0023 0.0167 0.0667
Echinococcus granulosus glutamate receptor 2 0.0011 0.0035 0.007
Echinococcus granulosus tar DNA binding protein 0.0065 0.0632 0.1264
Onchocerca volvulus 0.0023 0.0167 0.0667
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0035 0.007
Onchocerca volvulus 0.0023 0.0167 0.0667
Schistosoma mansoni hypothetical protein 0.0023 0.0167 0.0335
Schistosoma mansoni rab6-interacting 0.0022 0.0156 0.0313
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0175 0.0413
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0278
Schistosoma mansoni ran 0.0024 0.0175 0.0351
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0246 0.0604
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0419 0.0838
Entamoeba histolytica hypothetical protein 0.0011 0.0035 0.0482
Brugia malayi hypothetical protein 0.0023 0.0167 0.0446
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Echinococcus granulosus lamin dm0 0.003 0.0246 0.0493
Echinococcus multilocularis cpg binding protein 0.0034 0.0289 0.0289
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0419 0.0838
Loa Loa (eye worm) hypothetical protein 0.0022 0.0156 0.0362
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0023 0.0167 0.0391
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0112 0.0112
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0112 0.029
Schistosoma mansoni biogenic amine receptor 0.0023 0.0167 0.0335
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0167 0.0391
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0511 0.8081
Echinococcus multilocularis receptor type guanylyl cyclase 0.0011 0.0035 0.0035
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0298 0.0745
Brugia malayi RE15519p 0.0023 0.0167 0.0446
Brugia malayi putative neuropeptide receptor NPR1 0.0023 0.0167 0.0446
Schistosoma mansoni hypothetical protein 0.0018 0.0107 0.0215
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0023 0.0167 0.0335
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0202 0.0451
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0346 0.3741 1
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0602 0.1204
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0167 0.0335
Entamoeba histolytica hypothetical protein 0.0026 0.0202 0.5509
Brugia malayi RNA binding protein 0.0065 0.0632 0.1858
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0511 0.1822
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0282 0.3026 0.8078
Brugia malayi Serotonin receptor 0.0023 0.0167 0.0446
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0167 0.0335
Schistosoma mansoni hypothetical protein 0.0018 0.0107 0.0215
Echinococcus multilocularis nmda type glutamate receptor 0.0011 0.0035 0.0035
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0011 0.0035 0.007
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0167 0.0335
Schistosoma mansoni neuropeptide receptor 0.0023 0.0167 0.0335
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0602 0.2127
Loa Loa (eye worm) hypothetical protein 0.0126 0.1305 0.345
Echinococcus granulosus orexin receptor type 2 0.0023 0.0167 0.0335
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Echinococcus granulosus neuropeptide s receptor 0.0023 0.0167 0.0335
Schistosoma mansoni hypothetical protein 0.0346 0.3741 0.7482
Onchocerca volvulus 0.0022 0.0156 0.0611
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0331 0.0685
Onchocerca volvulus 0.0077 0.0762 0.3667
Onchocerca volvulus Poor gastrulation protein homolog 0.0019 0.0125 0.0454
Schistosoma mansoni hypothetical protein 0.019 0.2017 0.4034
Schistosoma mansoni neuropeptide receptor 0.0023 0.0167 0.0335
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0167 0.0167
Brugia malayi GnHR receptor homolog 0.0023 0.0167 0.0446
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.027 0.0812
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.1654 0.4962
Onchocerca volvulus 0.0023 0.0167 0.0667
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0331 0.1151
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.1654 0.3307
Echinococcus multilocularis metabotropic glutamate receptor 2 0.01 0.1015 0.1015
Brugia malayi hypothetical protein 0.0126 0.1305 0.3903
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0131 0.0233
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0131 0.0131
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0391 0.7563
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0112 0.2807
Brugia malayi neuropeptide F receptor 0.0023 0.0167 0.0446
Schistosoma mansoni transmemberane protein 0.0125 0.1295 0.2591
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0055 0.0075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0167 0.0335
Loa Loa (eye worm) hypothetical protein 0.0011 0.0035 0.0036
Onchocerca volvulus 0.0023 0.0167 0.0667
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0031 0.0249 0.0611
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0167 0.0167
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0107 0.0107
Schistosoma mansoni alpha-1 adrenergic receptor 0.0023 0.0167 0.0335
Echinococcus granulosus g protein coupled receptor 0.0023 0.0167 0.0335
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0112 0.0225
Plasmodium falciparum importin beta, putative 0.0032 0.027 0.3951
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0107 0.0215
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0246 0.0687
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0156 0.0313
Echinococcus multilocularis somatostatin receptor 0.0023 0.0167 0.0167
Onchocerca volvulus 0.0023 0.0167 0.0667
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0298 0.8391
Brugia malayi hypothetical protein 0.0023 0.0167 0.0446
Brugia malayi G protein-coupled receptor F59B2.13 0.0023 0.0167 0.0446
Brugia malayi Dopamine receptor protein 2 0.0023 0.0167 0.0446
Echinococcus multilocularis geminin 0.019 0.2017 0.2017
Echinococcus multilocularis tyrosine kinase 0.0011 0.0035 0.0035
Brugia malayi glutaminase DH11.1 0.0308 0.3312 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0632 0.1858
Schistosoma mansoni protein kinase 0.0011 0.0035 0.007
Echinococcus granulosus intermediate filament protein 0.003 0.0246 0.0493
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0632 0.0632
Schistosoma mansoni hypothetical protein 0.0023 0.0167 0.0335
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0023 0.0167 0.0167
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0167 0.0335
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0131 0.0474
Onchocerca volvulus 0.0023 0.0167 0.0667
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0269 0.0663
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0022 0.0044
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0331 0.0331
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0035 0.0035
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0298 0.0745
Schistosoma mansoni hypothetical protein 0.0023 0.0167 0.0335
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0035 0.0035
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0167 0.0167
Echinococcus granulosus GPCR family 2 0.0018 0.0107 0.0215
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0079 0.0781 0.3762
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Brugia malayi hypothetical protein 0.0035 0.0299 0.0845
Schistosoma mansoni neuropeptide f receptor 76f 0.0023 0.0167 0.0335
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0023 0.0167 0.0335
Echinococcus granulosus somatostatin receptor 0.0023 0.0167 0.0335
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Echinococcus multilocularis RUN 0.0022 0.0156 0.0156
Trichomonas vaginalis glucosylceramidase, putative 0.0201 0.2131 0.6372
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.1654 0.4388
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0602 0.0602
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0632 0.1264
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0175 0.1576
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0167 0.0335
Schistosoma mansoni alpha glucosidase 0.0035 0.0298 0.0596
Onchocerca volvulus 0.003 0.0246 0.1066
Echinococcus granulosus neuropeptide receptor 0.0023 0.0167 0.0335
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0035 0.0036
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0023 0.0167 0.0391
Echinococcus multilocularis glutamate receptor 2 0.0011 0.0035 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0632 0.1264
Trypanosoma cruzi phytoene synthase, putative 0.0079 0.0781 0.2829
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0419 0.0838
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1654 0.1654
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0298 0.0745
Echinococcus granulosus nervana 2 0.0077 0.0762 0.1524
Echinococcus granulosus serotonin receptor 0.0023 0.0167 0.0335
Leishmania major importin beta-1 subunit, putative 0.0026 0.0202 0.0626
Loa Loa (eye worm) glutamate receptor 0.0119 0.1229 0.3245
Echinococcus granulosus metabotropic glutamate receptor 5 0.0147 0.1533 0.3067
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0131 0.0131
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0167 0.0391
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0112 0.0332
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0175 0.0471
Schistosoma mansoni DNA helicase recq5 0.002 0.0131 0.0263
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0121
Leishmania major hypothetical protein, conserved 0.0079 0.0781 0.2797
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0055 0.0119
Echinococcus multilocularis sex peptide receptor 0.0023 0.0167 0.0167
Brugia malayi sulfakinin receptor protein 0.0023 0.0167 0.0446
Echinococcus granulosus glutamate receptor 2 0.0011 0.0035 0.007
Brugia malayi ORL1-like opioid receptor 0.0023 0.0167 0.0446
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0035 0.0036
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0331 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0023 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.002 0.0131 0.0294
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0023 0.0167 0.0335
Schistosoma mansoni lamin 0.003 0.0246 0.0493
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0011 0.0035 0.0035
Schistosoma mansoni cpg binding protein 0.0034 0.0289 0.0578
Onchocerca volvulus 0.0023 0.0167 0.0667
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0077 0.0762 0.1524
Loa Loa (eye worm) hypothetical protein 0.0018 0.0107 0.023
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0125 0.1295 0.1295
Onchocerca volvulus Neuropeptide F receptor homolog 0.0023 0.0167 0.0667
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0023 0.0167 0.0446
Echinococcus granulosus bloom syndrome protein 0.002 0.0131 0.0263
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.2017 0.6024
Schistosoma mansoni amine GPCR 0.0023 0.0167 0.0335
Loa Loa (eye worm) hypothetical protein 0.0011 0.0035 0.0036
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0167 0.0167
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0167 0.0335
Brugia malayi metabotropic glutamate receptor type 2 0.0058 0.0553 0.1619
Toxoplasma gondii exonuclease III APE 0.0018 0.0112 0.1531
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0167 0.0335
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0023 0.0167 0.0446
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0167 0.0335
Loa Loa (eye worm) hypothetical protein 0.0011 0.0035 0.0036
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0167 0.0335
Schistosoma mansoni polycystin 1-related 0.0022 0.0156 0.0313
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0055 0.0119
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0055 0.0106
Brugia malayi Serotonin receptor 0.0023 0.0167 0.0446
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0298 0.0742
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0419 0.1211
Echinococcus granulosus snurportin 1 0.0346 0.3741 0.7482
Echinococcus multilocularis glutamate receptor 2 0.0011 0.0035 0.0035
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0135 0.1409 0.2819
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0531 0.1553
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0167 0.0167
Schistosoma mansoni hypothetical protein 0.0079 0.0781 0.1561
Loa Loa (eye worm) hypothetical protein 0.0011 0.0035 0.0036
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0023 0.0167 0.0446
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0167 0.0167
Schistosoma mansoni amine GPCR 0.0023 0.0167 0.0335
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0112 0.0332
Brugia malayi hypothetical protein 0.0011 0.0035 0.0045
Brugia malayi hypothetical protein 0.0023 0.0167 0.0446
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0112 0.0216
Onchocerca volvulus 0.0023 0.0167 0.0667
Echinococcus multilocularis G-protein coupled receptor, putative 0.0023 0.0167 0.0167
Schistosoma mansoni hypothetical protein 0.0018 0.0107 0.0215
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0156 0.2787
Schistosoma mansoni glutamate receptor NMDA 0.0011 0.0035 0.007
Loa Loa (eye worm) glutamate receptor 0.0047 0.043 0.1096
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0167 0.0335
Brugia malayi Dopamine receptor 0.0023 0.0167 0.0446
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0632 0.1264
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0167 0.0335
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0287 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0167 0.0167
Echinococcus multilocularis nervana 2 0.0077 0.0762 0.0762
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0131 0.0337
Brugia malayi Metabotropic glutamate receptor precursor. 0.0119 0.1229 0.3671
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0298 0.0843
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0298 0.0745
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0131 0.0791
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0331 0.1151
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0125 0.1295 0.2591
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0167 0.0335
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Echinococcus granulosus dnaJ subfamily B 0.046 0.5 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0419 0.0419
Leishmania major GTP-binding protein, putative 0.0024 0.0175 0.0526
Schistosoma mansoni ap endonuclease 0.0018 0.0112 0.0225
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0131 0.0233
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0167 0.0167
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0167 0.0335
Loa Loa (eye worm) hypothetical protein 0.0126 0.1305 0.345
Loa Loa (eye worm) hypothetical protein 0.0054 0.0511 0.1316
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0112 0.0175
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0331 0.0663
Loa Loa (eye worm) hypothetical protein 0.003 0.024 0.0587
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0331 0.0848
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0167 0.0391
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0023 0.0167 0.0335
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0167 0.0335
Brugia malayi intermediate filament protein 0.003 0.0246 0.0687
Onchocerca volvulus 0.0023 0.0167 0.0667
Schistosoma mansoni opsin-like receptor 0.0023 0.0167 0.0335
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Loa Loa (eye worm) hypothetical protein 0.0056 0.0531 0.137
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0167 0.0335
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0331 0.0848
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.3121 0.9413
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Echinococcus granulosus Squalene phytoene synthase 0.0079 0.0781 0.1561
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0131 0.0287
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0391 0.0783
Brugia malayi hypothetical protein 0.0023 0.0167 0.0446
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.3121 0.9413
Loa Loa (eye worm) hypothetical protein 0.0022 0.0156 0.0362
Schistosoma mansoni ap endonuclease 0.0018 0.0112 0.0225
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.0667
Brugia malayi Dopamine receptor protein 1 0.0023 0.0167 0.0446
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0035 0.007
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0331 0.9401
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0167 0.0335
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0335 0.0956
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0419 0.0419
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0602 0.153
Echinococcus multilocularis allatostatin A receptor 0.0023 0.0167 0.0167
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0632 0.1264
Brugia malayi G-protein coupled receptor 0.0023 0.0167 0.0446
Schistosoma mansoni hypothetical protein 0.0018 0.0107 0.0215
Loa Loa (eye worm) glutaminase 0.0308 0.3312 0.8847
Echinococcus multilocularis G protein coupled receptor 139 0.0023 0.0167 0.0167
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0131 0.0337
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0131 0.1842
Echinococcus multilocularis serotonin receptor 0.0023 0.0167 0.0167
Brugia malayi AKH receptor 0.0023 0.0167 0.0446
Echinococcus granulosus g protein coupled receptor 0.0023 0.0167 0.0335
Onchocerca volvulus 0.0091 0.0919 0.446
Schistosoma mansoni importin beta-1 0.0032 0.027 0.054
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.3121 0.9413
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0055 0.1087
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0298 0.1025
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0167 0.0167
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0023 0.0167 0.0167
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0511 0.1822
Brugia malayi Importin beta-1 subunit 0.0032 0.027 0.0758
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0019 0.0038
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0175 0.3172
Schistosoma mansoni hypothetical protein 0.0022 0.0156 0.0313
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0298 0.0745
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0004
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0079 0.0781 1
Echinococcus granulosus metabotropic glutamate receptor 2 0.01 0.1015 0.203
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0167 0.0167
Echinococcus granulosus tyrosine kinase 0.0011 0.0035 0.007
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.029 0.3121 0.8333
Brugia malayi hypothetical protein 0.0023 0.0167 0.0446
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0511 1
Onchocerca volvulus 0.0023 0.0167 0.0667
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0131 0.0474
Trypanosoma brucei glucosidase, putative 0.0035 0.0298 0.0917
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0602 0.1204
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0167 0.0167
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0023 0.007
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0112 0.1895
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0167 0.0335
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0602 0.1204
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0287 0.2619
Brugia malayi hypothetical protein 0.0023 0.0167 0.0446
Schistosoma mansoni alpha-glucosidase 0.0136 0.1411 0.2822
Schistosoma mansoni hypothetical protein 0.0019 0.0125 0.025
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0167 0.0167
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0175 0.0567
Echinococcus granulosus g-protein coupled receptor 0.0023 0.0167 0.0335
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0107 0.0107
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0147 0.1533 0.1533
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0167 0.0335
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0511 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.1533 0.4064
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0062 0.0597 0.0597
Brugia malayi hypothetical protein 0.0023 0.0167 0.0446
Echinococcus granulosus nervana 2 0.0125 0.1295 0.2591
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0131 0.0294
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0023 0.0167 0.0446
Loa Loa (eye worm) hypothetical protein 0.0011 0.0035 0.0036
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0131 0.1842
Trypanosoma cruzi squalene synthase, putative 0.0252 0.2701 1
Onchocerca volvulus Huntingtin homolog 0.0126 0.1305 0.6407
Echinococcus granulosus neuropeptide receptor A26 0.0023 0.0167 0.0335
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0175 0.0567
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0351 0.599
Echinococcus granulosus geminin 0.019 0.2017 0.4034
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0023 0.0167 0.0446
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0167 0.0335
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0167 0.0335
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0023 0.0167 0.0391
Echinococcus multilocularis dnaJ subfamily B 0.046 0.5 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0023 0.0167 0.0167
Echinococcus multilocularis GPCR, family 2 0.0018 0.0107 0.0107
Entamoeba histolytica Ran family GTPase 0.0024 0.0175 0.47
Schistosoma mansoni DNA helicase recq1 0.002 0.0131 0.0263
Schistosoma mansoni tyrosine kinase 0.0011 0.0035 0.007
Schistosoma mansoni biogenic amine receptor 0.0023 0.0167 0.0335
Schistosoma mansoni alpha-glucosidase 0.0136 0.1411 0.2822
Echinococcus multilocularis lamin dm0 0.003 0.0246 0.0246
Echinococcus granulosus atrial natriuretic peptide receptor 0.0011 0.0035 0.007
Schistosoma mansoni intermediate filament proteins 0.003 0.0246 0.0493
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.1544 0.1544
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0175 0.2632
Brugia malayi G protein-coupled receptor 0.0023 0.0167 0.0446
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0107 0.0265
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.1654 0.1654
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0175 0.0175
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0108 0.1105 0.3295
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0298 0.0745
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0167 0.0167
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0511 1
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0602 0.9571
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0391 0.1032
Echinococcus granulosus RUN 0.0022 0.0156 0.0313
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0391 0.1032
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0125 0.1295 0.2591
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0055 0.0102
Loa Loa (eye worm) TYRA-2 protein 0.0023 0.0167 0.0391
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0167 0.0167
Brugia malayi hypothetical protein 0.0054 0.0511 0.1491
Mycobacterium ulcerans phytoene synthase, CrtB 0.0079 0.0781 0.2089
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0602 0.153
Echinococcus multilocularis importin subunit beta 1 0.0032 0.027 0.027
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0602 0.153
Echinococcus multilocularis bloom syndrome protein 0.002 0.0131 0.0131
Loa Loa (eye worm) intermediate filament protein 0.003 0.0246 0.0604
Echinococcus multilocularis nervana 2 0.0125 0.1295 0.1295
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0011 0.0035 0.0036
Echinococcus granulosus GPCR family 3 C terminal 0.0019 0.0125 0.025
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0331 0.1112
Trypanosoma cruzi squalene synthase, putative 0.0252 0.2701 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Loa Loa (eye worm) inositol-1 0.0038 0.0331 0.0833
Brugia malayi hypothetical protein 0.0023 0.0167 0.0446
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0023 0.0167 0.0335
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0167 0.0167
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0202 0.0668
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0073 0.0146
Loa Loa (eye worm) RecQ helicase 0.002 0.0131 0.0294
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0091 0.0214
Onchocerca volvulus 0.0023 0.0167 0.0667
Brugia malayi Doublecortin family protein 0.0022 0.0156 0.0413
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Onchocerca volvulus 0.0023 0.0167 0.0667
Echinococcus multilocularis Squalene phytoene synthase 0.0079 0.0781 0.0781
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0107 0.023
Echinococcus multilocularis GPCR, family 3, C terminal 0.0019 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Schistosoma mansoni biogenic amine receptor 0.0023 0.0167 0.0335
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0632 0.1264
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0156 0.1101
Brugia malayi hypothetical protein 0.0022 0.0156 0.0413
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0167 0.0335
Schistosoma mansoni neuropeptide receptor 0.0023 0.0167 0.0335
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0035 0.0035
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0351 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0156 0.0313
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0107 0.0215
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0167 0.0335
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0391 0.6111
Trypanosoma brucei squalene synthase, putative 0.0252 0.2701 1
Leishmania major hypothetical protein, conserved 0.0054 0.0511 0.1786
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0419 0.0838
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0167 0.0335
Schistosoma mansoni neuropeptide receptor 0.0023 0.0167 0.0335
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0167 0.0167
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0331 0.5128
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0156 0.0362
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.2017 0.6024
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0298 0.0745
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0175 0.0351
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0019 0.0125 0.0318
Echinococcus granulosus hypothetical protein 0.0023 0.0167 0.0335
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0125 0.1295 0.1295
Brugia malayi Receptor family ligand binding region containing protein 0.0011 0.0035 0.0045
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Echinococcus granulosus g protein coupled receptor 0.0023 0.0167 0.0335
Loa Loa (eye worm) hypothetical protein 0.0031 0.0249 0.0611
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0298 0.0298
Echinococcus multilocularis neuropeptide s receptor 0.0023 0.0167 0.0167
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0175 0.2564
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0298 0.1025
Brugia malayi putative neuropeptide receptor 0.0023 0.0167 0.0446
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0202 0.0451
Trichomonas vaginalis glutaminase, putative 0.0308 0.3312 1
Entamoeba histolytica recQ family helicase, putative 0.002 0.0131 0.3376
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0167 0.0335
Loa Loa (eye worm) hypothetical protein 0.0013 0.0055 0.009
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0632 0.1641
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0167 0.0335
Brugia malayi Inositol-1 0.0038 0.0331 0.0945
Echinococcus multilocularis nervana 2 0.0125 0.1295 0.1295
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0391
Onchocerca volvulus 0.0023 0.0167 0.0667
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0125 0.1295 0.2591
Schistosoma mansoni rab6-interacting 0.0022 0.0156 0.0313
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0167 0.0335
Loa Loa (eye worm) hypothetical protein 0.0079 0.0781 0.2041
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0298 0.8391
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.2017 0.6024
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.2017 0.6024
Brugia malayi CXXC zinc finger family protein 0.0032 0.0269 0.0754
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0023 0.0167 0.0335

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1 uM Binding affinity towards Na+,K+ -ATPase isolated from dog kidney. ChEMBL. 11689068

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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