Detailed information for compound 272968

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 542.707 | Formula: C19H22K3O7PS
  • H donors: 0 H acceptors: 6 LogP: 2.74 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCc1cccc(c1)Oc1cccc(c1)CCCC(S(=O)(=O)[O-])P(=O)([O-])[O-].[K+].[K+].[K+]
  • InChi: 1S/C19H25O7PS.3K/c1-2-6-15-7-3-10-17(13-15)26-18-11-4-8-16(14-18)9-5-12-19(27(20,21)22)28(23,24)25;;;/h3-4,7-8,10-11,13-14,19H,2,5-6,9,12H2,1H3,(H2,20,21,22)(H,23,24,25);;;/q;3*+1/p-3
  • InChiKey: KWCMPDMWBCWRHM-UHFFFAOYSA-K  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Squalene synthetase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Trypanosoma congolense squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Trypanosoma brucei squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Trypanosoma congolense squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Trypanosoma congolense squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Candida albicans squalene synthase similar to S. cerevisiae ERG9 (YHR190W) involved in ergosterol biosynthesis Get druggable targets OG5_129470 All targets in OG5_129470
Leishmania mexicana farnesyltransferase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Leishmania braziliensis squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Trypanosoma cruzi squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Leishmania infantum squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Trypanosoma brucei gambiense farnesyltransferase, putative,squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Candida albicans squalene synthase similar to S. cerevisiae ERG9 (YHR190W) involved in ergosterol biosynthesis Get druggable targets OG5_129470 All targets in OG5_129470
Leishmania major squalene synthase, putative Get druggable targets OG5_129470 All targets in OG5_129470
Leishmania donovani farnesyltransferase, putative Get druggable targets OG5_129470 All targets in OG5_129470
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Protein patched homolog 0.0026 0.0054 0.0405
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0097 0.0071
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0121 0.0413 0.1344
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Brugia malayi beta-lactamase 0.0121 0.0413 0.1344
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0036 0.0536
Brugia malayi hypothetical protein 0.0032 0.0075 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0092 0.1389
Entamoeba histolytica hypothetical protein 0.0032 0.0075 0.0444
Brugia malayi Patched related family protein 10 0.0026 0.0054 0.014
Loa Loa (eye worm) hypothetical protein 0.0102 0.0343 0.111
Mycobacterium tuberculosis Probable esterase LipL 0.0121 0.0413 0.1194
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0038 0.0098 0.033
Onchocerca volvulus 0.0121 0.0413 0.3929
Leishmania major squalene synthase, putative 0.07 0.2622 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0112 0.0335
Entamoeba histolytica acyl-CoA synthetase, putative 0.0129 0.0443 0.2737
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0038 0.0097 0.0095
Entamoeba histolytica hypothetical protein 0.0121 0.0413 0.2547
Schistosoma mansoni hypothetical protein 0.0016 0.0015 0.0013
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0038 0.0097 0.0095
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0073 0.0204
Toxoplasma gondii patched family protein 0.0026 0.0054 0.0104
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0012 0.0002
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0214 0.0211
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0097 0.0095
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0078 0.0084
Loa Loa (eye worm) hypothetical protein 0.0027 0.0057 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0083 0.1253
Echinococcus multilocularis nibrin 0.0032 0.0075 0.0072
Schistosoma mansoni hypothetical protein 0.0033 0.0078 0.0084
Onchocerca volvulus 0.0038 0.0097 0.0831
Mycobacterium tuberculosis Conserved protein 0.0121 0.0413 0.1194
Brugia malayi hypothetical protein 0.0026 0.0054 0.014
Mycobacterium tuberculosis Conserved protein 0.0121 0.0413 0.1194
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0038 0.0097 0.0095
Brugia malayi Patched related family protein 4 0.0026 0.0054 0.014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0134 0.0148
Brugia malayi protein C24B5.3 0.0026 0.0054 0.014
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0012 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0057 0.0852
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0038 0.0097 0.0285
Trichomonas vaginalis antibiotic synthetase, putative 0.0038 0.0097 0.146
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0036 0.0536
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0083 0.1253
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0075 0.113
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0065 0.007
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0083 0.0594
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0012 0.0184
Schistosoma mansoni hypothetical protein 0.018 0.0638 0.0719
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0012 0.0177
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Echinococcus multilocularis netrin receptor unc 5 0.0034 0.0081 0.0078
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0038 0.0097 0.0071
Brugia malayi Patched family protein 0.0026 0.0054 0.014
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0075 0.0242
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0026 0.0054
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0128 0.0389
Loa Loa (eye worm) hypothetical protein 0.0058 0.0172 0.0538
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0212
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0078 0.0221
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0091 0.0299 0.079
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.003 0.003
Brugia malayi Patched family protein 0.0026 0.0054 0.014
Mycobacterium tuberculosis Conserved protein 0.0121 0.0413 0.1194
Loa Loa (eye worm) hypothetical protein 0.0121 0.0413 0.1344
Loa Loa (eye worm) patched family protein 0.0026 0.0054 0.014
Entamoeba histolytica hypothetical protein 0.0121 0.0413 0.2547
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0112 0.1685
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0012 0.0002
Mycobacterium ulcerans hypothetical protein 0.0129 0.0443 0.1595
Trypanosoma cruzi squalene synthase, putative 0.07 0.2622 1
Brugia malayi hypothetical protein 0.0798 0.2999 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0047 0.0714
Echinococcus multilocularis expressed conserved protein 0.0408 0.1509 0.1507
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0032 0.0075 0.113
Schistosoma mansoni topbp1 0.0032 0.0075 0.0081
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0112 0.0335
Brugia malayi Patched family protein 0.0026 0.0054 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0058 0.0868
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0032 0.0075 0.113
Brugia malayi Bromodomain containing protein 0.004 0.0107 0.032
Schistosoma mansoni hypothetical protein 0.0071 0.0222 0.0248
Echinococcus granulosus Niemann Pick C1 protein 0.0621 0.2321 0.2622
Onchocerca volvulus 0.0038 0.0097 0.0831
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0121 0.0413 0.0463
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.0669 0.0666
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0048 0.0716
Brugia malayi AMP-binding enzyme family protein 0.0038 0.0097 0.0285
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0134 0.0408
Plasmodium falciparum lipid/sterol:H+ symporter 0.0026 0.0054 0.1578
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Trypanosoma cruzi FHA domain containing protein, putative 0.0032 0.0075 0.0242
Loa Loa (eye worm) hypothetical protein 0.0096 0.0319 0.103
Schistosoma mansoni cpg binding protein 0.0095 0.0317 0.0355
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0038 0.0097 0.0095
Trichomonas vaginalis penicillin-binding protein, putative 0.0121 0.0413 0.6222
Echinococcus granulosus tar DNA binding protein 0.014 0.0488 0.0548
Schistosoma mansoni tar DNA-binding protein 0.014 0.0488 0.0548
Echinococcus multilocularis expressed protein 0.0039 0.0101 0.0098
Echinococcus granulosus nibrin 0.0032 0.0075 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0036 0.0536
Onchocerca volvulus 0.0026 0.0054 0.0405
Leishmania major hypothetical protein, conserved 0.0283 0.1033 0.3911
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0047 0.0119
Echinococcus multilocularis cpg binding protein 0.0103 0.0346 0.0343
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0075 0.113
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0036 0.0082
Schistosoma mansoni lamin 0.0059 0.0177 0.0196
Plasmodium falciparum replication factor C subunit 1, putative 0.0032 0.0075 0.2259
Brugia malayi hypothetical protein 0.0026 0.0054 0.014
Loa Loa (eye worm) RNA binding protein 0.014 0.0488 0.1594
Brugia malayi Patched family protein 0.0026 0.0054 0.014
Echinococcus multilocularis dnaJ subfamily B 0.0947 0.3566 0.3564
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Plasmodium falciparum importin beta, putative 0.0034 0.0081 0.2449
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0347 0.1122
Brugia malayi Bromodomain containing protein 0.0085 0.0276 0.0885
Brugia malayi Glycosyl hydrolases family 31 protein 0.0188 0.0669 0.22
Schistosoma mansoni importin beta-1 0.0034 0.0081 0.0088
Echinococcus granulosus dual specificity 0.0103 0.0345 0.0387
Echinococcus multilocularis protein patched 0.0186 0.0664 0.0661
Schistosoma mansoni alpha-glucosidase 0.0162 0.0569 0.064
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0112 0.1068
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.003 0.0027
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0022 0.0019
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0078 0.0084
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0012 0.0002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0036 0.0536
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0047 0.0044
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0057 0.0856
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Plasmodium vivax patched family protein, putative 0.0026 0.0054 0.0171
Loa Loa (eye worm) hypothetical protein 0.0121 0.0413 0.1344
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0103 0.0345 0.1278
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.007 0.1061
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0222 0.0704
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0223 0.0639
Plasmodium vivax acetyl-CoA synthetase, putative 0.0038 0.0097 0.1359
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0771 0.2893 1
Echinococcus granulosus snurportin 1 0.0358 0.1319 0.1489
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0285
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0036 0.0536
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0134 0.0148
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0012 0.0184
Schistosoma mansoni tar DNA-binding protein 0.014 0.0488 0.0548
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.0121 0.0413 0.1344
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0036 0.0536
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0038 0.0097 0.0071
Schistosoma mansoni netrin receptor unc5 0.0034 0.0081 0.0088
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0038 0.0097 0.0327
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0036 0.0536
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0285
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0212
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0044 0.004
Plasmodium vivax hypothetical protein, conserved 0.0121 0.0413 1
Onchocerca volvulus 0.0026 0.0054 0.0405
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0081 0.0265
Schistosoma mansoni DNA ligase IV 0.0032 0.0075 0.0081
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0121 0.0413 0.0464
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0036 0.0536
Loa Loa (eye worm) hypothetical protein 0.0129 0.0443 0.1445
Loa Loa (eye worm) hypothetical protein 0.0798 0.2999 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0083 0.1253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0047 0.0714
Entamoeba histolytica protein kinase, putative 0.0103 0.0345 0.2126
Trichomonas vaginalis ran, putative 0.0025 0.0047 0.0711
Loa Loa (eye worm) hypothetical protein 0.0034 0.0081 0.0232
Mycobacterium ulcerans acyl-CoA synthetase 0.0129 0.0443 0.1595
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0092 0.1389
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0214 0.0239
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0065 0.0483
Echinococcus multilocularis dual specificity 0.0103 0.0345 0.0342
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0128 0.0446
Echinococcus granulosus lamin 0.0059 0.0177 0.0196
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0039 0.0101 0.03
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0012 0.0177
Plasmodium vivax importin-beta 2, putative 0.0034 0.0081 0.0923
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0065 0.0204
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0065 0.1939
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0129 0.0443 0.1595
Loa Loa (eye worm) hypothetical protein 0.0034 0.0081 0.0232
Entamoeba histolytica Ran family GTPase 0.0025 0.0047 0.0271
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0128 0.0141
Trypanosoma brucei squalene synthase, putative 0.07 0.2622 1
Trichomonas vaginalis rotamase, putative 0.0039 0.0101 0.1525
Echinococcus multilocularis lamin dm0 0.0059 0.0177 0.0173
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Loa Loa (eye worm) patched family protein 0.0026 0.0054 0.014
Brugia malayi RNA binding protein 0.014 0.0488 0.1594
Schistosoma mansoni myst-related protein 0.0013 0.0004 0.0001
Schistosoma mansoni rotamase 0.0039 0.0101 0.0111
Trypanosoma cruzi ISWI complex protein 0.0016 0.0015 0.0011
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0186 0.0664 0.2184
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0112 0.1685
Loa Loa (eye worm) beta-lactamase 0.0121 0.0413 0.1344
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0038 0.0097 0.0095
Loa Loa (eye worm) hypothetical protein 0.0028 0.0061 0.0165
Leishmania major acetyl-CoA synthetase, putative 0.0038 0.0097 0.0327
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0012 0.0002
Brugia malayi Importin beta-1 subunit 0.0034 0.0081 0.0232
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0097 0.0071
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0039 0.0101 0.03
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0048 0.0716
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0036 0.0536
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0066 0.0071
Entamoeba histolytica protein kinase, putative 0.0103 0.0345 0.2126
Mycobacterium tuberculosis Probable hydrolase 0.0121 0.0413 0.1194
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0022 0.0021
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0038 0.0097 0.0285
Echinococcus multilocularis microtubule associated protein 2 0.233 0.8842 0.8842
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0036 0.0536
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0328 0.1205 0.1202
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0038 0.0097 0.0596
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0097 0.0095
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0012 0.001
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0038 0.0097 0.0095
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0098 0.0095
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0112 0.0674
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0083 0.1253
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0032 0.0075 0.113
Brugia malayi hypothetical protein 0.0121 0.0413 0.1343
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0129 0.0443 0.1595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0058 0.0868
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0097 0.0095
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0034 0.0082 0.0089
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.0669 0.0666
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0128 0.0446
Onchocerca volvulus 0.0026 0.0054 0.0405
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0091 0.0299 0.079
Brugia malayi Patched protein homolog 1 0.0026 0.0054 0.014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Leishmania major acetyl-CoA synthetase, putative 0.0038 0.0097 0.0327
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0038 0.0098 0.033
Loa Loa (eye worm) hypothetical protein 0.0075 0.0238 0.0758
Schistosoma mansoni hypothetical protein 0.0121 0.0413 0.0463
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0002
Plasmodium vivax acyl-CoA synthetase, putative 0.0096 0.0319 0.7436
Brugia malayi beta-lactamase family protein 0.0121 0.0413 0.1344
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0129 0.0443 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0108 0.0321
Loa Loa (eye worm) patched family protein 0.0026 0.0054 0.014
Schistosoma mansoni hypothetical protein 0.0033 0.0078 0.0084
Entamoeba histolytica acyl-coA synthetase, putative 0.0129 0.0443 0.2737
Mycobacterium tuberculosis Probable lipase LipE 0.0121 0.0413 0.1194
Trichomonas vaginalis replication factor C large subunit, putative 0.0032 0.0075 0.113
Schistosoma mansoni alpha glucosidase 0.0042 0.0112 0.0123
Onchocerca volvulus 0.0059 0.0177 0.1611
Toxoplasma gondii hypothetical protein 0.0026 0.0054 0.0104
Brugia malayi Patched related family protein 12 0.0026 0.0054 0.014
Echinococcus granulosus lysosomal alpha glucosidase 0.0188 0.0669 0.0753
Echinococcus granulosus survival motor neuron protein 1 0.0798 0.2999 0.3389
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Toxoplasma gondii patched family protein 0.0026 0.0054 0.0104
Echinococcus multilocularis survival motor neuron protein 1 0.0798 0.2999 0.2997
Entamoeba histolytica protein kinase domain containing protein 0.0103 0.0345 0.2126
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0103 0.0345 0.1278
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0128 0.0141
Trichomonas vaginalis esterase, putative 0.0121 0.0413 0.6222
Treponema pallidum DNA ligase (lig) 0.0032 0.0075 0.5
Schistosoma mansoni hypothetical protein 0.0358 0.1319 0.1489
Echinococcus granulosus Protein patched homolog 1 0.0186 0.0664 0.0748
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0103 0.0345 0.1278
Loa Loa (eye worm) hypothetical protein 0.0102 0.0343 0.111
Leishmania major hypothetical protein, conserved 0.0121 0.0413 0.1538
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0128 0.0774
Brugia malayi Patched family protein 0.0026 0.0054 0.014
Echinococcus multilocularis replication factor c subunit 1 0.0032 0.0075 0.0072
Loa Loa (eye worm) hypothetical protein 0.0096 0.0319 0.103
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0112 0.0123
Echinococcus multilocularis zinc finger protein 0.0026 0.0053 0.005
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0092 0.0309
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.0234
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0223 0.0639
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0038 0.0097 0.0581
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0347 0.1122
Trypanosoma brucei hypothetical protein, conserved 0.0121 0.0413 0.1538
Echinococcus multilocularis lamin 0.0059 0.0177 0.0173
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0034 0.0081 0.0232
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0223 0.0639
Onchocerca volvulus 0.0095 0.0317 0.299
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0044 0.0046
Trypanosoma cruzi squalene synthase, putative 0.07 0.2622 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0146 0.0449
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0081 0.0558
Schistosoma mansoni hypothetical protein 0.0163 0.0574 0.0646
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0065 0.1939
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0128 0.0774
Loa Loa (eye worm) hypothetical protein 0.0029 0.0065 0.0178
Entamoeba histolytica acyl-CoA synthetase, putative 0.0129 0.0443 0.2737
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0223 0.0219
Loa Loa (eye worm) TAR-binding protein 0.014 0.0488 0.1594
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Echinococcus multilocularis Niemann Pick C1 protein 0.0621 0.2321 0.2318
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0091 0.0299 0.079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0083 0.1253
Leishmania major GTP-binding protein, putative 0.0025 0.0047 0.0136
Mycobacterium ulcerans esterase/lipase LipP 0.0121 0.0413 0.1465
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0078 0.0074
Brugia malayi Patched family protein 0.0026 0.0054 0.014
Brugia malayi Protein kinase domain containing protein 0.0103 0.0345 0.1116
Brugia malayi Death domain containing protein 0.0034 0.0081 0.0232
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0112 0.0384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0057 0.0852
Schistosoma mansoni acetyl-CoA synthetase 0.0038 0.0097 0.0106
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0034 0.0081 0.0078
Echinococcus granulosus mixed lineage leukemia protein mll 0.0024 0.0044 0.0046
Brugia malayi intermediate filament protein 0.0059 0.0177 0.0552
Leishmania major 4-coumarate:coa ligase-like protein 0.0129 0.0443 0.1653
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0032 0.0075 0.0242
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.014 0.0488 0.1594
Echinococcus multilocularis GPCR, family 2 0.0033 0.0078 0.0074
Loa Loa (eye worm) hypothetical protein 0.0033 0.0078 0.0221
Schistosoma mansoni hypothetical protein 0.0022 0.0036 0.0037
Brugia malayi CXXC zinc finger family protein 0.0095 0.0317 0.1023
Mycobacterium leprae conserved hypothetical protein 0.0121 0.0413 0.9183
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0075 0.113
Loa Loa (eye worm) histone methyltransferase 0.003 0.0066 0.0181
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0121 0.0413 0.1344
Loa Loa (eye worm) CXXC zinc finger family protein 0.0095 0.0317 0.1023
Echinococcus granulosus intermediate filament protein 0.0059 0.0177 0.0196
Trypanosoma cruzi ISWI complex protein 0.0016 0.0015 0.0011
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0073 0.0204
Mycobacterium ulcerans beta-lactamase 0.0121 0.0413 0.1465
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0092 0.1389
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0038 0.0097 0.0094
Brugia malayi RNA recognition motif domain containing protein 0.014 0.0488 0.1594
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0097 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0128 0.1929
Brugia malayi Immunoglobulin I-set domain containing protein 0.0034 0.0081 0.0232
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0061 0.0065
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0223 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0036 0.0536
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0047 0.005
Brugia malayi hypothetical protein 0.0026 0.0054 0.014
Echinococcus granulosus importin subunit beta 1 0.0034 0.0081 0.0088
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0038 0.0097 0.0327
Toxoplasma gondii patched family protein 0.0026 0.0054 0.0104
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0036 0.0536
Loa Loa (eye worm) hypothetical protein 0.0434 0.161 0.535
Trichomonas vaginalis penicillin-binding protein, putative 0.0121 0.0413 0.6222
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0024 0.0042
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0038 0.0097 0.0327
Echinococcus multilocularis Niemann Pick C1 protein 0.0434 0.161 0.1607
Brugia malayi AMP-binding enzyme family protein 0.0129 0.0443 0.1445
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0047 0.1379
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0223 0.0248
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0012 0.0184
Loa Loa (eye worm) patched family protein 0.0026 0.0054 0.014
Loa Loa (eye worm) hypothetical protein 0.0059 0.0177 0.0552
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0078 0.0221
Schistosoma mansoni ran 0.0025 0.0047 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0036 0.0536
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0188 0.0669 0.22
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0036 0.0092
Echinococcus granulosus dnaJ subfamily B 0.0947 0.3566 0.4031
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0066 0.0063
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0112 0.0384
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0637 0.2384 0.8192
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0134 0.0408
Schistosoma mansoni cpg binding protein 0.0103 0.0346 0.0388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0058 0.0868
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0134 0.013
Brugia malayi Myosin head containing protein 0.0026 0.0054 0.014
Leishmania major 4-coumarate:coa ligase-like protein 0.0129 0.0443 0.1653
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0112 0.1685
Brugia malayi Patched family protein 0.0026 0.0054 0.014
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0434 0.161 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0038 0.0097 0.0071
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0032 0.0075 0.0242
Trypanosoma brucei ISWI complex protein 0.0016 0.0015 0.0011
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0081 0.0265
Schistosoma mansoni transcription factor LCR-F1 0.0121 0.0413 0.0463
Onchocerca volvulus 0.0121 0.0413 0.3929
Entamoeba histolytica hypothetical protein 0.0103 0.0345 0.2126
Onchocerca volvulus 0.0129 0.0443 0.4224
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0016 0.0012 0.0053
Echinococcus granulosus GPCR family 2 0.0033 0.0078 0.0084
Schistosoma mansoni ran 0.0025 0.0047 0.005
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0112 0.1685
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0098 0.033
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0112 0.1685
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0012 0.0002
Schistosoma mansoni topbp1 0.0032 0.0075 0.0081
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0223 0.0248
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Schistosoma mansoni tar DNA-binding protein 0.014 0.0488 0.0548
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0092 0.0309
Echinococcus granulosus microtubule associated protein 2 0.233 0.8842 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0134 0.013
Onchocerca volvulus 0.0026 0.0054 0.0405
Schistosoma mansoni ankyrin 23/unc44 0.0034 0.0081 0.0088
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0038 0.0097 0.0596
Echinococcus multilocularis musashi 0.0059 0.0177 0.0173
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0097 0.0095
Trichomonas vaginalis D-aminoacylase, putative 0.0121 0.0413 0.6222
Loa Loa (eye worm) hypothetical protein 0.0096 0.0319 0.103
Brugia malayi Patched family protein 0.0026 0.0054 0.014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Echinococcus granulosus Ankyrin 0.0034 0.0082 0.0089
Schistosoma mansoni tar DNA-binding protein 0.014 0.0488 0.0548
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Trypanosoma cruzi phytoene synthase, putative 0.0283 0.1033 0.3911
Trypanosoma cruzi hypothetical protein, conserved 0.0121 0.0413 0.1538
Onchocerca volvulus 0.0109 0.0367 0.3478
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0065 0.0061
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0047 0.0136
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0097 0.0095
Brugia malayi Patched family protein 0.0026 0.0054 0.014
Mycobacterium ulcerans hypothetical protein 0.0121 0.0413 0.1465
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0075 0.113
Echinococcus multilocularis Squalene phytoene synthase 0.0283 0.1033 0.103
Schistosoma mansoni lamin 0.0059 0.0177 0.0196
Loa Loa (eye worm) hypothetical protein 0.0121 0.0413 0.1344
Onchocerca volvulus 0.0163 0.0574 0.5508
Brugia malayi TAR-binding protein 0.014 0.0488 0.1594
Onchocerca volvulus Protein patched homolog 0.0026 0.0054 0.0405
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0012 0.0184
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0022 0.0021
Schistosoma mansoni chromosome transmission fidelity factor 0.0032 0.0075 0.0081
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0212
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0032 0.0075 0.0459
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0047 0.0714
Schistosoma mansoni hypothetical protein 0.0283 0.1033 0.1165
Plasmodium vivax replication factor C subunit 1, putative 0.0032 0.0075 0.0759
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0038 0.0097 0.0071
Schistosoma mansoni cpg binding protein 0.0103 0.0346 0.0388
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0038 0.0097 0.0071
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0177 0.0552
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0177 0.0552
Brugia malayi PHD-finger family protein 0.0032 0.0074 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0067 0.1004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0083 0.1253
Onchocerca volvulus 0.0026 0.0054 0.0405
Entamoeba histolytica hypothetical protein 0.0027 0.0057 0.0331
Mycobacterium leprae Probable lipase LipE 0.0121 0.0413 0.9183
Loa Loa (eye worm) oxidoreductase 0.0038 0.0097 0.0285
Schistosoma mansoni survival motor neuron protein 0.0163 0.0574 0.0646
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0103 0.0345 0.1116
Leishmania major hypothetical protein, conserved 0.0016 0.0015 0.0011
Echinococcus multilocularis protein dispatched 1 0.0213 0.0765 0.0762
Toxoplasma gondii ABC1 family protein 0.0121 0.0413 0.6045
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0012 0.0184
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0057 0.0856
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.003 0.003
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0081 0.0078
Loa Loa (eye worm) hypothetical protein 0.0043 0.0117 0.0353
Leishmania major 4-coumarate:coa ligase-like protein 0.0129 0.0443 0.1653
Echinococcus granulosus zinc finger protein 0.0026 0.0053 0.0056
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.003 0.003
Brugia malayi AMP-binding enzyme family protein 0.0038 0.0097 0.0285
Toxoplasma gondii ATPase, AAA family protein 0.0032 0.0075 0.0459
Onchocerca volvulus Netrin receptor homolog 0.0034 0.0081 0.0675
Schistosoma mansoni hypothetical protein 0.018 0.0638 0.0719
Trichomonas vaginalis D-aminoacylase, putative 0.0121 0.0413 0.6222
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.0129 0.0443 0.1445
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0096 0.0319 0.1058
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Toxoplasma gondii patched family protein 0.0026 0.0054 0.0104
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0065 0.0292
Schistosoma mansoni microtubule-associated protein tau 0.233 0.8842 1
Schistosoma mansoni tar DNA-binding protein 0.014 0.0488 0.0548
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0078 0.0221
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0112 0.0109
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0112 0.0674
Echinococcus multilocularis beta LACTamase domain containing family member 0.0121 0.0413 0.041
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0038 0.0097 0.0285
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0097 0.0095
Mycobacterium ulcerans acyl-CoA synthetase 0.0129 0.0443 0.1595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0092 0.1389
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0128 0.0446
Loa Loa (eye worm) hypothetical protein 0.0027 0.0057 0.0151
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0032 0.0075 0.0212
Echinococcus granulosus replication factor c subunit 1 0.0032 0.0075 0.0081
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0047 0.0136
Brugia malayi hypothetical protein 0.0032 0.0075 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0012 0.0177
Onchocerca volvulus 0.0026 0.0054 0.0405
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0121 0.0413 0.0464
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0097 0.0071
Brugia malayi Niemann-Pick C1 protein precursor 0.0434 0.161 0.535
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0121 0.0413 0.1194
Mycobacterium ulcerans acyl-CoA synthetase 0.0129 0.0443 0.1595
Schistosoma mansoni hypothetical protein 0.0947 0.3566 0.4031
Trichomonas vaginalis conserved hypothetical protein 0.0186 0.0664 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0347 0.1122
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0038 0.0097 0.0596
Echinococcus granulosus Niemann Pick C1 protein 0.0434 0.161 0.1818
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0038 0.0097 0.2955
Brugia malayi AMP-binding enzyme family protein 0.0038 0.0097 0.0285
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0032 0.0075 0.5
Loa Loa (eye worm) hypothetical protein 0.0071 0.0222 0.0704
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0129 0.0443 0.1301
Schistosoma mansoni patched 1 0.0186 0.0664 0.0748
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0038 0.0097 0.0071
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0121 0.0413 0.1465
Schistosoma mansoni zinc finger protein 0.0026 0.0053 0.0056
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0129 0.0443 0.1595
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0358 0.1319 0.4377
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0129 0.0443 1
Entamoeba histolytica hypothetical protein 0.0121 0.0413 0.2547
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0096 0.0319 0.0861
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0112 0.1685
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0098 0.033
Brugia malayi hypothetical protein 0.0029 0.0065 0.0178
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0121 0.0413 0.1194
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0097 0.0071
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0038 0.0097 0.0822
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0047 0.0119
Brugia malayi Uncoordinated protein 44 0.0034 0.0081 0.0232
Brugia malayi Patched family protein 0.0026 0.0054 0.014
Schistosoma mansoni hypothetical protein 0.018 0.0638 0.0719
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0098 0.0586
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0223 0.0517
Loa Loa (eye worm) hypothetical protein 0.0121 0.0413 0.1344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0048 0.0716
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0112 0.1685
Echinococcus granulosus nuclear factor of activated T cells 5 0.0328 0.1205 0.136
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0038 0.0097 0.0071
Brugia malayi DKFZp564C0469 protein 0.0032 0.0075 0.0212
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0098 0.0107
Brugia malayi Patched family protein 0.0026 0.0054 0.014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0203 0.0726 0.0817
Trichomonas vaginalis rotamase, putative 0.0038 0.0098 0.1473
Loa Loa (eye worm) hypothetical protein 0.0096 0.0319 0.103
Brugia malayi Patched family protein 0.0026 0.0054 0.014
Leishmania major importin beta-1 subunit, putative 0.0027 0.0057 0.0173
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0038 0.0097 0.0327
Schistosoma mansoni hypothetical protein 0.0033 0.0078 0.0084
Loa Loa (eye worm) hypothetical protein 0.0283 0.1033 0.3418
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0121 0.0413 0.1194
Entamoeba histolytica hypothetical protein 0.0121 0.0413 0.2547
Brugia malayi topoisomerase 0.0032 0.0075 0.0212
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0061 0.0058
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0032 0.0075 0.0444
Leishmania major hypothetical protein, conserved 0.0029 0.0065 0.0204
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Brugia malayi hypothetical protein 0.0026 0.0054 0.014
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0121 0.0413 0.041
Schistosoma mansoni bromodomain containing protein 0.0072 0.0229 0.0255
Toxoplasma gondii peptidylprolyl isomerase 0.0038 0.0098 0.0835
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0134 0.0148
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0065 0.007
Echinococcus granulosus expressed protein 0.0039 0.0101 0.0111
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0065 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0128 0.1929
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0034 0.0081 0.0088
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0044 0.0046
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0038 0.0097 0.0285
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0345 0.0387
Trichomonas vaginalis antibiotic synthetase, putative 0.0038 0.0097 0.146
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0036 0.0536
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0128 0.0446
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0024 0.0044 0.004
Onchocerca volvulus 0.0032 0.0075 0.0616
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0128 0.0446
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0078 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0075 0.113
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0129 0.0443 0.1595
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Echinococcus granulosus Squalene phytoene synthase 0.0283 0.1033 0.1165
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0065 0.0204
Brugia malayi hypothetical protein 0.0019 0.0025 0.0045
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0038 0.0097 0.0095
Echinococcus multilocularis sterol regulatory element binding protein 0.0186 0.0664 0.0661
Brugia malayi Protein kinase domain containing protein 0.0034 0.0083 0.0239
Echinococcus granulosus cpg binding protein 0.0103 0.0346 0.0388
Schistosoma mansoni hypothetical protein 0.018 0.0638 0.0719
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0128 0.1929
Brugia malayi AMP-binding enzyme family protein 0.0129 0.0443 0.1445
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0012 0.0009
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0223 0.2896
Brugia malayi Pax transcription activation domain interacting protein 0.0032 0.0075 0.0212
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0096 0.0319 1
Mycobacterium ulcerans phytoene synthase, CrtB 0.0637 0.2384 1
Onchocerca volvulus 0.0038 0.0097 0.0831
Schistosoma mansoni intermediate filament proteins 0.0059 0.0177 0.0196
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0072 0.0202
Brugia malayi AMP-binding enzyme family protein 0.0038 0.0097 0.0285
Schistosoma mansoni myst-related protein 0.0013 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0212
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0223 0.0808
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0012 0.001
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0112 0.1685
Echinococcus multilocularis snurportin 1 0.0358 0.1319 0.1317
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0032 0.0075 0.113
Schistosoma mansoni hypothetical protein 0.0033 0.0078 0.0084
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0177 0.0552
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0091 0.0299 0.079
Brugia malayi AMP-binding enzyme family protein 0.0129 0.0443 0.1445
Giardia lamblia Replication factor C, subunit 1 0.0032 0.0075 0.3437
Trichomonas vaginalis helicase, putative 0.0022 0.0036 0.0536
Onchocerca volvulus 0.0026 0.0054 0.0405
Onchocerca volvulus 0.0121 0.0413 0.3929
Echinococcus granulosus sterol regulatory element binding protein 0.0186 0.0664 0.0748
Brugia malayi CHE-14 protein 0.0186 0.0664 0.2184
Loa Loa (eye worm) hypothetical protein 0.0121 0.0413 0.1344
Echinococcus multilocularis tar DNA binding protein 0.014 0.0488 0.0485
Toxoplasma gondii histone lysine methyltransferase SET1 0.0183 0.0653 1
Schistosoma mansoni hypothetical protein 0.0034 0.0081 0.0088
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0036 0.0536
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0092 0.0309
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0038 0.0097 0.0327
Loa Loa (eye worm) hypothetical protein 0.0103 0.0347 0.1122
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0128 0.0446
Trichomonas vaginalis D-aminoacylase, putative 0.0121 0.0413 0.6222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0012 0.0177
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0038 0.0097 0.0822
Brugia malayi beta-lactamase family protein 0.0121 0.0413 0.1344
Brugia malayi Patched family protein 0.0026 0.0054 0.014
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0075 0.0242
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0129 0.0443 0.1301
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0097 0.0095
Echinococcus granulosus netrin receptor unc 5 0.0034 0.0081 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0036 0.0536
Brugia malayi protein C24B5.3 0.0026 0.0054 0.014
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0441 0.1635 0.1847
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0134 0.0148
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0038 0.0097 0.0327
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0128 0.0125
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0163 0.0574 0.1883
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0012 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0048 0.0716
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0083 0.1253
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0038 0.0097 0.0106
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.006
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0012 0.0184
Echinococcus granulosus beta LACTamase domain containing family member 0.0121 0.0413 0.0464
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0101 0.1525
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0057 0.0856
Echinococcus granulosus death domain containing protein 0.0034 0.0081 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0102 0.1543
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0057 0.0173
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0134 0.0148
Loa Loa (eye worm) hypothetical protein 0.0129 0.0443 0.1445
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0036 0.0536
Loa Loa (eye worm) hypothetical protein 0.0186 0.0664 0.2184
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0112 0.1685
Loa Loa (eye worm) hypothetical protein 0.0096 0.0319 0.103
Brugia malayi Patched family protein 0.0026 0.0054 0.014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Brugia malayi Patched family protein 0.0026 0.0054 0.014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0212
Trypanosoma brucei glucosidase, putative 0.0042 0.0112 0.0384
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0038 0.0097 0.0327
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0103 0.0345 0.1278
Echinococcus granulosus lamin dm0 0.0059 0.0177 0.0196
Onchocerca volvulus 0.0038 0.0097 0.0831
Schistosoma mansoni zinc finger protein 0.0016 0.0015 0.0013
Schistosoma mansoni alpha-glucosidase 0.0162 0.0569 0.064
Echinococcus granulosus expressed conserved protein 0.0408 0.1509 0.1704
Echinococcus multilocularis Ankyrin 0.0034 0.0082 0.0078
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0092 0.1389
Brugia malayi RNA, U transporter 1 0.0095 0.0317 0.1022
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0283 0.1033 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0054 0.014
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0047 0.0136
Plasmodium falciparum acyl-CoA synthetase 0.0096 0.0319 1
Loa Loa (eye worm) hypothetical protein 0.0228 0.0824 0.2719
Onchocerca volvulus 0.0059 0.0177 0.1611
Mycobacterium tuberculosis Probable lipase LipD 0.0121 0.0413 0.1194
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0038 0.0097 0.0095
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0012 0.0184
Giardia lamblia GTOR 0.0046 0.0128 1
Loa Loa (eye worm) patched family protein 0.0026 0.0054 0.014
Mycobacterium ulcerans lipase LipD 0.0121 0.0413 0.1465
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0128 0.0389
Toxoplasma gondii propionate-CoA ligase 0.0038 0.0097 0.0822
Mycobacterium ulcerans acetyl-CoA synthetase 0.0038 0.0097 0.0095
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0112 0.0384
Trypanosoma cruzi hypothetical protein, conserved 0.0121 0.0413 0.1538

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6900 nM Inhibitory activity against rat liver microsomal squalene synthase was determined using [3H]-FPP as radioligand ChEMBL. 8576905
IC50 (binding) = 6900 nM Inhibitory activity against rat liver microsomal squalene synthase was determined using [3H]-FPP as radioligand ChEMBL. 8576905

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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