Detailed information for compound 160931

Basic information

Technical information
  • TDR Targets ID: 160931
  • Name: (2R)-2-[[2-[[(2R)-1,3-dihydroxy-1-oxopropan-2 -yl]carbamoyl]benzoyl]amino]-3-hydroxypropano ic acid
  • MW: 340.285 | Formula: C14H16N2O8
  • H donors: 6 H acceptors: 8 LogP: -1.63 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H](C(=O)O)NC(=O)c1ccccc1C(=O)N[C@@H](C(=O)O)CO
  • InChi: 1S/C14H16N2O8/c17-5-9(13(21)22)15-11(19)7-3-1-2-4-8(7)12(20)16-10(6-18)14(23)24/h1-4,9-10,17-18H,5-6H2,(H,15,19)(H,16,20)(H,21,22)(H,23,24)/t9-,10-/m1/s1
  • InChiKey: OQRLJAJUULRPPX-NXEZZACHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R)-3-hydroxy-2-[[2-[[(1R)-2-hydroxy-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]benzoyl]amino]propanoic acid
  • (2R)-3-hydroxy-2-[[[2-[[[(1R)-2-hydroxy-1-(hydroxymethyl)-2-oxoethyl]amino]-oxomethyl]phenyl]-oxomethyl]amino]propanoic acid
  • (2R)-2-[[2-[[(2R)-1,3-dihydroxy-1-oxo-propan-2-yl]carbamoyl]phenyl]carbonylamino]-3-hydroxy-propanoic acid
  • (2R)-3-hydroxy-2-[[2-[[(1R)-2-hydroxy-2-keto-1-methylol-ethyl]carbamoyl]benzoyl]amino]propionic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.2623 0.2656
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Echinococcus granulosus nAChR subunit 0.0042 0.024 0.024
Mycobacterium tuberculosis Probable oxidoreductase 0.0274 0.242 0.9759
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0306 0.0566
Plasmodium falciparum histone deacetylase, putative 0.1066 0.9868 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0163 0.0162
Echinococcus multilocularis phd:f box containing protein 0.0034 0.0163 0.0163
Echinococcus granulosus Chromobox protein 3 0.0022 0.0054 0.0054
Plasmodium vivax heterochromatin protein 1, putative 0.0022 0.0054 0.0052
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0055 0.0361 0.0361
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0054 0.0096
Schistosoma mansoni nAChR subunit 0.0036 0.0183 0.0183
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0078 0.058 0.058
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Loa Loa (eye worm) CHromoDomain protein family member 0.0024 0.0072 0.007
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0078 0.058 0.0586
Onchocerca volvulus 0.0055 0.0361 0.0808
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0035 0.0173 0.0173
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0306 0.0308
Plasmodium vivax histone deacetylase 1, putative 0.0587 0.5364 0.5435
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0019 0.0017
Echinococcus granulosus pyruvate kinase 0.0018 0.0017 0.0017
Onchocerca volvulus 0.0022 0.0054 0.0075
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0054 0.0096
Echinococcus granulosus glycine receptor subunit beta 0.0078 0.058 0.058
Trypanosoma brucei histone deacetylase 4 0.1066 0.9868 1
Schistosoma mansoni acetylcholine receptor-related 0.0036 0.0183 0.0183
Plasmodium falciparum histone deacetylase 2 0.1066 0.9868 1
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0181 0.0332
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0574 0.5238 0.9763
Echinococcus granulosus serotonin transporter 0.006 0.0412 0.0412
Brugia malayi larval opioid receptor 0.0055 0.0361 0.0363
Toxoplasma gondii histone deacetylase HDAC5 0.0276 0.2438 0.2469
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0039 0.0036
Loa Loa (eye worm) hypothetical protein 0.0037 0.0196 0.0196
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0361 0.0361
Leishmania major pyruvate kinase 0.0036 0.0181 0.018
Loa Loa (eye worm) hypothetical protein 0.0078 0.058 0.0586
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0451 0.0454
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0163 0.0162
Loa Loa (eye worm) hypothetical protein 0.0149 0.1246 0.126
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0022 0.002
Brugia malayi Pre-SET motif family protein 0.0059 0.0394 0.0397
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0354 0.0656
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0039 0.0036
Onchocerca volvulus 0.0149 0.1246 0.2918
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0039 0.0036
Leishmania major histone deacetylase, putative 0.0587 0.5364 0.5435
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0054 0.0096
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0738 0.0738
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0055 0.0361 0.0361
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0181 0.0583
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0039 0.0036
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0017 0.0003 0.0003
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0181 0.018
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0078 0.058 0.0586
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0173 0.0173
Leishmania major DNA polymerase kappa, putative 0.0021 0.0039 0.0036
Brugia malayi AKH receptor 0.0055 0.0361 0.0363
Echinococcus multilocularis allatostatin A receptor 0.0055 0.0361 0.0361
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0574 0.5238 0.9763
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0039 0.0036
Schistosoma mansoni adenoreceptor 0.0055 0.0361 0.0361
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0034 0.0163 0.0162
Loa Loa (eye worm) hypothetical protein 0.0042 0.024 0.0241
Onchocerca volvulus 0.0055 0.0361 0.0808
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0079 0.0141
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0361 0.0361
Echinococcus granulosus orexin receptor type 2 0.0055 0.0361 0.0361
Brugia malayi Melatonin receptor type 1A 0.0055 0.0361 0.0363
Echinococcus multilocularis neuropeptide receptor A26 0.05 0.4539 0.4539
Loa Loa (eye worm) hypothetical protein 0.0042 0.0235 0.0235
Trypanosoma brucei squalene synthase, putative 0.0283 0.2508 0.254
Brugia malayi jmjC domain containing protein 0.0034 0.0163 0.0162
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Loa Loa (eye worm) hypothetical protein 0.0036 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0587 0.5364 0.5435
Echinococcus multilocularis peregrin 0.006 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0291 0.2575 0.2607
Brugia malayi Bromodomain containing protein 0.0037 0.0195 0.0195
Loa Loa (eye worm) TYRA-2 protein 0.0055 0.0361 0.0363
Loa Loa (eye worm) hypothetical protein 0.0395 0.3553 0.3598
Schistosoma mansoni hypothetical protein 0.0055 0.0361 0.0361
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0042 0.024 0.0241
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0039 0.0036
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0055 0.0361 0.0363
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0039 0.0036
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0361 0.0361
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0181 0.018
Echinococcus granulosus g protein coupled receptor 0.0055 0.0361 0.0361
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0181 0.018
Onchocerca volvulus 0.0055 0.0361 0.0808
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0055 0.0361 0.0363
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0039 0.0036
Schistosoma mansoni ran 0.0021 0.0039 0.0039
Echinococcus granulosus peregrin 0.006 0.0403 0.0403
Leishmania major DNA polymerase eta, putative 0.0021 0.0039 0.0036
Loa Loa (eye worm) hypothetical protein 0.0078 0.058 0.0586
Onchocerca volvulus 0.0055 0.0361 0.0808
Loa Loa (eye worm) hypothetical protein 0.0078 0.058 0.0586
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0034 0.0163 0.0163
Onchocerca volvulus 0.006 0.0409 0.0922
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0072 0.007
Trypanosoma brucei histone deacetylase, putative 0.1066 0.9868 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0401 0.1485
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0054 0.0096
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0022 0.0054 0.0052
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0033 0.003
Schistosoma mansoni hypothetical protein 0.0022 0.0054 0.0054
Trypanosoma cruzi histone deacetylase, putative 0.0276 0.2438 0.2469
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0017 0.0003 0.0003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0054 0.0096
Onchocerca volvulus Histone deacetylase 10 homolog 0.0276 0.2438 0.5763
Echinococcus multilocularis histone deacetylase 0.1066 0.9868 0.9868
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0451 0.0454
Echinococcus multilocularis PHD finger protein rhinoceros 0.0057 0.0381 0.0381
Brugia malayi jmjC domain containing protein 0.0245 0.2151 0.2178
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0361 0.0363
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0053 0.0345 0.0345
Brugia malayi Doublecortin family protein 0.0019 0.0022 0.002
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.2623 0.2656
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0039 0.0039
Trichomonas vaginalis histone deacetylase, putative 0.0587 0.5364 1
Brugia malayi Dopamine receptor protein 1 0.0499 0.4532 0.4591
Brugia malayi PHD-finger family protein 0.0024 0.0072 0.007
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0381 0.0384
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0039 0.0036
Schistosoma mansoni jumonji domain containing protein 0.0207 0.1789 0.1789
Schistosoma mansoni polycystin 1-related 0.0019 0.0022 0.0022
Schistosoma mansoni amine GPCR 0.0055 0.0361 0.0361
Echinococcus granulosus dna polymerase eta 0.0021 0.0039 0.0039
Leishmania major squalene synthase, putative 0.0283 0.2508 0.254
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0055 0.0361 0.0363
Loa Loa (eye worm) hypothetical protein 0.0036 0.0181 0.018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0394 0.0394
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0361 0.0361
Brugia malayi CHD4 protein 0.0024 0.0072 0.007
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0179 0.0179
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0306 0.0308
Loa Loa (eye worm) solute carrier family 6 member 4 0.006 0.0412 0.0415
Brugia malayi neuropeptide F receptor 0.0055 0.0361 0.0363
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1159 0.1172
Echinococcus granulosus jumonji domain containing 1A 0.0034 0.0163 0.0163
Onchocerca volvulus 0.0036 0.0183 0.0384
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Echinococcus granulosus fmrfamide receptor 0.0055 0.0361 0.0361
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0039 0.0036
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0022 0.0054 0.0054
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0078 0.058 0.058
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0451 0.0836
Echinococcus multilocularis tyrosine protein kinase Abl 0.0084 0.0632 0.0632
Echinococcus multilocularis chromobox protein 2 0.0022 0.0054 0.0054
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0181 0.0583
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0409 0.3684 0.3732
Trichomonas vaginalis histone deacetylase, putative 0.0587 0.5364 1
Echinococcus granulosus glycine receptor subunit beta 0.0078 0.058 0.058
Loa Loa (eye worm) heterochromatin protein 1 0.0137 0.1131 0.1143
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0179 0.0329
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0306 0.0308
Schistosoma mansoni pyruvate kinase 0.0036 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0078 0.058 0.0586
Echinococcus granulosus g-protein coupled receptor 0.0055 0.0361 0.0361
Schistosoma mansoni zinc finger protein 0.0019 0.0023 0.0023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0075 0.0551 0.0551
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0017 0.0003 0.0003
Echinococcus granulosus pyruvate kinase 0.0018 0.0017 0.0017
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0361 0.0361
Leishmania major C-8 sterol isomerase-like protein 0.0395 0.3553 0.3598
Loa Loa (eye worm) hypothetical protein 0.0036 0.0183 0.0183
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0179 0.0179
Echinococcus granulosus sex peptide receptor 0.0055 0.0361 0.0361
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0361 0.0361
Echinococcus multilocularis pyruvate kinase 0.0018 0.0017 0.0017
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0006 0.0003
Echinococcus granulosus 7tm_1 domain containing protein 0.0055 0.0361 0.0361
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0078 0.058 0.0586
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0039 0.0036
Plasmodium falciparum JmjC domain-containing protein, putative 0.0034 0.0163 0.0162
Echinococcus multilocularis jumonji domain containing protein 0.008 0.0592 0.0592
Brugia malayi hypothetical protein 0.0055 0.0361 0.0363
Echinococcus granulosus neuropeptide receptor 0.0055 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0415
Loa Loa (eye worm) hypothetical protein 0.0034 0.0163 0.0162
Trypanosoma brucei histone deacetylase 2 0.0276 0.2438 0.2469
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0181 0.018
Echinococcus multilocularis sex peptide receptor 0.0055 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0069 0.0493 0.0497
Brugia malayi histone deacetylase 11 0.0276 0.2438 0.2469
Brugia malayi Dopamine receptor 0.0055 0.0361 0.0363
Schistosoma mansoni nAChR subunit 0.0078 0.058 0.058
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0293 0.0293
Echinococcus granulosus histone deacetylase 1 0.0587 0.5364 0.5364
Echinococcus granulosus histone deacetylase 3 0.0587 0.5364 0.5364
Echinococcus granulosus muscleblind protein 0.0291 0.2575 0.2575
Trichomonas vaginalis histone deacetylase, putative 0.0587 0.5364 1
Schistosoma mansoni bromodomain containing protein 0.0062 0.0424 0.0424
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0078 0.058 0.0586
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0234 0.0235
Brugia malayi hypothetical protein 0.0019 0.0022 0.002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0738 0.0738
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0587 0.5364 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.058 0.0586
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0054 0.0096
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0055 0.0361 0.0361
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0361 0.0361
Echinococcus multilocularis histone deacetylase 1 0.0587 0.5364 0.5364
Brugia malayi hypothetical protein 0.0055 0.0361 0.0363
Trichomonas vaginalis ran, putative 0.0021 0.0039 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0054 0.0096
Brugia malayi chromobox protein homolog 3 0.0077 0.0565 0.057
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0022 0.0054 0.0052
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0179 0.0179
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.005 0.005
Loa Loa (eye worm) GABA receptor subunit 0.0042 0.024 0.0241
Brugia malayi Muscleblind-like protein 0.0291 0.2575 0.2607
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0078 0.058 0.0586
Brugia malayi Protein cec-1. 0.0022 0.0054 0.0052
Trypanosoma cruzi histone deacetylase 1, putative 0.0587 0.5364 0.5435
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0054 0.0096
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0022 0.0054 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0054 0.0096
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0078 0.058 0.0586
Schistosoma mansoni DNA polymerase eta 0.0021 0.0039 0.0039
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0078 0.058 0.058
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0078 0.058 0.058
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0039 0.0036
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0055 0.0361 0.0361
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0036 0.018 0.018
Echinococcus multilocularis histone deacetylase 6 0.1066 0.9868 0.9868
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0451 0.0451
Schistosoma mansoni nAChR subunit 0.0078 0.058 0.058
Echinococcus granulosus chromobox protein 1 0.0137 0.1131 0.1131
Trypanosoma cruzi histone deacetylase 1, putative 0.0587 0.5364 0.5435
Trypanosoma cruzi phytoene synthase, putative 0.0088 0.0674 0.068
Schistosoma mansoni opsin-like receptor 0.0055 0.0361 0.0361
Brugia malayi sulfakinin receptor protein 0.0055 0.0361 0.0363
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0361 0.0361
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.005 0.005
Brugia malayi Pre-SET motif family protein 0.0409 0.3684 0.3732
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0361 0.0361
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.1308 0.5202
Plasmodium vivax SET domain protein, putative 0.0059 0.0394 0.0397
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0361 0.0361
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0179 0.0179
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0401 0.0404
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0078 0.058 0.0586
Leishmania major pyruvate kinase 0.0036 0.0181 0.018
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0149 0.1246 0.1246
Loa Loa (eye worm) hypothetical protein 0.0036 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0361 0.0361
Echinococcus granulosus tachykinin peptides receptor 99D 0.0055 0.0361 0.0361
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0017 0.0003 0.0003
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0361 0.0361
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0042 0.024 0.0241
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0078 0.058 0.058
Leishmania major importin beta-1 subunit, putative 0.0023 0.0059 0.0057
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0179 0.0179
Loa Loa (eye worm) serotonin transporter b 0.006 0.0412 0.0415
Brugia malayi hypothetical protein 0.0022 0.0054 0.0052
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0055 0.0361 0.0361
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0361 0.0361
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0361 0.0361
Echinococcus multilocularis orexin receptor type 2 0.0055 0.0361 0.0361
Entamoeba histolytica hypothetical protein 0.0022 0.0054 0.0096
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0036 0.0183 0.0183
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0587 0.5364 1
Schistosoma mansoni hypothetical protein 0.002 0.0033 0.0033
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0181 0.0377
Loa Loa (eye worm) hypothetical protein 0.0042 0.024 0.0241
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Schistosoma mansoni amine GPCR 0.0055 0.0361 0.0361
Schistosoma mansoni tyrosine kinase 0.0203 0.175 0.175
Echinococcus multilocularis serotonin receptor 0.0055 0.0361 0.0361
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0181 0.0377
Brugia malayi Associated with TFs and helicases family protein 0.0022 0.0054 0.0052
Schistosoma mansoni chromobox protein 0.0022 0.0054 0.0054
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0055 0.0361 0.0808
Loa Loa (eye worm) hypothetical protein 0.0088 0.0674 0.068
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.0361 0.0361
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0149 0.1246 0.126
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0022 0.0054 0.0054
Echinococcus multilocularis tumor protein p63 0.0326 0.2912 0.2912
Loa Loa (eye worm) TK/ABL protein kinase 0.0206 0.1778 0.1799
Loa Loa (eye worm) hypothetical protein 0.0078 0.0577 0.0582
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0361 0.0361
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0381 0.0384
Onchocerca volvulus 0.0055 0.0361 0.0808
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0036 0.0183 0.0183
Onchocerca volvulus 0.0055 0.0361 0.0808
Schistosoma mansoni neurotransmitter gated ion channel 0.0042 0.024 0.024
Schistosoma mansoni nAChR subunit 0.0078 0.058 0.058
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0078 0.058 0.0586
Onchocerca volvulus 0.0055 0.0361 0.0808
Entamoeba histolytica hypothetical protein 0.0035 0.017 0.0312
Loa Loa (eye worm) histone deacetylase 11 0.0276 0.2438 0.2469
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0054 0.0052
Onchocerca volvulus 0.0055 0.0361 0.0808
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0173 0.0173
Echinococcus granulosus glycine receptor subunit alpha 1 0.0078 0.058 0.058
Echinococcus multilocularis pyruvate kinase 0.0018 0.0017 0.0017
Brugia malayi Bromodomain containing protein 0.006 0.0403 0.0406
Trichomonas vaginalis chromobox protein, putative 0.0022 0.0054 0.0096
Schistosoma mansoni jumonji domain containing protein 0.0034 0.0163 0.0163
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0181 0.018
Plasmodium vivax histone deacetylase 2, putative 0.1066 0.9868 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0054 0.0096
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0055 0.0361 0.0361
Echinococcus multilocularis histone deacetylase 6 0.1066 0.9868 0.9868
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Onchocerca volvulus 0.0055 0.0361 0.0808
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0034 0.0163 0.0162
Echinococcus granulosus histone deacetylase 6 0.1066 0.9868 0.9868
Brugia malayi hypothetical protein 0.0055 0.0361 0.0363
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0078 0.058 0.0586
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0361 0.0361
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0306 0.0306
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0361 0.0361
Echinococcus multilocularis chromobox protein 1 0.0137 0.1131 0.1131
Brugia malayi hypothetical protein 0.0055 0.0361 0.0363
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0054 0.0096
Loa Loa (eye worm) hypothetical protein 0.0516 0.4695 0.4756
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.028 0.2478 1
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0039 0.0039
Onchocerca volvulus 0.0078 0.058 0.1331
Toxoplasma gondii hypothetical protein 0.0048 0.0292 0.0293
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0019 0.0017
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.1159 0.1172
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0053 0.0345 0.0345
Loa Loa (eye worm) helicase 0.0022 0.0054 0.0052
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0326 0.0328
Plasmodium falciparum importin beta, putative 0.0028 0.0109 0.0107
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0361 0.0361
Trichomonas vaginalis chromobox protein, putative 0.0083 0.062 0.1151
Onchocerca volvulus 0.0081 0.0605 0.139
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0055 0.0361 0.0361
Schistosoma mansoni amine GPCR 0.0055 0.0361 0.0361
Toxoplasma gondii histone deacetylase HDAC3 0.0587 0.5364 0.5435
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0019 0.0017
Loa Loa (eye worm) hypothetical protein 0.0042 0.024 0.0241
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0078 0.058 0.058
Loa Loa (eye worm) hypothetical protein 0.0036 0.0183 0.0183
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0195 0.0195
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0306 0.0566
Echinococcus granulosus tyrosine protein kinase ABL1 0.0206 0.1778 0.1778
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0306 0.0308
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0055 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0048 0.0293 0.0294
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0401 0.1485
Trypanosoma cruzi histone deacetylase, putative 0.1066 0.9868 1
Loa Loa (eye worm) hypothetical protein 0.0499 0.4532 0.4591
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0055 0.0361 0.0363
Trichomonas vaginalis chromobox protein, putative 0.0137 0.1131 0.2104
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0179 0.0329
Schistosoma mansoni lipoxygenase 0.0053 0.0345 0.0345
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0306 0.0308
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0415
Echinococcus granulosus neuropeptide receptor 0.0912 0.8413 0.8413
Brugia malayi Histone deacetylase family protein 0.1066 0.9868 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0025 0.0079 0.0077
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0036 0.0183 0.0183
Echinococcus multilocularis muscleblind protein 1 0.0291 0.2575 0.2575
Giardia lamblia Pyruvate kinase 0.0018 0.0017 0.0026
Brugia malayi G protein-coupled receptor 0.0055 0.0361 0.0363
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0163 0.0162
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.0034
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0039 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0054 0.0096
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0109 0.0109
Echinococcus granulosus neuropeptide s receptor 0.05 0.4539 0.4539
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0361 0.0361
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0072 0.007
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.2623 0.2656
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0055 0.0361 0.0361
Chlamydia trachomatis pyruvate kinase 0.0036 0.0181 0.5
Echinococcus multilocularis lysine specific demethylase 5A 0.0127 0.104 0.104
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.017 0.017
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0078 0.058 0.058
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0017 0.0014
Schistosoma mansoni chromobox protein 0.0022 0.0054 0.0054
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0039 0.0036
Loa Loa (eye worm) hypothetical protein 0.004 0.0217 0.0218
Brugia malayi GnHR receptor homolog 0.0055 0.0361 0.0363
Loa Loa (eye worm) hypothetical protein 0.0075 0.0551 0.0556
Onchocerca volvulus 0.0022 0.0054 0.0075
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0039 0.0039
Toxoplasma gondii histone deacetylase HDAC1 0.1066 0.9868 1
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0565 0.1049
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0039 0.0036
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.0078 0.058 0.0586
Brugia malayi hypothetical protein 0.0036 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0077 0.0565 0.057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0574 0.5238 0.9763
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Brugia malayi hypothetical protein 0.0036 0.0183 0.0183
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0039 0.0036
Echinococcus multilocularis dna polymerase eta 0.0021 0.0039 0.0039
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0451 0.0451
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0075 0.0551 0.0551
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0072 0.0072
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0361 0.0361
Brugia malayi Valyl-tRNA synthetase 0.0022 0.0054 0.0052
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0181 0.0377
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0234 0.0235
Onchocerca volvulus 0.0055 0.0361 0.0808
Onchocerca volvulus 0.0078 0.058 0.1331
Loa Loa (eye worm) norepinephrine transporter 0.006 0.0412 0.0415
Loa Loa (eye worm) hypothetical protein 0.0042 0.024 0.0241
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.028 0.2478 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0107
Onchocerca volvulus 0.0048 0.0293 0.0644
Schistosoma mansoni histone deacetylase hda2 0.108 1 1
Echinococcus granulosus Squalene phytoene synthase 0.0088 0.0674 0.0674
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0361 0.0361
Echinococcus multilocularis pyruvate kinase 0.0018 0.0017 0.0017
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0055 0.0361 0.0363
Brugia malayi Tyrosine-protein kinase abl-1 0.0084 0.0632 0.0638
Brugia malayi jmjC domain containing protein 0.0034 0.0163 0.0162
Echinococcus multilocularis nAChR subunit 0.0042 0.024 0.024
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0361 0.0361
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.004 0.004
Schistosoma mansoni sodium/chloride dependent transporter 0.006 0.0412 0.0412
Trichomonas vaginalis chromobox protein, putative 0.0022 0.0054 0.0096
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0079 0.0077
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0039 0.0036
Schistosoma mansoni nAChR subunit 0.0078 0.058 0.058
Plasmodium vivax importin-beta 2, putative 0.0028 0.0109 0.0107
Onchocerca volvulus 0.0465 0.4215 1
Plasmodium vivax histone deacetylase, putative 0.0276 0.2438 0.2469
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0022 0.0022
Schistosoma mansoni protein phosphatase 2C 0.0034 0.0163 0.0163
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0054 0.0096
Schistosoma mansoni hypothetical protein 0.0019 0.0022 0.0022
Trypanosoma cruzi histone deacetylase, putative 0.0276 0.2438 0.2469
Loa Loa (eye worm) jmjC domain-containing protein 0.0129 0.1058 0.1069
Trichomonas vaginalis chromobox protein, putative 0.0022 0.0054 0.0096
Schistosoma mansoni opsin-like receptor 0.0055 0.0361 0.0361
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0738 0.0745
Brugia malayi hypothetical protein 0.0055 0.0361 0.0363
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0039 0.0036
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0022 0.0054 0.0052
Brugia malayi histone deacetylase 1 (HD1) 0.0587 0.5364 0.5435
Trypanosoma cruzi histone deacetylase, putative 0.1066 0.9868 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0361 0.0361
Schistosoma mansoni jumonji/arid domain-containing protein 0.0129 0.1058 0.1058
Entamoeba histolytica histone deacetylase, putative 0.0587 0.5364 1
Echinococcus granulosus nAChR subunit 0.0078 0.058 0.058
Schistosoma mansoni neuropeptide f receptor 76f 0.0055 0.0361 0.0361
Schistosoma mansoni nAChR subunit 0.0036 0.0183 0.0183
Giardia lamblia Fructose-bisphosphate aldolase 0.0574 0.5238 0.9763
Echinococcus multilocularis snurportin 1 0.0301 0.2677 0.2677
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.006 0.0412 0.0412
Echinococcus granulosus chromobox protein 1 0.0137 0.1131 0.1131
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0277 0.245 0.2481
Loa Loa (eye worm) hypothetical protein 0.0036 0.0179 0.0179
Echinococcus granulosus pyruvate kinase 0.0018 0.0017 0.0017
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0181 0.018
Schistosoma mansoni growth hormone secretagogue receptor 0.0055 0.0361 0.0361
Giardia lamblia PHD finger protein 15 0.0057 0.0381 0.0706
Echinococcus granulosus Chromo domain 0.0022 0.0054 0.0054
Trypanosoma brucei C-8 sterol isomerase, putative 0.0395 0.3553 0.3598
Schistosoma mansoni nAChR subunit 0.0078 0.058 0.058
Schistosoma mansoni hypothetical protein 0.0055 0.0361 0.0361
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0039 0.0039
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0234 0.0235
Brugia malayi hypothetical protein 0.0055 0.0361 0.0363
Onchocerca volvulus 0.0036 0.0183 0.0384
Loa Loa (eye worm) hypothetical protein 0.0149 0.1246 0.126
Entamoeba histolytica hypothetical protein 0.0022 0.0054 0.0096
Schistosoma mansoni pyruvate kinase 0.0018 0.0017 0.0017
Schistosoma mansoni chromobox protein 0.0137 0.1131 0.1131
Trichomonas vaginalis Heterochromatin protein, putative 0.0022 0.0054 0.0096
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0057 0.0055
Brugia malayi G protein-coupled receptor F59B2.13 0.0055 0.0361 0.0363
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0039 0.0067
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0078 0.058 0.058
Brugia malayi hypothetical protein 0.0055 0.0361 0.0363
Echinococcus granulosus lysine specific demethylase 6a 0.0034 0.0163 0.0163
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0306 0.0566
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0326 0.0328
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0083 0.062 0.1425
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0109 0.0107
Loa Loa (eye worm) hypothetical protein 0.0042 0.024 0.0241
Schistosoma mansoni hypothetical protein 0.0088 0.0674 0.0674
Trypanosoma cruzi squalene synthase, putative 0.0283 0.2508 0.254
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0059 0.0057
Schistosoma mansoni lipoxygenase 0.0019 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.0035 0.017 0.0312
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0361 0.0361
Brugia malayi RNA, U transporter 1 0.008 0.0598 0.0604
Onchocerca volvulus 0.0055 0.0361 0.0808
Brugia malayi Cation transporter family protein 0.0078 0.058 0.0586
Onchocerca volvulus 0.0042 0.024 0.052
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0361 0.0361
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0024 0.0072 0.0072
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0451 0.0451
Echinococcus granulosus histone deacetylase 6 0.1066 0.9868 0.9868
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0451 0.0454
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0022 0.002
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Schistosoma mansoni chromobox protein 0.0137 0.1131 0.1131
Schistosoma mansoni hypothetical protein 0.0301 0.2677 0.2677
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0179 0.0179
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0394 0.0394
Loa Loa (eye worm) histone deacetylase 0.1066 0.9868 1
Echinococcus multilocularis somatostatin receptor 0.0055 0.0361 0.0361
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0017 0.0003 0.0003
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0055 0.0361 0.0361
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0022 0.0054 0.0054
Leishmania major hypothetical protein, conserved 0.0024 0.0072 0.007
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0039 0.0036
Brugia malayi MAP kinase sur-1 0.0049 0.0306 0.0308
Echinococcus granulosus chromobox protein 2 0.0022 0.0054 0.0054
Schistosoma mansoni histone deacetylase 4 5 0.1066 0.9868 0.9868
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0078 0.058 0.058
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0055 0.0361 0.0361
Echinococcus granulosus jumonji domain containing protein 0.008 0.0592 0.0592
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.0361 0.0361
Brugia malayi putative neuropeptide receptor 0.0055 0.0361 0.0363
Brugia malayi jmjC domain containing protein 0.0034 0.0163 0.0162
Echinococcus multilocularis dro:myosuppressin receptor 0.0055 0.0361 0.0361
Brugia malayi putative neuropeptide receptor NPR1 0.0055 0.0361 0.0363
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0078 0.058 0.058
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0059 0.0104
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0078 0.058 0.0586
Brugia malayi hypothetical protein 0.0024 0.0072 0.007
Echinococcus granulosus phd:f box containing protein 0.0034 0.0163 0.0163
Echinococcus granulosus tumor protein p63 0.0326 0.2912 0.2912
Brugia malayi Heterochromatin protein 1 0.0137 0.1131 0.1143
Schistosoma mansoni histone deacetylase 1 2 3 0.0276 0.2438 0.2438
Brugia malayi hypothetical protein 0.0035 0.017 0.017
Onchocerca volvulus Neuropeptide F receptor homolog 0.0055 0.0361 0.0808
Echinococcus multilocularis pyruvate kinase 0.0028 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0078 0.058 0.0586
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0022 0.0054 0.0052
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0024 0.0072 0.0072
Echinococcus granulosus pyruvate kinase 0.0036 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0036 0.0183 0.0183
Trypanosoma brucei histone deacetylase 1 0.0587 0.5364 0.5435
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0361 0.0361
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0361 0.0361
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0179 0.0179
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0022 0.0022
Echinococcus granulosus neuropeptide FF receptor 2 0.0055 0.0361 0.0361
Onchocerca volvulus Putative nachr subunit 0.0149 0.1246 0.2918
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0039 0.0036
Brugia malayi Sodium:neurotransmitter symporter family protein 0.006 0.0412 0.0415
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0361 0.0361
Echinococcus multilocularis muscleblind protein 0.0291 0.2575 0.2575
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0574 0.5238 0.9763
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0361 0.0361
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0078 0.058 0.0586
Echinococcus multilocularis chromobox protein 1 0.0137 0.1131 0.1131
Echinococcus multilocularis g-protein coupled receptor 0.0055 0.0361 0.0361
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0055 0.0361 0.0363
Brugia malayi ORL1-like opioid receptor 0.0055 0.0361 0.0363
Schistosoma mansoni hypothetical protein 0.0055 0.0361 0.0361
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0054 0.0096
Brugia malayi PHD-finger family protein 0.0021 0.0037 0.0034
Echinococcus granulosus hypothetical protein 0.0055 0.0361 0.0361
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0078 0.058 0.058
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0036 0.0183 0.0183
Loa Loa (eye worm) histone deacetylase 1 0.0587 0.5364 0.5435
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0149 0.1246 0.126
Schistosoma mansoni hypothetical protein 0.0035 0.0173 0.0173
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.0361 0.0361
Entamoeba histolytica hypothetical protein 0.0042 0.024 0.0443
Echinococcus multilocularis Chromo domain 0.0022 0.0054 0.0054
Plasmodium falciparum histone deacetylase 1 0.0587 0.5364 0.5435
Loa Loa (eye worm) hypothetical protein 0.006 0.0409 0.0412
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0042 0.024 0.0241
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0019 0.0017
Loa Loa (eye worm) hypothetical protein 0.0036 0.0183 0.0183
Trichomonas vaginalis histone deacetylase, putative 0.0587 0.5364 1
Plasmodium vivax JmjC domain containing protein 0.0034 0.0163 0.0162
Schistosoma mansoni phosphatidylserine receptor 0.0034 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0036 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Brugia malayi jmjC domain containing protein 0.0034 0.0163 0.0162
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0072 0.007
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0039 0.0036
Schistosoma mansoni neurotransmitter gated ion channel 0.0036 0.0183 0.0183
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0245 0.2151 0.2151
Loa Loa (eye worm) acetylcholine receptor protein 0.0036 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0042 0.024 0.0241
Brugia malayi histone deacetylase 3 (HD3) 0.0587 0.5364 0.5435
Brugia malayi jmjC domain containing protein 0.0129 0.1058 0.1069
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0039 0.0039
Loa Loa (eye worm) ACC-1 protein 0.0078 0.058 0.0586
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0451 0.0454
Loa Loa (eye worm) LGC-31 protein 0.0078 0.058 0.0586
Onchocerca volvulus 0.0055 0.0361 0.0808
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.2677 0.2711
Entamoeba histolytica Ran family GTPase 0.0021 0.0039 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0054 0.0096
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0361 0.0361
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0574 0.5238 0.9763
Echinococcus multilocularis histone deacetylase 6 0.108 1 1
Schistosoma mansoni biogenic amine receptor 0.0055 0.0361 0.0361
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0019 0.0017
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0149 0.1246 0.1246
Echinococcus multilocularis RUN 0.0019 0.0022 0.0022
Brugia malayi Importin beta-1 subunit 0.0028 0.0109 0.0107
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0054 0.0096
Echinococcus granulosus lysine specific demethylase 5A 0.0129 0.1058 0.1058
Brugia malayi G-protein coupled receptor 0.0055 0.0361 0.0363
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0054 0.0096
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Loa Loa (eye worm) histone deacetylase 7A 0.1066 0.9868 1
Echinococcus multilocularis pyruvate kinase 0.0036 0.0181 0.0181
Plasmodium falciparum phd finger protein, putative 0.0057 0.0381 0.0384
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0039 0.0036
Toxoplasma gondii histone deacetylase HDAC4 0.0276 0.2438 0.2469
Leishmania major histone deacetylase, putative 0.1066 0.9868 1
Echinococcus multilocularis neuropeptide s receptor 0.05 0.4539 0.4539
Entamoeba histolytica hypothetical protein 0.0035 0.017 0.0312
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0587 0.5364 1
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0395 0.3553 0.3598
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0078 0.058 0.0586
Loa Loa (eye worm) hypothetical protein 0.0114 0.0911 0.0921
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0394 0.0397
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0181 0.018
Trichomonas vaginalis histone deacetylase, putative 0.0587 0.5364 1
Onchocerca volvulus Alhambra homolog 0.0057 0.0381 0.0856
Schistosoma mansoni amine GPCR 0.0055 0.0361 0.0361
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0072 0.007
Schistosoma mansoni rab6-interacting 0.0019 0.0022 0.0022
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0078 0.058 0.0586
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0181 0.018
Schistosoma mansoni histamine h1 receptor 0.0055 0.0361 0.0361
Echinococcus granulosus PHD finger protein rhinoceros 0.0057 0.0381 0.0381
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0149 0.1246 0.1246
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0361 0.0361
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0361 0.0361
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0072 0.007
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0245 0.2151 0.2151
Loa Loa (eye worm) hypothetical protein 0.0804 0.7405 0.7503
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0022 0.0022
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0306 0.0308
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0179 0.0329
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0078 0.058 0.0586
Echinococcus multilocularis neuropeptide receptor 0.0912 0.8413 0.8413
Loa Loa (eye worm) hypothetical protein 0.0078 0.058 0.0586
Brugia malayi Histone deacetylase 1 0.0587 0.5364 0.5435
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0361 0.0361
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0036 0.0183 0.0183
Echinococcus multilocularis pyruvate kinase 0.0036 0.0181 0.0181
Brugia malayi PHD-finger family protein 0.0057 0.0381 0.0384
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0055 0.0361 0.0361
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0077 0.0565 0.1294
Echinococcus granulosus glycine receptor subunit alpha 1 0.0078 0.058 0.058
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0163 0.0162
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0039 0.0036
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0039 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0054 0.0096
Giardia lamblia DINP protein human, muc B family 0.0021 0.0039 0.0067
Echinococcus multilocularis serotonin transporter 0.006 0.0412 0.0412
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0022 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Onchocerca volvulus 0.0055 0.0361 0.0808
Schistosoma mansoni hypothetical protein 0.0035 0.017 0.017
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0022 0.0054 0.0052
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0149 0.1246 0.1246
Onchocerca volvulus 0.0055 0.0361 0.0808
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0039 0.0036
Echinococcus granulosus zinc finger protein 0.0019 0.0023 0.0023
Brugia malayi Tachykinin-like peptides receptor 99D 0.0055 0.0361 0.0363
Echinococcus granulosus JmjC domain containing protein 4 0.0034 0.0163 0.0163
Schistosoma mansoni histone deacetylase 0.0587 0.5364 0.5364
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0078 0.058 0.058
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0306 0.0566
Echinococcus granulosus somatostatin receptor 0.0055 0.0361 0.0361
Schistosoma mansoni neuropeptide receptor 0.0055 0.0361 0.0361
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0036 0.0183 0.0183
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0042 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Leishmania major histone deacetylase, putative 0.0587 0.5364 0.5435
Entamoeba histolytica hypothetical protein 0.0023 0.0059 0.0104
Loa Loa (eye worm) hypothetical protein 0.0078 0.058 0.0586
Schistosoma mansoni neuropeptide receptor 0.0912 0.8413 0.8413
Trichomonas vaginalis chromobox protein, putative 0.0083 0.062 0.1151
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0738 0.0745
Schistosoma mansoni hypothetical protein 0.0055 0.0361 0.0361
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0179 0.0179
Schistosoma mansoni acetylcholine receptor subunit beta 0.0036 0.0183 0.0183
Schistosoma mansoni histone deacetylase 4 5 0.1066 0.9868 0.9868
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0078 0.058 0.0586
Brugia malayi hypothetical protein 0.0036 0.0183 0.0183
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0072 0.007
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0361 0.0361
Echinococcus multilocularis jumonji domain containing 1A 0.0034 0.0163 0.0163
Schistosoma mansoni neurotransmitter gated ion channel 0.0036 0.0183 0.0183
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0054 0.0096
Echinococcus granulosus histone lysine methyltransferase setb 0.0075 0.0551 0.0551
Echinococcus granulosus snurportin 1 0.0301 0.2677 0.2677
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0392 0.0392
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0052
Echinococcus granulosus histone deacetylase 7 0.1066 0.9868 0.9868
Loa Loa (eye worm) hypothetical protein 0.0276 0.2438 0.2469
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0039 0.0039
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Echinococcus granulosus dro:myosuppressin receptor 0.0055 0.0361 0.0361
Mycobacterium ulcerans phytoene synthase, CrtB 0.0088 0.0674 0.2604
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.2623 0.2656
Onchocerca volvulus 0.0036 0.0183 0.0384
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0574 0.5238 0.9763
Onchocerca volvulus 0.0149 0.1246 0.2918
Brugia malayi hypothetical protein 0.0055 0.0361 0.0363
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0306 0.0306
Schistosoma mansoni alpha-1 adrenergic receptor 0.0055 0.0361 0.0361
Schistosoma mansoni nAChR subunit 0.0078 0.058 0.058
Trichomonas vaginalis set domain proteins, putative 0.0465 0.4215 0.7856
Onchocerca volvulus 0.0055 0.0361 0.0808
Brugia malayi hypothetical protein 0.0036 0.0183 0.0183
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0039 0.0036
Loa Loa (eye worm) hypothetical protein 0.0078 0.058 0.0586
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0039 0.0036
Trypanosoma brucei protein kinase, putative 0.0049 0.0306 0.0308
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0024 0.0072 0.007
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0036 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Echinococcus granulosus histone deacetylase 8 0.0276 0.2438 0.2438
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0042 0.024 0.024
Onchocerca volvulus 0.0078 0.058 0.1331
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0055 0.0361 0.0361
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0055 0.0361 0.0363
Loa Loa (eye worm) hypothetical protein 0.0078 0.058 0.0586
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0401 0.0401
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0149 0.1246 0.1246
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0022 0.002
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0036 0.0183 0.0183
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0451 0.0454
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0017 0.0003 0.0003
Brugia malayi hypothetical protein 0.0036 0.0183 0.0183
Mycobacterium ulcerans hypothetical protein 0.0156 0.1308 0.5202
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0075 0.0551 0.0551
Schistosoma mansoni amine GPCR 0.0055 0.0361 0.0361
Echinococcus multilocularis histone deacetylase 3 0.0587 0.5364 0.5364
Onchocerca volvulus 0.0042 0.024 0.052
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0057 0.0381 0.0381
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0738 0.0738
Loa Loa (eye worm) hypothetical protein 0.0051 0.0326 0.0328
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Plasmodium vivax histone deacetylase, putative 0.1066 0.9868 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0078 0.058 0.058
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0401 0.0401
Brugia malayi follicle stimulating hormone receptor 0.0277 0.245 0.2481
Schistosoma mansoni hypothetical protein 0.0057 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0021 0.0039 0.0036
Schistosoma mansoni phd/f-box containing protein 0.0034 0.0163 0.0163
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0054 0.0096
Plasmodium falciparum pyruvate kinase 0.0036 0.0181 0.018
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0181 0.0332
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0052
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0181 0.018
Loa Loa (eye worm) hypothetical protein 0.0149 0.1246 0.126
Onchocerca volvulus 0.0055 0.0361 0.0808
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0392 0.0392
Plasmodium falciparum heterochromatin protein 1 0.0022 0.0054 0.0052
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0036 0.0183 0.0183
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0306 0.0306
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0361 0.0361
Loa Loa (eye worm) jmjC domain-containing protein 0.0118 0.0954 0.0965
Brugia malayi hypothetical protein 0.0055 0.0361 0.0363
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0054 0.0096
Schistosoma mansoni hypothetical protein 0.0019 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0202 0.1739 0.176
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0234 0.0235
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0401 0.0401
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0022 0.0054 0.0054
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0361 0.0361
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0017 0.0014
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0072 0.007
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0034 0.0163 0.0162
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0361 0.0361
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0206 0.1778 0.1778
Loa Loa (eye worm) PHD-finger family protein 0.0057 0.0381 0.0384
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0055 0.0361 0.0361
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0361 0.0361
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0401 0.0404
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0179 0.0329
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0042 0.024 0.0241
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0361 0.0361
Mycobacterium ulcerans short chain dehydrogenase 0.0274 0.242 0.9759
Loa Loa (eye worm) hypothetical protein 0.0036 0.0183 0.0183
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0179 0.0179
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0179 0.0329
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0181 0.018
Loa Loa (eye worm) hypothetical protein 0.0036 0.0183 0.0183
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0361 0.0361
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0022 0.0022
Schistosoma mansoni neuropeptide receptor 0.0055 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0036 0.0183 0.0183
Toxoplasma gondii histone deacetylase HDAC2 0.0587 0.5364 0.5435
Echinococcus multilocularis JmjC domain containing protein 4 0.0034 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0415
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0738 0.0738
Echinococcus granulosus RUN 0.0019 0.0022 0.0022
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0052
Leishmania major hypothetical protein, conserved 0.0088 0.0674 0.068
Trypanosoma cruzi histone deacetylase, putative 0.1066 0.9868 1
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0181 0.018
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0039 0.0067
Loa Loa (eye worm) hypothetical protein 0.0078 0.058 0.0586
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.032 0.0321
Echinococcus granulosus peptide allatostatin:somatostatin 0.0055 0.0361 0.0361
Brugia malayi AF-10 protein 0.0019 0.0019 0.0017
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0078 0.058 0.0586
Echinococcus multilocularis glycine receptor subunit beta 0.0078 0.058 0.058
Echinococcus granulosus serotonin receptor 0.0055 0.0361 0.0361
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0361 0.0361
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0055 0.0361 0.0361
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0017 0.0003 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0574 0.5238 0.9763
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.002
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0019 0.0017
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0361 0.0363
Leishmania major histone deacetylase, putative 0.1066 0.9868 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0574 0.5238 0.9763
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0052
Echinococcus multilocularis lysine specific demethylase 6a 0.0034 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0179 0.0179
Leishmania major hypothetical protein, conserved 0.0034 0.0163 0.0162
Echinococcus granulosus allatostatin A receptor 0.0055 0.0361 0.0361
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0017 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.079 0.7273 0.7369
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Giardia lamblia Pyruvate kinase 0.0036 0.0181 0.0332
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0149 0.1246 0.1246
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0055 0.0361 0.0361
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0401 0.1485
Schistosoma mansoni ran 0.0021 0.0039 0.0039
Trichomonas vaginalis chromobox protein, putative 0.0137 0.1131 0.2104
Schistosoma mansoni jumonji/arid domain-containing protein 0.0129 0.1058 0.1058
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0022 0.0022
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0088 0.0674 0.1554
Treponema pallidum fructose-bisphosphate aldolase 0.0574 0.5238 1
Giardia lamblia Histone deacetylase 0.0587 0.5364 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0034 0.0163 0.0162
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0055 0.0361 0.0361
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0042 0.024 0.0241
Loa Loa (eye worm) hypothetical protein 0.0036 0.0183 0.0183
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0022 0.0022
Echinococcus multilocularis neuropeptide FF receptor 2 0.0055 0.0361 0.0361
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0306 0.0566
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0361 0.0361
Echinococcus multilocularis histone deacetylase 8 0.0276 0.2438 0.2438
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0361 0.0361
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0354 0.0656
Brugia malayi Serotonin receptor 0.0055 0.0361 0.0363
Echinococcus granulosus glycine receptor subunit alpha 1 0.0078 0.058 0.058
Entamoeba histolytica hypothetical protein 0.0022 0.0054 0.0096
Trypanosoma brucei unspecified product 0.0021 0.0039 0.0036
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0054 0.0096
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0574 0.5238 0.9763
Loa Loa (eye worm) hypothetical protein 0.0042 0.024 0.0241
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0306 0.0306
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0401 0.0401
Loa Loa (eye worm) hypothetical protein 0.0057 0.0381 0.0384
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0036 0.0183 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0565 0.1049
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0054 0.0096
Schistosoma mansoni biogenic amine receptor 0.0055 0.0361 0.0361
Echinococcus granulosus pyruvate kinase 0.0036 0.0181 0.0181
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0055 0.0361 0.0363
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Brugia malayi Serotonin receptor 0.0055 0.0361 0.0363
Entamoeba histolytica hypothetical protein 0.0035 0.017 0.0312
Brugia malayi RE15519p 0.0055 0.0361 0.0363
Brugia malayi SET domain containing protein 0.0025 0.0074 0.0073
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0078 0.058 0.0586
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0361 0.0361
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0078 0.058 0.058
Echinococcus granulosus importin subunit beta 1 0.0028 0.0109 0.0109
Trichomonas vaginalis histone deacetylase, putative 0.0587 0.5364 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.028 0.2478 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0078 0.058 0.058
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0195 0.0195
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0451 0.0454
Loa Loa (eye worm) melatonin receptor type 1A 0.0055 0.0361 0.0363
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0381 0.0384
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0326 0.0328
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0039 0.0036
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0039 0.0036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0183 0.0183
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0054 0.0096
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0361 0.0361
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0078 0.058 0.0586
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0036 0.0183 0.0183
Schistosoma mansoni pyruvate kinase 0.0036 0.0181 0.0181
Onchocerca volvulus 0.006 0.0412 0.0928
Brugia malayi Bromodomain containing protein 0.0073 0.0532 0.0537
Echinococcus multilocularis G protein coupled receptor 139 0.0912 0.8413 0.8413
Loa Loa (eye worm) hypothetical protein 0.0078 0.058 0.0586
Schistosoma mansoni myosin xvIII 0.0055 0.0361 0.0361
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0179 0.0179
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.017 0.017
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0039 0.0067
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0361 0.0361
Trichomonas vaginalis hypothetical protein 0.0022 0.0054 0.0096
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1159 0.1172
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0055 0.0361 0.0361
Loa Loa (eye worm) ACC-1 protein 0.0078 0.058 0.0586
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0054 0.0096
Brugia malayi G-protein coupled receptor 0.0055 0.0361 0.0363
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Schistosoma mansoni histone deacetylase hda2 0.0276 0.2438 0.2438
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0109 0.0107
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0179 0.0179
Echinococcus granulosus neuropeptide receptor A26 0.05 0.4539 0.4539
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0149 0.1246 0.1246
Schistosoma mansoni opsin-like receptor 0.0055 0.0361 0.0361
Schistosoma mansoni histone deacetylase 0.0587 0.5364 0.5364
Echinococcus multilocularis glycine receptor subunit beta 0.0078 0.058 0.058
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0055 0.0361 0.0363
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0113 0.0906 0.0915
Echinococcus multilocularis nAChR subunit 0.0078 0.058 0.058
Schistosoma mansoni neuropeptide receptor 0.0055 0.0361 0.0361
Onchocerca volvulus 0.0055 0.0361 0.0808
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0395 0.3553 0.3598
Echinococcus granulosus 7TM GPCR rhodopsin 0.0055 0.0361 0.0361
Brugia malayi M-phase phosphoprotein, mpp8 0.0022 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0078 0.058 0.0586
Brugia malayi Cation transporter family protein 0.0149 0.1246 0.126
Brugia malayi Tyrosine-protein kinase abl-1 0.0125 0.1016 0.1027
Echinococcus granulosus dna polymerase kappa 0.0021 0.0039 0.0039
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0078 0.058 0.0586
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0361 0.0363
Brugia malayi neuropeptide F receptor 0.0055 0.0361 0.0363
Trypanosoma brucei histone deacetylase 3 0.1066 0.9868 1
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0361 0.0363
Loa Loa (eye worm) hypothetical protein 0.0291 0.2575 0.2607
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0361 0.0361
Leishmania major GTP-binding protein, putative 0.0021 0.0039 0.0036
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0078 0.058 0.0586
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0036 0.0183 0.0183
Onchocerca volvulus 0.0149 0.1246 0.2918
Brugia malayi hypothetical protein 0.0019 0.0022 0.002
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0039 0.0036
Echinococcus multilocularis histone deacetylase 7 0.1066 0.9868 0.9868
Schistosoma mansoni nAChR subunit 0.0078 0.058 0.058
Brugia malayi Histone deacetylase family protein 0.1066 0.9868 1
Loa Loa (eye worm) histone deacetylase 3 0.0587 0.5364 0.5435
Loa Loa (eye worm) hypothetical protein 0.0022 0.0054 0.0052
Echinococcus granulosus alpha 1A adrenergic receptor 0.0055 0.0361 0.0361
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0039 0.0036
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0059 0.0104
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0039 0.0039
Brugia malayi excitatory GABA receptor EXP-1A 0.0078 0.058 0.0586
Echinococcus granulosus G protein coupled receptor 139 0.0055 0.0361 0.0361
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0054 0.0052
Echinococcus multilocularis neuropeptide receptor 0.0055 0.0361 0.0361
Brugia malayi Cation transporter family protein 0.0078 0.058 0.0586
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0081 0.0605 0.0605
Schistosoma mansoni importin beta-1 0.0028 0.0109 0.0109
Echinococcus multilocularis Chromobox protein 3 0.0022 0.0054 0.0054
Brugia malayi hypothetical protein 0.0055 0.0361 0.0363
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0078 0.058 0.0586
Schistosoma mansoni rab6-interacting 0.0019 0.0022 0.0022
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0036 0.0183 0.0183
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0109 0.0107
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0306 0.0308
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0088 0.0674 0.2604
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0306 0.0308
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0363
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0036 0.018 0.018
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0059 0.0104
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0055 0.0361 0.0361
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0516 0.4695 0.4756
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0738 0.0738
Echinococcus granulosus histone deacetylase 0.1066 0.9868 0.9868
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0036 0.0183 0.0183
Echinococcus multilocularis Squalene phytoene synthase 0.0088 0.0674 0.0674
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0306 0.0308
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.002
Echinococcus multilocularis G-protein coupled receptor, putative 0.0055 0.0361 0.0361
Schistosoma mansoni biogenic amine receptor 0.0055 0.0361 0.0361
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0078 0.058 0.058
Brugia malayi Dopamine receptor protein 2 0.0055 0.0361 0.0363
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0401 0.1485
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0574 0.5238 0.9763
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.0036 0.0183 0.0183
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0039 0.0036
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0173 0.0173
Echinococcus multilocularis serotonin receptor 0.0055 0.0361 0.0361
Trypanosoma cruzi squalene synthase, putative 0.0283 0.2508 0.254
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0163 0.0162
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0078 0.058 0.0586
Schistosoma mansoni loxhd1 0.0019 0.0022 0.0022
Echinococcus granulosus g protein coupled receptor 0.0055 0.0361 0.0361
Echinococcus granulosus g protein coupled receptor 0.0055 0.0361 0.0361
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0149 0.1246 0.1246
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0361 0.0361
Echinococcus multilocularis zinc finger protein 0.0019 0.0023 0.0023

Activities

Activity type Activity value Assay description Source Reference
HSF (functional) = 0 ml HSF produced by bone marrow-derived stromal cell lines C6.4 on stimulation with the compound at (1000 ng/mL) was determined in vitro in an GM-CFC assay. ChEMBL. 9288169

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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