Detailed information for compound 1210293

Basic information

Technical information
  • TDR Targets ID: 1210293
  • Name: 2-ethyl-4-(2-morpholin-4-yl-2-oxoethyl)-1,4-b enzoxazin-3-one
  • MW: 304.341 | Formula: C16H20N2O4
  • H donors: 0 H acceptors: 2 LogP: 1.14 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC1Oc2ccccc2N(C1=O)CC(=O)N1CCOCC1
  • InChi: 1S/C16H20N2O4/c1-2-13-16(20)18(12-5-3-4-6-14(12)22-13)11-15(19)17-7-9-21-10-8-17/h3-6,13H,2,7-11H2,1H3
  • InChiKey: BPTVHLNLEXMJPQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-ethyl-4-(2-morpholino-2-oxo-ethyl)-1,4-benzoxazin-3-one
  • 2-ethyl-4-(2-morpholino-2-oxoethyl)-1,4-benzoxazin-3-one
  • 2-ethyl-4-(2-keto-2-morpholino-ethyl)-1,4-benzoxazin-3-one
  • 2-ethyl-4-(2-morpholin-4-yl-2-oxo-ethyl)-1,4-benzoxazin-3-one
  • ChemDiv3_013393
  • IDI1_029543
  • BAS 06912320
  • 2-Ethyl-4-(2-morpholin-4-yl-2-oxo-ethyl)-4H-benzo[1,4]oxazin-3-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis heat shock protein, putative 0.0071 0.1701 0.855
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0023 0.0379 0.0519
Echinococcus multilocularis GPCR, family 2 0.0016 0.0195 0.0073
Echinococcus granulosus nuclear factor of activated T cells 5 0.0294 0.7864 0.7837
Brugia malayi Animal haem peroxidase family protein 0.0052 0.1183 0.1839
Schistosoma mansoni importin beta-1 0.0035 0.0709 0.0592
Brugia malayi RNA, U transporter 1 0.0099 0.2479 0.3855
Echinococcus granulosus Smad4 0.0017 0.0203 0.0081
Onchocerca volvulus 0.0017 0.0212 0.0832
Loa Loa (eye worm) transcription factor SMAD2 0.0242 0.643 0.643
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0067 0.1593 0.1488
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0383 0.0447
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 0.643 0.643
Brugia malayi Animal haem peroxidase family protein 0.0052 0.1183 0.1839
Trypanosoma brucei heat shock protein, putative 0.008 0.1968 0.3993
Brugia malayi notch-like transmembrane receptor 0.0017 0.0212 0.0329
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0014 0.0123 0.0125
Leishmania major heat shock protein 83-1 0.008 0.1968 0.3993
Leishmania major heat shock protein 83-1 0.008 0.1968 0.3993
Schistosoma mansoni cell polarity protein 0.0017 0.0212 0.0089
Plasmodium falciparum importin beta, putative 0.0035 0.0709 0.1188
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0181 0.4744 0.4744
Entamoeba histolytica transcription factor BTF3, putative 0.0036 0.0739 0.1333
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0017 0.0212 0.0089
Loa Loa (eye worm) acyl carrier protein 0.0011 0.0061 0.0061
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0709 0.1266
Loa Loa (eye worm) hypothetical protein 0.0052 0.1183 0.1183
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0203 0.0081
Entamoeba histolytica Ran family GTPase 0.0026 0.0455 0.0718
Onchocerca volvulus 0.0017 0.0212 0.0832
Loa Loa (eye worm) hypothetical protein 0.0014 0.0129 0.0129
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0627 0.051
Echinococcus granulosus neurogenic locus protein delta 0.0017 0.0212 0.0089
Trichomonas vaginalis heat shock protein, putative 0.0071 0.1701 0.855
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0014 0.0123 0.0125
Schistosoma mansoni hypothetical protein 0.0017 0.0212 0.0089
Leishmania major heat shock protein 83-1 0.008 0.1968 0.3993
Leishmania major heat shock protein 83-1 0.008 0.1968 0.3993
Schistosoma mansoni hypothetical protein 0.0017 0.0212 0.0089
Brugia malayi MH2 domain containing protein 0.0017 0.0203 0.0316
Echinococcus multilocularis 0.0023 0.0379 0.0259
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0014 0.0123 0.0065
Trypanosoma brucei heat shock protein, putative 0.008 0.1968 0.3993
Giardia lamblia High cysteine protein 0.0017 0.0212 0.0478
Echinococcus multilocularis tar DNA binding protein 0.0063 0.1498 0.1392
Brugia malayi heat shock protein 90 0.008 0.1968 0.3061
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0144 0.3728 0.7803
Toxoplasma gondii heat shock protein 75, putative 0.0045 0.0989 0.181
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0123
Entamoeba histolytica hypothetical protein 0.0181 0.4744 1
Entamoeba histolytica protein kinase, putative 0.0181 0.4744 1
Schistosoma mansoni amine oxidase 0.0023 0.0379 0.0259
Toxoplasma gondii NAC domain-containing protein 0.0036 0.0739 0.1307
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0017 0.0212 0.0212
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0014 0.0123 0.0125
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0017 0.0212 0.0329
Echinococcus granulosus protein jagged 2 0.0017 0.0212 0.0089
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0714 0.1111
Loa Loa (eye worm) hypothetical protein 0.0035 0.0709 0.0709
Onchocerca volvulus Fatty acid synthase homolog 0.0044 0.0972 0.8016
Mycobacterium ulcerans polyketide synthase 0.0025 0.0427 0.0354
Brugia malayi RNA binding protein 0.0063 0.1498 0.233
Schistosoma mansoni hypothetical protein 0.0035 0.0714 0.0598
Loa Loa (eye worm) hypothetical protein 0.018 0.4718 0.4718
Mycobacterium tuberculosis Possible two component sensor kinase 0.0014 0.0123 0.0125
Leishmania major heat shock protein 83-1 0.008 0.1968 0.3993
Trypanosoma cruzi heat shock protein 85, putative 0.008 0.1968 0.3993
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0014 0.0123 0.0065
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0023 0.0379 0.058
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0071 0.1701 1
Onchocerca volvulus Chorion peroxidase homolog 0.0052 0.1183 1
Trypanosoma cruzi heat shock protein 90, putative 0.008 0.1968 0.3993
Onchocerca volvulus 0.0043 0.093 0.7618
Echinococcus multilocularis smad 0.0017 0.0203 0.0081
Brugia malayi EGF-like domain containing protein 0.0017 0.0212 0.0329
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1498 0.1392
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0527 0.0873
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0455 0.0673
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0014 0.0123 0.0192
Loa Loa (eye worm) hypothetical protein 0.0052 0.1183 0.1183
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0014 0.0123 0.0125
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0427 0.1927
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0455 0.0336
Loa Loa (eye worm) heat shock protein 75 0.0045 0.0989 0.0989
Echinococcus granulosus neurogenic locus notch protein 4 0.0017 0.0212 0.0089
Trypanosoma brucei trans-sialidase, putative 0.0144 0.3728 0.7803
Schistosoma mansoni heat shock protein 0.0045 0.0989 0.0876
Onchocerca volvulus Slit protein homolog 0.0017 0.0212 0.0832
Brugia malayi hypothetical protein 0.0023 0.0379 0.059
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0203 0.0081
Loa Loa (eye worm) hypothetical protein 0.0052 0.1183 0.1183
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0203 0.0081
Entamoeba histolytica heat shock protein 90, putative 0.008 0.1968 0.3993
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.047 0.0403
Loa Loa (eye worm) hypothetical protein 0.0017 0.0212 0.0212
Loa Loa (eye worm) ICD-1 protein 0.0036 0.0739 0.0739
Schistosoma mansoni hypothetical protein 0.0174 0.4551 0.4483
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0212 0.0329
Plasmodium falciparum heat shock protein 90, putative 0.0192 0.5048 1
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0212 0.0329
Loa Loa (eye worm) hypothetical protein 0.0017 0.0212 0.0212
Brugia malayi MH2 domain containing protein 0.0017 0.0203 0.0316
Loa Loa (eye worm) hypothetical protein 0.0051 0.1161 0.1161
Trypanosoma cruzi heat shock protein 90, putative 0.0067 0.1593 0.3181
Trypanosoma cruzi trans-sialidase, putative 0.0144 0.3728 0.7802
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0045 0.0989 0.1872
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0627 0.0627
Plasmodium falciparum basic transcription factor 3b, putative 0.0036 0.0739 0.125
Echinococcus granulosus dual specificity 0.0181 0.4744 0.4678
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0627 0.1023
Trichomonas vaginalis heat shock protein, putative 0.0041 0.0881 0.4105
Echinococcus granulosus peroxidasin 0.0052 0.1183 0.1072
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0023 0.0379 0.0298
Schistosoma mansoni hypothetical protein 0.0016 0.0195 0.0073
Toxoplasma gondii Hsp90 domain-containing protein 0.0192 0.5048 1
Echinococcus granulosus protein jagged 2 0.0017 0.0212 0.0089
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0014 0.0123 0.0192
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0144 0.3728 0.7803
Schistosoma mansoni hypothetical protein 0.0016 0.0195 0.0073
Brugia malayi Blistered cuticle protein 3 0.0052 0.1183 0.1839
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0383 0.0383
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0195 0.0304
Echinococcus multilocularis heat shock protein 90 0.0067 0.1593 0.1488
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0627 0.1081
Onchocerca volvulus Peroxidasin homolog 0.0052 0.1183 1
Schistosoma mansoni hypothetical protein 0.0017 0.0212 0.0089
Loa Loa (eye worm) notch protein 0.0017 0.0212 0.0212
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0709 0.0592
Brugia malayi SWIRM domain containing protein 0.0023 0.0379 0.059
Echinococcus granulosus notch 0.0017 0.0212 0.0089
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0212 0.0089
Onchocerca volvulus Peroxidase homolog 0.0052 0.1183 1
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0212 0.0089
Brugia malayi Delta serrate ligand family protein 0.0017 0.0212 0.0329
Loa Loa (eye worm) hypothetical protein 0.0052 0.1183 0.1183
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0023 0.0379 0.0519
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0016 0.0197 0.0468
Leishmania major importin beta-1 subunit, putative 0.0028 0.0527 0.0873
Echinococcus multilocularis heat shock protein 90 0.008 0.1968 0.1868
Loa Loa (eye worm) hypothetical protein 0.0023 0.0379 0.0379
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0071 0.1701 0.2084
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0427 0.1927
Echinococcus multilocularis endoplasmin 0.0071 0.1701 0.1597
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1498 0.1392
Loa Loa (eye worm) hypothetical protein 0.0052 0.1183 0.1183
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0181 0.4744 1
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.1183 0.1183
Loa Loa (eye worm) Notch2 0.0017 0.0212 0.0212
Trypanosoma brucei trans-sialidase 0.0144 0.3728 0.7803
Schistosoma mansoni hypothetical protein 0.0372 1 1
Echinococcus multilocularis protein jagged 1 0.0017 0.0212 0.0089
Leishmania major heat shock protein 83-1 0.008 0.1968 0.3993
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0045 0.0989 0.0876
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0427 0.0354
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.1161 0.1806
Echinococcus granulosus protein jagged 1 0.0017 0.0212 0.0089
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0045 0.0989 0.8168
Echinococcus multilocularis slit 2 protein 0.0017 0.0212 0.0089
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0144 0.3728 0.7803
Schistosoma mansoni amine oxidase 0.0023 0.0379 0.0259
Loa Loa (eye worm) hypothetical protein 0.0017 0.0212 0.0212
Onchocerca volvulus 0.0017 0.0212 0.0832
Echinococcus granulosus fibropellin Ia 0.0017 0.0212 0.0089
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0627 0.051
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0295 0.0199
Mycobacterium ulcerans monoamine oxidase 0.0023 0.0379 0.0298
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0212 0.0089
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0016 0.0197 0.0086
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0627 0.109
Plasmodium falciparum heat shock protein 90 0.008 0.1968 0.3746
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0627 0.051
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1498 0.1392
Plasmodium vivax basic transcription factor 3b, putative 0.0036 0.0739 0.125
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0018 0.0236 0.0265
Schistosoma mansoni hypothetical protein 0.0016 0.0195 0.0073
Schistosoma mansoni notch 0.0017 0.0212 0.0089
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0195 0.0195
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0195 0.0073
Echinococcus multilocularis Smad4 0.0017 0.0203 0.0081
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0739 0.1333
Brugia malayi GCC2 and GCC3 family protein 0.0017 0.0212 0.0329
Leishmania major UDP-galactopyranose mutase 0.0023 0.0379 0.0553
Echinococcus multilocularis snurportin 1 0.0372 1 1
Schistosoma mansoni smad1 5 8 and 0.0017 0.0203 0.0081
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0203 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0739 0.3338
Trypanosoma cruzi UDP-galactopyranose mutase 0.0023 0.0379 0.0553
Brugia malayi EGF-like domain containing protein 0.0017 0.0212 0.0329
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1498 0.1392
Brugia malayi Peroxidasin 0.0052 0.1183 0.1839
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.1183 0.1183
Echinococcus granulosus heat shock protein 0.008 0.1968 0.1868
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0144 0.3728 0.7803
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0709 0.1266
Plasmodium vivax heat shock protein 86, putative 0.008 0.1968 0.3746
Plasmodium falciparum protoporphyrinogen oxidase 0.0023 0.0379 0.0519
Entamoeba histolytica protein kinase, putative 0.0181 0.4744 1
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0212 0.0089
Echinococcus granulosus heat shock protein 90 0.0067 0.1593 0.1488
Schistosoma mansoni slit 0.0017 0.0212 0.0089
Brugia malayi Cadherin domain containing protein 0.0017 0.0212 0.0329
Mycobacterium leprae Polyketide synthase Pks13 0.0037 0.0763 0.4056
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0023 0.0379 0.0519
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.1161 0.1806
Onchocerca volvulus Peroxidasin homolog 0.0052 0.1183 1
Brugia malayi EGF-like domain containing protein 0.0017 0.0212 0.0329
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0627 0.051
Schistosoma mansoni heat shock protein 0.008 0.1968 0.1868
Echinococcus granulosus lysine specific histone demethylase 1A 0.0023 0.0379 0.0259
Brugia malayi beta-NAC-like protein 0.0036 0.0739 0.115
Plasmodium vivax heat shock protein, putative 0.0192 0.5048 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0295 0.0199
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.047 0.2194
Trypanosoma cruzi trans-sialidase, putative 0.0144 0.3728 0.7803
Giardia lamblia Heat shock protein HSP 90-alpha 0.0067 0.1593 0.7966
Brugia malayi EGF-like domain containing protein 0.0017 0.0212 0.0329
Loa Loa (eye worm) hypothetical protein 0.0017 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0017 0.0212 0.0212
Brugia malayi Cadherin domain containing protein 0.0017 0.0212 0.0329
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0739 0.3338
Echinococcus granulosus geminin 0.0174 0.4551 0.4483
Onchocerca volvulus 0.0052 0.1183 1
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0144 0.3728 0.7803
Mycobacterium ulcerans heat shock protein 90 0.0071 0.1701 0.1838
Loa Loa (eye worm) hypothetical protein 0.0052 0.1183 0.1183
Loa Loa (eye worm) hypothetical protein 0.0023 0.0379 0.0379
Onchocerca volvulus 0.0023 0.0383 0.2448
Giardia lamblia Heat shock protein HSP 90-alpha 0.008 0.1968 1
Trypanosoma brucei heat shock protein, putative 0.008 0.1968 0.3993
Onchocerca volvulus 0.0052 0.1183 1
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0527 0.2187
Onchocerca volvulus 0.0052 0.1183 1
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0023 0.0379 0.0259
Brugia malayi hypothetical protein 0.0052 0.1183 0.1839
Brugia malayi Endoplasmin precursor 0.008 0.1968 0.3061
Loa Loa (eye worm) hypothetical protein 0.0017 0.0212 0.0212
Brugia malayi Smad1 0.0017 0.0203 0.0316
Loa Loa (eye worm) hypothetical protein 0.0052 0.1183 0.1183
Loa Loa (eye worm) hypothetical protein 0.0017 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0052 0.1183 0.1183
Plasmodium falciparum endoplasmin, putative 0.0055 0.1256 0.23
Schistosoma mansoni ran 0.0026 0.0455 0.0336
Schistosoma mansoni laminin gamma-3 chain 0.0017 0.0212 0.0089
Trichomonas vaginalis endoplasmin, putative 0.0055 0.1256 0.6139
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0325 0.8707 1
Schistosoma mansoni endoplasmin 0.008 0.1968 0.1868
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0427 0.0665
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0455 0.0718
Brugia malayi isocitrate dehydrogenase 0.0032 0.0627 0.0975
Schistosoma mansoni heat shock protein 0.008 0.1968 0.1868
Loa Loa (eye worm) hypothetical protein 0.0017 0.0212 0.0212
Toxoplasma gondii type I fatty acid synthase, putative 0.0018 0.0232 0.0283
Loa Loa (eye worm) hypothetical protein 0.0052 0.1183 0.1183
Onchocerca volvulus 0.0017 0.0212 0.0832
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0455 0.0336
Mycobacterium ulcerans dehydrogenase 0.0023 0.0379 0.0298
Leishmania major heat shock protein 83-1 0.008 0.1968 0.3993
Plasmodium vivax importin-beta 2, putative 0.0035 0.0709 0.1188
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0627 0.109
Trypanosoma brucei heat shock protein, putative 0.008 0.1968 0.3993
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0379 0.0442
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0627 0.109
Loa Loa (eye worm) hypothetical protein 0.0017 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0017 0.0212 0.0212
Schistosoma mansoni hypothetical protein 0.0017 0.0212 0.0089
Loa Loa (eye worm) hypothetical protein 0.0052 0.1183 0.1183
Brugia malayi amine oxidase, flavin-containing family protein 0.0023 0.0379 0.059
Trypanosoma brucei heat shock protein, putative 0.008 0.1968 0.3993
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0017 0.0212 0.0832
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0212 0.0089
Schistosoma mansoni smad1 5 8 and 0.0017 0.0203 0.0081
Trypanosoma cruzi heat shock protein 85, putative 0.008 0.1968 0.3993
Loa Loa (eye worm) hypothetical protein 0.0016 0.0195 0.0195
Toxoplasma gondii heat shock protein 90, putative 0.008 0.1968 0.3786
Giardia lamblia Grp94/Hsp90 0.0071 0.1701 0.855
Onchocerca volvulus Dual oxidase homolog 0.0052 0.1183 1
Leishmania major heat shock protein 83-1 0.008 0.1968 0.3993
Brugia malayi MH1 domain containing protein 0.0017 0.0203 0.0316
Onchocerca volvulus 0.0017 0.0212 0.0832
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.1498 0.1498
Onchocerca volvulus Neurogenic locus notch homolog 0.0017 0.0212 0.0832
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0427 0.0502
Schistosoma mansoni endoplasmin 0.008 0.1968 0.1868
Trypanosoma cruzi heat shock protein 85, putative 0.0067 0.1593 0.3181
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0407 0.0476
Schistosoma mansoni hypothetical protein 0.0017 0.0212 0.0089
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0627 0.0975
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.047 0.0403
Trypanosoma cruzi trans-sialidase, putative 0.0144 0.3728 0.7803
Schistosoma mansoni transcription factor btf3 0.0036 0.0739 0.0623
Leishmania major heat shock protein 83-1 0.008 0.1968 0.3993
Schistosoma mansoni tar DNA-binding protein 0.0063 0.1498 0.1392
Echinococcus granulosus endoplasmin 0.0071 0.1701 0.1597
Loa Loa (eye worm) endoplasmin 0.008 0.1968 0.1968
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0627 0.1081
Onchocerca volvulus Peroxidase homolog 0.0052 0.1183 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0627 0.109
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0302 0.8076 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.0017 0.0212 0.0212
Entamoeba histolytica heat shock protein 90, putative 0.008 0.1968 0.3993
Echinococcus granulosus GPCR family 2 0.0016 0.0195 0.0073
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.047 0.2194
Echinococcus multilocularis notch 0.0017 0.0212 0.0089
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0181 0.4744 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0627 0.075
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0014 0.0123 0.0125
Schistosoma mansoni serine/threonine protein kinase 0.0181 0.4744 0.4678
Leishmania major heat shock protein 83-1 0.008 0.1968 0.3993
Mycobacterium ulcerans polyketide synthase 0.0026 0.047 0.0403
Toxoplasma gondii EGF family domain-containing protein 0.0017 0.0212 0.0242
Onchocerca volvulus 0.0023 0.0379 0.2414
Echinococcus granulosus tar DNA binding protein 0.0063 0.1498 0.1392
Trichomonas vaginalis heat shock protein, putative 0.0067 0.1593 0.7966
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0014 0.0123 0.0125
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0427 0.0502
Brugia malayi EGF-like domain containing protein 0.0017 0.0212 0.0329
Echinococcus granulosus importin subunit beta 1 0.0035 0.0709 0.0592
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0427 0.0502
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0203 0.0081
Trypanosoma brucei heat shock protein 90, putative 0.008 0.1968 0.3993
Plasmodium falciparum heat shock protein 90, putative 0.0041 0.0881 0.1538
Echinococcus multilocularis protoporphyrinogen oxidase 0.0023 0.0379 0.0259
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0379 0.0519
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0739 0.1333
Schistosoma mansoni hypothetical protein 0.0016 0.0195 0.0073
Loa Loa (eye worm) hypothetical protein 0.0017 0.0212 0.0212
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0455 0.0718
Echinococcus granulosus lysine specific histone demethylase 1A 0.0023 0.0379 0.0259
Echinococcus granulosus neural cadherin 0.0017 0.0212 0.0089
Schistosoma mansoni hypothetical protein 0.0174 0.4551 0.4483
Schistosoma mansoni hypothetical protein 0.0017 0.0212 0.0089
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0014 0.0123 0.0125
Echinococcus multilocularis dual specificity 0.0181 0.4744 0.4678
Trichomonas vaginalis heat shock protein, putative 0.0055 0.1256 0.6139
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0203 0.0081
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0014 0.0123 0.0125
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0144 0.3728 0.7803
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0014 0.0134 0.0138
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0047 0.1035 0.161
Plasmodium vivax heat shock protein 90, putative 0.0045 0.0989 0.1757
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0195 0.0304
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0455 0.0733
Brugia malayi Animal haem peroxidase family protein 0.0052 0.1183 0.1839
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0014 0.0123 0.0125
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0021 0.0314 0.1209
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0455 0.1797
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0836 0.1542
Brugia malayi EGF-like domain containing protein 0.0017 0.0212 0.0329
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0304 0.0349
Leishmania major heat shock protein 83-1 0.008 0.1968 0.3993
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.1161 0.1161
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0379 0.0519
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.047 0.0555
Schistosoma mansoni smad1 5 8 and 0.0017 0.0203 0.0081
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0212 0.0329
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0294 0.7864 0.7837
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0427 0.0354
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0014 0.0123 0.0125
Echinococcus multilocularis heat shock protein 0.008 0.1968 0.1868
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.047 0.0763
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0181 0.4744 1
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0407 0.0476
Loa Loa (eye worm) fatty acid synthase 0.0024 0.0418 0.0418
Mycobacterium tuberculosis Possible oxidoreductase 0.0023 0.0379 0.0442
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0379 0.0519
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0071 0.1701 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0023 0.0379 0.0553
Loa Loa (eye worm) hypothetical protein 0.0023 0.0379 0.0379
Echinococcus granulosus smad 0.0017 0.0203 0.0081
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0427 0.0354
Toxoplasma gondii heat shock protein HSP90 0.008 0.1968 0.3786
Trichomonas vaginalis ran, putative 0.0026 0.0455 0.1797
Loa Loa (eye worm) hypothetical protein 0.0017 0.0212 0.0212
Leishmania major heat shock protein 83-1 0.008 0.1968 0.3993
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0123
Schistosoma mansoni notch 0.0017 0.0212 0.0089
Echinococcus granulosus heat shock protein 90 0.008 0.1968 0.1868
Trypanosoma cruzi trans-sialidase, putative 0.0144 0.3728 0.7802
Trypanosoma brucei heat shock protein 90, putative 0.008 0.1968 0.3993
Leishmania major heat shock protein 83-1 0.008 0.1968 0.3993
Schistosoma mansoni septate junction protein 0.0017 0.0212 0.0089
Echinococcus multilocularis protein jagged 1 0.0017 0.0212 0.0089
Trypanosoma cruzi trans-sialidase, putative 0.0144 0.3728 0.7803
Leishmania major GTP-binding protein, putative 0.0026 0.0455 0.0718
Schistosoma mansoni Smad4 0.0017 0.0203 0.0081
Loa Loa (eye worm) hypothetical protein 0.0023 0.0379 0.0379
Mycobacterium ulcerans polyketide synthase Pks9 0.0016 0.0197 0.0086
Echinococcus multilocularis peroxidasin 0.0052 0.1183 0.1072
Schistosoma mansoni notch 0.0017 0.0212 0.0089
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0427 0.0354
Mycobacterium tuberculosis Conserved protein 0.0014 0.0123 0.0125
Schistosoma mansoni notch 0.0017 0.0212 0.0089
Onchocerca volvulus Putative cubilin 0.0017 0.0212 0.0832
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0023 0.0379 0.0259
Schistosoma mansoni hypothetical protein 0.0017 0.0212 0.0089
Brugia malayi Animal haem peroxidase family protein 0.0052 0.1183 0.1839
Loa Loa (eye worm) hypothetical protein 0.0041 0.0889 0.0889
Loa Loa (eye worm) hypothetical protein 0.0017 0.0212 0.0212
Leishmania major heat shock protein 83-1 0.008 0.1968 0.3993
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0023 0.0379 0.0259
Mycobacterium ulcerans thioesterase 0.0021 0.0314 0.0222
Trypanosoma cruzi Heat shock protein 83, putative 0.008 0.1968 0.3993
Loa Loa (eye worm) hypothetical protein 0.0017 0.0212 0.0212
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.047 0.0555
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0455 0.0708
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0627 0.109
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0709 0.1245
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0383 0.0595
Echinococcus multilocularis neural cadherin 0.0017 0.0212 0.0089
Loa Loa (eye worm) hypothetical protein 0.0052 0.1183 0.1183
Mycobacterium ulcerans oxidoreductase 0.0023 0.0379 0.0298
Brugia malayi Protein kinase domain containing protein 0.0181 0.4744 0.7377
Trypanosoma cruzi heat shock protein, putative 0.0045 0.0989 0.1872
Loa Loa (eye worm) hypothetical protein 0.0035 0.0714 0.0714
Loa Loa (eye worm) RNA binding protein 0.0063 0.1498 0.1498
Schistosoma mansoni ran 0.0026 0.0455 0.0336
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0212 0.0089
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0627 0.051
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.047 0.0555
Schistosoma mansoni peroxidasin 0.0052 0.1183 0.1072
Trypanosoma brucei transcription factor BTF3, putative 0.0036 0.0739 0.1333
Schistosoma mansoni smad 0.0017 0.0203 0.0081
Loa Loa (eye worm) hypothetical protein 0.0017 0.0212 0.0212
Loa Loa (eye worm) TOPoisomerase family member 0.0014 0.0123 0.0123
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.1498 0.233
Leishmania major heat shock protein 83-1 0.008 0.1968 0.3993
Loa Loa (eye worm) TAR-binding protein 0.0063 0.1498 0.1498
Loa Loa (eye worm) hypothetical protein 0.0017 0.0212 0.0212
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.047 0.2194
Leishmania major basic transcription factor 3a, putative 0.0036 0.0739 0.1333
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0527 0.2187
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.0189 0.0196
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0014 0.0123 0.0065
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0325 0.8707 1
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0144 0.3728 0.7803
Trypanosoma cruzi trans-sialidase, putative 0.0144 0.3728 0.7802
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0014 0.0123 0.0125
Trypanosoma brucei trans-sialidase, putative 0.0144 0.3728 0.7803
Mycobacterium ulcerans thioesterase TesA 0.0021 0.0314 0.0222
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0037 0.0763 0.0919
Entamoeba histolytica hypothetical protein 0.0036 0.0739 0.1333
Loa Loa (eye worm) hypothetical protein 0.0052 0.1183 0.1183
Entamoeba histolytica hypothetical protein 0.0028 0.0527 0.0873
Echinococcus granulosus transcription factor btf3 0.0036 0.0739 0.0623
Trypanosoma cruzi heat shock protein 85, putative 0.008 0.1968 0.3993
Mycobacterium tuberculosis Probable two component sensor kinase 0.0014 0.0123 0.0125
Treponema pallidum heat shock protein 90 0.0071 0.1701 1
Trypanosoma cruzi trans-sialidase, putative 0.0144 0.3728 0.7802
Loa Loa (eye worm) hypothetical protein 0.0023 0.0379 0.0379
Trypanosoma brucei trans-sialidase, putative 0.0144 0.3728 0.7803
Schistosoma mansoni notch 0.0017 0.0212 0.0089
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0071 0.1701 0.3414
Trypanosoma brucei trans-sialidase, putative 0.0144 0.3728 0.7803
Echinococcus multilocularis fat cadherin tumor suppressor 0.0017 0.0212 0.0089
Leishmania major heat shock protein, putative 0.0045 0.0989 0.1872
Loa Loa (eye worm) hypothetical protein 0.0017 0.0212 0.0212
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0295 0.1085
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0144 0.3728 0.7803
Loa Loa (eye worm) hypothetical protein 0.0052 0.1183 0.1183
Echinococcus granulosus protein jagged 1 0.0017 0.0212 0.0089
Loa Loa (eye worm) hypothetical protein 0.0017 0.0212 0.0212
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0144 0.3728 0.7803
Brugia malayi Animal haem peroxidase family protein 0.0052 0.1183 0.1839
Loa Loa (eye worm) hypothetical protein 0.0052 0.1183 0.1183
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0527 0.2187
Echinococcus granulosus slit 2 protein 0.0017 0.0212 0.0089
Brugia malayi EGF-like domain containing protein 0.0017 0.0212 0.0329
Loa Loa (eye worm) hypothetical protein 0.0017 0.0212 0.0212
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0455 0.0673
Brugia malayi MH2 domain containing protein 0.0242 0.643 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0123
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Brugia malayi Probable DNA topoisomerase II 0.0014 0.0123 0.0192
Trypanosoma brucei trans-sialidase, putative 0.0144 0.3728 0.7803
Chlamydia trachomatis protoporphyrinogen oxidase 0.0023 0.0379 1
Toxoplasma gondii histone lysine-specific demethylase 0.0023 0.0379 0.058
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.1183 0.1183
Brugia malayi Hsp90 protein 0.0045 0.0989 0.1537
Entamoeba histolytica protein kinase domain containing protein 0.0181 0.4744 1
Trichomonas vaginalis heat shock protein, putative 0.008 0.1968 1
Trypanosoma brucei heat shock protein, putative 0.008 0.1968 0.3993
Plasmodium vivax endoplasmin, putative 0.008 0.1968 0.3746
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.1183 0.1183
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0195 0.0073
Leishmania major heat shock protein 83-1 0.008 0.1968 0.3993
Echinococcus multilocularis fibropellin Ia 0.0017 0.0212 0.0089
Echinococcus multilocularis geminin 0.0174 0.4551 0.4483
Brugia malayi MH1 domain containing protein 0.0017 0.0203 0.0316
Brugia malayi Importin beta-1 subunit 0.0035 0.0709 0.1102
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0627 0.051
Echinococcus multilocularis neurogenic locus notch protein 4 0.0017 0.0212 0.0089
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0045 0.0989 0.0876
Mycobacterium ulcerans polyketide synthase Pks13 0.0037 0.0763 0.0745
Schistosoma mansoni peroxidasin 0.0052 0.1183 0.1072
Brugia malayi TAR-binding protein 0.0063 0.1498 0.233
Loa Loa (eye worm) hypothetical protein 0.0017 0.0212 0.0212
Trypanosoma brucei Heat shock protein 83, putative 0.008 0.1968 0.3993
Toxoplasma gondii DNA topoisomerase 2, putative 0.0014 0.0123 0.0065
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0627 0.1023
Trypanosoma brucei heat shock protein 84, putative 0.0045 0.0989 0.1872
Loa Loa (eye worm) blistered cuticle protein 3 0.0052 0.1183 0.1183
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0144 0.3728 0.7803
Loa Loa (eye worm) hypothetical protein 0.0023 0.0379 0.0379
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0455 0.0718
Schistosoma mansoni notch 0.0017 0.0212 0.0089
Echinococcus multilocularis transcription factor btf3 0.0036 0.0739 0.0623
Echinococcus multilocularis protein jagged 2 0.0017 0.0212 0.0089
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0037 0.0763 0.0919
Trypanosoma brucei heat shock protein, putative 0.008 0.1968 0.3993
Brugia malayi Muscle positioning protein 4 0.0017 0.0212 0.0329
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0195 0.0073
Loa Loa (eye worm) heat shock protein 90 0.008 0.1968 0.1968
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0195 0.0073
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0627 0.051
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0739 0.3338
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0181 0.4744 1
Mycobacterium tuberculosis Probable thioesterase TesA 0.0021 0.0314 0.0362
Brugia malayi kinase, mitochondrial precursor 0.0014 0.0123 0.0192
Loa Loa (eye worm) Smad1 0.0017 0.0203 0.0203
Trypanosoma brucei heat shock protein, putative 0.008 0.1968 0.3993
Loa Loa (eye worm) hypothetical protein 0.018 0.4718 0.4718
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0023 0.0379 0.1621
Leishmania major heat shock protein 83-1 0.008 0.1968 0.3993
Echinococcus granulosus delta-like protein 1 0.0017 0.0212 0.0089
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0144 0.3728 0.7803

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.4581 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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