Detailed information for compound 1232483

Basic information

Technical information
  • TDR Targets ID: 1232483
  • Name: 2-[4-[(1-ethyl-3,5-dimethylpyrazol-4-yl)methy l]-1-[(3-methoxyphenyl)methyl]piperazin-2-yl] ethanol
  • MW: 386.531 | Formula: C22H34N4O2
  • H donors: 1 H acceptors: 2 LogP: 2.19 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCC1CN(CCN1Cc1cccc(c1)OC)Cc1c(C)nn(c1C)CC
  • InChi: 1S/C22H34N4O2/c1-5-26-18(3)22(17(2)23-26)16-24-10-11-25(20(15-24)9-12-27)14-19-7-6-8-21(13-19)28-4/h6-8,13,20,27H,5,9-12,14-16H2,1-4H3
  • InChiKey: GPQUUNSIFSVCAZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-[(1-ethyl-3,5-dimethyl-pyrazol-4-yl)methyl]-1-[(3-methoxyphenyl)methyl]piperazin-2-yl]ethanol
  • 2-[4-[(1-ethyl-3,5-dimethyl-4-pyrazolyl)methyl]-1-[(3-methoxyphenyl)methyl]-2-piperazinyl]ethanol
  • 2-[4-[(1-ethyl-3,5-dimethyl-pyrazol-4-yl)methyl]-1-(3-methoxybenzyl)piperazin-2-yl]ethanol
  • SMR000316065
  • 2-[4-[(1-ethyl-3,5-dimethyl-1H-pyrazol-4-yl)methyl]-1-(3-methoxybenzyl)piperazin-2-yl]ethanol
  • MLS000732861

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni transient receptor potential channel 0.0083 0.0623 0.0623
Leishmania major cathepsin L-like protease 0.063 0.5263 1
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Onchocerca volvulus Cathepsin L homolog 0.063 0.5263 1
Trypanosoma cruzi cysteine proteinase, putative 0.034 0.2804 0.2802
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0222 0.5687
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0143 0.1128 0.2143
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0466 0.3872 0.387
Leishmania major hypothetical protein, conserved 0.0212 0.1717 0.3151
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Brugia malayi beta-lactamase family protein 0.0036 0.0222 0.0207
Brugia malayi Papain family cysteine protease containing protein 0.0143 0.1128 0.1114
Leishmania major hypothetical protein, conserved 0.0036 0.0222 0.0264
Brugia malayi PHD-finger family protein 0.0029 0.0164 0.0149
Brugia malayi Cathepsin L-like precursor 0.063 0.5263 0.5255
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0559 0.0559
Echinococcus granulosus hyperpolarization activated cyclic 0.0083 0.0623 0.0623
Trichomonas vaginalis esterase, putative 0.0036 0.0222 0.0264
Echinococcus granulosus transient receptor potential cation channel 0.0083 0.0623 0.0623
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Brugia malayi jmjC domain containing protein 0.0095 0.0725 0.0711
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Entamoeba histolytica cysteine protease, putative 0.0143 0.1128 0.2143
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Echinococcus granulosus cathepsin L cysteine proteinase 0.063 0.5263 0.5263
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0143 0.1128 0.2014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.063 0.5263 1
Brugia malayi Papain family cysteine protease containing protein 0.063 0.5263 0.5255
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.063 0.5263 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0083 0.0623 0.0623
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.063 0.5263 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0083 0.0623 0.0608
Schistosoma mansoni cathepsin s 0.0198 0.1594 0.1594
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0222 0.0264
Plasmodium falciparum phd finger protein, putative 0.0029 0.0164 0.0282
Onchocerca volvulus 0.0035 0.0212 0.0093
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1189 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0083 0.0623 0.0623
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0143 0.1128 0.2753
Brugia malayi fibroinase precursor 0.0143 0.1128 0.1114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.063 0.5263 1
Plasmodium falciparum serine repeat antigen 5 0.0143 0.1128 0.2119
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0085 0.0132
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0725 0.0725
Schistosoma mansoni cathepsin F (C01 family) 0.063 0.5263 0.5263
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0143 0.1128 0.2119
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0083 0.0623 0.0623
Loa Loa (eye worm) calcium channel 0.0083 0.0623 0.062
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0083 0.0623 0.0623
Giardia lamblia Cathepsin L precursor 0.0143 0.1128 0.2753
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0296 0.0407
Schistosoma mansoni ryanodine receptor related 0.0083 0.0623 0.0623
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.063 0.5263 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0143 0.1128 0.2143
Plasmodium vivax serine-repeat antigen (SERA) 0.0143 0.1128 0.2143
Giardia lamblia Cathepsin B precursor 0.0143 0.1128 0.2753
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0143 0.1128 0.1128
Entamoeba histolytica hypothetical protein 0.0143 0.1128 0.2143
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0143 0.1128 0.1128
Brugia malayi cathepsin L precursor 0.0143 0.1128 0.1114
Echinococcus multilocularis sodium channel protein 0.0083 0.0623 0.0623
Echinococcus multilocularis transient receptor potential gamma protein 0.0083 0.0623 0.0623
Entamoeba histolytica cysteine proteinase, putative 0.034 0.2804 0.5328
Loa Loa (eye worm) hypothetical protein 0.0029 0.0164 0.0161
Echinococcus granulosus cathepsin l1 0.063 0.5263 0.5263
Entamoeba histolytica recQ family helicase, putative 0.002 0.0085 0.0162
Echinococcus granulosus transient receptor potential cation channel 0.0083 0.0623 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0143 0.1128 0.2014
Brugia malayi Papain family cysteine protease containing protein 0.034 0.2804 0.2793
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0083 0.0623 0.0623
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0083 0.0623 0.0623
Onchocerca volvulus 0.0433 0.3586 0.6712
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0083 0.0623 0.0623
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0233 0.0233
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0083 0.0623 0.0623
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0296 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0433 0.3586 0.6762
Echinococcus multilocularis cathepsin L cysteine protease 0.063 0.5263 0.5263
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0143 0.1128 0.1128
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0177 0.0177
Echinococcus granulosus potassium large conductance calcium activated 0.0083 0.0623 0.0623
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0083 0.0623 0.0623
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0083 0.0623 0.0623
Entamoeba histolytica cysteine proteinase, putative 0.034 0.2804 0.5328
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0296 0.0296
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Loa Loa (eye worm) hypothetical protein 0.0143 0.1128 0.1125
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0296 0.0293
Echinococcus granulosus short transient receptor potential channel 6 0.0089 0.0669 0.0669
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0083 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.1684 0.1682
Giardia lamblia Cathepsin L precursor 0.0143 0.1128 0.2753
Loa Loa (eye worm) hypothetical protein 0.0143 0.1128 0.1125
Loa Loa (eye worm) hypothetical protein 0.0036 0.0222 0.0219
Echinococcus multilocularis cysteine protease 0.063 0.5263 0.5263
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0296 0.0296
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0083 0.0623 0.062
Plasmodium vivax vivapain-1 0.034 0.2804 0.5328
Echinococcus multilocularis cathepsin l cysteine peptidase 0.063 0.5263 0.5263
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0143 0.1128 0.2014
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0083 0.0623 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Echinococcus multilocularis transient receptor potential cation channel 0.0089 0.0669 0.0669
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.063 0.5263 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.063 0.5263 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0083 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.0031 0.0177 0.0174
Toxoplasma gondii preprocathepsin c precursor, putative 0.0143 0.1128 0.2143
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0085 0.0085
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0164 0.0164
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0085 0.007
Echinococcus granulosus transient receptor potential cation channel 0.0083 0.0623 0.0623
Trypanosoma cruzi cysteine peptidase, putative 0.0198 0.1594 0.1591
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.1128 0.2014
Trypanosoma cruzi cysteine peptidase, putative 0.063 0.5263 0.5261
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.034 0.2804 0.5251
Plasmodium vivax unspecified product 0.0143 0.1128 0.2143
Brugia malayi Cathepsin L-like precursor 0.063 0.5263 0.5255
Plasmodium falciparum cysteine proteinase falcipain 2b 0.063 0.5263 1
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0083 0.0623 0.1038
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0466 0.3872 0.7314
Echinococcus multilocularis shaker cognate 0.0083 0.0623 0.0623
Brugia malayi olfactory channel protein osm-9 0.0089 0.0669 0.0655
Echinococcus multilocularis transient receptor potential cation channel 0.0083 0.0623 0.0623
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Loa Loa (eye worm) inositol-1 0.0045 0.0296 0.0293
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0083 0.0623 0.0623
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0125 0.0125
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0143 0.1128 0.2753
Schistosoma mansoni 60S ribosomal protein L21 0.0083 0.0623 0.0623
Echinococcus multilocularis potassium large conductance calcium activated 0.0083 0.0623 0.0623
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0222 0.0422
Echinococcus multilocularis bloom syndrome protein 0.002 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Leishmania major cathepsin L-like protease 0.063 0.5263 1
Schistosoma mansoni cathepsin S (C01 family) 0.0143 0.1128 0.1128
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0083 0.0623 0.0623
Toxoplasma gondii hypothetical protein 0.0083 0.0623 0.1183
Loa Loa (eye worm) voltage-gated calcium channel 0.0083 0.0623 0.062
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0177 0.0177
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0177 0.0177
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1189 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.034 0.2804 0.5251
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0083 0.0623 0.0623
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0083 0.0623 0.062
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0085 0.0162
Loa Loa (eye worm) hypothetical protein 0.0089 0.0669 0.0666
Echinococcus granulosus transient receptor potential cation channel 0.0083 0.0623 0.0623
Echinococcus granulosus cathepsin L cysteine protease 0.034 0.2804 0.2804
Echinococcus multilocularis two pore calcium channel protein 2 0.0083 0.0623 0.0623
Brugia malayi Cyclic-nucleotide gated cation channel 0.0083 0.0623 0.0608
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0083 0.0623 0.0608
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0143 0.1128 0.2119
Entamoeba histolytica cysteine protease, putative 0.063 0.5263 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0143 0.1128 0.2014
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Trypanosoma cruzi hypothetical protein, conserved 0.0212 0.1717 0.1714
Onchocerca volvulus 0.0083 0.0623 0.0899
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0222 0.0264
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0083 0.0623 0.0623
Loa Loa (eye worm) voltage-dependent calcium channel 0.0083 0.0623 0.062
Echinococcus multilocularis hyperpolarization activated cyclic 0.0083 0.0623 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0143 0.1128 0.2014
Giardia lamblia Cathepsin B precursor 0.0143 0.1128 0.2753
Loa Loa (eye worm) papain family cysteine protease containing protein 0.063 0.5263 0.5261
Plasmodium falciparum cysteine proteinase falcipain 1 0.034 0.2804 0.5314
Loa Loa (eye worm) hypothetical protein 0.0143 0.1128 0.1125
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0222 0.056
Echinococcus multilocularis potassium voltage gated channel protein 0.0083 0.0623 0.0623
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0081 0.0081
Echinococcus multilocularis voltage dependent calcium channel 0.0083 0.0623 0.0623
Echinococcus granulosus potassium voltage gated channel protein 0.0083 0.0623 0.0623
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0085 0.0132
Giardia lamblia Cathepsin B precursor 0.0466 0.3872 1
Entamoeba histolytica cysteine protease, putative 0.0143 0.1128 0.2143
Trypanosoma cruzi hypothetical protein, conserved 0.0212 0.1717 0.1714
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0083 0.0623 0.0623
Entamoeba histolytica cysteine proteinase, putative 0.0433 0.3586 0.6815
Loa Loa (eye worm) voltage-gated potassium channel 0.0083 0.0623 0.062
Giardia lamblia Cathepsin L precursor 0.0143 0.1128 0.2753
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Mycobacterium ulcerans beta-lactamase 0.0036 0.0222 0.5687
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Echinococcus granulosus shaker cognate 0.0083 0.0623 0.0623
Giardia lamblia Cysteine protease 0.0143 0.1128 0.2753
Echinococcus granulosus transient receptor potential gamma protein 0.0083 0.0623 0.0623
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0083 0.0623 0.0608
Plasmodium falciparum serine repeat antigen 9 0.0143 0.1128 0.2119
Loa Loa (eye worm) cathepsin B 0.0466 0.3872 0.387
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0083 0.0623 0.0899
Brugia malayi beta-lactamase family protein 0.0036 0.0222 0.0207
Echinococcus granulosus potassium voltage gated channel protein 0.0083 0.0623 0.0623
Echinococcus multilocularis transient receptor potential cation channel 0.0083 0.0623 0.0623
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0083 0.0623 0.0623
Echinococcus multilocularis transient receptor potential cation channel 0.0089 0.0669 0.0669
Echinococcus granulosus calcium activated potassium channel 0.0083 0.0623 0.0623
Brugia malayi cathepsin F-like cysteine proteinase 0.0143 0.1128 0.1114
Echinococcus multilocularis peregrin 0.0029 0.0164 0.0164
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0083 0.0623 0.0623
Entamoeba histolytica cysteine protease, putative 0.0143 0.1128 0.2143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0083 0.0623 0.0608
Brugia malayi Bromodomain containing protein 0.0029 0.0164 0.0149
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1189 1 1
Schistosoma mansoni two-pore calcium channel 0.0083 0.0623 0.0623
Leishmania major cathepsin L-like protease 0.063 0.5263 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0143 0.1128 0.2143
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.0014 0.0014
Giardia lamblia Cathepsin L precursor 0.0143 0.1128 0.2753
Onchocerca volvulus 0.0036 0.0222 0.0114
Toxoplasma gondii cathepsin CPC1 0.0143 0.1128 0.2143
Echinococcus multilocularis cpg binding protein 0.0037 0.0229 0.0229
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0222 0.0207
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0083 0.0623 0.062
Schistosoma mansoni cathepsin F (C01 family) 0.0433 0.3586 0.3586
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0083 0.0623 0.0608
Plasmodium vivax vivapain-2 0.063 0.5263 1
Schistosoma mansoni hypothetical protein 0.0083 0.0623 0.0623
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0143 0.1128 0.2143
Trypanosoma cruzi cysteine protease, putative 0.034 0.2804 0.2802
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0256 1
Echinococcus granulosus cathepsin L 0.034 0.2804 0.2804
Echinococcus granulosus short transient receptor potential channel 6 0.0083 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.0198 0.1594 0.1591
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.063 0.5263 1
Onchocerca volvulus 0.063 0.5263 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0164 0.0164
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0143 0.1128 0.2014
Trypanosoma cruzi cysteine peptidase, putative 0.063 0.5263 0.5261
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0085 0.0085
Echinococcus multilocularis two pore calcium channel protein 1 0.0083 0.0623 0.0623
Loa Loa (eye worm) voltage-gated potassium channel 0.0083 0.0623 0.062
Mycobacterium tuberculosis Conserved protein 0.0036 0.0222 0.056
Echinococcus granulosus hypothetical protein 0.0083 0.0623 0.0623
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0296 0.0407
Echinococcus granulosus dnaJ subfamily B 0.0494 0.4107 0.4107
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0083 0.0623 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0433 0.3586 0.6762
Entamoeba histolytica cysteine proteinase 1, putative 0.034 0.2804 0.5328
Trypanosoma cruzi cysteine peptidase, putative 0.063 0.5263 0.5261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.063 0.5263 1
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0083 0.0623 0.0623
Onchocerca volvulus Cathepsin F homolog 0.063 0.5263 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0222 0.056
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0083 0.0623 0.0623
Echinococcus granulosus potassium voltage gated channel protein 0.0083 0.0623 0.0623
Brugia malayi cathepsin L-like cysteine proteinase 0.0143 0.1128 0.1114
Loa Loa (eye worm) hypothetical protein 0.0143 0.1128 0.1125
Brugia malayi cathepsin Z-like cysteine proteinase 0.0143 0.1128 0.1114
Loa Loa (eye worm) hypothetical protein 0.063 0.5263 0.5261
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0164 0.0312
Schistosoma mansoni DNA helicase recq5 0.002 0.0085 0.0085
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0143 0.1128 0.2143
Echinococcus granulosus cathepsin L 0.0143 0.1128 0.1128
Loa Loa (eye worm) hypothetical protein 0.002 0.0085 0.0082
Plasmodium falciparum cysteine proteinase falcipain 3 0.063 0.5263 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0085 0.0162
Schistosoma mansoni cpg binding protein 0.0037 0.0229 0.0229
Schistosoma mansoni cpg binding protein 0.0037 0.0229 0.0229
Plasmodium vivax SET domain protein, putative 0.0031 0.0177 0.0336
Giardia lamblia Hypothetical protein 0.0143 0.1128 0.2753
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0143 0.1128 0.1128
Loa Loa (eye worm) hypothetical protein 0.0036 0.0222 0.0219
Giardia lamblia Encystation-specific protease 0.0143 0.1128 0.2753
Schistosoma mansoni inositol monophosphatase 0.0045 0.0296 0.0296
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0296 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0222 0.056
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0143 0.1128 0.2143
Plasmodium falciparum serine repeat antigen 7 0.0143 0.1128 0.2119
Echinococcus granulosus sodium leak channel non selective protein 0.0083 0.0623 0.0623
Onchocerca volvulus 0.063 0.5263 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.063 0.5263 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0143 0.1128 0.1125
Plasmodium vivax vivapain-3 0.034 0.2804 0.5328
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0222 0.0222
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0083 0.0623 0.1038
Echinococcus multilocularis transfer RNA-Gly 0.0083 0.0623 0.0623
Plasmodium vivax vivapain-2 0.063 0.5263 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0222 0.0219
Plasmodium vivax serine-repeat antigen (SERA) 0.0143 0.1128 0.2143
Schistosoma mansoni hypothetical protein 0.0494 0.4107 0.4107
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0083 0.0623 0.1183
Echinococcus multilocularis cathepsin b 0.1189 1 1
Echinococcus granulosus transient receptor potential cation channel 0.0089 0.0669 0.0669
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0233 0.0233
Schistosoma mansoni cathepsin C 0.0143 0.1128 0.1128
Echinococcus multilocularis conserved hypothetical protein 0.0083 0.0623 0.0623
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0083 0.0623 0.0623
Leishmania major cathepsin L-like protease 0.063 0.5263 1
Echinococcus multilocularis cysteine protease 0.063 0.5263 0.5263
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0083 0.0623 0.0608
Brugia malayi Papain family cysteine protease containing protein 0.0143 0.1128 0.1114
Echinococcus granulosus two pore calcium channel protein 1 0.0083 0.0623 0.0623
Brugia malayi Cathepsin L-like precursor 0.0433 0.3586 0.3577
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.034 0.2804 0.2804
Schistosoma mansoni transient receptor potential channel 0.0089 0.0669 0.0669
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0484 0.092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0083 0.0623 0.0608
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0177 0.0177
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0083 0.0623 0.0623
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0018 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Entamoeba histolytica cysteine protease, putative 0.0143 0.1128 0.2143
Brugia malayi cation channel family protein 0.0083 0.0623 0.0608
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0222 0.056
Mycobacterium ulcerans lipase LipD 0.0036 0.0222 0.5687
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0125 0.0122
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0296 1
Onchocerca volvulus 0.0036 0.0222 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Loa Loa (eye worm) ion channel NompC 0.0083 0.0623 0.062
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Giardia lamblia Cysteine protease 0.0143 0.1128 0.2753
Giardia lamblia Cathepsin B precursor 0.0143 0.1128 0.2753
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0083 0.0623 0.0623
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0083 0.0623 0.0608
Echinococcus granulosus peregrin 0.0029 0.0164 0.0164
Brugia malayi Pre-SET motif family protein 0.0208 0.1684 0.1672
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0125 0.0076
Brugia malayi Transient-receptor-potential like protein 0.0083 0.0623 0.0608
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Plasmodium falciparum serine repeat antigen 1 0.0143 0.1128 0.2119
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0177 0.0336
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0083 0.0623 0.0623
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0083 0.0623 0.0608
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0222 0.0222
Echinococcus multilocularis transient receptor potential cation channel 0.0083 0.0623 0.0623
Giardia lamblia Cathepsin L-like protease 0.0143 0.1128 0.2753
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.0014 0.0014
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.1863 1
Plasmodium falciparum serine repeat antigen 2 0.0143 0.1128 0.2119
Onchocerca volvulus 0.063 0.5263 1
Onchocerca volvulus 0.0036 0.0222 0.0114
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0222 0.0264
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0143 0.1128 0.2014
Brugia malayi Cathepsin L-like cysteine proteinase 0.0433 0.3586 0.3577
Schistosoma mansoni inositol monophosphatase 0.0045 0.0296 0.0296
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0143 0.1128 0.2143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.063 0.5263 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0466 0.3872 0.7314
Brugia malayi beta-lactamase 0.0036 0.0222 0.0207
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0083 0.0623 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0143 0.1128 0.2014
Echinococcus multilocularis cathepsin l cysteine peptidase 0.063 0.5263 0.5263
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0098 0.0082
Loa Loa (eye worm) hypothetical protein 0.0036 0.0222 0.0219
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.063 0.5263 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0164 0.0312
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0177 0.0177
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0143 0.1128 0.1128
Giardia lamblia Cathepsin B precursor 0.0466 0.3872 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0083 0.0623 0.062
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.063 0.5263 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.063 0.5263 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.063 0.5263 1
Schistosoma mansoni calcium-activated potassium channel 0.0083 0.0623 0.0623
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0222 0.0219
Leishmania major cysteine peptidase A (CPA) 0.063 0.5263 1
Loa Loa (eye worm) hypothetical protein 0.0433 0.3586 0.3584
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0212 0.0209
Brugia malayi Cathepsin L-like precursor 0.0198 0.1594 0.1581
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0143 0.1128 0.2753
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0083 0.0623 0.0623
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0466 0.3872 0.3872
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0003 0.0006
Loa Loa (eye worm) beta-lactamase 0.0036 0.0222 0.0219
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0083 0.0623 0.0623
Plasmodium falciparum serine repeat antigen 8 0.0143 0.1128 0.2119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.063 0.5263 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0296 0.0407
Onchocerca volvulus 0.063 0.5263 1
Echinococcus granulosus potassium voltage gated channel protein 0.0083 0.0623 0.0623
Echinococcus granulosus cpg binding protein 0.0037 0.0229 0.0229
Echinococcus multilocularis short transient receptor potential channel 6 0.0089 0.0669 0.0669
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Brugia malayi hypothetical protein 0.0083 0.0623 0.0608
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0083 0.0623 0.0623
Entamoeba histolytica cysteine proteinase, putative 0.034 0.2804 0.5328
Echinococcus multilocularis short transient receptor potential channel 6 0.0083 0.0623 0.0623
Plasmodium falciparum serine repeat antigen 6 0.0143 0.1128 0.2119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0466 0.3872 0.7314
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0222 0.056
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Echinococcus granulosus jumonji domain containing protein 0.004 0.0261 0.0261
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0083 0.0623 0.0608
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Giardia lamblia Cathepsin B precursor 0.0466 0.3872 1
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0083 0.0623 0.0623
Leishmania major hypothetical protein, conserved 0.0083 0.0623 0.1038
Onchocerca volvulus 0.0031 0.0177 0.0024
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0083 0.0623 0.0623
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0164 0.0164
Trypanosoma cruzi cruzipain precursor, putative 0.0198 0.1594 0.1591
Entamoeba histolytica cysteine protease, putative 0.0143 0.1128 0.2143
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0222 0.0219
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0143 0.1128 0.1125
Loa Loa (eye worm) hypothetical protein 0.0198 0.1594 0.1591
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0125 0.0125
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.034 0.2804 0.2804
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0085 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0143 0.1128 0.2014
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0143 0.1128 0.2119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.034 0.2804 0.5251
Loa Loa (eye worm) hypothetical protein 0.1189 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0083 0.0623 0.0623
Plasmodium falciparum serine repeat antigen 4 0.0143 0.1128 0.2119
Loa Loa (eye worm) hypothetical protein 0.0433 0.3586 0.3584
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0083 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0083 0.0623 0.1038
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0296 0.0563
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0083 0.0623 0.0623
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0083 0.0623 0.1183
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0083 0.0623 0.0623
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.034 0.2804 0.2804
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0143 0.1128 0.1128
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0222 0.0219
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.1128 0.2014
Leishmania major cathepsin L-like protease 0.063 0.5263 1
Leishmania major hypothetical protein, unknown function 0.0083 0.0623 0.1038
Entamoeba histolytica cysteine proteinase, putative 0.063 0.5263 1
Echinococcus granulosus voltage gated potassium channel 0.0083 0.0623 0.0623
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0161 0.0161
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0083 0.0623 0.0623
Onchocerca volvulus Cathepsin L homolog 0.063 0.5263 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0198 0.1594 0.1581
Toxoplasma gondii hypothetical protein 0.0083 0.0623 0.1183
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0003 0.5
Toxoplasma gondii transporter, cation channel family protein 0.0083 0.0623 0.1183
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0222 0.5687
Echinococcus multilocularis voltage gated potassium channel 0.0083 0.0623 0.0623
Brugia malayi Cathepsin L-like precursor 0.063 0.5263 0.5255
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0143 0.1128 0.1114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.063 0.5263 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0143 0.1128 0.2143
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0427 0.0424
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0143 0.1128 0.2014
Loa Loa (eye worm) ryanodine receptor 0.0083 0.0623 0.062
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Echinococcus multilocularis potassium voltage gated channel protein 0.0083 0.0623 0.0623
Toxoplasma gondii ABC1 family protein 0.0036 0.0222 0.0422
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0016 0.0031
Schistosoma mansoni cathepsin F (C01 family) 0.063 0.5263 0.5263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Entamoeba histolytica cysteine proteinase 2 0.034 0.2804 0.5328
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0083 0.0623 0.0623
Leishmania major cathepsin L-like protease 0.063 0.5263 1
Giardia lamblia Cathepsin L precursor 0.0143 0.1128 0.2753
Giardia lamblia Cathepsin L precursor 0.0143 0.1128 0.2753
Plasmodium vivax unspecified product 0.0198 0.1594 0.3029
Trypanosoma cruzi cysteine proteinase, putative 0.034 0.2804 0.2802
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0083 0.0623 0.062
Echinococcus multilocularis voltage dependent calcium channel 0.0083 0.0623 0.0623
Echinococcus granulosus voltage dependent calcium channel 0.0083 0.0623 0.0623
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0143 0.1128 0.1128
Onchocerca volvulus 0.063 0.5263 1
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0085 0.0082
Loa Loa (eye worm) hypothetical protein 0.0036 0.0222 0.0219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Echinococcus multilocularis cathepsin L cysteine protease 0.063 0.5263 0.5263
Loa Loa (eye worm) hypothetical protein 0.0433 0.3586 0.3584
Entamoeba histolytica cysteine proteinase, putative 0.034 0.2804 0.5328
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0083 0.0623 0.0623
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0083 0.0623 0.0623
Leishmania major cathepsin L-like protease 0.063 0.5263 1
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0164 0.0161
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0143 0.1128 0.2014
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0083 0.0623 0.1038
Loa Loa (eye worm) hypothetical protein 0.005 0.0341 0.0337
Onchocerca volvulus 0.0242 0.1974 0.355
Brugia malayi voltage-dependent calcium channel 0.0083 0.0623 0.0608
Echinococcus granulosus cathepsin l cysteine peptidase 0.063 0.5263 0.5263
Echinococcus multilocularis ryanodine receptor 44f 0.0083 0.0623 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0143 0.1128 0.2014
Schistosoma mansoni transient receptor potential channel 0.0083 0.0623 0.0623
Echinococcus granulosus TRP transient receptor potential channel 0.0083 0.0623 0.0623
Echinococcus multilocularis potassium voltage gated channel protein 0.0083 0.0623 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0143 0.1128 0.2014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.034 0.2804 0.5251
Echinococcus multilocularis calcium activated potassium channel 0.0083 0.0623 0.0623
Brugia malayi Cathepsin L-like precursor 0.0433 0.3586 0.3577
Brugia malayi Cathepsin L-like precursor 0.063 0.5263 0.5255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0233 0.023
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0083 0.0623 0.0608
Brugia malayi ion channel NompC 0.0083 0.0623 0.0608
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.063 0.5263 1
Giardia lamblia Cathepsin L-like protease 0.0143 0.1128 0.2753
Schistosoma mansoni DNA helicase recq1 0.002 0.0085 0.0085
Toxoplasma gondii cathepsin CPL 0.063 0.5263 1
Echinococcus multilocularis voltage gated potassium channel 0.0083 0.0623 0.0623
Schistosoma mansoni voltage-gated ion channel 0.0083 0.0623 0.0623
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0083 0.0623 0.1038
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0233 0.0233
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0083 0.0623 0.0608
Leishmania major cathepsin L-like protease 0.063 0.5263 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.063 0.5263 0.5261
Schistosoma mansoni voltage-gated cation channel 0.0083 0.0623 0.0623
Echinococcus granulosus voltage gated potassium channel 0.0083 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.0036 0.0222 0.0219
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.063 0.5263 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0143 0.1128 0.2014
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0083 0.0623 0.0623
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1189 1 1
Brugia malayi jmjC domain containing protein 0.0037 0.0233 0.0218
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0083 0.0623 0.0623
Trypanosoma cruzi major cysteine proteinase, putative 0.0143 0.1128 0.1125
Brugia malayi Papain family cysteine protease containing protein 0.034 0.2804 0.2793
Echinococcus granulosus cathepsin l1 0.0433 0.3586 0.3586
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0083 0.0623 0.0608
Trypanosoma cruzi cysteine peptidase, putative 0.034 0.2804 0.2802
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0198 0.1594 0.1591
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0083 0.0623 0.0608
Onchocerca volvulus 0.063 0.5263 1
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0003 0.0003
Toxoplasma gondii transporter, cation channel family protein 0.0083 0.0623 0.1183
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0083 0.0623 0.0899
Toxoplasma gondii cathepsin B 0.0466 0.3872 0.7357
Loa Loa (eye worm) hypothetical protein 0.0143 0.1128 0.1125
Brugia malayi CXXC zinc finger family protein 0.0035 0.0212 0.0197
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0725 0.0725
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0296 0.0407
Brugia malayi cathepsin Z-like cysteine proteinase 0.0143 0.1128 0.1114
Entamoeba histolytica recQ family DNA helicase 0.001 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Echinococcus granulosus two pore calcium channel protein 2 0.0083 0.0623 0.0623
Onchocerca volvulus Cathepsin L homolog 0.0143 0.1128 0.189
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0433 0.3586 0.3584
Brugia malayi Cathepsin L-like precursor 0.063 0.5263 0.5255
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Loa Loa (eye worm) ctsf protein 0.063 0.5263 0.5261
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0222 0.056
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0085 0.007
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0222 0.056
Echinococcus multilocularis cathepsin L 0.034 0.2804 0.2804
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0222 0.056
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0177 0.0177
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.063 0.5263 1
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Schistosoma mansoni hypothetical protein 0.0029 0.0164 0.0164
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0085 0.007
Brugia malayi cation channel family protein 0.0083 0.0623 0.0608
Echinococcus granulosus ryanodine receptor 44f 0.0083 0.0623 0.0623
Giardia lamblia PHD finger protein 15 0.0029 0.0164 0.0209
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0125 0.0122
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.4107 0.4107
Echinococcus granulosus sodium channel protein 0.0083 0.0623 0.0623
Trypanosoma cruzi major cysteine proteinase, putative 0.0143 0.1128 0.1125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Giardia lamblia Hypothetical protein 0.0143 0.1128 0.2753
Plasmodium falciparum cysteine proteinase falcipain 2a 0.063 0.5263 1
Toxoplasma gondii cathepsin CPC2 0.0143 0.1128 0.2143
Schistosoma mansoni cathepsin B (C01 family) 0.0143 0.1128 0.1128
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0216 0.0216
Plasmodium vivax unspecified product 0.034 0.2804 0.5328
Echinococcus multilocularis cathepsin b 0.1189 1 1
Toxoplasma gondii transporter, cation channel family protein 0.0083 0.0623 0.1183
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0143 0.1128 0.2014
Plasmodium falciparum serine repeat antigen 3 0.0143 0.1128 0.2119
Loa Loa (eye worm) fibroinase 0.063 0.5263 0.5261
Giardia lamblia Cathepsin B precursor 0.0143 0.1128 0.2753
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0164 0.0312
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.034 0.2804 0.2802
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0083 0.0623 0.0623
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0222 0.056
Echinococcus granulosus bloom syndrome protein 0.002 0.0085 0.0085
Echinococcus granulosus voltage dependent calcium channel 0.0083 0.0623 0.0623
Brugia malayi Papain family cysteine protease containing protein 0.0143 0.1128 0.1114
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0083 0.0623 0.0623
Echinococcus granulosus hyperpolarization activated cyclic 0.0083 0.0623 0.0623
Loa Loa (eye worm) cysteine protease 0.063 0.5263 0.5261
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0261 0.0261
Brugia malayi Cathepsin L-like precursor 0.063 0.5263 0.5255
Echinococcus multilocularis hyperpolarization activated cyclic 0.0083 0.0623 0.0623
Echinococcus multilocularis sodium leak channel non selective protein 0.0083 0.0623 0.0623
Echinococcus granulosus voltage gated hydrogen channel 1 0.0083 0.0623 0.0623
Trypanosoma cruzi cruzipain precursor, putative 0.063 0.5263 0.5261
Onchocerca volvulus 0.0143 0.1128 0.189
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0083 0.0623 0.0623
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1189 1 1
Echinococcus granulosus transient receptor potential cation channel 0.0083 0.0623 0.0623
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0083 0.0623 0.0623
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0296 0.0407
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0143 0.1128 0.1125
Giardia lamblia Cysteine protease 0.0143 0.1128 0.2753
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Echinococcus multilocularis potassium voltage gated channel protein 0.0083 0.0623 0.0623
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.063 0.5263 1
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0143 0.1128 0.2014
Echinococcus granulosus cathepsin b 0.1189 1 1
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0083 0.0623 0.0623
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0222 0.0222
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.063 0.5263 1
Schistosoma mansoni voltage-dependent calcium channel 0.0083 0.0623 0.0623
Trypanosoma cruzi cysteine peptidase, putative 0.063 0.5263 0.5261
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0177 0.0177
Echinococcus granulosus potassium voltage gated channel protein 0.0083 0.0623 0.0623
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0083 0.0623 0.0623
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0143 0.1128 0.2753
Schistosoma mansoni vesicular amine transporter 0.0083 0.0623 0.0623
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0018 0.0018
Echinococcus granulosus cysteine protease 0.034 0.2804 0.2804
Trypanosoma brucei hypothetical protein, conserved 0.0212 0.1717 0.3151
Echinococcus multilocularis cathepsin L 0.0143 0.1128 0.1128
Loa Loa (eye worm) hypothetical protein 0.0198 0.1594 0.1591
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0143 0.1128 0.2143
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0198 0.1594 0.1581
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0256 0.0756
Giardia lamblia Cysteine protease 0.0143 0.1128 0.2753
Entamoeba histolytica cysteine proteinase, putative 0.063 0.5263 1
Brugia malayi Inositol-1 0.0045 0.0296 0.0281
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0222 0.0264
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Echinococcus multilocularis transient receptor potential cation channel 0.0083 0.0623 0.0623
Schistosoma mansoni cpg binding protein 0.0035 0.0212 0.0212
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0143 0.1128 0.2014
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0222 0.0264
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0143 0.1128 0.1128
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0296 0.0563
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0143 0.1128 0.1128
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0143 0.1128 0.2143
Entamoeba histolytica cysteine protease, putative 0.0143 0.1128 0.2143
Mycobacterium ulcerans hypothetical protein 0.0036 0.0222 0.5687
Trichomonas vaginalis set domain proteins, putative 0.0237 0.1928 0.3558
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0085 0.0085
Giardia lamblia Cathepsin B precursor 0.0143 0.1128 0.2753
Brugia malayi cathepsin L-like precursor 0.0433 0.3586 0.3577
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0143 0.1128 0.2143
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0083 0.0623 0.0623
Schistosoma mansoni transient receptor potential channel 4 0.0083 0.0623 0.0623
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0018 0.0018
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0222 0.0264
Brugia malayi Pre-SET motif family protein 0.0031 0.0177 0.0162
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.000000000069138
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0551 0.0551
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0125 0.0076
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0143 0.1128 0.2143
Loa Loa (eye worm) hypothetical protein 0.0143 0.1128 0.1125
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0083 0.0623 0.0608
Echinococcus granulosus cathepsin b 0.1189 1 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0083 0.0623 0.0623
Onchocerca volvulus 0.063 0.5263 1
Loa Loa (eye worm) RecQ helicase 0.002 0.0085 0.0082

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 79.4328 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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