Detailed information for compound 1285129

Basic information

Technical information
  • TDR Targets ID: 1285129
  • Name: 6-methoxy-2-methylquinoline-3-carbohydrazide
  • MW: 231.251 | Formula: C12H13N3O2
  • H donors: 2 H acceptors: 2 LogP: 1.09 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NNC(=O)c1cc2cc(OC)ccc2nc1C
  • InChi: 1S/C12H13N3O2/c1-7-10(12(16)15-13)6-8-5-9(17-2)3-4-11(8)14-7/h3-6H,13H2,1-2H3,(H,15,16)
  • InChiKey: FIBNRQLTJHSITF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-methoxy-2-methyl-quinoline-3-carbohydrazide
  • 6-Methoxy-2-methyl-3-quinolinecarbohydrazide
  • AF-407/31882052
  • ZINC00268732
  • Oprea1_634306
  • MLS000699643
  • SMR000225383
  • Quinoline-3-carbohydrazide, 6-methoxy-2-methyl-
  • A2137/0089740

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Heterochromatin protein 1 0.0081 0.12 0.12
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0064 0.0134
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0026 0.0175 0.0216
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0142 0.0172
Echinococcus granulosus CREB binding protein 0.0178 0.2981 0.6019
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0026 0.0175 0.0173
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0029 0.0238 0.0254
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.141 0.1823
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0257 0.0279
Mycobacterium ulcerans hypothetical protein 0.0026 0.0175 0.0216
Mycobacterium ulcerans lysophospholipase 0.0434 0.7686 1
Schistosoma mansoni hypothetical protein 0.0172 0.2874 0.5999
Schistosoma mansoni hypothetical protein 0.0172 0.2874 0.5999
Toxoplasma gondii heat shock protein 90, putative 0.01 0.1545 0.2284
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0048 0.0049
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0049 0.0598 0.0766
Loa Loa (eye worm) carboxylesterase 0.0017 0.001 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0064 0.013
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0026 0.0175 0.0366
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0175 0.0216
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0018 0.0011
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.4952 1
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0094 0.1432 0.171
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0148 0.0008
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0026 0.0175 0.0173
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.014 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Echinococcus granulosus BC026374 protein S09 family 0.0017 0.001 0.002
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0098 0.1508 0.1935
Plasmodium falciparum alpha/beta hydrolase, putative 0.0026 0.0175 0.0196
Entamoeba histolytica ;Alias 0.0026 0.0175 0.0173
Echinococcus multilocularis heat shock protein 90 0.0086 0.1279 0.2584
Brugia malayi Bromodomain containing protein 0.0034 0.0331 0.0331
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.126 0.2544
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0175 0.0216
Giardia lamblia Grp94/Hsp90 0.0094 0.1432 0.4505
Plasmodium falciparum thioredoxin reductase 0.003 0.0257 0.0302
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.009 0.136 0.9442
Giardia lamblia Heat shock protein HSP 90-alpha 0.0086 0.1279 0.4016
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0198 0.3336 0.4234
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.3148 0.4089
Brugia malayi serine/threonine-protein kinase plk-2 0.0187 0.3148 0.3148
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0064 0.0064
Schistosoma mansoni gliotactin 0.0017 0.001 0.0021
Plasmodium falciparum glutathione reductase 0.003 0.0257 0.0302
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0064 0.013
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0043 0.0043
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0049 0.0598 0.0726
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0064 0.0064
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0064 0.0134
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0026 0.0175 0.0173
Entamoeba histolytica 60S ribosomal protein L19, putative 0.0027 0.0195 0.0198
Schistosoma mansoni coup transcription factor 0.002 0.0064 0.0134
Plasmodium falciparum phd finger protein, putative 0.0034 0.0331 0.0399
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0064 0.0064
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0142 0.0153
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0434 0.7686 1
Brugia malayi MH2 domain containing protein 0.0122 0.1938 0.1938
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0064 0.013
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.0257 0.0348
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0026 0.0175 0.0173
Echinococcus granulosus endoplasmin 0.0094 0.1432 0.2892
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0048 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0298 0.0376
Entamoeba histolytica hypothetical protein 0.0024 0.0142 0.013
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0148 0.0148
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0257 0.0321
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0346 0.0723
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0067 0.0928 0.1873
Schistosoma mansoni thyroid hormone receptor 0.002 0.0064 0.0134
Plasmodium vivax heat shock protein, putative 0.038 0.668 0.8687
Trichomonas vaginalis conserved hypothetical protein 0.0434 0.7686 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0043 0.0087
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0064 0.0132
Trypanosoma brucei heat shock protein, putative 0.01 0.1545 0.1965
Echinococcus granulosus CREB binding protein 0.0178 0.2981 0.6019
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0064 0.0134
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0034 0.0331 0.0331
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0331 0.0668
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.003 0.0253 0.0275
Brugia malayi Carboxylesterase family protein 0.0017 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0064
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0049 0.0598 0.0766
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0263 0.055
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0048 0.0048
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0026 0.0175 0.0173
Echinococcus multilocularis para nitrobenzyl esterase 0.0017 0.001 0.002
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0026 0.0175 0.0173
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0257 0.0279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Onchocerca volvulus Huntingtin homolog 0.0125 0.1996 0.4815
Entamoeba histolytica hypothetical protein 0.0026 0.0175 0.0173
Schistosoma mansoni pyruvate kinase 0.0034 0.0329 0.0686
Echinococcus multilocularis heat shock protein 90 0.01 0.1545 0.3121
Plasmodium falciparum lysophospholipase, putative 0.0026 0.0175 0.0196
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0048 0.0096
Echinococcus multilocularis chromobox protein 1 0.0081 0.12 0.2424
Giardia lamblia GTOR 0.0018 0.0043 0.0058
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.009 0.136 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0175 0.0216
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1052 0.2125
Brugia malayi Hsp90 protein 0.0067 0.0928 0.0928
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0017 0.001 0.0021
Echinococcus granulosus heat shock protein 90 0.01 0.1545 0.3121
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.017 0.0165
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0112 0.1754 0.3542
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0049 0.0598 0.0766
Trichomonas vaginalis conserved hypothetical protein 0.0434 0.7686 1
Leishmania major pyruvate kinase 0.0034 0.0329 0.0374
Loa Loa (eye worm) carboxylesterase 0.0098 0.151 0.151
Echinococcus granulosus pyruvate kinase 0.0034 0.0329 0.0664
Echinococcus multilocularis BC026374 protein (S09 family) 0.0017 0.001 0.002
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0329 0.0415
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0064 0.0134
Echinococcus granulosus abhydrolase domain containing protein 13 0.0026 0.0175 0.0354
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Toxoplasma gondii hypothetical protein 0.0026 0.0175 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0329 0.0374
Echinococcus granulosus chromobox protein 1 0.0081 0.12 0.2424
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0098 0.151 0.151
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0043 0.009
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0142 0.0172
Loa Loa (eye worm) hypothetical protein 0.0098 0.151 0.151
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0329 0.0329
Plasmodium falciparum epoxide hydrolase 2 0.0026 0.0175 0.0196
Entamoeba histolytica 60S ribosomal protein L19, putative 0.0027 0.0195 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0064 0.013
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.009 0.136 0.2747
Plasmodium falciparum 60S ribosomal protein L19 0.0027 0.0195 0.0221
Plasmodium vivax PST-A protein 0.0026 0.0175 0.0196
Schistosoma mansoni hypothetical protein 0.0034 0.0331 0.069
Plasmodium falciparum BEM46-like protein, putative 0.0026 0.0175 0.0196
Loa Loa (eye worm) acetylcholinesterase 1 0.0098 0.151 0.151
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0064 0.013
Plasmodium vivax alpha/beta hydrolase, putative 0.0026 0.0175 0.0196
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0067 0.0928 0.2225
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0064 0.0064
Giardia lamblia DINP protein human, muc B family 0.0019 0.0048 0.0072
Plasmodium falciparum pyruvate kinase 0.0034 0.0329 0.0396
Entamoeba histolytica hypothetical protein 0.0035 0.0346 0.0396
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0026 0.0175 0.0226
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.003 0.0257 0.1664
Plasmodium vivax PST-A protein 0.0026 0.0175 0.0196
Echinococcus multilocularis ribosomal protein L19 0.0027 0.0195 0.0393
Leishmania major DNA polymerase eta, putative 0.003 0.0264 0.0288
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0142 0.013
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.3148 0.4089
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0064 0.013
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0064 0.0064
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0043 0.0043
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0175 0.0196
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0257 0.0302
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0257 0.0279
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0026 0.0175 0.0226
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0329 0.0374
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0257 0.0279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.0257 0.0741
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0331 0.0331
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0148 0.018
Echinococcus multilocularis thioredoxin glutathione reductase 0.0087 0.1306 0.2638
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0257 0.0279
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0064 0.013
Echinococcus granulosus acetylcholinesterase 0.0098 0.151 0.3049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0036
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.017 0.017
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Trichomonas vaginalis heat shock protein, putative 0.01 0.1545 0.2
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Loa Loa (eye worm) hypothetical protein 0.0051 0.0637 0.0637
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.017 0.0342
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0064 0.0064
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0329 0.0374
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0148 0.018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0257 0.0279
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0048 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0036 0.0014
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0142 0.013
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0064 0.013
Leishmania major 60S ribosomal protein L19, putative 0.0027 0.0195 0.0198
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1052 0.2197
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0263 0.0358
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Brugia malayi TAR-binding protein 0.0064 0.089 0.089
Mycobacterium ulcerans hypothetical protein 0.0024 0.0148 0.018
Mycobacterium tuberculosis Probable dehydrogenase 0.0198 0.3336 0.4333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Plasmodium falciparum lysophospholipase, putative 0.0026 0.0175 0.0196
Loa Loa (eye worm) hypothetical protein 0.0024 0.0148 0.0148
Schistosoma mansoni heat shock protein 0.0067 0.0928 0.1936
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0043 0.0087
Schistosoma mansoni pyruvate kinase 0.0017 0.0025 0.0053
Loa Loa (eye worm) hypothetical protein 0.0035 0.0342 0.0342
Brugia malayi Thioredoxin reductase 0.0087 0.1297 0.1297
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0027 0.0195 0.0198
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0462 0.0934
Toxoplasma gondii thioredoxin reductase 0.0087 0.1297 0.1911
Plasmodium falciparum lysophospholipase, putative 0.0434 0.7686 1
Brugia malayi Carboxylesterase family protein 0.0017 0.001 0.001
Trypanosoma cruzi monoglyceride lipase, putative 0.0434 0.7686 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0048 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0058 0.0778 0.0778
Echinococcus multilocularis pyruvate kinase 0.0027 0.0197 0.0399
Plasmodium falciparum alpha/beta hydrolase, putative 0.0026 0.0175 0.0196
Leishmania major hypothetical protein, conserved 0.0422 0.746 0.9704
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0142 0.0153
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0175 0.0196
Schistosoma mansoni neuroligin 3 (S09 family) 0.0017 0.001 0.0021
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0148 0.018
Trichomonas vaginalis chromobox protein, putative 0.0081 0.12 0.1551
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0329 0.0415
Trypanosoma brucei monoglyceride lipase, putative 0.0434 0.7686 1
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0607 0.0778
Schistosoma mansoni 60S ribosomal protein L19 0.0027 0.0195 0.0407
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.009 0.136 0.1723
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0098 0.151 0.3152
Schistosoma mansoni tar DNA-binding protein 0.0064 0.089 0.1857
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.009 0.136 0.1759
Onchocerca volvulus 0.0058 0.0775 0.1855
Brugia malayi glucose-6-phosphate dehydrogenase 0.009 0.136 0.136
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0257 0.0257
Echinococcus granulosus Phospholipase carboxylesterase 0.0026 0.0175 0.0354
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0031 0.0279 0.0351
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0175 0.0216
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0329 0.0396
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0434 0.7686 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0198 0.3336 0.4333
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0434 0.7686 1
Plasmodium falciparum prodrug activation and resistance esterase 0.0026 0.0175 0.0196
Echinococcus multilocularis Phospholipase carboxylesterase 0.0026 0.0175 0.0354
Schistosoma mansoni endoplasmin 0.01 0.1545 0.3226
Brugia malayi 60S ribosomal protein L19 0.0027 0.0195 0.0195
Schistosoma mansoni tar DNA-binding protein 0.0064 0.089 0.1857
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.009 0.136 0.1723
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Schistosoma mansoni kinase 0.0095 0.1455 0.3037
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.3148 0.4089
Trypanosoma brucei hypothetical protein, conserved 0.0422 0.746 0.9704
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1052 0.1358
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0434 0.7686 1
Plasmodium vivax heat shock protein 90, putative 0.0067 0.0928 0.1178
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0026 0.0175 0.0216
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0187 0.3148 0.6358
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0257 0.0279
Loa Loa (eye worm) CBP-B 0.0178 0.2981 0.2981
Trypanosoma brucei heat shock protein 90, putative 0.01 0.1545 0.1965
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.126 0.263
Plasmodium vivax lysophospholipase, putative 0.0026 0.0175 0.0196
Loa Loa (eye worm) hypothetical protein 0.0024 0.0148 0.0148
Echinococcus multilocularis chromobox protein 1 0.0081 0.12 0.2424
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0094 0.1432 0.1817
Trypanosoma brucei heat shock protein, putative 0.01 0.1545 0.1965
Onchocerca volvulus 0.0036 0.0362 0.0854
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0048 0.0049
Echinococcus multilocularis pyruvate kinase 0.0017 0.0025 0.0051
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0086 0.1279 0.2584
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0263 0.055
Trichomonas vaginalis chromobox protein, putative 0.0081 0.12 0.1551
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0064 0.0134
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0064 0.0064
Loa Loa (eye worm) thioredoxin reductase 0.0087 0.1297 0.1297
Loa Loa (eye worm) hypothetical protein 0.0022 0.0104 0.0104
Trypanosoma cruzi DNA polymerase eta, putative 0.003 0.0264 0.0288
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0329 0.0374
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0175
Trypanosoma cruzi heat shock protein 85, putative 0.01 0.1545 0.1965
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Trichomonas vaginalis endoplasmin, putative 0.0073 0.1041 0.1343
Loa Loa (eye worm) hypothetical protein 0.003 0.0263 0.0263
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0257 0.0279
Trypanosoma brucei 60S ribosomal protein L19, putative 0.0027 0.0195 0.0198
Brugia malayi hypothetical protein 0.0125 0.1996 0.1996
Plasmodium vivax glutathione reductase, putative 0.0087 0.1297 0.166
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0064 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0257 0.0886
Trypanosoma cruzi trypanothione reductase, putative 0.0087 0.1297 0.164
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Trypanosoma brucei monoglyceride lipase, putative 0.0434 0.7686 1
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0098 0.1508 0.1935
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0148 0.0148
Entamoeba histolytica hypothetical protein 0.0026 0.0175 0.0173
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0257 0.0279
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.0257 0.0348
Mycobacterium tuberculosis Conserved protein 0.0049 0.0598 0.0766
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0094 0.1432 1
Chlamydia trachomatis pyruvate kinase 0.0034 0.0329 0.221
Schistosoma mansoni CREB-binding protein 2 0.0178 0.2981 0.6221
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0329 0.0773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0329 0.0415
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.089 0.089
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0257 0.0321
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0036 0.0034
Brugia malayi Carboxylesterase family protein 0.0017 0.001 0.001
Echinococcus granulosus serine protein kinase ATM 0.0025 0.017 0.0342
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0142 0.0176
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0064
Echinococcus granulosus heat shock protein 90 0.0086 0.1279 0.2584
Plasmodium vivax PST-A protein 0.0026 0.0175 0.0196
Trypanosoma brucei heat shock protein, putative 0.01 0.1545 0.1965
Schistosoma mansoni acetylcholinesterase 0.0017 0.001 0.0021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0018 0.0011
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0064 0.013
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0087 0.1297 0.1676
Loa Loa (eye worm) heterochromatin protein 1 0.0081 0.12 0.12
Trypanosoma brucei heat shock protein, putative 0.01 0.1545 0.1965
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0026 0.0175 0.0173
Leishmania major 60S ribosomal protein L19, putative 0.0027 0.0195 0.0198
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0098 0.1508 0.4747
Plasmodium vivax PST-A protein 0.0026 0.0175 0.0196
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0187 0.3148 0.4063
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0064 0.0132
Trypanosoma brucei heat shock protein, putative 0.01 0.1545 0.1965
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0049 0.0607 0.1447
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0257 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0543 0.0695
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0064
Schistosoma mansoni DNA polymerase eta 0.0043 0.05 0.1043
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0026 0.0175 0.0216
Giardia lamblia PHD finger protein 15 0.0034 0.0331 0.0978
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0142 0.0176
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0434 0.7686 1
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0576 0.1163
Schistosoma mansoni tar DNA-binding protein 0.0064 0.089 0.1857
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0064 0.0064
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0576 0.1163
Echinococcus granulosus geminin 0.0172 0.2874 0.5804
Plasmodium vivax lysophospholipase, putative 0.0026 0.0175 0.0196
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0142 0.0801
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1052 0.1358
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0048 0.0006
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0048 0.0049
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.4952 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0508 0.106
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0342 0.0342
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0064 0.0134
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0637 0.0637
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.05 0.0597
Loa Loa (eye worm) hypothetical protein 0.0046 0.0543 0.0543
Entamoeba histolytica hypothetical protein 0.0025 0.017 0.0165
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0257 0.0536
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0044 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Echinococcus granulosus FTZ F1 alpha 0.002 0.0064 0.013
Chlamydia trachomatis acyltransferase family protein 0.0026 0.0175 0.1051
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.014 0.014
Mycobacterium ulcerans hypothetical protein 0.0049 0.0598 0.0766
Entamoeba histolytica hypothetical protein 0.0035 0.0346 0.0396
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0064 0.0064
Trypanosoma brucei heat shock protein, putative 0.01 0.1545 0.1965
Trichomonas vaginalis heat shock protein, putative 0.0094 0.1432 0.1853
Brugia malayi nuclear hormone receptor 0.002 0.0064 0.0064
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0017 0.001 0.0021
Loa Loa (eye worm) hypothetical protein 0.056 1 1
Brugia malayi MGC83647 protein 0.0026 0.0175 0.0175
Plasmodium falciparum thioredoxin reductase 0.0087 0.1297 0.166
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0026 0.0175 0.0481
Schistosoma mansoni tar DNA-binding protein 0.0064 0.089 0.1857
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0331 0.0459
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0331 0.069
Echinococcus granulosus abhydrolase domain containing 3 0.0026 0.0175 0.0354
Loa Loa (eye worm) heat shock protein 90 0.01 0.1545 0.1545
Trichomonas vaginalis heat shock protein, putative 0.0086 0.1279 0.1654
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0175 0.0216
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0462 0.0462
Leishmania major hypothetical protein, conserved 0.0026 0.0175 0.0173
Loa Loa (eye worm) hypothetical protein 0.0125 0.1996 0.1996
Brugia malayi Carboxylesterase family protein 0.0098 0.151 0.151
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0198 0.3336 0.4333
Treponema pallidum NADH oxidase 0.003 0.0257 0.0886
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0049 0.0598 0.0766
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1052 0.132
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0026 0.0175 0.0196
Echinococcus multilocularis pyruvate kinase 0.0017 0.0025 0.0051
Plasmodium vivax lysophospholipase, putative 0.0026 0.0175 0.0196
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0112 0.1754 0.3542
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.009 0.136 0.1723
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0607 0.0778
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0017 0.001 0.002
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0257 0.0321
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0148 0.018
Giardia lamblia Heat shock protein HSP 90-alpha 0.01 0.1545 0.4867
Echinococcus granulosus heat shock protein 0.01 0.1545 0.3121
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0027 0.0195 0.0198
Toxoplasma gondii ribosomal protein RPL19 0.0027 0.0195 0.0255
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1052 0.1358
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0036 0.0014
Toxoplasma gondii FATC domain-containing protein 0.0025 0.017 0.0217
Schistosoma mansoni pyruvate kinase 0.0034 0.0329 0.0686
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.141 0.1823
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0329 0.0247
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0027 0.0195 0.0241
Echinococcus granulosus chromobox protein 1 0.0081 0.12 0.2424
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0257 0.0279
Trypanosoma cruzi serine peptidase, putative 0.0026 0.0175 0.0173
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1052 0.1543
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0048 0.0049
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0175
Trypanosoma cruzi polo-like protein kinase, putative 0.0187 0.3148 0.4063
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.3148 0.4089
Brugia malayi Carboxylesterase family protein 0.0098 0.151 0.151
Plasmodium vivax 60S ribosomal protein L19, putative 0.0027 0.0195 0.0221
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0026 0.0175 0.0354
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0026 0.0175 0.0216
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0036
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0064 0.013
Echinococcus granulosus neuroligin 0.0017 0.001 0.002
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0064 0.0064
Onchocerca volvulus 0.0241 0.4135 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0148 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0175 0.0216
Schistosoma mansoni hypothetical protein 0.0035 0.0342 0.0715
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0064 0.013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0036
Trypanosoma brucei polo-like protein kinase 0.0187 0.3148 0.4063
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0257 0.0321
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0175 0.0216
Onchocerca volvulus Huntingtin homolog 0.0125 0.1996 0.4815
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0064 0.0064
Echinococcus multilocularis pyruvate kinase 0.0017 0.0025 0.0051
Trypanosoma brucei heat shock protein 90, putative 0.01 0.1545 0.1965
Brugia malayi Carboxylesterase family protein 0.0017 0.001 0.001
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0017 0.001 0.0021
Plasmodium falciparum exported lipase 2 0.0026 0.0175 0.0196
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0043 0.0027
Schistosoma mansoni jumonji domain containing protein 0.0089 0.1333 0.2783
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0175 0.0216
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0026 0.0175 0.0366
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0018 0.0011
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0036 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.3148 0.4089
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0346 0.0699
Schistosoma mansoni endoplasmin 0.01 0.1545 0.3226
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0043 0.009
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0064 0.013
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.3597 0.3597
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0064
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.009 0.136 0.136
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0026 0.0175 0.0354
Plasmodium vivax heat shock protein 86, putative 0.01 0.1545 0.1984
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0059 0.0786 0.1011
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0257 0.0302
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0064 0.013
Toxoplasma gondii hypothetical protein 0.0026 0.0175 0.0226
Loa Loa (eye worm) hypothetical protein 0.0043 0.05 0.05
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0331 0.0459
Loa Loa (eye worm) RNA binding protein 0.0064 0.089 0.089
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0148 0.0138
Trypanosoma cruzi Heat shock protein 83, putative 0.01 0.1545 0.1965
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0027 0.0195 0.0241
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0048 0.0096
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0027 0.0195 0.0241
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0175
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0064 0.0064
Trypanosoma cruzi serine peptidase, putative 0.0026 0.0175 0.0173
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0148 0.0138
Plasmodium falciparum esterase, putative 0.0026 0.0175 0.0196
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0175
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0178 0.2981 0.6221
Plasmodium falciparum lysophospholipase, putative 0.0434 0.7686 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0257 0.0279
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0098 0.1508 0.1951
Loa Loa (eye worm) hypothetical protein 0.0036 0.0362 0.0362
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0059 0.0786 0.1143
Mycobacterium ulcerans hypothetical protein 0.0049 0.0598 0.0766
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0148 0.018
Echinococcus multilocularis neuroligin 0.0017 0.001 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0018 0.0011
Schistosoma mansoni hypothetical protein 0.0035 0.0346 0.0723
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.009 0.136 0.2747
Plasmodium vivax PST-A protein 0.0434 0.7686 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0329 0.0329
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0331 0.0399
Plasmodium falciparum alpha/beta hydrolase, putative 0.0026 0.0175 0.0196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.0422 0.746 0.9704
Giardia lamblia Pyruvate kinase 0.0034 0.0329 0.0972
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Mycobacterium ulcerans hypothetical protein 0.0434 0.7686 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.1996 0.1996
Brugia malayi Endoplasmin precursor 0.01 0.1545 0.1545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.3148 0.6572
Trypanosoma cruzi heat shock protein 85, putative 0.01 0.1545 0.1965
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0024 0.014 0.014
Onchocerca volvulus 0.0085 0.126 0.303
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0148 0.018
Schistosoma mansoni chromobox protein 0.0081 0.12 0.2505
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0064 0.0064
Plasmodium vivax unspecified product 0.0026 0.0175 0.0196
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0257 0.0279
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0026 0.0175 0.0196
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.05 0.0597
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0064 0.013
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0064 0.0134
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0434 0.7686 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0434 0.7686 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Echinococcus granulosus dna polymerase eta 0.0043 0.05 0.1009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.017 0.0208
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0175 0.0196
Echinococcus granulosus dna polymerase kappa 0.0019 0.0048 0.0096
Echinococcus multilocularis endoplasmin 0.0094 0.1432 0.2892
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0997 0.0997
Brugia malayi Protein C20orf22 0.0026 0.0175 0.0175
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0064 0.0064
Plasmodium falciparum esterase, putative 0.0434 0.7686 1
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0027 0.0195 0.0198
Loa Loa (eye worm) hypothetical protein 0.0034 0.0329 0.0329
Plasmodium falciparum heat shock protein 90, putative 0.0058 0.0775 0.0978
Plasmodium falciparum esterase, putative 0.0026 0.0175 0.0196
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0148 0.0138
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0257 0.0279
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0043 0.0043
Mycobacterium tuberculosis Probable reductase 0.0198 0.3336 0.4333
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0064 0.013
Brugia malayi steroid hormone receptor 0.002 0.0064 0.0064
Mycobacterium tuberculosis Possible lysophospholipase 0.0434 0.7686 1
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0067 0.0928 0.1873
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0049 0.0598 0.0766
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0026 0.0175 0.0216
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0434 0.7686 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Loa Loa (eye worm) hypothetical protein 0.0085 0.126 0.126
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0175 0.0216
Plasmodium falciparum lysophospholipase, putative 0.0434 0.7686 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0048 0.0006
Onchocerca volvulus Alhambra homolog 0.0034 0.0331 0.0777
Echinococcus multilocularis CREB binding protein 0.0178 0.2981 0.6019
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.001
Plasmodium falciparum alpha/beta hydrolase, putative 0.0026 0.0175 0.0196
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0257 0.0302
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0026 0.0175 0.0216
Trypanosoma brucei heat shock protein 84, putative 0.0067 0.0928 0.1157
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0346 0.0699
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1052 0.1358
Trypanosoma brucei Heat shock protein 83, putative 0.01 0.1545 0.1965
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0257 0.0518
Echinococcus granulosus pyruvate kinase 0.0017 0.0025 0.0051
Entamoeba histolytica heat shock protein 90, putative 0.01 0.1545 0.1965
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0064 0.0064
Toxoplasma gondii heat shock protein HSP90 0.01 0.1545 0.2284
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0094 0.1432 0.1853
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0148 0.0148
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0263 0.0532
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0064 0.0132
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0637 0.0637
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0775 0.0775
Leishmania major DNA polymerase eta, putative 0.0043 0.05 0.0597
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0017 0.001 0.002
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0098 0.1508 0.1951
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0043 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.017 0.0165
Trichomonas vaginalis set domain proteins, putative 0.0241 0.4135 0.5374
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0148 0.0008
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0329 0.0329
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0026 0.0175 0.0216
Echinococcus granulosus acetylcholinesterase 0.0098 0.151 0.3049
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0048 0.0006
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.022 0.3741 0.4861
Toxoplasma gondii protein c14orf29, putative 0.0026 0.0175 0.0226
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0098 0.1508 0.2228
Schistosoma mansoni peptidase 0.0026 0.0175 0.0366
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0462 0.0934
Mycobacterium tuberculosis Conserved hypothetical protein 0.0026 0.0175 0.0216
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0142 0.0172
Leishmania major trypanothione reductase 0.0087 0.1297 0.164
Schistosoma mansoni heat shock protein 0.01 0.1545 0.3226
Echinococcus multilocularis geminin 0.0172 0.2874 0.5804
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0257 0.0321
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0048 0.0049
Schistosoma mansoni survival motor neuron protein 0.0058 0.0775 0.1618
Schistosoma mansoni thyroid hormone receptor 0.002 0.0064 0.0134
Plasmodium falciparum heat shock protein 90, putative 0.038 0.668 0.8687
Trypanosoma brucei 60S ribosomal protein L19, putative 0.0027 0.0195 0.0198
Trypanosoma cruzi heat shock protein 90, putative 0.0086 0.1279 0.1618
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0257 0.0321
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0027 0.0195 0.0241
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1052 0.2125
Brugia malayi glutathione reductase 0.0087 0.1297 0.1297
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0257 0.0279
Loa Loa (eye worm) carboxylesterase 0.0017 0.001 0.001
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.126 0.126
Onchocerca volvulus 0.002 0.0064 0.0132
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0048 0.0096
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0329 0.0773
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0434 0.7686 1
Chlamydia trachomatis hydrolase 0.0026 0.0175 0.1051
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1052 0.2197
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0064 0.0064
Entamoeba histolytica hypothetical protein 0.0035 0.0346 0.0396
Brugia malayi hypothetical protein 0.0017 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0064 0.0064
Brugia malayi heat shock protein 90 0.01 0.1545 0.1545
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0148 0.018
Loa Loa (eye worm) hypothetical protein 0.0027 0.0195 0.0195
Schistosoma mansoni BC026374 protein (S09 family) 0.0017 0.001 0.0021
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0048 0.0099
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.05 0.05
Schistosoma mansoni heat shock protein 0.01 0.1545 0.3226
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0263 0.0532
Brugia malayi chromobox protein homolog 3 0.0046 0.0543 0.0543
Trypanosoma cruzi heat shock protein 90, putative 0.01 0.1545 0.1965
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0331 0.0668
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0067 0.0928 0.1157
Brugia malayi ecdysteroid receptor 0.002 0.0064 0.0064
Leishmania major monoglyceride lipase, putative 0.0434 0.7686 1
Toxoplasma gondii hypothetical protein 0.0026 0.0175 0.0226
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.3148 0.4089
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0198 0.3336 0.4333
Echinococcus multilocularis abhydrolase domain containing 3 0.0026 0.0175 0.0354
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0064 0.013
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0026 0.0175 0.0173
Plasmodium falciparum heat shock protein 90 0.01 0.1545 0.1984
Echinococcus granulosus thioredoxin glutathione reductase 0.0087 0.1306 0.2638
Entamoeba histolytica heat shock protein 90, putative 0.01 0.1545 0.1965
Brugia malayi TAZ zinc finger family protein 0.0178 0.2981 0.2981
Onchocerca volvulus Serine\/threonine kinase homolog 0.0187 0.3148 0.7608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Echinococcus multilocularis carboxylesterase 5A 0.0098 0.151 0.3049
Brugia malayi jmjC domain containing protein 0.0041 0.0462 0.0462
Brugia malayi RNA binding protein 0.0064 0.089 0.089
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0329 0.0773
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0064 0.0064
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0257 0.0302
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.1938 0.1938
Trypanosoma cruzi heat shock protein, putative 0.0067 0.0928 0.1157
Toxoplasma gondii phospholipase/carboxylesterase 0.0026 0.0175 0.0226
Brugia malayi nuclear receptor NHR-88 0.002 0.0064 0.0064
Loa Loa (eye worm) glutathione reductase 0.0087 0.1297 0.1297
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0187 0.3148 0.6358
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0637 0.0637
Plasmodium vivax alpha/beta hydrolase, putative 0.0026 0.0175 0.0196
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0148 0.018
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0064 0.013
Toxoplasma gondii peptidase S15, putative 0.0026 0.0175 0.0226
Giardia lamblia Kinase, PLK 0.0187 0.3148 1
Echinococcus multilocularis tar DNA binding protein 0.0064 0.089 0.1797
Brugia malayi Pre-SET motif family protein 0.003 0.0263 0.0263
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0329 0.0329
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.011 0.011
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0064 0.0134
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0175
Echinococcus multilocularis citrate lyase subunit beta protein 0.0049 0.0598 0.1208
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0064 0.0064
Schistosoma mansoni nuclear hormone receptor 0.002 0.0064 0.0134
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0049 0.0598 0.0726
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0257 0.0518
Plasmodium falciparum alpha/beta hydrolase, putative 0.0026 0.0175 0.0196
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.089 0.089
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0064 0.0064
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Echinococcus multilocularis pyruvate kinase 0.0034 0.0329 0.0664
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.022 0.3741 0.4771
Plasmodium falciparum endoplasmin, putative 0.0073 0.1041 0.1326
Echinococcus granulosus carboxylesterase 5A 0.0098 0.151 0.3049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0462 0.0965
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Echinococcus granulosus tar DNA binding protein 0.0064 0.089 0.1797
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0049 0.0598 0.0726
Echinococcus multilocularis acetylcholinesterase 0.0098 0.151 0.3049
Onchocerca volvulus 0.0044 0.0508 0.1207
Echinococcus granulosus citrate lyase subunit beta protein 0.0049 0.0598 0.1208
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0243 0.049
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.017 0.0354
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.0422 0.746 0.9704
Trypanosoma cruzi polo-like protein kinase, putative 0.0187 0.3148 0.4063
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0329 0.0329
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0064 0.0064
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0462 0.0965
Trichomonas vaginalis heat shock protein, putative 0.0094 0.1432 0.1853
Trichomonas vaginalis heat shock protein, putative 0.0073 0.1041 0.1343
Plasmodium vivax thioredoxin reductase, putative 0.0087 0.1297 0.166
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.022 0.3741 0.4861
Giardia lamblia Ribosomal protein L19 0.0027 0.0195 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0298 0.0376
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0263 0.0532
Trypanosoma brucei trypanothione reductase 0.0087 0.1297 0.164
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0148 0.0138
Mycobacterium ulcerans hydrolase 0.0026 0.0175 0.0216
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Echinococcus multilocularis heat shock protein 0.01 0.1545 0.3121
Toxoplasma gondii Hsp90 domain-containing protein 0.038 0.668 1
Echinococcus multilocularis dna polymerase eta 0.0043 0.05 0.1009
Trichomonas vaginalis heat shock protein, putative 0.0058 0.0775 0.0996
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.009 0.136 0.2839
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Echinococcus multilocularis pyruvate kinase 0.0034 0.0329 0.0664
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0329 0.0415
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Leishmania major heat shock protein 83-1 0.01 0.1545 0.1965
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0026 0.0175 0.0216
Leishmania major pyruvate kinase 0.0034 0.0329 0.0374
Mycobacterium ulcerans hypothetical protein 0.0026 0.0175 0.0216
Entamoeba histolytica serine/threonine protein kinase, putative 0.0187 0.3148 0.4063
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0257 0.0279
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0148 0.0138
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.126 0.2544
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0048 0.0006
Trypanosoma cruzi 60S ribosomal protein L19, putative 0.0027 0.0195 0.0198
Trypanosoma cruzi heat shock protein 85, putative 0.01 0.1545 0.1965
Echinococcus multilocularis peregrin 0.0034 0.0331 0.0668
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0187 0.3148 0.3148
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.1938 0.1938
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0098 0.1508 0.1951
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0026 0.0175 0.0226
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0263 0.055
Echinococcus granulosus pyruvate kinase 0.0034 0.0329 0.0664
Brugia malayi MGC79044 protein 0.0026 0.0175 0.0175
Plasmodium vivax endoplasmin, putative 0.01 0.1545 0.1984
Brugia malayi hypothetical protein 0.0286 0.4952 0.4952
Loa Loa (eye worm) endoplasmin 0.01 0.1545 0.1545
Echinococcus multilocularis ribosomal protein L19 0.0027 0.0195 0.0393
Trypanosoma brucei heat shock protein, putative 0.01 0.1545 0.1965
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0104 0.008
Schistosoma mansoni chromobox protein 0.0081 0.12 0.2505
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0048 0.0099
Brugia malayi PHD-finger family protein 0.0034 0.0331 0.0331
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0043 0.0087
Loa Loa (eye worm) hypothetical protein 0.0286 0.4952 0.4952
Schistosoma mansoni hypothetical protein 0.0058 0.0775 0.1618
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0329 0.0456
Toxoplasma gondii phospholipase 0.0026 0.0175 0.0226
Brugia malayi Pre-SET motif family protein 0.0212 0.3597 0.3597
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0044 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0257 0.0279
Echinococcus granulosus peregrin 0.0034 0.0331 0.0668
Loa Loa (eye worm) hypothetical protein 0.0024 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0036
Plasmodium falciparum glutathione reductase 0.0087 0.1297 0.166
Loa Loa (eye worm) heat shock protein 75 0.0067 0.0928 0.0928
Leishmania major hypothetical protein, conserved 0.0026 0.0175 0.0173
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0543 0.1293
Plasmodium vivax PST-A protein 0.0026 0.0175 0.0196
Echinococcus granulosus pyruvate kinase 0.0017 0.0025 0.0051
Entamoeba histolytica hypothetical protein 0.0035 0.0346 0.0396
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0257 0.0886
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0064
Treponema pallidum heat shock protein 90 0.0094 0.1432 1
Echinococcus granulosus pyruvate kinase 0.0017 0.0025 0.0051
Brugia malayi hypothetical protein 0.0035 0.0346 0.0346
Toxoplasma gondii hypothetical protein 0.0026 0.0175 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Plasmodium falciparum exported lipase 1 0.0026 0.0175 0.0196
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0043 0.0043
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0026 0.0175 0.0216
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0148 0.018
Echinococcus granulosus ribosomal protein L19 0.0027 0.0195 0.0393
Echinococcus multilocularis acetylcholinesterase 0.0098 0.151 0.3049
Onchocerca volvulus 0.0024 0.0148 0.0336
Leishmania major heat shock protein, putative 0.0067 0.0928 0.1157
Trypanosoma cruzi heat shock protein 90, putative 0.0042 0.0476 0.0566
Trypanosoma cruzi heat shock protein 85, putative 0.0086 0.1279 0.1618
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0043 0.0043
Toxoplasma gondii ImpB/MucB/SamB family protein 0.003 0.0264 0.0358
Echinococcus granulosus para nitrobenzyl esterase 0.0017 0.001 0.002
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0198 0.3336 0.4333
Brugia malayi jmjC domain containing protein 0.0112 0.1754 0.1754
Trichomonas vaginalis CAMK family protein kinase 0.0187 0.3148 0.4089
Toxoplasma gondii heat shock protein 75, putative 0.0067 0.0928 0.1356
Mycobacterium ulcerans heat shock protein 90 0.0094 0.1432 0.1853
Loa Loa (eye worm) TAR-binding protein 0.0064 0.089 0.089
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0064 0.0134
Trypanosoma brucei unspecified product 0.0019 0.0048 0.0006
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.011 0.011
Plasmodium vivax unspecified product 0.0026 0.0175 0.0196
Plasmodium vivax SET domain protein, putative 0.003 0.0263 0.0311
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0064 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0064 0.089 0.1857
Leishmania major DNA polymerase kappa, putative 0.0019 0.0048 0.0006
Echinococcus granulosus ribosomal protein L19 0.0027 0.0195 0.0393
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0543 0.0695
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0026 0.0175 0.0173
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0064 0.0064
Mycobacterium tuberculosis Probable oxidoreductase 0.022 0.3741 0.4861
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0026 0.0175 0.0173
Trypanosoma brucei heat shock protein, putative 0.01 0.1545 0.1965

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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