Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Schistosoma mansoni | Thioredoxin glutathione reductase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | 0.0104 | 0.0151 | 0.0151 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0104 | 0.015 | 0.8342 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0104 | 0.015 | 0.8342 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0104 | 0.0151 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0104 | 0.0151 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0116 | 0.018 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0104 | 0.015 | 0.8342 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0116 | 0.018 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0104 | 0.0151 | 0.0151 |
Trypanosoma brucei | cytochrome P450, putative | 0.0104 | 0.0151 | 1 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.394 | 1 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.394 | 1 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0104 | 0.015 | 0.8342 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0104 | 0.0151 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0104 | 0.0151 | 0.0151 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.394 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0104 | 0.015 | 0.8342 |
Giardia lamblia | Ceramide glucosyltransferase | 0.1786 | 0.4469 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0 | 0.5 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.394 | 1 | 1 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.394 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0 | 0.5 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.394 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0074 | 0.0074 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0116 | 0.018 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0104 | 0.015 | 0.8342 |
Leishmania major | cytochrome p450-like protein | 0.0104 | 0.0151 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0116 | 0.018 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0104 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0104 | 0.0151 | 0.0151 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.2818 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.