Detailed information for compound 1333550

Basic information

Technical information
  • TDR Targets ID: 1333550
  • Name: 2-[4-[(3,5-dimethyl-1-propan-2-ylpyrazol-4-yl )methyl]-1-[(3-methoxyphenyl)methyl]piperazin -2-yl]ethanol
  • MW: 400.558 | Formula: C23H36N4O2
  • H donors: 1 H acceptors: 2 LogP: 2.59 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCC1CN(CCN1Cc1cccc(c1)OC)Cc1c(C)nn(c1C)C(C)C
  • InChi: 1S/C23H36N4O2/c1-17(2)27-19(4)23(18(3)24-27)16-25-10-11-26(21(15-25)9-12-28)14-20-7-6-8-22(13-20)29-5/h6-8,13,17,21,28H,9-12,14-16H2,1-5H3
  • InChiKey: VKVZPCGNDLZCFO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-[(1-isopropyl-3,5-dimethyl-pyrazol-4-yl)methyl]-1-[(3-methoxyphenyl)methyl]piperazin-2-yl]ethanol
  • 2-[4-[(1-isopropyl-3,5-dimethyl-4-pyrazolyl)methyl]-1-[(3-methoxyphenyl)methyl]-2-piperazinyl]ethanol
  • 2-[4-[(1-isopropyl-3,5-dimethyl-pyrazol-4-yl)methyl]-1-(3-methoxybenzyl)piperazin-2-yl]ethanol
  • 2-[4-[(3,5-dimethyl-1-propan-2-yl-pyrazol-4-yl)methyl]-1-[(3-methoxyphenyl)methyl]piperazin-2-yl]ethanol
  • MLS000733953
  • SMR000317070
  • 2-[4-[(1-isopropyl-3,5-dimethyl-1H-pyrazol-4-yl)methyl]-1-(3-methoxybenzyl)piperazin-2-yl]ethanol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.063 0.5263 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0143 0.1128 0.2014
Echinococcus granulosus cathepsin L cysteine proteinase 0.063 0.5263 0.5263
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Entamoeba histolytica cysteine protease, putative 0.0143 0.1128 0.2143
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Brugia malayi jmjC domain containing protein 0.0095 0.0725 0.0711
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Echinococcus granulosus transient receptor potential cation channel 0.0083 0.0623 0.0623
Trichomonas vaginalis esterase, putative 0.0036 0.0222 0.0264
Echinococcus granulosus hyperpolarization activated cyclic 0.0083 0.0623 0.0623
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0559 0.0559
Brugia malayi Cathepsin L-like precursor 0.063 0.5263 0.5255
Brugia malayi PHD-finger family protein 0.0029 0.0164 0.0149
Leishmania major hypothetical protein, conserved 0.0036 0.0222 0.0264
Brugia malayi Papain family cysteine protease containing protein 0.0143 0.1128 0.1114
Brugia malayi beta-lactamase family protein 0.0036 0.0222 0.0207
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0222 0.0222
Leishmania major hypothetical protein, conserved 0.0212 0.1717 0.3151
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0466 0.3872 0.387
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0143 0.1128 0.2143
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0222 0.5687
Trypanosoma cruzi cysteine proteinase, putative 0.034 0.2804 0.2802
Onchocerca volvulus Cathepsin L homolog 0.063 0.5263 1
Leishmania major cathepsin L-like protease 0.063 0.5263 1
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Schistosoma mansoni transient receptor potential channel 0.0083 0.0623 0.0623
Echinococcus granulosus transient receptor potential cation channel 0.0083 0.0623 0.0623
Entamoeba histolytica recQ family helicase, putative 0.002 0.0085 0.0162
Echinococcus granulosus cathepsin l1 0.063 0.5263 0.5263
Loa Loa (eye worm) hypothetical protein 0.0029 0.0164 0.0161
Entamoeba histolytica cysteine proteinase, putative 0.034 0.2804 0.5328
Echinococcus multilocularis transient receptor potential gamma protein 0.0083 0.0623 0.0623
Echinococcus multilocularis sodium channel protein 0.0083 0.0623 0.0623
Brugia malayi cathepsin L precursor 0.0143 0.1128 0.1114
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0143 0.1128 0.1128
Entamoeba histolytica hypothetical protein 0.0143 0.1128 0.2143
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0143 0.1128 0.1128
Giardia lamblia Cathepsin B precursor 0.0143 0.1128 0.2753
Plasmodium vivax serine-repeat antigen (SERA) 0.0143 0.1128 0.2143
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0143 0.1128 0.2143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.063 0.5263 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0296 0.0407
Schistosoma mansoni ryanodine receptor related 0.0083 0.0623 0.0623
Giardia lamblia Cathepsin L precursor 0.0143 0.1128 0.2753
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0083 0.0623 0.0623
Loa Loa (eye worm) calcium channel 0.0083 0.0623 0.062
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0083 0.0623 0.0623
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0143 0.1128 0.2119
Schistosoma mansoni cathepsin F (C01 family) 0.063 0.5263 0.5263
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0725 0.0725
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0085 0.0132
Plasmodium falciparum serine repeat antigen 5 0.0143 0.1128 0.2119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.063 0.5263 1
Brugia malayi fibroinase precursor 0.0143 0.1128 0.1114
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0143 0.1128 0.2753
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1189 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0083 0.0623 0.0623
Onchocerca volvulus 0.0035 0.0212 0.0093
Plasmodium falciparum phd finger protein, putative 0.0029 0.0164 0.0282
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0222 0.0264
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0083 0.0623 0.0608
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.063 0.5263 1
Schistosoma mansoni cathepsin s 0.0198 0.1594 0.1594
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0083 0.0623 0.0623
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.063 0.5263 1
Brugia malayi Papain family cysteine protease containing protein 0.063 0.5263 0.5255
Plasmodium vivax vivapain-1 0.034 0.2804 0.5328
Echinococcus multilocularis cathepsin l cysteine peptidase 0.063 0.5263 0.5263
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0083 0.0623 0.062
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0296 0.0296
Echinococcus multilocularis cysteine protease 0.063 0.5263 0.5263
Loa Loa (eye worm) hypothetical protein 0.0036 0.0222 0.0219
Loa Loa (eye worm) hypothetical protein 0.0143 0.1128 0.1125
Giardia lamblia Cathepsin L precursor 0.0143 0.1128 0.2753
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.1684 0.1682
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0083 0.0623 0.0623
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Echinococcus granulosus short transient receptor potential channel 6 0.0089 0.0669 0.0669
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0296 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0143 0.1128 0.1125
Entamoeba histolytica cysteine proteinase, putative 0.034 0.2804 0.5328
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0083 0.0623 0.0623
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0083 0.0623 0.0623
Echinococcus granulosus potassium large conductance calcium activated 0.0083 0.0623 0.0623
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0177 0.0177
Echinococcus multilocularis cathepsin L cysteine protease 0.063 0.5263 0.5263
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0143 0.1128 0.1128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0433 0.3586 0.6762
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0296 0.5
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0083 0.0623 0.0623
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0083 0.0623 0.0623
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0233 0.0233
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Onchocerca volvulus 0.0433 0.3586 0.6712
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0083 0.0623 0.0623
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0083 0.0623 0.0623
Brugia malayi Papain family cysteine protease containing protein 0.034 0.2804 0.2793
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0143 0.1128 0.2014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.034 0.2804 0.5251
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0083 0.0623 0.0623
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1189 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0177 0.0177
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0177 0.0177
Loa Loa (eye worm) voltage-gated calcium channel 0.0083 0.0623 0.062
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0083 0.0623 0.0623
Toxoplasma gondii hypothetical protein 0.0083 0.0623 0.1183
Schistosoma mansoni cathepsin S (C01 family) 0.0143 0.1128 0.1128
Leishmania major cathepsin L-like protease 0.063 0.5263 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0222 0.0422
Echinococcus multilocularis bloom syndrome protein 0.002 0.0085 0.0085
Schistosoma mansoni 60S ribosomal protein L21 0.0083 0.0623 0.0623
Echinococcus multilocularis potassium large conductance calcium activated 0.0083 0.0623 0.0623
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0143 0.1128 0.2753
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0125 0.0125
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0083 0.0623 0.0623
Loa Loa (eye worm) inositol-1 0.0045 0.0296 0.0293
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Echinococcus multilocularis transient receptor potential cation channel 0.0083 0.0623 0.0623
Echinococcus multilocularis shaker cognate 0.0083 0.0623 0.0623
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0466 0.3872 0.7314
Brugia malayi olfactory channel protein osm-9 0.0089 0.0669 0.0655
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0083 0.0623 0.1038
Brugia malayi Cathepsin L-like precursor 0.063 0.5263 0.5255
Plasmodium falciparum cysteine proteinase falcipain 2b 0.063 0.5263 1
Plasmodium vivax unspecified product 0.0143 0.1128 0.2143
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.1128 0.2014
Trypanosoma cruzi cysteine peptidase, putative 0.063 0.5263 0.5261
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.034 0.2804 0.5251
Trypanosoma cruzi cysteine peptidase, putative 0.0198 0.1594 0.1591
Echinococcus granulosus transient receptor potential cation channel 0.0083 0.0623 0.0623
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0085 0.007
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0003 0.0006
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0085 0.0085
Toxoplasma gondii preprocathepsin c precursor, putative 0.0143 0.1128 0.2143
Loa Loa (eye worm) hypothetical protein 0.0031 0.0177 0.0174
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0083 0.0623 0.0623
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.063 0.5263 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.063 0.5263 1
Echinococcus multilocularis transient receptor potential cation channel 0.0089 0.0669 0.0669
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0083 0.0623 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0143 0.1128 0.2014
Echinococcus granulosus calcium activated potassium channel 0.0083 0.0623 0.0623
Echinococcus multilocularis transient receptor potential cation channel 0.0089 0.0669 0.0669
Echinococcus multilocularis transient receptor potential cation channel 0.0083 0.0623 0.0623
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0083 0.0623 0.0623
Echinococcus granulosus potassium voltage gated channel protein 0.0083 0.0623 0.0623
Brugia malayi beta-lactamase family protein 0.0036 0.0222 0.0207
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0083 0.0623 0.0899
Loa Loa (eye worm) cathepsin B 0.0466 0.3872 0.387
Plasmodium falciparum serine repeat antigen 9 0.0143 0.1128 0.2119
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0083 0.0623 0.0608
Echinococcus granulosus transient receptor potential gamma protein 0.0083 0.0623 0.0623
Giardia lamblia Cysteine protease 0.0143 0.1128 0.2753
Echinococcus granulosus shaker cognate 0.0083 0.0623 0.0623
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Mycobacterium ulcerans beta-lactamase 0.0036 0.0222 0.5687
Loa Loa (eye worm) voltage-gated potassium channel 0.0083 0.0623 0.062
Giardia lamblia Cathepsin L precursor 0.0143 0.1128 0.2753
Entamoeba histolytica cysteine proteinase, putative 0.0433 0.3586 0.6815
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0083 0.0623 0.0623
Entamoeba histolytica cysteine protease, putative 0.0143 0.1128 0.2143
Trypanosoma cruzi hypothetical protein, conserved 0.0212 0.1717 0.1714
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0085 0.0132
Giardia lamblia Cathepsin B precursor 0.0466 0.3872 1
Echinococcus granulosus potassium voltage gated channel protein 0.0083 0.0623 0.0623
Echinococcus multilocularis voltage dependent calcium channel 0.0083 0.0623 0.0623
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0081 0.0081
Echinococcus multilocularis potassium voltage gated channel protein 0.0083 0.0623 0.0623
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0222 0.056
Loa Loa (eye worm) hypothetical protein 0.0143 0.1128 0.1125
Plasmodium falciparum cysteine proteinase falcipain 1 0.034 0.2804 0.5314
Loa Loa (eye worm) papain family cysteine protease containing protein 0.063 0.5263 0.5261
Giardia lamblia Cathepsin B precursor 0.0143 0.1128 0.2753
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0143 0.1128 0.2014
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0083 0.0623 0.0623
Echinococcus multilocularis hyperpolarization activated cyclic 0.0083 0.0623 0.0623
Loa Loa (eye worm) voltage-dependent calcium channel 0.0083 0.0623 0.062
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0222 0.0264
Trypanosoma cruzi hypothetical protein, conserved 0.0212 0.1717 0.1714
Onchocerca volvulus 0.0083 0.0623 0.0899
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0143 0.1128 0.2014
Entamoeba histolytica cysteine protease, putative 0.063 0.5263 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0143 0.1128 0.2119
Brugia malayi Cyclic-nucleotide gated cation channel 0.0083 0.0623 0.0608
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0083 0.0623 0.0608
Echinococcus granulosus cathepsin L cysteine protease 0.034 0.2804 0.2804
Echinococcus multilocularis two pore calcium channel protein 2 0.0083 0.0623 0.0623
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0083 0.0623 0.062
Loa Loa (eye worm) hypothetical protein 0.0089 0.0669 0.0666
Echinococcus granulosus transient receptor potential cation channel 0.0083 0.0623 0.0623
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0085 0.0162
Echinococcus granulosus potassium voltage gated channel protein 0.0083 0.0623 0.0623
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0083 0.0623 0.0623
Mycobacterium tuberculosis Conserved protein 0.0036 0.0222 0.056
Onchocerca volvulus Cathepsin F homolog 0.063 0.5263 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.063 0.5263 1
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0083 0.0623 0.0623
Trypanosoma cruzi cysteine peptidase, putative 0.063 0.5263 0.5261
Entamoeba histolytica cysteine proteinase 1, putative 0.034 0.2804 0.5328
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0433 0.3586 0.6762
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0083 0.0623 0.0623
Echinococcus granulosus dnaJ subfamily B 0.0494 0.4107 0.4107
Echinococcus granulosus hypothetical protein 0.0083 0.0623 0.0623
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0296 0.0407
Loa Loa (eye worm) voltage-gated potassium channel 0.0083 0.0623 0.062
Mycobacterium tuberculosis Conserved protein 0.0036 0.0222 0.056
Echinococcus multilocularis two pore calcium channel protein 1 0.0083 0.0623 0.0623
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0085 0.0085
Trypanosoma cruzi cysteine peptidase, putative 0.063 0.5263 0.5261
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0143 0.1128 0.2014
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0164 0.0164
Onchocerca volvulus 0.063 0.5263 1
Loa Loa (eye worm) hypothetical protein 0.0198 0.1594 0.1591
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.063 0.5263 1
Echinococcus granulosus short transient receptor potential channel 6 0.0083 0.0623 0.0623
Echinococcus granulosus cathepsin L 0.034 0.2804 0.2804
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0256 1
Trypanosoma cruzi cysteine protease, putative 0.034 0.2804 0.2802
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0143 0.1128 0.2143
Schistosoma mansoni hypothetical protein 0.0083 0.0623 0.0623
Plasmodium vivax vivapain-2 0.063 0.5263 1
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0083 0.0623 0.0608
Schistosoma mansoni cathepsin F (C01 family) 0.0433 0.3586 0.3586
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0083 0.0623 0.062
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0222 0.0207
Toxoplasma gondii cathepsin CPC1 0.0143 0.1128 0.2143
Echinococcus multilocularis cpg binding protein 0.0037 0.0229 0.0229
Onchocerca volvulus 0.0036 0.0222 0.0114
Giardia lamblia Cathepsin L precursor 0.0143 0.1128 0.2753
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0143 0.1128 0.2143
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.0014 0.0014
Leishmania major cathepsin L-like protease 0.063 0.5263 1
Schistosoma mansoni two-pore calcium channel 0.0083 0.0623 0.0623
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1189 1 1
Brugia malayi Bromodomain containing protein 0.0029 0.0164 0.0149
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0083 0.0623 0.0608
Entamoeba histolytica cysteine protease, putative 0.0143 0.1128 0.2143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0083 0.0623 0.0623
Echinococcus multilocularis peregrin 0.0029 0.0164 0.0164
Brugia malayi cathepsin F-like cysteine proteinase 0.0143 0.1128 0.1114
Brugia malayi Papain family cysteine protease containing protein 0.0143 0.1128 0.1114
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0083 0.0623 0.0608
Echinococcus multilocularis cysteine protease 0.063 0.5263 0.5263
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0083 0.0623 0.0623
Leishmania major cathepsin L-like protease 0.063 0.5263 1
Schistosoma mansoni cathepsin C 0.0143 0.1128 0.1128
Echinococcus multilocularis conserved hypothetical protein 0.0083 0.0623 0.0623
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0233 0.0233
Echinococcus granulosus transient receptor potential cation channel 0.0089 0.0669 0.0669
Echinococcus multilocularis cathepsin b 0.1189 1 1
Schistosoma mansoni hypothetical protein 0.0494 0.4107 0.4107
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0083 0.0623 0.1183
Plasmodium vivax serine-repeat antigen (SERA) 0.0143 0.1128 0.2143
Loa Loa (eye worm) hypothetical protein 0.0036 0.0222 0.0219
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0083 0.0623 0.1038
Plasmodium vivax vivapain-2 0.063 0.5263 1
Echinococcus multilocularis transfer RNA-Gly 0.0083 0.0623 0.0623
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0222 0.0222
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0143 0.1128 0.1125
Plasmodium vivax vivapain-3 0.034 0.2804 0.5328
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.063 0.5263 1
Onchocerca volvulus 0.063 0.5263 1
Plasmodium falciparum serine repeat antigen 7 0.0143 0.1128 0.2119
Echinococcus granulosus sodium leak channel non selective protein 0.0083 0.0623 0.0623
Mycobacterium tuberculosis Conserved protein 0.0036 0.0222 0.056
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0143 0.1128 0.2143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0296 0.0293
Schistosoma mansoni inositol monophosphatase 0.0045 0.0296 0.0296
Giardia lamblia Encystation-specific protease 0.0143 0.1128 0.2753
Loa Loa (eye worm) hypothetical protein 0.0036 0.0222 0.0219
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0143 0.1128 0.1128
Giardia lamblia Hypothetical protein 0.0143 0.1128 0.2753
Plasmodium vivax SET domain protein, putative 0.0031 0.0177 0.0336
Schistosoma mansoni cpg binding protein 0.0037 0.0229 0.0229
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0085 0.0162
Schistosoma mansoni cpg binding protein 0.0037 0.0229 0.0229
Plasmodium falciparum cysteine proteinase falcipain 3 0.063 0.5263 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0085 0.0082
Echinococcus granulosus cathepsin L 0.0143 0.1128 0.1128
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0143 0.1128 0.2143
Schistosoma mansoni DNA helicase recq5 0.002 0.0085 0.0085
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0164 0.0312
Loa Loa (eye worm) hypothetical protein 0.063 0.5263 0.5261
Brugia malayi cathepsin Z-like cysteine proteinase 0.0143 0.1128 0.1114
Loa Loa (eye worm) hypothetical protein 0.0143 0.1128 0.1125
Brugia malayi cathepsin L-like cysteine proteinase 0.0143 0.1128 0.1114
Schistosoma mansoni inositol monophosphatase 0.0045 0.0296 0.0296
Brugia malayi Cathepsin L-like cysteine proteinase 0.0433 0.3586 0.3577
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0143 0.1128 0.2014
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0222 0.0264
Onchocerca volvulus 0.0036 0.0222 0.0114
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.1863 1
Plasmodium falciparum serine repeat antigen 2 0.0143 0.1128 0.2119
Onchocerca volvulus 0.063 0.5263 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.0014 0.0014
Giardia lamblia Cathepsin L-like protease 0.0143 0.1128 0.2753
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0222 0.0222
Echinococcus multilocularis transient receptor potential cation channel 0.0083 0.0623 0.0623
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0083 0.0623 0.0608
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0083 0.0623 0.0623
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0085 0.0085
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0177 0.0336
Plasmodium falciparum serine repeat antigen 1 0.0143 0.1128 0.2119
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0125 0.0076
Brugia malayi Transient-receptor-potential like protein 0.0083 0.0623 0.0608
Brugia malayi Pre-SET motif family protein 0.0208 0.1684 0.1672
Echinococcus granulosus peregrin 0.0029 0.0164 0.0164
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0083 0.0623 0.0608
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0083 0.0623 0.0623
Giardia lamblia Cysteine protease 0.0143 0.1128 0.2753
Giardia lamblia Cathepsin B precursor 0.0143 0.1128 0.2753
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Onchocerca volvulus 0.0036 0.0222 0.0114
Loa Loa (eye worm) ion channel NompC 0.0083 0.0623 0.062
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0125 0.0122
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0296 1
Mycobacterium ulcerans lipase LipD 0.0036 0.0222 0.5687
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0222 0.056
Brugia malayi cation channel family protein 0.0083 0.0623 0.0608
Entamoeba histolytica cysteine protease, putative 0.0143 0.1128 0.2143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0018 0.0015
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0083 0.0623 0.0623
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0177 0.0177
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0083 0.0623 0.0608
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0484 0.092
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.034 0.2804 0.2804
Schistosoma mansoni transient receptor potential channel 0.0089 0.0669 0.0669
Brugia malayi Cathepsin L-like precursor 0.0433 0.3586 0.3577
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Echinococcus granulosus two pore calcium channel protein 1 0.0083 0.0623 0.0623
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0222 0.056
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0466 0.3872 0.7314
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0083 0.0623 0.0623
Plasmodium falciparum serine repeat antigen 6 0.0143 0.1128 0.2119
Entamoeba histolytica cysteine proteinase, putative 0.034 0.2804 0.5328
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0083 0.0623 0.0623
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Brugia malayi hypothetical protein 0.0083 0.0623 0.0608
Echinococcus granulosus cpg binding protein 0.0037 0.0229 0.0229
Echinococcus multilocularis short transient receptor potential channel 6 0.0089 0.0669 0.0669
Echinococcus granulosus potassium voltage gated channel protein 0.0083 0.0623 0.0623
Onchocerca volvulus 0.063 0.5263 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0296 0.0407
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0083 0.0623 0.0623
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.063 0.5263 1
Plasmodium falciparum serine repeat antigen 8 0.0143 0.1128 0.2119
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0003 0.0006
Loa Loa (eye worm) beta-lactamase 0.0036 0.0222 0.0219
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0466 0.3872 0.3872
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0083 0.0623 0.0623
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0143 0.1128 0.2753
Brugia malayi Cathepsin L-like precursor 0.0198 0.1594 0.1581
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0212 0.0209
Loa Loa (eye worm) hypothetical protein 0.0433 0.3586 0.3584
Leishmania major cysteine peptidase A (CPA) 0.063 0.5263 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0222 0.0219
Schistosoma mansoni calcium-activated potassium channel 0.0083 0.0623 0.0623
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.063 0.5263 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.063 0.5263 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.063 0.5263 1
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0083 0.0623 0.062
Giardia lamblia Cathepsin B precursor 0.0466 0.3872 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0143 0.1128 0.1128
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0177 0.0177
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0164 0.0312
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.063 0.5263 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0222 0.0219
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0098 0.0082
Echinococcus multilocularis cathepsin l cysteine peptidase 0.063 0.5263 0.5263
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0083 0.0623 0.0623
Brugia malayi beta-lactamase 0.0036 0.0222 0.0207
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0143 0.1128 0.2014
Trypanosoma brucei cysteine peptidase C (CPC) 0.0466 0.3872 0.7314
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0143 0.1128 0.2143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.063 0.5263 1
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0083 0.0623 0.0623
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0161 0.0161
Echinococcus granulosus voltage gated potassium channel 0.0083 0.0623 0.0623
Entamoeba histolytica cysteine proteinase, putative 0.063 0.5263 1
Leishmania major hypothetical protein, unknown function 0.0083 0.0623 0.1038
Leishmania major cathepsin L-like protease 0.063 0.5263 1
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.1128 0.2014
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0222 0.0219
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0143 0.1128 0.1128
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.034 0.2804 0.2804
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0083 0.0623 0.0623
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0083 0.0623 0.1183
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0083 0.0623 0.0623
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0296 0.0563
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0083 0.0623 0.1038
Plasmodium falciparum serine repeat antigen 4 0.0143 0.1128 0.2119
Loa Loa (eye worm) hypothetical protein 0.0433 0.3586 0.3584
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0083 0.0623 0.0623
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0083 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Loa Loa (eye worm) hypothetical protein 0.1189 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.034 0.2804 0.5251
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0143 0.1128 0.2119
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0085 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0143 0.1128 0.2014
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.034 0.2804 0.2804
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0198 0.1594 0.1591
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0143 0.1128 0.1125
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0222 0.0219
Trypanosoma cruzi cruzipain precursor, putative 0.0198 0.1594 0.1591
Entamoeba histolytica cysteine protease, putative 0.0143 0.1128 0.2143
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0164 0.0164
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0083 0.0623 0.0623
Onchocerca volvulus 0.0031 0.0177 0.0024
Leishmania major hypothetical protein, conserved 0.0083 0.0623 0.1038
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0083 0.0623 0.0623
Giardia lamblia Cathepsin B precursor 0.0466 0.3872 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Echinococcus granulosus jumonji domain containing protein 0.004 0.0261 0.0261
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0083 0.0623 0.0608
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0085 0.0082
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Onchocerca volvulus 0.063 0.5263 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0143 0.1128 0.1128
Echinococcus granulosus voltage dependent calcium channel 0.0083 0.0623 0.0623
Echinococcus multilocularis voltage dependent calcium channel 0.0083 0.0623 0.0623
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0083 0.0623 0.062
Trypanosoma cruzi cysteine proteinase, putative 0.034 0.2804 0.2802
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Plasmodium vivax unspecified product 0.0198 0.1594 0.3029
Giardia lamblia Cathepsin L precursor 0.0143 0.1128 0.2753
Giardia lamblia Cathepsin L precursor 0.0143 0.1128 0.2753
Leishmania major cathepsin L-like protease 0.063 0.5263 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0083 0.0623 0.0623
Entamoeba histolytica cysteine proteinase 2 0.034 0.2804 0.5328
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Schistosoma mansoni cathepsin F (C01 family) 0.063 0.5263 0.5263
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0016 0.0031
Toxoplasma gondii ABC1 family protein 0.0036 0.0222 0.0422
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Echinococcus multilocularis potassium voltage gated channel protein 0.0083 0.0623 0.0623
Loa Loa (eye worm) ryanodine receptor 0.0083 0.0623 0.062
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0143 0.1128 0.2014
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0143 0.1128 0.2143
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0427 0.0424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.063 0.5263 1
Brugia malayi Cathepsin L-like precursor 0.063 0.5263 0.5255
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0143 0.1128 0.1114
Echinococcus multilocularis voltage gated potassium channel 0.0083 0.0623 0.0623
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0222 0.5687
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Toxoplasma gondii transporter, cation channel family protein 0.0083 0.0623 0.1183
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0003 0.5
Toxoplasma gondii hypothetical protein 0.0083 0.0623 0.1183
Brugia malayi cathepsin F-like cysteine proteinase 0.0198 0.1594 0.1581
Onchocerca volvulus Cathepsin L homolog 0.063 0.5263 1
Giardia lamblia Cathepsin L-like protease 0.0143 0.1128 0.2753
Schistosoma mansoni DNA helicase recq1 0.002 0.0085 0.0085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.063 0.5263 1
Brugia malayi ion channel NompC 0.0083 0.0623 0.0608
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0083 0.0623 0.0608
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0233 0.023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Brugia malayi Cathepsin L-like precursor 0.063 0.5263 0.5255
Brugia malayi Cathepsin L-like precursor 0.0433 0.3586 0.3577
Echinococcus multilocularis calcium activated potassium channel 0.0083 0.0623 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0143 0.1128 0.2014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.034 0.2804 0.5251
Echinococcus multilocularis potassium voltage gated channel protein 0.0083 0.0623 0.0623
Echinococcus granulosus TRP transient receptor potential channel 0.0083 0.0623 0.0623
Schistosoma mansoni transient receptor potential channel 0.0083 0.0623 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0143 0.1128 0.2014
Echinococcus multilocularis ryanodine receptor 44f 0.0083 0.0623 0.0623
Echinococcus granulosus cathepsin l cysteine peptidase 0.063 0.5263 0.5263
Brugia malayi voltage-dependent calcium channel 0.0083 0.0623 0.0608
Onchocerca volvulus 0.0242 0.1974 0.355
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0083 0.0623 0.1038
Loa Loa (eye worm) hypothetical protein 0.005 0.0341 0.0337
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0143 0.1128 0.2014
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0164 0.0161
Leishmania major cathepsin L-like protease 0.063 0.5263 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0083 0.0623 0.0623
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Entamoeba histolytica cysteine proteinase, putative 0.034 0.2804 0.5328
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0083 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.0433 0.3586 0.3584
Loa Loa (eye worm) hypothetical protein 0.0036 0.0222 0.0219
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Echinococcus multilocularis cathepsin L cysteine protease 0.063 0.5263 0.5263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0433 0.3586 0.3584
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Onchocerca volvulus Cathepsin L homolog 0.0143 0.1128 0.189
Echinococcus granulosus two pore calcium channel protein 2 0.0083 0.0623 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Entamoeba histolytica recQ family DNA helicase 0.001 0.0003 0.0006
Brugia malayi cathepsin Z-like cysteine proteinase 0.0143 0.1128 0.1114
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0296 0.0407
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0012
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0725 0.0725
Brugia malayi CXXC zinc finger family protein 0.0035 0.0212 0.0197
Loa Loa (eye worm) hypothetical protein 0.0143 0.1128 0.1125
Toxoplasma gondii cathepsin B 0.0466 0.3872 0.7357
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0083 0.0623 0.0899
Toxoplasma gondii transporter, cation channel family protein 0.0083 0.0623 0.1183
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0003 0.0003
Onchocerca volvulus 0.063 0.5263 1
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0083 0.0623 0.0608
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0198 0.1594 0.1591
Trypanosoma cruzi cysteine peptidase, putative 0.034 0.2804 0.2802
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0083 0.0623 0.0608
Echinococcus granulosus cathepsin l1 0.0433 0.3586 0.3586
Brugia malayi Papain family cysteine protease containing protein 0.034 0.2804 0.2793
Trypanosoma cruzi major cysteine proteinase, putative 0.0143 0.1128 0.1125
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0083 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Brugia malayi jmjC domain containing protein 0.0037 0.0233 0.0218
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1189 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0083 0.0623 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0143 0.1128 0.2014
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.063 0.5263 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0222 0.0219
Schistosoma mansoni voltage-gated cation channel 0.0083 0.0623 0.0623
Echinococcus granulosus voltage gated potassium channel 0.0083 0.0623 0.0623
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.063 0.5263 0.5261
Leishmania major cathepsin L-like protease 0.063 0.5263 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0083 0.0623 0.0608
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0233 0.0233
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0083 0.0623 0.1038
Schistosoma mansoni voltage-gated ion channel 0.0083 0.0623 0.0623
Toxoplasma gondii cathepsin CPL 0.063 0.5263 1
Echinococcus multilocularis voltage gated potassium channel 0.0083 0.0623 0.0623
Echinococcus granulosus bloom syndrome protein 0.002 0.0085 0.0085
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0222 0.056
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0083 0.0623 0.0623
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.034 0.2804 0.2802
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0164 0.0312
Giardia lamblia Cathepsin B precursor 0.0143 0.1128 0.2753
Loa Loa (eye worm) fibroinase 0.063 0.5263 0.5261
Plasmodium falciparum serine repeat antigen 3 0.0143 0.1128 0.2119
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0143 0.1128 0.2014
Toxoplasma gondii transporter, cation channel family protein 0.0083 0.0623 0.1183
Echinococcus multilocularis cathepsin b 0.1189 1 1
Plasmodium vivax unspecified product 0.034 0.2804 0.5328
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0216 0.0216
Schistosoma mansoni cathepsin B (C01 family) 0.0143 0.1128 0.1128
Plasmodium falciparum cysteine proteinase falcipain 2a 0.063 0.5263 1
Toxoplasma gondii cathepsin CPC2 0.0143 0.1128 0.2143
Giardia lamblia Hypothetical protein 0.0143 0.1128 0.2753
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.063 0.5263 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0143 0.1128 0.1125
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.4107 0.4107
Echinococcus granulosus sodium channel protein 0.0083 0.0623 0.0623
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0125 0.0122
Giardia lamblia PHD finger protein 15 0.0029 0.0164 0.0209
Echinococcus granulosus ryanodine receptor 44f 0.0083 0.0623 0.0623
Brugia malayi cation channel family protein 0.0083 0.0623 0.0608
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0085 0.007
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Schistosoma mansoni hypothetical protein 0.0029 0.0164 0.0164
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.063 0.5263 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0177 0.0177
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0222 0.056
Echinococcus multilocularis cathepsin L 0.034 0.2804 0.2804
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0222 0.056
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0085 0.007
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0222 0.056
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Loa Loa (eye worm) ctsf protein 0.063 0.5263 0.5261
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Brugia malayi Cathepsin L-like precursor 0.063 0.5263 0.5255
Schistosoma mansoni vesicular amine transporter 0.0083 0.0623 0.0623
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0143 0.1128 0.2753
Echinococcus granulosus potassium voltage gated channel protein 0.0083 0.0623 0.0623
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0083 0.0623 0.0623
Trypanosoma cruzi cysteine peptidase, putative 0.063 0.5263 0.5261
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0177 0.0177
Schistosoma mansoni voltage-dependent calcium channel 0.0083 0.0623 0.0623
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.063 0.5263 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0222 0.0222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0143 0.1128 0.2014
Echinococcus granulosus cathepsin b 0.1189 1 1
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0083 0.0623 0.0623
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Echinococcus multilocularis potassium voltage gated channel protein 0.0083 0.0623 0.0623
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.063 0.5263 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Giardia lamblia Cysteine protease 0.0143 0.1128 0.2753
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0143 0.1128 0.1125
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0296 0.0407
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0083 0.0623 0.0623
Echinococcus granulosus transient receptor potential cation channel 0.0083 0.0623 0.0623
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1189 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0083 0.0623 0.0623
Onchocerca volvulus 0.0143 0.1128 0.189
Trypanosoma cruzi cruzipain precursor, putative 0.063 0.5263 0.5261
Echinococcus granulosus voltage gated hydrogen channel 1 0.0083 0.0623 0.0623
Echinococcus multilocularis sodium leak channel non selective protein 0.0083 0.0623 0.0623
Echinococcus multilocularis hyperpolarization activated cyclic 0.0083 0.0623 0.0623
Brugia malayi Cathepsin L-like precursor 0.063 0.5263 0.5255
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0261 0.0261
Loa Loa (eye worm) cysteine protease 0.063 0.5263 0.5261
Echinococcus granulosus hyperpolarization activated cyclic 0.0083 0.0623 0.0623
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0083 0.0623 0.0623
Entamoeba histolytica cysteine protease, putative 0.034 0.2804 0.5328
Brugia malayi Papain family cysteine protease containing protein 0.0143 0.1128 0.1114
Echinococcus granulosus voltage dependent calcium channel 0.0083 0.0623 0.0623
Loa Loa (eye worm) RecQ helicase 0.002 0.0085 0.0082
Onchocerca volvulus 0.063 0.5263 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0083 0.0623 0.0623
Echinococcus granulosus cathepsin b 0.1189 1 1
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0083 0.0623 0.0608
Loa Loa (eye worm) hypothetical protein 0.0143 0.1128 0.1125
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0143 0.1128 0.2143
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0125 0.0076
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0551 0.0551
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.000000000069138
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Brugia malayi Pre-SET motif family protein 0.0031 0.0177 0.0162
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0222 0.0264
Schistosoma mansoni transient receptor potential channel 4 0.0083 0.0623 0.0623
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0018 0.0018
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0143 0.1128 0.2143
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0083 0.0623 0.0623
Brugia malayi cathepsin L-like precursor 0.0433 0.3586 0.3577
Giardia lamblia Cathepsin B precursor 0.0143 0.1128 0.2753
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0085 0.0085
Trichomonas vaginalis set domain proteins, putative 0.0237 0.1928 0.3558
Mycobacterium ulcerans hypothetical protein 0.0036 0.0222 0.5687
Entamoeba histolytica cysteine protease, putative 0.0143 0.1128 0.2143
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0143 0.1128 0.2143
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0143 0.1128 0.1128
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0296 0.0563
Schistosoma mansoni voltage-gated potassium channel 0.0083 0.0623 0.0623
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0143 0.1128 0.1128
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0222 0.0264
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0143 0.1128 0.2014
Schistosoma mansoni cpg binding protein 0.0035 0.0212 0.0212
Echinococcus multilocularis transient receptor potential cation channel 0.0083 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Loa Loa (eye worm) hypothetical protein 0.0083 0.0623 0.062
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0222 0.0264
Brugia malayi Inositol-1 0.0045 0.0296 0.0281
Entamoeba histolytica cysteine proteinase, putative 0.063 0.5263 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0198 0.1594 0.1581
Giardia lamblia Cysteine protease 0.0143 0.1128 0.2753
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0256 0.0756
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0143 0.1128 0.2143
Loa Loa (eye worm) hypothetical protein 0.0198 0.1594 0.1591
Echinococcus multilocularis cathepsin L 0.0143 0.1128 0.1128
Trypanosoma brucei hypothetical protein, conserved 0.0212 0.1717 0.3151
Echinococcus granulosus cysteine protease 0.034 0.2804 0.2804
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0018 0.0018

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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