Detailed information for compound 1364006

Basic information

Technical information
  • TDR Targets ID: 1364006
  • Name: [2-[(4-methoxyphenyl)methylamino]-2-oxoethyl] 2-(2,4-dichlorophenyl)acetate
  • MW: 382.238 | Formula: C18H17Cl2NO4
  • H donors: 1 H acceptors: 2 LogP: 3.78 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CNC(=O)COC(=O)Cc1ccc(cc1Cl)Cl
  • InChi: 1S/C18H17Cl2NO4/c1-24-15-6-2-12(3-7-15)10-21-17(22)11-25-18(23)8-13-4-5-14(19)9-16(13)20/h2-7,9H,8,10-11H2,1H3,(H,21,22)
  • InChiKey: YYOCLLREEJNSSS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[(4-methoxyphenyl)methylamino]-2-oxo-ethyl] 2-(2,4-dichlorophenyl)acetate
  • 2-(2,4-dichlorophenyl)acetic acid [2-[(4-methoxyphenyl)methylamino]-2-oxoethyl] ester
  • 2-(2,4-dichlorophenyl)acetic acid [2-keto-2-[(4-methoxybenzyl)amino]ethyl] ester
  • [2-[(4-methoxyphenyl)methylamino]-2-oxo-ethyl] 2-(2,4-dichlorophenyl)ethanoate
  • MLS000391611
  • SMR000260646
  • ZINC03246298
  • T0509-6816

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Immunoglobulin I-set domain containing protein 0.0054 0.2294 0.2431
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.3671 0.5
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Echinococcus multilocularis hemicentin 1 0.0039 0.1255 0.1255
Loa Loa (eye worm) hypothetical protein 0.0047 0.182 0.2053
Schistosoma mansoni slit 0.0039 0.1255 0.1255
Schistosoma mansoni hypothetical protein 0.0039 0.1255 0.1255
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Echinococcus granulosus titin 0.0085 0.4509 0.4928
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0085 0.4509 0.5086
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0047 0.182 0.182
Brugia malayi Lethal protein 805 0.0047 0.182 0.1885
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0047 0.182 0.2053
Schistosoma mansoni titin 0.0039 0.1255 0.1255
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0085 0.4509 0.5086
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0039 0.1255 0.1372
Loa Loa (eye worm) myotactin form A 0.0047 0.182 0.2053
Schistosoma mansoni bromodomain containing protein 0.0076 0.3886 0.3886
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0047 0.182 0.182
Schistosoma mansoni hypothetical protein 0.0047 0.182 0.182
Onchocerca volvulus 0.0047 0.182 0.0742
Schistosoma mansoni hypothetical protein 0.0039 0.1255 0.1255
Loa Loa (eye worm) hypothetical protein 0.0047 0.182 0.2053
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.1255 0.1235
Onchocerca volvulus 0.0047 0.182 0.0742
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0047 0.182 0.182
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0085 0.4509 0.4509
Echinococcus multilocularis Fibronectin type III domain containing protein 0.0047 0.182 0.182
Echinococcus granulosus cell adhesion molecule 0.0047 0.182 0.1989
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0047 0.182 0.182
Echinococcus granulosus titin 0.0039 0.1255 0.1372
Loa Loa (eye worm) TK/ROR protein kinase 0.0054 0.2294 0.2587
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.1255 0.1235
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0301 0.0339
Onchocerca volvulus 0.0047 0.182 0.0742
Echinococcus multilocularis anosmin 1 0.0047 0.182 0.182
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Loa Loa (eye worm) hypothetical protein 0.0047 0.182 0.2053
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0023 0.0183 0.0183
Echinococcus granulosus contactin 0.0085 0.4509 0.4928
Brugia malayi Immunoglobulin I-set domain containing protein 0.0085 0.4509 0.4982
Echinococcus multilocularis fibronectin type III domain-containing protein 0.0047 0.182 0.182
Brugia malayi Leucine Rich Repeat family protein 0.0039 0.1255 0.1235
Schistosoma mansoni hemicentin 0.0085 0.4509 0.4509
Brugia malayi Immunoglobulin I-set domain containing protein 0.0085 0.4509 0.4982
Loa Loa (eye worm) UNCoordinated family member 0.0047 0.182 0.2053
Echinococcus granulosus lachesin 0.0039 0.1255 0.1372
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.182 0.1885
Brugia malayi Fibronectin type III domain containing protein 0.0047 0.182 0.1885
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0085 0.4509 0.5086
Echinococcus multilocularis zinc finger protein 0.0024 0.0212 0.0212
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0023 0.0183 0.0183
Schistosoma mansoni ephrin receptor 0.0062 0.2859 0.2859
Echinococcus granulosus tyrosine protein kinase Src42A 0.0023 0.0183 0.02
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Loa Loa (eye worm) lethal protein 805 0.0047 0.182 0.2053
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0023 0.0183 0.0183
Schistosoma mansoni tyrosine kinase 0.0023 0.0183 0.0183
Schistosoma mansoni hypothetical protein 0.0039 0.1255 0.1255
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0047 0.182 0.1885
Onchocerca volvulus 0.0047 0.182 0.0742
Onchocerca volvulus 0.0047 0.182 0.0742
Brugia malayi Fibronectin type III domain containing protein 0.0047 0.182 0.1885
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Schistosoma mansoni hypothetical protein 0.0039 0.1255 0.1255
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.1255 0.1235
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0054 0.2294 0.2507
Echinococcus granulosus peroxidasin 0.0039 0.1255 0.1372
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.1255 0.1235
Schistosoma mansoni thyroid hormone receptor 0.0164 1 1
Echinococcus granulosus zinc finger protein 0.0024 0.0212 0.0232
Brugia malayi Immunoglobulin I-set domain containing protein 0.0085 0.4509 0.4982
Echinococcus multilocularis neuroglian 0.0085 0.4509 0.4509
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.3671 0.3671
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.1255 0.1235
Brugia malayi Fibronectin type III domain containing protein 0.0047 0.182 0.1885
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0023 0.0183 0.0183
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.3671 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.1255 0.1235
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0462 0.0504
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.182 0.1885
Brugia malayi Immunoglobulin I-set domain containing protein 0.0085 0.4509 0.4982
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Echinococcus granulosus Netrin receptor DCC 0.0047 0.182 0.1989
Echinococcus multilocularis lachesin 0.0039 0.1255 0.1255
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0085 0.4509 0.5086
Schistosoma mansoni hypothetical protein 0.0039 0.1255 0.1255
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0047 0.182 0.1885
Loa Loa (eye worm) hypothetical protein 0.0148 0.8866 1
Schistosoma mansoni roundabout 0.0039 0.1255 0.1255
Echinococcus granulosus anosmin 1 0.0047 0.182 0.1989
Echinococcus granulosus neuroglian 0.0039 0.1255 0.1372
Brugia malayi myotactin form B 0.0047 0.182 0.1885
Loa Loa (eye worm) hypothetical protein 0.0046 0.1792 0.2021
Echinococcus multilocularis anosmin 1 0.0047 0.182 0.182
Echinococcus granulosus roundabout 2 0.0085 0.4509 0.4928
Echinococcus multilocularis roundabout 2 0.0085 0.4509 0.4509
Brugia malayi myotactin form A 0.0047 0.182 0.1885
Echinococcus multilocularis Netrin receptor DCC 0.0047 0.182 0.182
Echinococcus granulosus Fibronectin type III 0.0047 0.182 0.1989
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.1255 0.1235
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0462 0.0462
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0039 0.1255 0.1416
Onchocerca volvulus 0.0085 0.4509 0.4275
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Schistosoma mansoni hypothetical protein 0.0085 0.4509 0.4509
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.1255 0.1235
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0023 0.0183 0.0183
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.1255 0.1235
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Schistosoma mansoni hypothetical protein 0.0039 0.1255 0.1255
Brugia malayi Immunoglobulin I-set domain containing protein 0.0085 0.4509 0.4982
Brugia malayi Prion-like- 0.0039 0.1255 0.1235
Loa Loa (eye worm) hypothetical protein 0.0085 0.4509 0.5086
Brugia malayi Immunoglobulin I-set domain containing protein 0.0085 0.4509 0.4982
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.1587 0.1587
Schistosoma mansoni cell adhesion molecule 0.0047 0.182 0.182
Echinococcus granulosus Fibronectin type III domain containing protein 0.0047 0.182 0.1989
Schistosoma mansoni titin 0.0039 0.1255 0.1255
Echinococcus granulosus roundabout 2 0.0085 0.4509 0.4928
Onchocerca volvulus 0.0047 0.182 0.0742
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0085 0.4509 0.4928
Echinococcus multilocularis c src tyrosine kinase 0.0023 0.0183 0.0183
Brugia malayi SPRY domain containing protein 0.0047 0.182 0.1885
Echinococcus granulosus leucine rich repeats and immunoglobulin 0.0039 0.1255 0.1372
Echinococcus granulosus tyrosine protein kinase Fyn 0.0023 0.0183 0.02
Brugia malayi Immunoglobulin I-set domain containing protein 0.0085 0.4509 0.4982
Loa Loa (eye worm) hypothetical protein 0.0047 0.182 0.2053
Brugia malayi Prion-like- 0.0039 0.1255 0.1235
Onchocerca volvulus 0.0085 0.4509 0.4275
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0062 0.2859 0.3124
Schistosoma mansoni tyrosine kinase 0.0054 0.2294 0.2294
Schistosoma mansoni protein tyrosine phosphatase 0.0047 0.182 0.182
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0047 0.182 0.1989
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0023 0.0183 0.02
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.3671 0.5
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0023 0.0183 0.02
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Echinococcus multilocularis titin 0.0039 0.1255 0.1255
Brugia malayi Immunoglobulin I-set domain containing protein 0.0085 0.4509 0.4982
Schistosoma mansoni titin 0.0039 0.1255 0.1255
Echinococcus granulosus down syndrome cell adhesion 0.0039 0.1255 0.1372
Loa Loa (eye worm) hypothetical protein 0.0047 0.182 0.2053
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0039 0.1255 0.1416
Schistosoma mansoni factor for adipocyte differentiation 0.0047 0.182 0.182
Brugia malayi Prion-like- 0.0039 0.1255 0.1235
Echinococcus multilocularis neuroglian 0.0039 0.1255 0.1255
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.4509 0.4509
Schistosoma mansoni nephrin 0.0085 0.4509 0.4509
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.1255 0.1235
Loa Loa (eye worm) CAMK protein kinase 0.0085 0.4509 0.5086
Echinococcus multilocularis roundabout 2 0.0085 0.4509 0.4509
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.1255 0.1235
Schistosoma mansoni hypothetical protein 0.0152 0.915 0.915
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0085 0.4509 0.4509
Schistosoma mansoni tyrosine kinase 0.0023 0.0183 0.0183
Brugia malayi hypothetical protein 0.0148 0.8866 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.3585 0.3585
Loa Loa (eye worm) hypothetical protein 0.0047 0.182 0.2053
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Schistosoma mansoni hypothetical protein 0.0025 0.0301 0.0301
Echinococcus granulosus Opioid binding protein:cell adhesion molecule 0.0039 0.1255 0.1372
Schistosoma mansoni titin 0.0085 0.4509 0.4509
Brugia malayi Fibronectin type III domain containing protein 0.0047 0.182 0.1885
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0039 0.1255 0.1416
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0023 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.915 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0047 0.182 0.182
Echinococcus multilocularis insulin growth factor binding 0.0039 0.1255 0.1255
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.1255 0.1235
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0047 0.182 0.5
Schistosoma mansoni septate junction protein 0.0039 0.1255 0.1255
Loa Loa (eye worm) hypothetical protein 0.0049 0.1991 0.2246
Brugia malayi Disorganized muscle protein 1 0.0039 0.1255 0.1235
Onchocerca volvulus Huntingtin homolog 0.0148 0.8866 1
Brugia malayi Lethal protein 805 0.0047 0.182 0.1885
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0023 0.0183 0.0183
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0054 0.2294 0.2294
Onchocerca volvulus 0.0047 0.182 0.0742
Echinococcus multilocularis Opioid binding protein:cell adhesion molecule 0.0039 0.1255 0.1255
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0047 0.182 0.2053
Loa Loa (eye worm) hypothetical protein 0.0047 0.182 0.2053
Echinococcus granulosus roundabout 2 0.0085 0.4509 0.4928
Echinococcus granulosus nephrin 0.0085 0.4509 0.4928
Echinococcus granulosus leucine rich repeat containing protein 4 0.0039 0.1255 0.1372
Brugia malayi Bromodomain containing protein 0.0091 0.4872 0.54
Brugia malayi Wrapper/rega-1/klingon homolog protein 1 0.0039 0.1255 0.1235
Brugia malayi kettin 0.0039 0.1255 0.1235
Schistosoma mansoni zinc finger protein 0.0024 0.0212 0.0212
Echinococcus multilocularis leucine rich repeats and immunoglobulin 0.0039 0.1255 0.1255
Echinococcus multilocularis titin 0.0039 0.1255 0.1255
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.1255 0.1416
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0023 0.0183 0.0183
Echinococcus granulosus titin 0.0039 0.1255 0.1372
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0039 0.1255 0.1255
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0039 0.1255 0.1255
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0085 0.4509 0.4509
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Brugia malayi Myb-like DNA-binding domain containing protein 0.0039 0.1255 0.1235
Echinococcus granulosus titin 0.0039 0.1255 0.1372
Brugia malayi Immunoglobulin I-set domain containing protein 0.0085 0.4509 0.4982
Schistosoma mansoni thyroid hormone receptor 0.0164 1 1
Schistosoma mansoni titin 0.0039 0.1255 0.1255
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0023 0.0183 0.0183
Schistosoma mansoni titin 0.0039 0.1255 0.1255
Echinococcus multilocularis titin 0.0039 0.1255 0.1255
Loa Loa (eye worm) hypothetical protein 0.0047 0.182 0.2053
Loa Loa (eye worm) hypothetical protein 0.0047 0.182 0.2053
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.915 0.915
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.0047 0.182 0.5
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Loa Loa (eye worm) projectin 0.0085 0.4509 0.5086
Loa Loa (eye worm) hypothetical protein 0.0047 0.182 0.2053
Schistosoma mansoni tyrosine kinase 0.0023 0.0183 0.0183
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.3671 0.4012
Schistosoma mansoni tyrosine kinase 0.0023 0.0183 0.0183
Schistosoma mansoni cell adhesion molecule 0.0039 0.1255 0.1255
Echinococcus granulosus Phosphotidylinositol phosphatase PTPRQ 0.0047 0.182 0.1989
Echinococcus granulosus titin 0.0085 0.4509 0.4928
Schistosoma mansoni tripartite motif protein trim9 0.0047 0.182 0.182
Echinococcus granulosus fibronectin type III domain-containing protein 0.0047 0.182 0.1989
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0052 0.0058
Brugia malayi Fibronectin type III domain containing protein 0.0047 0.182 0.1885
Brugia malayi Peroxidasin 0.0039 0.1255 0.1235
Echinococcus multilocularis cell adhesion molecule 0.0047 0.182 0.182
Brugia malayi Animal haem peroxidase family protein 0.0039 0.1255 0.1235
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0039 0.1255 0.1416
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0085 0.4509 0.5086
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0023 0.0183 0.0183
Schistosoma mansoni titin 0.0047 0.182 0.182
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0047 0.182 0.5
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0047 0.182 0.2053
Echinococcus granulosus tyrosine protein kinase otk 0.0039 0.1255 0.1372
Loa Loa (eye worm) hypothetical protein 0.0052 0.2152 0.2427
Schistosoma mansoni nephrin related 0.0039 0.1255 0.1255
Echinococcus multilocularis twitchin 0.0039 0.1255 0.1255
Onchocerca volvulus 0.0047 0.182 0.0742
Echinococcus granulosus tyrosine protein kinase Fyn 0.0023 0.0183 0.02
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.182 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0085 0.4509 0.4982
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.1255 0.1235
Loa Loa (eye worm) hypothetical protein 0.0047 0.182 0.2053
Schistosoma mansoni factor for adipocyte differentiation 0.0047 0.182 0.182
Echinococcus granulosus neuroglian 0.0085 0.4509 0.4928
Echinococcus granulosus usherin 0.0047 0.182 0.1989
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.1587 0.1735
Schistosoma mansoni titin 0.0039 0.1255 0.1255
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.3671 0.5
Loa Loa (eye worm) hypothetical protein 0.0148 0.8866 1
Onchocerca volvulus 0.0047 0.182 0.0742
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.3671 0.3671
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0039 0.1255 0.1416
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0047 0.182 0.182
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0047 0.182 0.1989
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0023 0.0183 0.0183
Echinococcus multilocularis Phosphotidylinositol phosphatase PTPRQ 0.0047 0.182 0.182
Schistosoma mansoni cell adhesion molecule 0.0085 0.4509 0.4509
Echinococcus granulosus c src tyrosine kinase 0.0023 0.0183 0.02
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0085 0.4509 0.5086
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0462 0.0462
Echinococcus multilocularis usherin 0.0047 0.182 0.182
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.1255 0.1235
Schistosoma mansoni cell adhesion molecule 0.0085 0.4509 0.4509
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0039 0.1255 0.1255
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.3671 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.1255 0.1235
Echinococcus multilocularis down syndrome cell adhesion 0.0039 0.1255 0.1255
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0062 0.2859 0.2859
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0085 0.4509 0.4509
Echinococcus multilocularis peroxidasin 0.0039 0.1255 0.1255
Echinococcus multilocularis roundabout 2 0.0085 0.4509 0.4509
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0047 0.182 0.182
Loa Loa (eye worm) hypothetical protein 0.0047 0.182 0.2053
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0039 0.1255 0.1255
Echinococcus granulosus tyrosine protein kinase Fyn 0.0023 0.0183 0.02
Loa Loa (eye worm) SRC-1 0.0023 0.0183 0.0206
Schistosoma mansoni hypothetical protein 0.0047 0.182 0.182
Loa Loa (eye worm) hypothetical protein 0.0047 0.182 0.2053
Echinococcus granulosus insulin growth factor binding 0.0039 0.1255 0.1372
Brugia malayi PHD-finger family protein 0.003 0.0661 0.055
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0039 0.1255 0.1416
Schistosoma mansoni cell adhesion molecule 0.0085 0.4509 0.4509
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0047 0.182 0.1989
Echinococcus granulosus Netrin receptor DCC 0.0047 0.182 0.1989
Loa Loa (eye worm) hypothetical protein 0.0047 0.182 0.2053
Onchocerca volvulus Huntingtin homolog 0.0148 0.8866 1
Echinococcus multilocularis Netrin receptor DCC 0.0047 0.182 0.182
Onchocerca volvulus 0.0047 0.182 0.0742
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0085 0.4509 0.4509
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Echinococcus multilocularis transfer RNA-Phe 0.0085 0.4509 0.4509
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0047 0.182 0.2053
Schistosoma mansoni factor for adipocyte differentiation 0.0047 0.182 0.182
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Schistosoma mansoni neuroglian 0.0085 0.4509 0.4509
Echinococcus granulosus anosmin 1 0.0047 0.182 0.1989
Brugia malayi protein unc-22 0.0085 0.4509 0.4982
Onchocerca volvulus Tyrosine kinase homolog 0.0054 0.2294 0.1365
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0085 0.4509 0.4928
Echinococcus granulosus G1Y162 protein 0.0047 0.182 0.1989
Echinococcus granulosus anosmin 1 0.0047 0.182 0.1989
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0047 0.182 0.1989
Loa Loa (eye worm) hypothetical protein 0.0085 0.4512 0.5089
Onchocerca volvulus 0.0085 0.4509 0.4275
Echinococcus multilocularis tyrosine protein kinase otk 0.0039 0.1255 0.1255
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.1255 0.1235
Echinococcus multilocularis anosmin 1 0.0047 0.182 0.182
Brugia malayi Bromodomain containing protein 0.0046 0.1786 0.1846
Echinococcus granulosus tyrosine protein kinase Src64B 0.0023 0.0183 0.02
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.3585 0.3918
Loa Loa (eye worm) hypothetical protein 0.0047 0.182 0.2053
Loa Loa (eye worm) hypothetical protein 0.0085 0.4509 0.5086
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.1255 0.1235
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0047 0.182 0.2053
Echinococcus multilocularis titin 0.0085 0.4509 0.4509
Loa Loa (eye worm) hypothetical protein 0.0047 0.182 0.2053
Loa Loa (eye worm) disorganized muscle protein 1 0.0039 0.1255 0.1416
Schistosoma mansoni cell adhesion molecule 0.0085 0.4509 0.4509
Schistosoma mansoni myosin-binding protein-related 0.0085 0.4509 0.4509
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0047 0.182 0.1885
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.3671 0.3671
Echinococcus granulosus hemicentin 1 0.0039 0.1255 0.1372
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.3671 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.1255 0.1255
Brugia malayi Immunoglobulin I-set domain containing protein 0.0039 0.1255 0.1235
Loa Loa (eye worm) hypothetical protein 0.0039 0.1255 0.1416
Onchocerca volvulus 0.0047 0.182 0.0742
Brugia malayi Protein-tyrosine phosphatase 0.0047 0.182 0.1885
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0039 0.1255 0.1416
Schistosoma mansoni titin 0.0085 0.4509 0.4509
Echinococcus multilocularis tyrosine protein kinase Abl 0.0023 0.0183 0.0183
Brugia malayi Prion-like- 0.0039 0.1255 0.1235
Echinococcus granulosus tyrosine protein kinase Lyn 0.0023 0.0183 0.02
Loa Loa (eye worm) hypothetical protein 0.0085 0.4509 0.5086
Brugia malayi hypothetical protein 0.0047 0.182 0.1885
Echinococcus multilocularis Fibronectin, type III 0.0047 0.182 0.182
Echinococcus multilocularis hemicentin 1 0.0039 0.1255 0.1255
Loa Loa (eye worm) TK protein kinase 0.0054 0.2294 0.2587
Echinococcus multilocularis titin 0.0047 0.182 0.182
Schistosoma mansoni cell adhesion molecule 0.0039 0.1255 0.1255
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0047 0.182 0.182
Loa Loa (eye worm) hypothetical protein 0.0047 0.182 0.2053
Schistosoma mansoni septate junction protein 0.0039 0.1255 0.1255
Echinococcus granulosus EG95 0.0047 0.182 0.1989
Echinococcus multilocularis 0.0039 0.1255 0.1255
Brugia malayi hypothetical protein 0.0047 0.182 0.1885
Schistosoma mansoni nephrin 0.0085 0.4509 0.4509
Brugia malayi Fibronectin type III domain containing protein 0.0047 0.182 0.1885
Loa Loa (eye worm) one IG domain family member 0.0039 0.1255 0.1416
Loa Loa (eye worm) hypothetical protein 0.0047 0.182 0.2053
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0023 0.0183 0.02
Echinococcus granulosus twitchin 0.0039 0.1255 0.1372

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.5623 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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