Detailed view for EgrG_000952600

Basic information

TDR Targets ID: 583256
Echinococcus granulosus, titin
Source Database / ID:  GeneDB

pI: 5.3491 | Length (AA): 6406 | MW (Da): 702755 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00041   Fibronectin type III domain
PF00069   Protein kinase domain
PF07679   Immunoglobulin I-set domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004672   protein kinase activity  
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 50 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 500 3dmk (A) 303 774 21.00 0 1 0.0175518 1.26
110 193 3qr2 (A) 2 92 21.00 0.64 0.37 0.0676127 -0.32
226 501 5ope (A) 82 349 32.00 0.0000000046 0.61 0.0524846 1.47
311 856 5t89 (X) 38 653 18.00 0.000000013 1 -0.169267 1.9
335 480 1iil (G) 187 341 29.00 0.27 0.48 0.0921911 0.44
411 486 2ywz (A) 5 88 26.00 0.6 1 0.268364 -1.41
482 1126 5oj2 (A) 28 725 24.00 0.00000012 1 -0.0189131 1.75
690 764 2lu7 (A) 9 82 35.00 0.046 1 0.476108 -0.99
693 764 2e6p (A) 28 98 35.00 0.66 0.98 0.388639 -0.44
768 1329 4pbx (A) 35 596 21.00 0 1 0.0692303 1.04
787 852 1x44 (A) 28 94 42.00 0.18 0.98 0.418703 -0.05
1139 1235 1uey (A) 13 112 40.00 0.000012 1 0.455542 -0.65
1233 1927 4yh7 (A) 28 612 22.00 0 1 -0.071008 1.45
1436 1536 1bpv (A) 2 103 39.00 0 0.39 0.378266 -0.99
1437 1527 4je4 (B) 3 90 23.00 0.072 0.55 0.212705 -1.08
1564 1636 1wwb (X) 303 382 33.00 0.78 0.89 0.382796 -1.17
1736 1841 2ed7 (A) 18 117 38.00 0.047 1 0.386947 -0.65
1737 1828 2rb8 (A) 804 891 18.00 0.26 0.49 0.133862 -1.25
2046 2540 3l5h (A) 87 582 23.00 0.00003 1 0.0966713 0.96
2160 2253 1x5y (A) 8 104 40.00 0.000000011 1 0.646074 -2.36
2455 2544 4u3h (A) 14 97 56.00 0.00000000035 1 0.734449 -2.05
3230 3659 4pbx (A) 179 590 30.00 0 1 0.226525 0.56
3370 3760 3t1w (A) 1180 1527 28.00 0.000018 1 0.148437 0.48
3775 3863 2doc (A) 16 104 38.00 0.00022 0.99 0.529293 -1.11
4392 4689 5e55 (A) 596 899 20.00 0 1 0.160019 -0.08
4492 4585 4u3h (A) 11 99 47.00 0 1 0.573074 -2
4580 4879 5whz (L) 6 332 15.00 0.19 0.88 -0.0896689 0.8
4595 4680 2yuw (A) 5 93 43.00 0.000038 1 0.530825 -0.92
4697 5275 3b43 (A) 1 564 21.00 0 1 0.110884 0.75
4987 5084 5fm5 (M) 510 607 38.00 0.0000000059 1 0.599698 -1.79
5089 5371 2nzi (A) 1 290 30.00 0 1 0.321677 -0.42
5200 5282 2cqv (A) 22 104 27.00 0.095 0.93 0.372357 -0.71
5277 5842 3uto (A) 5 570 45.00 0 1 0.577855 -0.94
5397 5749 1kob (A) 23 374 58.00 0 1 0.806505 -1.46
5419 5685 2x4f (A) 96 364 44.00 0 1 0.58018 -1.53
5748 5953 3pxh (A) 30 214 31.00 0.00000000029 1 0.249557 -0.02
5751 5964 2vr9 (A) 56 252 35.00 0.000001 0.99 0.0988062 0.69
5751 5963 2v5t (A) 115 298 26.00 0 0.95 -0.0173499 0.6
5757 6159 3dmk (A) 315 696 27.00 0.0000000057 1 0.0563098 1.32
5862 5963 1ie5 (A) 2 104 35.00 0.012 0.98 0.294323 0.45
5869 5964 1fhg (A) 34 133 32.00 0.00000073 0.73 0.305486 -0.82
5873 5964 1g1c (A) 5 97 22.00 0 1 0.270762 -1.03
6209 6402 5noi (A) 312 508 26.00 0.000000011 1 0.0517841 0.84
6216 6300 2bk8 (A) 6 92 33.00 0.14 1 0.442669 -1.14
1 500 3dmk (A) 303 774 23.00 0.000000000033 1 0.99415 1.25
7 497 3b43 (A) 96 564 28.00 0 1 1.04123 1.11
7 41 2v9t (A) 66 102 23.00 0.68 0.05 0.0556895 1.22
232 306 3knb (B) 32 103 39.00 0.024 0.33 0.419277 0.14
407 500 3knb (A) 6 98 28.00 0.00069 1 0.670992 -1.55
407 502 2cqv (A) 8 100 20.00 0 1 0.480251 -1.21

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126738)

Species Accession Gene Product
Brugia malayi Bm1_26690   Prion-like-
Brugia malayi Bm1_54260   Prion-like-
Brugia malayi Bm1_02325   Immunoglobulin I-set domain containing protein
Brugia malayi Bm1_17625   muscle M-line assembly protein unc-89
Brugia malayi Bm1_39425   protein unc-22
Brugia malayi Bm1_55550   kettin
Brugia malayi Bm1_12515   Immunoglobulin I-set domain containing protein
Caenorhabditis elegans CELE_F54E2.4   Protein F54E2.4
Caenorhabditis elegans CELE_C09D1.1   Protein UNC-89, isoform B
Caenorhabditis elegans CELE_F15G9.4   Protein HIM-4, isoform D
Caenorhabditis elegans CELE_F54E2.3   Protein KETN-1, isoform C
Caenorhabditis elegans CELE_ZK617.1   Protein UNC-22, isoform F
Caenorhabditis elegans CELE_F15G9.4a   Protein HIM-4, isoform C
Dictyostelium discoideum DDB_G0294611   hypothetical protein
Drosophila melanogaster Dmel_CG1915   sallimus
Drosophila melanogaster Dmel_CG42768   Muscle-specific protein 300 kDa
Drosophila melanogaster Dmel_CG32019   bent
Drosophila melanogaster Dmel_CG33519   CG33519 gene product from transcript CG33519-RH
Echinococcus granulosus EgrG_000597700   titin
Echinococcus granulosus EgrG_000952600   titin
Echinococcus granulosus EgrG_000422350   hemicentin 1
Echinococcus granulosus EgrG_000226000   titin
Echinococcus multilocularis EmuJ_000422400   hemicentin 1
Echinococcus multilocularis EmuJ_000597700   titin
Echinococcus multilocularis EmuJ_000226000   titin
Echinococcus multilocularis EmuJ_000952600  
Echinococcus multilocularis EmuJ_000039200   titin
Echinococcus multilocularis EmuJ_000422300   hemicentin 1
Homo sapiens 101930376   hemicentin-2-like
Homo sapiens ENSG00000143341   hemicentin 1
Homo sapiens ENSG00000124006   obscurin-like 1
Homo sapiens ENSG00000155657   titin
Homo sapiens ENSG00000148357   hemicentin 2
Homo sapiens ENSG00000072195   SPEG complex locus
Homo sapiens ENSG00000154358   obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Homo sapiens ENSG00000072195   CAVP-target protein-like
Homo sapiens 101929220   WAS/WASL-interacting protein family member 1-like
Loa Loa (eye worm) LOAG_01020   hypothetical protein
Loa Loa (eye worm) LOAG_04436   hypothetical protein
Loa Loa (eye worm) LOAG_01021   hypothetical protein
Loa Loa (eye worm) LOAG_15451   hypothetical protein
Loa Loa (eye worm) LOAG_04544   hypothetical protein
Loa Loa (eye worm) LOAG_01925   CAMK/MLCK protein kinase
Loa Loa (eye worm) LOAG_05722   hypothetical protein
Loa Loa (eye worm) LOAG_15557   hypothetical protein
Loa Loa (eye worm) LOAG_02065   hypothetical protein
Loa Loa (eye worm) LOAG_09000   projectin
Loa Loa (eye worm) LOAG_04438   hypothetical protein
Loa Loa (eye worm) LOAG_07554   hypothetical protein
Loa Loa (eye worm) LOAG_07292   hypothetical protein
Loa Loa (eye worm) LOAG_04081   hypothetical protein
Loa Loa (eye worm) LOAG_02063   hypothetical protein
Loa Loa (eye worm) LOAG_02064   hypothetical protein
Mus musculus ENSMUSG00000061462   obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Mus musculus ENSMUSG00000055632   hemicentin 2
Mus musculus ENSMUSG00000066842   hemicentin 1
Mus musculus 102641264   titin-like
Mus musculus ENSMUSG00000051747   titin
Mus musculus ENSMUSG00000026211   obscurin-like 1
Mus musculus ENSMUSG00000026207   SPEG complex locus
Neospora caninum NCLIV_040610   Virulent strain associated lipoprotein, related
Onchocerca volvulus OVOC3498   Putative titin
Onchocerca volvulus OVOC7179  
Schistosoma japonicum Sjp_0109770   IPR013098,Immunoglobulin I-set,domain-containing
Schistosoma japonicum Sjp_0134570   IPR000215,Proteinase inhibitor I4, serpin,domain-containing
Schistosoma japonicum Sjp_0208700   ko:K00907 myosin-light-chain kinase [EC2.7.11.18], putative
Schistosoma japonicum Sjp_0098070   Titin, putative
Schistosoma japonicum Sjp_0115810   Hemicentin-1 precursor, putative
Schistosoma japonicum Sjp_0056280   ko:K06841 semaphorin 5, putative
Schistosoma japonicum Sjp_0094680   Hemicentin-1 precursor, putative
Schistosoma japonicum Sjp_0011210   Hemicentin-1 precursor, putative
Schistosoma japonicum Sjp_0097290   Hemicentin-1 precursor, putative
Schistosoma japonicum Sjp_0308120   IPR007110,Immunoglobulin-like,domain-containing
Schistosoma japonicum Sjp_0097890   ko:K00907 myosin-light-chain kinase [EC2.7.11.18], putative
Schistosoma japonicum Sjp_0094690   Hemicentin-1 precursor, putative
Schistosoma japonicum Sjp_0104450   Hemicentin-1 precursor, putative
Schistosoma japonicum Sjp_0088120   IPR013098,Immunoglobulin I-set;IPR003599,Immunoglobulin subtype;IPR007110,Immunoglobulin-like,domain-containing
Schistosoma mansoni Smp_126240   titin
Schistosoma mansoni Smp_157010   titin
Schistosoma mansoni Smp_105020   titin
Schistosoma mansoni Smp_157020   hemicentin
Schistosoma mansoni Smp_163920   titin
Schmidtea mediterranea mk4.000677.06  
Schmidtea mediterranea mk4.003018.00  
Schmidtea mediterranea mk4.000643.04  
Schmidtea mediterranea mk4.001029.10  
Schmidtea mediterranea mk4.000677.07  
Schmidtea mediterranea mk4.030799.00  
Schmidtea mediterranea mk4.000677.05  
Schmidtea mediterranea mk4.000643.06  
Schmidtea mediterranea mk4.000677.08   Twitchin
Schmidtea mediterranea mk4.001095.04  
Schmidtea mediterranea mk4.001029.07   Putative titin
Schmidtea mediterranea mk4.000677.04  
Schmidtea mediterranea mk4.007460.00  
Schmidtea mediterranea mk4.000677.03  
Schmidtea mediterranea mk4.001029.09  
Schmidtea mediterranea mk4.008079.00  
Schmidtea mediterranea mk4.000643.03  
Schmidtea mediterranea mk4.020649.02  
Schmidtea mediterranea mk4.001519.04  
Schmidtea mediterranea mk4.007626.00   Kettin/titin-related protein
Schmidtea mediterranea mk4.001252.09  
Schmidtea mediterranea mk4.003939.00  
Schmidtea mediterranea mk4.006111.00  
Schmidtea mediterranea mk4.001519.01   Putative titin
Schmidtea mediterranea mk4.014446.03  
Schmidtea mediterranea mk4.001029.11  
Schmidtea mediterranea mk4.000643.05   Putative titin

Essentiality

EgrG_000952600 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F54E2.3 Caenorhabditis elegans slow growth wormbase
CELE_ZK617.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_ZK617.1 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus MAP kinase p38 alpha 360 aa 25.8% 295 aa Compounds References
Sus scrofa Casein kinase I isoform alpha 125 aa 25.6% 117 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 26.4% 292 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 27.4% 303 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 24.1% 303 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 21.6% 296 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 25.1% 287 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 26.4% 280 aa Compounds References
Patiria pectinifera Cdc2 300 aa 27.2% 287 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0448 0.7636 0.7636
0.0156 0.5375 0.5361
0.0348 0.3967 0.3967
0.0111 0.334 1
0.0227 0.4912 0.4912
0.0088 0.4477 0.4477
0.0152 0.2843 0.282
0.0336 0.4662 0.4662
0.0155 0.3568 0.706
0.0181 0.3158 0.3158
0.0095 0.4151 0.4151
0.0084 0.4625 0.5036
0.0378 0.586 0.586
0.008 0.4641 0
0.0089 0.442 0.8994
0.0132 0.3394 0.3394
0.0012 0.5 0.5
0.0089 0.4623 0.477
0.0236 0.3002 0.2854
0.0177 0.292 0.1383
0.0348 0.3967 0.3967
0.0178 0.5983 0
0.0227 0.4912 0.4912
0.00855091 0.284971 0.19403
0.0006 1 1
0.0343 0.706 0.706
0.0003 0.5 0.5
0.0177 0.2559 0.2335
0.0134 0.3027 0.3027
0.0462 0.2821 0.2816
0.0006 1 1
0.0093 0.8828 0
0.012 0.739 0.739
0.0042 0.5 0.5
0.0348 0.3967 0.3967
0.0047 0.445 0.506
0.0347 0.7058 0.0281
0.0104 0.2523 0.376
0.0084 0.6788 0.6788
0.0403 0.706 0.706
0.0114 0.6153 0.3459
0.0209 0.4772 0.4772
0.0039 0.5 0.5
0.0178 0.5983 0
0.0255 0.706 0.706
0.02 0.7068 0.706
0.0471 0.341 0.3405
0.0078 0.2971 0.5699
0.0135 0.3697 0.4223
0.0079 0.9462 1
0.0203 0.2854 0.2854
0.0205 0.2635 0.2635
0.00855091 0.284971 0.19403
0.0107 0.3748 0.3639
0.0008 0.5 0.5
0.0348 0.3967 0.3967
0.0007 0.5 0.5
0.0023 0.5 0.5
0.0142 0.4625 0.4545
0.0216 0.706 0.706
0.0212 0.4381 0.4291
0.0016 0.5 0.5
0.017 0.2614 0.7011
0.045 0.3044 0.3044
0.0007 0.5 0.5
0.0039 0.5 0.5
0.0008 1 1
0.037 0.706 0.706
0.0059 1 1
0.0061 0.6883 0.6883
0.0029 0.5 0.5
0.0088 1 1
0.0039 0.4389 0.0263
0.00855091 0.284971 0.19403
0.0063 0.7244 0
0.0084 0.6788 0.6788
0.0176 0.397 0.3939
0.012 0.739 0.739
0.0042 0.415 0
0.0034 0.2581 0.2581
0.0018 0.5 0.5
0.0081 1 1
0.0092 0.3268 0.3268
0.0146 0.4027 0.4027
0.0164 0.7647 0.7647
0.0343 0.706 0.706
0.0004 0.5 0.5
0.0305 0.4857 0.4857
0.0086 0.3597 1
0.0063 1 1
0.0222 0.2595 0.259
0.0121 0.3448 0.344
0.0338 0.7566 0.7382
0.0033 1 1
0.0016 1 0.5
0.0212 0.4381 0.4291
0.0056 1 1
0.0009 0.5 0.5
0.0272 0.706 0.706
0.0312 0.5397 0
0.0069 0.3067 0.3067
0.0209 0.4772 0.4772
0.0251 0.7407 0.7407
0.045 0.3044 0.3044
0.0022 0.5 0.5
0.0007 0.5 0.5
0.0116 0.6967 0.6967
0.0255 0.706 0.706
0.0008 1 1
0.0074 0.2516 0.2516
0.013 0.8813 0.8813
0.0462 0.2821 0.2816
0.0092 1 1
0.0037 1 1
0.0195 0.3401 0.3396
0.0251 0.7407 0.7407
0.0006 1 1
0.0083 1 0.5
0.0471 0.341 0.3405
0.045 0.3044 0.3044
0.0011 1 1
0.0374 0.7576 0.7576
0.0414 0.6115 0.6115
0.043 0.5151 0.5151
0.0032 0.5 0.5
0.0116 0.2785 0.2785
0.0348 0.3967 0.3967
0.0085 0.4509 0.4928
0.0184 0.706 0.706
0.045 0.3044 0.3044
0.0091 1 1
0.0088 1 1
0.0329 0.5062 0.5062
0.0488 0.3798 0.3794
0.0156 0.6042 0.6042
0.0156 0.6042 0.6042
0.0462 0.2821 0.2816
0.0462 0.2821 0.2816
0.0067 0.3543 0.5837
0.0322 0.4001 0.4001
0.045 0.3044 0.3044
0.045 0.3044 0.3044
0.0027 1 1
0.0059 1 1
0.0098 0.3242 0.2282
0.0067 0.5 0.5
0.0374 0.7576 0.7576
0.0036 0.5 0.5
0.045 0.3044 0.3044
0.0336 0.4662 0.4662
0.019 0.4071 0.3991
0.0351 0.6072 0
0.0012 0.5 0.5
0.0271 0.3613 0.7611
0.0301 0.2854 0.2854
0.0069 0.3271 0.8307
0.0059 1 1
0.045 0.3044 0.3044
0.0016 0.5 0.5
0.0089 0.442 0.8994
0.0008 1 1
0.0414 0.6115 0.6115
0.0326 0.5076 0.5059
0.0039 0.9485 0.9402
0.0071 0.8198 0.8166
0.0272 0.4658 0.4658
0.0266 0.2855 0.567
0.0329 0.4001 0.4001
0.0081 0.5 0.5
0.0313 0.5953 0.5953
0.0033 0.5 0.5
0.0104 0.8804 0.8611
0.0222 0.2595 0.259
0.0378 0.586 0.586
0.0305 0.5153 0.5153
0.0032 0.5 0.5
0.0026 0.5 0.5
0.0336 0.3462 0.4786
0.0012 0.5 0.5
0.0475 0.706 0.706
0.0106 0.4418 0.4134
0.0093 0.3031 0.3031

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier EgrG_000952600 (Echinococcus granulosus), titin
Title for this comment
Comment