TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 352.425 | Formula: C18H28N2O5
H donors: 3 H acceptors: 5 LogP: -0.93 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N1C[C@@H]2CNC[C@H](C1)C2)C1CCCCC1.OC(=O)/C=C/C(=O)O
InChi: 1S/C14H24N2O.C4H4O4/c17-14(13-4-2-1-3-5-13)16-9-11-6-12(10-16)8-15-7-11;5-3(6)1-2-4(7)8/h11-13,15H,1-10H2;1-2H,(H,5,6)(H,7,8)/b;2-1+/t11-,12+;
InChiKey: DGBBHTPLSRKOQP-HPJNZGNTSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Neuronal acetylcholine receptor protein alpha-7 subunit	Starlite/ChEMBL	References
Rattus norvegicus	Neuronal acetylcholine receptor; alpha4/beta2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Cation transporter family protein	Get druggable targets OG5_130932	All targets in OG5_130932
Schistosoma japonicum	IPR006201,Neurotransmitter-gated ion-channel;IPR006029,Neurotransmitter-gated ion-channel transmembrane region,domain-containing	Get druggable targets OG5_130932	All targets in OG5_130932
Schistosoma japonicum	Neuronal acetylcholine receptor subunit alpha-7 precursor, putative	Get druggable targets OG5_130932	All targets in OG5_130932
Onchocerca volvulus		Get druggable targets OG5_130932	All targets in OG5_130932
Schistosoma japonicum	ko:K04809 cholinergic receptor, nicotinic, alpha 7, putative	Get druggable targets OG5_130932	All targets in OG5_130932
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130932	All targets in OG5_130932
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130932	All targets in OG5_130932
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	Get druggable targets OG5_130932	All targets in OG5_130932
Onchocerca volvulus		Get druggable targets OG5_130932	All targets in OG5_130932
Onchocerca volvulus		Get druggable targets OG5_130932	All targets in OG5_130932
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130932	All targets in OG5_130932
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	Get druggable targets OG5_130932	All targets in OG5_130932
Schistosoma japonicum	Neuronal acetylcholine receptor subunit alpha-7 precursor, putative	Get druggable targets OG5_130932	All targets in OG5_130932
Schistosoma japonicum	Neuronal acetylcholine receptor subunit alpha-7 precursor, putative	Get druggable targets OG5_130932	All targets in OG5_130932

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	497 aa	35.0 %
Drosophila melanogaster	nicotinic Acetylcholine Receptor alpha2	Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	508 aa	38.6 %
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	486 aa	33.1 %
Onchocerca volvulus		Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	552 aa	24.3 %
Onchocerca volvulus		Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	482 aa	42.9 %
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	511 aa	27.2 %
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	485 aa	32.6 %
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	511 aa	36.0 %
Onchocerca volvulus	39S ribosomal protein L13, mitochondrial homolog	Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	475 aa	36.8 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type des-2 homolog	Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	530 aa	29.6 %
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	510 aa	36.1 %
Onchocerca volvulus	Putative zinc finger protein	Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	515 aa	36.9 %
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	527 aa	33.6 %
Echinococcus multilocularis	nAChR subunit	Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	488 aa	27.9 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	501 aa	36.5 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	513 aa	35.5 %
Schistosoma mansoni	nAChR subunit	Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	543 aa	27.8 %
Onchocerca volvulus		Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	496 aa	35.5 %
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	501 aa	32.1 %
Onchocerca volvulus	Acetylcholine receptor subunit alpha-type homolog	Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	513 aa	35.5 %
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	484 aa	34.3 %
Schistosoma japonicum	Neuronal acetylcholine receptor subunit alpha-3 precursor, putative	Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	518 aa	24.9 %
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	519 aa	25.6 %
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	507 aa	35.3 %
Loa Loa (eye worm)	hypothetical protein	Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	491 aa	36.0 %
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	Neuronal acetylcholine receptor protein alpha-7 subunit	502 aa	486 aa	32.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0123	0.2753	0.2753
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0064	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0216	0.706	1
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0	0.5
Entamoeba histolytica	receptor protein kinase, putative	0.0064	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0216	0.706	1
Onchocerca volvulus		0.0216	0.706	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0064	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0216	0.706	1
Schistosoma mansoni	nephrin	0.0216	0.706	0.706
Entamoeba histolytica	hypothetical protein	0.0064	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Entamoeba histolytica	hypothetical protein	0.0064	0	0.5
Brugia malayi	Cation transporter family protein	0.0123	0.2753	0.39
Schistosoma mansoni	factor for adipocyte differentiation	0.0216	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Echinococcus multilocularis	neuroglian	0.0216	0.706	0.706
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Entamoeba histolytica	hypothetical protein	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Entamoeba histolytica	cysteine surface protein, putative	0.0064	0	0.5
Echinococcus granulosus	contactin	0.0216	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0216	0.706	0.706
Entamoeba histolytica	hypothetical protein	0.0064	0	0.5
Onchocerca volvulus		0.0216	0.706	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0216	0.706	1
Trichomonas vaginalis	AGC family protein kinase	0.0064	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0064	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0	0.5
Trichomonas vaginalis	TK family protein kinase	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0216	0.706	0.706
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0064	0	0.5
Echinococcus granulosus	Fibronectin type III domain containing protein	0.0216	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0	0.5
Loa Loa (eye worm)	myotactin form A	0.0216	0.706	1
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Echinococcus granulosus	G1Y162 protein	0.0216	0.706	0.706
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0	0.5
Leishmania major	hypothetical protein, conserved	0.0216	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0216	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0	0.5
Echinococcus granulosus	roundabout 2	0.0216	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Entamoeba histolytica	hypothetical protein	0.0064	0	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0064	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0	0.5
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0216	0.706	1
Schistosoma mansoni	hypothetical protein	0.0216	0.706	0.706
Brugia malayi	Lethal protein 805	0.0216	0.706	1
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0216	0.706	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0216	0.706	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0064	0	0.5
Onchocerca volvulus		0.0216	0.706	1
Schistosoma mansoni	cell adhesion molecule	0.0216	0.706	0.706
Schistosoma mansoni	protein tyrosine phosphatase	0.0216	0.706	0.706
Schistosoma mansoni	factor for adipocyte differentiation	0.0216	0.706	0.706
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0216	0.706	1
Entamoeba histolytica	tyrosin kinase, putative	0.0064	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0	0.5
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0216	0.706	1
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Onchocerca volvulus		0.0216	0.706	1
Echinococcus granulosus	EG95	0.0216	0.706	0.706
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0216	0.706	0.706
Brugia malayi	hypothetical protein	0.0216	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0216	0.706	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0064	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0064	0	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0216	0.706	1
Echinococcus multilocularis	Fibronectin, type III	0.0216	0.706	0.706
Onchocerca volvulus		0.0216	0.706	1
Schistosoma mansoni	ephrin receptor	0.028	1	1
Loa Loa (eye worm)	hypothetical protein	0.0216	0.706	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0064	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0	0.5
Schistosoma mansoni	titin	0.0216	0.706	0.706
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0	0.5
Giardia lamblia	Kinase, NEK	0.0064	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0216	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0216	0.706	1
Schistosoma mansoni	tripartite motif protein trim9	0.0216	0.706	0.706
Echinococcus multilocularis	anosmin 1	0.0216	0.706	0.706
Onchocerca volvulus		0.0123	0.2753	0.39
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.0216	0.706	0.706
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0216	0.706	1
Echinococcus granulosus	Netrin receptor DCC	0.0216	0.706	0.706
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0064	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0	0.5
Echinococcus granulosus	titin	0.0216	0.706	0.706
Schistosoma mansoni	serine/threonine protein kinase	0.0216	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0216	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Echinococcus granulosus	anosmin 1	0.0216	0.706	0.706
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0216	0.706	1
Entamoeba histolytica	protein kinase, putative	0.0064	0	0.5
Loa Loa (eye worm)	projectin	0.0216	0.706	1
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0216	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.0216	0.706	1
Brugia malayi	myotactin form B	0.0216	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.0216	0.706	1
Schistosoma mansoni	cell adhesion molecule	0.0216	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Echinococcus granulosus	roundabout 2	0.0216	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Schistosoma mansoni	hemicentin	0.0216	0.706	0.706
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0	0.5
Schistosoma mansoni	titin	0.0216	0.706	0.706
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0	0.5
Onchocerca volvulus		0.0216	0.706	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0216	0.706	0.706
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.028	1	1
Loa Loa (eye worm)	hypothetical protein	0.0106	0.195	0.2763
Entamoeba histolytica	hypothetical protein	0.0064	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0216	0.706	1
Echinococcus multilocularis	anosmin 1	0.0216	0.706	0.706
Echinococcus granulosus	fibronectin type III domain-containing protein	0.0216	0.706	0.706
Plasmodium vivax	protein kinase, putative	0.0064	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0216	0.706	1
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0	0.5
Onchocerca volvulus		0.0216	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Onchocerca volvulus		0.0216	0.706	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0216	0.706	0.706
Onchocerca volvulus		0.0123	0.2753	0.39
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0064	0	0.5
Echinococcus granulosus	Fibronectin type III	0.0216	0.706	0.706
Echinococcus multilocularis	titin	0.0216	0.706	0.706
Entamoeba histolytica	protein kinase, putative	0.0064	0	0.5
Onchocerca volvulus		0.0216	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0	0.5
Giardia lamblia	Kinase	0.0064	0	0.5
Echinococcus granulosus	Netrin receptor DCC	0.0216	0.706	0.706
Echinococcus multilocularis	transfer RNA-Phe	0.0216	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0216	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0064	0	0.5
Entamoeba histolytica	hypothetical protein	0.0064	0	0.5
Echinococcus multilocularis	titin	0.0216	0.706	0.706
Brugia malayi	Protein-tyrosine phosphatase	0.0216	0.706	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0064	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0	0.5
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.0216	0.706	0.706
Echinococcus granulosus	nephrin	0.0216	0.706	0.706
Echinococcus granulosus	titin	0.0216	0.706	0.706
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0216	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0216	0.706	1
Entamoeba histolytica	tyrosin kinase, putative	0.0064	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0064	0	0.5
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0064	0	0.5
Trichomonas vaginalis	STE family protein kinase	0.0064	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0216	0.706	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0	0.5
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0216	0.706	0.706
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0216	0.706	0.706
Entamoeba histolytica	serine/threonine kinase, putative	0.0064	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0216	0.706	0.706
Loa Loa (eye worm)	hypothetical protein	0.0216	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2753	0.39
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0216	0.706	0.706
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0216	0.706	1
Schistosoma mansoni	cell adhesion molecule	0.0216	0.706	0.706
Entamoeba histolytica	receptor protein kinase, putative	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Trypanosoma brucei	Fibronectin type III domain containing protein, putative	0.0216	0.706	1
Schistosoma mansoni	cell adhesion molecule	0.0216	0.706	0.706
Giardia lamblia	Kinase, NEK	0.0064	0	0.5
Schistosoma mansoni	factor for adipocyte differentiation	0.0216	0.706	0.706
Echinococcus multilocularis	anosmin 1	0.0216	0.706	0.706
Brugia malayi	Fibronectin type III domain containing protein	0.0216	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Brugia malayi	Fibronectin type III domain containing protein	0.0216	0.706	1
Schistosoma mansoni	cell adhesion molecule	0.0216	0.706	0.706
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0216	0.706	0.706
Giardia lamblia	Protein 21.1	0.0064	0	0.5
Brugia malayi	hypothetical protein	0.0216	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0216	0.706	0.706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0216	0.706	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0216	0.706	1
Echinococcus multilocularis	Netrin receptor DCC	0.0216	0.706	0.706
Entamoeba histolytica	protein kinase, putative	0.0064	0	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0064	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0216	0.706	1
Entamoeba histolytica	protein kinase, putative	0.0064	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0216	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.0216	0.706	1
Onchocerca volvulus		0.0216	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0	0.5
Brugia malayi	Fibronectin type III domain containing protein	0.0216	0.706	1
Entamoeba histolytica	protein kinase, putative	0.0064	0	0.5
Schistosoma mansoni	nephrin	0.0216	0.706	0.706
Onchocerca volvulus		0.0216	0.706	1
Echinococcus multilocularis	roundabout 2	0.0216	0.706	0.706
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0123	0.2753	0.2753
Entamoeba histolytica	protein kinase, putative	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0216	0.706	1
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0216	0.706	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0216	0.706	0.706
Loa Loa (eye worm)	hypothetical protein	0.0216	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.0216	0.706	1
Echinococcus multilocularis	cell adhesion molecule	0.0216	0.706	0.706
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0216	0.706	0.706
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0216	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0216	0.706	1
Brugia malayi	myotactin form A	0.0216	0.706	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0064	0	0.5
Echinococcus granulosus	roundabout 2	0.0216	0.706	0.706
Echinococcus granulosus	anosmin 1	0.0216	0.706	0.706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0216	0.706	1
Entamoeba histolytica	protein kinase, putative	0.0064	0	0.5
Toxoplasma gondii	STE kinase	0.0064	0	0.5
Entamoeba histolytica	hypothetical protein	0.0064	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0216	0.706	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0216	0.706	0.706
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0064	0	0.5
Entamoeba histolytica	hypothetical protein	0.0064	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0064	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0	0.5
Echinococcus granulosus	usherin	0.0216	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Echinococcus granulosus	cell adhesion molecule	0.0216	0.706	0.706
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0	0.5
Brugia malayi	Fibronectin type III domain containing protein	0.0216	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.0216	0.706	1
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0216	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Schistosoma mansoni	hypothetical protein	0.0216	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0064	0	0.5
Onchocerca volvulus		0.0216	0.706	1
Echinococcus multilocularis	Netrin receptor DCC	0.0216	0.706	0.706
Plasmodium falciparum	protein kinase, putative	0.0064	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0216	0.706	1
Brugia malayi	Fibronectin type III domain containing protein	0.0216	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Schistosoma mansoni	titin	0.0216	0.706	0.706
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0216	0.706	0.706
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0216	0.706	1
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0216	0.706	0.706
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2753	0.39
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0216	0.706	1
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Echinococcus multilocularis	usherin	0.0216	0.706	0.706
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Entamoeba histolytica	hypothetical protein	0.0064	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0	0.5
Schistosoma mansoni	myosin-binding protein-related	0.0216	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0064	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0064	0	0.5
Schistosoma mansoni	hypothetical protein	0.0216	0.706	0.706
Brugia malayi	Fibronectin type III domain containing protein	0.0216	0.706	1
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0064	0	0.5
Schistosoma mansoni	neuroglian	0.0216	0.706	0.706
Entamoeba histolytica	protein kinase, putative	0.0064	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0	0.5
Onchocerca volvulus		0.0216	0.706	1
Echinococcus granulosus	anosmin 1	0.0216	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Brugia malayi	SPRY domain containing protein	0.0216	0.706	1
Loa Loa (eye worm)	lethal protein 805	0.0216	0.706	1
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0064	0	0.5
Brugia malayi	protein unc-22	0.0216	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0064	0	0.5
Plasmodium falciparum	tyrosine kinase-like protein	0.0064	0	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0064	0	0.5
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.0216	0.706	0.706
Entamoeba histolytica	protein kinase, putative	0.0064	0	0.5
Onchocerca volvulus		0.0216	0.706	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0216	0.706	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0216	0.706	1
Loa Loa (eye worm)	hypothetical protein	0.0216	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Echinococcus granulosus	neuroglian	0.0216	0.706	0.706
Loa Loa (eye worm)	CAMK protein kinase	0.0216	0.706	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0	0.5
Loa Loa (eye worm)	UNCoordinated family member	0.0216	0.706	1
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0064	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0216	0.706	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0064	0	0.5
Brugia malayi	Lethal protein 805	0.0216	0.706	1
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0064	0	0.5
Entamoeba histolytica	hypothetical protein	0.0064	0	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0064	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0064	0	0.5
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0216	0.706	0.706
Trichomonas vaginalis	TKL family protein kinase	0.0064	0	0.5
Echinococcus multilocularis	roundabout 2	0.0216	0.706	0.706
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0216	0.706	0.706
Plasmodium falciparum	protein kinase, putative	0.0064	0	0.5
Echinococcus multilocularis	roundabout 2	0.0216	0.706	0.706
Onchocerca volvulus		0.0123	0.2753	0.39
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0064	0	0.5
Toxoplasma gondii	protein kinase	0.0064	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0216	0.706	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	> 5000 nM	Displacement of [3H]epibatidine from alpha4beta2 nAChR in Sprague-Dawley rat forebrain P2 fraction after 90 mins by liquid scintillation counting analysis	ChEMBL.	24156938
Ki (binding)	> 10000 nM	Displacement of [3H]methyllycaconitine from alpha7 nAChR in Sprague-Dawley rat forebrain P2 fraction after 90 mins by liquid scintillation counting analysis	ChEMBL.	24156938

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3094073

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1824718