TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 273.332 | Formula: C18H15N3
H donors: 2 H acceptors: 1 LogP: 4.56 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccccc1Nc1ccnc2c1c1ccccc1[nH]2
InChi: 1S/C18H15N3/c1-12-6-2-4-8-14(12)20-16-10-11-19-18-17(16)13-7-3-5-9-15(13)21-18/h2-11H,1H3,(H2,19,20,21)
InChiKey: SJQFKWYTPBCICF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	erb-b2 receptor tyrosine kinase 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0313	0.5953	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0313	0.5953	0.7027
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0313	0.5953	1
Echinococcus multilocularis	cell adhesion molecule	0.0313	0.5953	0.5953
Echinococcus multilocularis	Netrin receptor DCC	0.0313	0.5953	0.5953
Echinococcus multilocularis	Fibronectin, type III	0.0313	0.5953	0.5953
Loa Loa (eye worm)	CAMK protein kinase	0.0313	0.5953	1
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Onchocerca volvulus		0.0313	0.5953	1
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0313	0.5953	0.5953
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Onchocerca volvulus		0.0313	0.5953	1
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0	0.5
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0313	0.5953	0.7027
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Schistosoma mansoni	titin	0.0313	0.5953	0.7027
Loa Loa (eye worm)	hypothetical protein	0.0313	0.5953	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0272	0.4844	0.8138
Echinococcus granulosus	nephrin	0.0313	0.5953	0.5953
Echinococcus granulosus	anosmin 1	0.0313	0.5953	0.5953
Schistosoma mansoni	factor for adipocyte differentiation	0.0313	0.5953	0.7027
Loa Loa (eye worm)	hypothetical protein	0.0313	0.5953	1
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Brugia malayi	Lethal protein 805	0.0313	0.5953	1
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0189	0.259	0.259
Schistosoma mansoni	ephrin receptor	0.0406	0.8471	1
Schistosoma mansoni	tripartite motif protein trim9	0.0313	0.5953	0.7027
Echinococcus granulosus	cell adhesion molecule	0.0313	0.5953	0.5953
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0	0.5
Entamoeba histolytica	hypothetical protein	0.0093	0	0.5
Loa Loa (eye worm)	UNCoordinated family member	0.0313	0.5953	1
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0093	0	0.5
Entamoeba histolytica	hypothetical protein	0.0093	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0093	0	0.5
Onchocerca volvulus		0.0313	0.5953	1
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Echinococcus granulosus	titin	0.0313	0.5953	0.5953
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0313	0.5953	1
Brugia malayi	Fibronectin type III domain containing protein	0.0313	0.5953	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0313	0.5953	0.5953
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0093	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Loa Loa (eye worm)	myotactin form A	0.0313	0.5953	1
Entamoeba histolytica	tyrosine kinase, putative	0.0093	0	0.5
Loa Loa (eye worm)	TK/INSR protein kinase	0.015	0.1529	0.2569
Echinococcus multilocularis	neuroglian	0.0313	0.5953	0.5953
Echinococcus granulosus	anosmin 1	0.0313	0.5953	0.5953
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0093	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0313	0.5953	1
Entamoeba histolytica	tyrosine kinase, putative	0.0093	0	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0313	0.5953	1
Echinococcus multilocularis	usherin	0.0313	0.5953	0.5953
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0093	0	0.5
Schistosoma mansoni	cell adhesion molecule	0.0313	0.5953	0.7027
Schistosoma mansoni	tyrosine kinase	0.0272	0.4844	0.5719
Onchocerca volvulus		0.0313	0.5953	1
Schistosoma mansoni	tyrosine kinase	0.0096	0.0072	0.0085
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0093	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0313	0.5953	1
Entamoeba histolytica	receptor protein kinase, putative	0.0093	0	0.5
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.0313	0.5953	0.5953
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Entamoeba histolytica	receptor protein kinase, putative	0.0093	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0093	0	0.5
Entamoeba histolytica	hypothetical protein	0.0093	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0093	0	0.5
Entamoeba histolytica	hypothetical protein	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Schistosoma mansoni	cell adhesion molecule	0.0313	0.5953	0.7027
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0313	0.5953	0.5953
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0	0.5
Echinococcus granulosus	EG95	0.0313	0.5953	0.5953
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0313	0.5953	0.5953
Giardia lamblia	Kinase, NEK	0.0093	0	0.5
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0313	0.5953	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0093	0	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0313	0.5953	0.7027
Loa Loa (eye worm)	hypothetical protein	0.0313	0.5953	1
Onchocerca volvulus		0.0313	0.5953	1
Entamoeba histolytica	protein kinase, putative	0.0093	0	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0093	0	0.5
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0313	0.5953	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.259	0.3058
Loa Loa (eye worm)	hypothetical protein	0.0313	0.5953	1
Schistosoma mansoni	factor for adipocyte differentiation	0.0313	0.5953	0.7027
Echinococcus multilocularis	anosmin 1	0.0313	0.5953	0.5953
Schistosoma mansoni	cell adhesion molecule	0.0313	0.5953	0.7027
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Entamoeba histolytica	hypothetical protein	0.0093	0	0.5
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0313	0.5953	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0313	0.5953	0.7027
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0093	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0313	0.5953	1
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0313	0.5953	0.5953
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0093	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0093	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0313	0.5953	1
Entamoeba histolytica	protein kinase, putative	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0093	0	0.5
Schistosoma mansoni	titin	0.0313	0.5953	0.7027
Echinococcus granulosus	Fibronectin type III domain containing protein	0.0313	0.5953	0.5953
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0093	0	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0313	0.5953	0.5953
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0093	0	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0313	0.5953	0.7027
Echinococcus multilocularis	epidermal growth factor receptor	0.0272	0.4844	0.4844
Trichomonas vaginalis	AGC family protein kinase	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0093	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0093	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0313	0.5953	1
Loa Loa (eye worm)	hypothetical protein	0.0313	0.5953	1
Giardia lamblia	Kinase	0.0093	0	0.5
Brugia malayi	SPRY domain containing protein	0.0313	0.5953	1
Schistosoma mansoni	hemicentin	0.0313	0.5953	0.7027
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0	0.5
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0313	0.5953	1
Entamoeba histolytica	protein kinase, putative	0.0093	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0093	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0093	0	0.5
Plasmodium vivax	protein kinase, putative	0.0093	0	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0189	0.259	0.259
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0093	0	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0093	0	0.5
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0313	0.5953	1
Onchocerca volvulus		0.0313	0.5953	1
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Schistosoma mansoni	tyrosine kinase	0.015	0.1529	0.1805
Entamoeba histolytica	tyrosine kinase, putative	0.0093	0	0.5
Schistosoma mansoni	tyrosine kinase	0.015	0.1529	0.1805
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0093	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0313	0.5953	1
Echinococcus granulosus	roundabout 2	0.0313	0.5953	0.5953
Entamoeba histolytica	ankyrin repeat protein	0.0093	0	0.5
Echinococcus granulosus	roundabout 2	0.0313	0.5953	0.5953
Entamoeba histolytica	protein kinase, putative	0.0093	0	0.5
Giardia lamblia	Kinase, NEK	0.0093	0	0.5
Echinococcus multilocularis	insulin receptor	0.015	0.1529	0.1529
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0	0.5
Onchocerca volvulus		0.0313	0.5953	1
Entamoeba histolytica	tyrosin kinase, putative	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0	0.5
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0313	0.5953	1
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0093	0	0.5
Leishmania major	hypothetical protein, conserved	0.0313	0.5953	1
Loa Loa (eye worm)	hypothetical protein	0.0313	0.5953	1
Schistosoma mansoni	serine/threonine protein kinase	0.0313	0.5953	0.7027
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0313	0.5953	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0093	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0	0.5
Echinococcus granulosus	Fibronectin type III	0.0313	0.5953	0.5953
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0093	0	0.5
Echinococcus granulosus	insulin receptor	0.015	0.1529	0.1529
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0	0.5
Loa Loa (eye worm)	lethal protein 805	0.0313	0.5953	1
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Onchocerca volvulus		0.0313	0.5953	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0313	0.5953	0.5953
Entamoeba histolytica	hypothetical protein	0.0093	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0093	0	0.5
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0093	0	0.5
Echinococcus multilocularis	transfer RNA-Phe	0.0313	0.5953	0.5953
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0	0.5
Schistosoma mansoni	nephrin	0.0313	0.5953	0.7027
Entamoeba histolytica	protein kinase, putative	0.0093	0	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0093	0	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0463	1	1
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0313	0.5953	1
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0313	0.5953	0.5953
Onchocerca volvulus		0.0313	0.5953	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0313	0.5953	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0313	0.5953	1
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Brugia malayi	Protein-tyrosine phosphatase	0.0313	0.5953	1
Echinococcus granulosus	G1Y162 protein	0.0313	0.5953	0.5953
Schistosoma mansoni	myosin-binding protein-related	0.0313	0.5953	0.7027
Onchocerca volvulus		0.0313	0.5953	1
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0	0.5
Brugia malayi	protein unc-22	0.0313	0.5953	1
Giardia lamblia	Protein 21.1	0.0093	0	0.5
Toxoplasma gondii	protein kinase	0.0093	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0093	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0313	0.5953	1
Schistosoma mansoni	titin	0.0313	0.5953	0.7027
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0313	0.5953	1
Loa Loa (eye worm)	hypothetical protein	0.0313	0.5953	1
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0313	0.5953	1
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0	0.5
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0093	0	0.5
Schistosoma mansoni	cell adhesion molecule	0.0313	0.5953	0.7027
Entamoeba histolytica	tyrosine kinase, putative	0.0093	0	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0093	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.015	0.1529	0.2569
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Onchocerca volvulus		0.0313	0.5953	1
Entamoeba histolytica	cysteine surface protein, putative	0.0093	0	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0093	0	0.5
Echinococcus multilocularis	anosmin 1	0.0313	0.5953	0.5953
Entamoeba histolytica	tyrosine kinase, putative	0.0093	0	0.5
Trichomonas vaginalis	TK family protein kinase	0.0093	0	0.5
Brugia malayi	Fibronectin type III domain containing protein	0.0313	0.5953	1
Echinococcus granulosus	epidermal growth factor receptor	0.0272	0.4844	0.4844
Echinococcus granulosus	anosmin 1	0.0313	0.5953	0.5953
Brugia malayi	Fibronectin type III domain containing protein	0.0313	0.5953	1
Loa Loa (eye worm)	projectin	0.0313	0.5953	1
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.0313	0.5953	0.5953
Brugia malayi	hypothetical protein	0.0313	0.5953	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0093	0	0.5
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0313	0.5953	0.5953
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0313	0.5953	0.5953
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0093	0	0.5
Schistosoma mansoni	neuroglian	0.0313	0.5953	0.7027
Toxoplasma gondii	STE kinase	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Brugia malayi	Fibronectin type III domain containing protein	0.0313	0.5953	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0093	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0	0.5
Echinococcus multilocularis	roundabout 2	0.0313	0.5953	0.5953
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0313	0.5953	1
Echinococcus multilocularis	titin	0.0313	0.5953	0.5953
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0313	0.5953	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0313	0.5953	1
Brugia malayi	hypothetical protein	0.0313	0.5953	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0313	0.5953	1
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Echinococcus multilocularis	roundabout 2	0.0313	0.5953	0.5953
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0093	0	0.5
Entamoeba histolytica	hypothetical protein	0.0093	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0093	0	0.5
Entamoeba histolytica	hypothetical protein	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0313	0.5953	1
Brugia malayi	Fibronectin type III domain containing protein	0.0313	0.5953	1
Entamoeba histolytica	tyrosine kinase, putative	0.0093	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0093	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0093	0	0.5
Brugia malayi	Furin-like cysteine rich region family protein	0.0272	0.4844	0.8138
Loa Loa (eye worm)	hypothetical protein	0.0313	0.5953	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0093	0	0.5
Echinococcus granulosus	neuroglian	0.0313	0.5953	0.5953
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0313	0.5953	0.5953
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Echinococcus granulosus	Netrin receptor DCC	0.0313	0.5953	0.5953
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0	0.5
Entamoeba histolytica	hypothetical protein	0.0093	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0093	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0313	0.5953	1
Entamoeba histolytica	protein kinase, putative	0.0093	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0096	0.0072	0.0085
Entamoeba histolytica	tyrosine kinase, putative	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0313	0.5953	1
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Echinococcus granulosus	usherin	0.0313	0.5953	0.5953
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0313	0.5953	0.5953
Brugia malayi	myotactin form B	0.0313	0.5953	1
Plasmodium falciparum	protein kinase, putative	0.0093	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0313	0.5953	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0093	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0093	0	0.5
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.0313	0.5953	0.5953
Onchocerca volvulus		0.0313	0.5953	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0313	0.5953	1
Onchocerca volvulus		0.0313	0.5953	1
Schistosoma mansoni	tyrosine kinase	0.0189	0.259	0.3058
Entamoeba histolytica	tyrosine kinase, putative	0.0093	0	0.5
Echinococcus granulosus	titin	0.0313	0.5953	0.5953
Echinococcus granulosus	contactin	0.0313	0.5953	0.5953
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Schistosoma mansoni	cell adhesion molecule	0.0313	0.5953	0.7027
Brugia malayi	Fibronectin type III domain containing protein	0.0313	0.5953	1
Entamoeba histolytica	hypothetical protein, conserved	0.0093	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0313	0.5953	1
Loa Loa (eye worm)	hypothetical protein	0.0313	0.5953	1
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0313	0.5953	0.5953
Onchocerca volvulus		0.0313	0.5953	1
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0313	0.5953	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0189	0.259	0.259
Trichomonas vaginalis	STE family protein kinase	0.0093	0	0.5
Echinococcus granulosus	Netrin receptor DCC	0.0313	0.5953	0.5953
Loa Loa (eye worm)	hypothetical protein	0.0313	0.5953	1
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Schistosoma mansoni	protein tyrosine phosphatase	0.0313	0.5953	0.7027
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0313	0.5953	1
Entamoeba histolytica	tyrosin kinase, putative	0.0093	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Schistosoma mansoni	hypothetical protein	0.0313	0.5953	0.7027
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0093	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0093	0	0.5
Schistosoma mansoni	hypothetical protein	0.0313	0.5953	0.7027
Entamoeba histolytica	tyrosine kinase, putative	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0093	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0093	0	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0093	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0093	0	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0313	0.5953	0.5953
Echinococcus granulosus	roundabout 2	0.0313	0.5953	0.5953
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0093	0	0.5
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0313	0.5953	1
Echinococcus granulosus	fibronectin type III domain-containing protein	0.0313	0.5953	0.5953
Entamoeba histolytica	serine/threonine kinase, putative	0.0093	0	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0313	0.5953	0.5953
Brugia malayi	Lethal protein 805	0.0313	0.5953	1
Echinococcus multilocularis	titin	0.0313	0.5953	0.5953
Loa Loa (eye worm)	hypothetical protein	0.0313	0.5953	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0093	0	0.5
Schistosoma mansoni	hypothetical protein	0.0313	0.5953	0.7027
Echinococcus multilocularis	roundabout 2	0.0313	0.5953	0.5953
Entamoeba histolytica	hypothetical protein	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Entamoeba histolytica	hypothetical protein	0.0093	0	0.5
Schistosoma mansoni	nephrin	0.0313	0.5953	0.7027
Entamoeba histolytica	protein kinase domain containing protein	0.0093	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0096	0.0072	0.0085
Brugia malayi	myotactin form A	0.0313	0.5953	1
Plasmodium falciparum	protein kinase, putative	0.0093	0	0.5
Echinococcus multilocularis	anosmin 1	0.0313	0.5953	0.5953
Echinococcus multilocularis	Netrin receptor DCC	0.0313	0.5953	0.5953
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0313	0.5953	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0093	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Schistosoma mansoni	factor for adipocyte differentiation	0.0313	0.5953	0.7027
Trichomonas vaginalis	TKL family protein kinase	0.0093	0	0.5
Trypanosoma brucei	Fibronectin type III domain containing protein, putative	0.0313	0.5953	1
Loa Loa (eye worm)	hypothetical protein	0.0313	0.5953	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0313	0.5953	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 978 nM	Inhibition of human recombinant GST-fused HER2 expressed in baculovirus Sf9 insect cells using poly(Glu,Tyr) as substrate after 60 mins by scintillation counting	ChEMBL.	No reference
IC50 (binding)	> 1000000 nM	Inhibition of human recombinant GST-fused Brk expressed in baculovirus Sf9 insect cells using poly(Glu,Tyr) as substrate after 60 mins by scintillation counting	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3133820

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1845975