Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Lethal protein 805 | 0.0156 | 0.6042 | 1 |
Echinococcus granulosus | usherin | 0.0156 | 0.6042 | 0.6042 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 32 | 0.0156 | 0.6042 | 1 |
Onchocerca volvulus | 0.0156 | 0.6042 | 1 | |
Echinococcus granulosus | anosmin 1 | 0.0156 | 0.6042 | 0.6042 |
Onchocerca volvulus | 0.0156 | 0.6042 | 1 | |
Echinococcus granulosus | Fibronectin type III domain containing protein | 0.0156 | 0.6042 | 0.6042 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.6042 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0156 | 0.6042 | 0.6042 |
Echinococcus multilocularis | Down syndrome cell adhesion molecule | 0.0156 | 0.6042 | 0.6042 |
Onchocerca volvulus | 0.0156 | 0.6042 | 1 | |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.0156 | 0.6042 | 0.6042 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0156 | 0.6042 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.6042 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.6042 | 1 |
Echinococcus granulosus | nephrin | 0.0156 | 0.6042 | 0.6042 |
Trypanosoma cruzi | Fibronectin type III domain containing protein, putative | 0.0156 | 0.6042 | 0.5 |
Brugia malayi | SPRY domain containing protein | 0.0156 | 0.6042 | 1 |
Onchocerca volvulus | 0.0156 | 0.6042 | 1 | |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0156 | 0.6042 | 1 |
Echinococcus multilocularis | usherin | 0.0156 | 0.6042 | 0.6042 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.6042 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.6042 | 1 |
Schistosoma mansoni | nephrin | 0.0156 | 0.6042 | 0.6042 |
Loa Loa (eye worm) | myotactin form A | 0.0156 | 0.6042 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0156 | 0.6042 | 0.6042 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0156 | 0.6042 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.6042 | 1 |
Echinococcus granulosus | G1Y162 protein | 0.0156 | 0.6042 | 0.6042 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0156 | 0.6042 | 1 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0156 | 0.6042 | 0.6042 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0156 | 0.6042 | 1 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0156 | 0.6042 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0202 | 1 | 1 |
Onchocerca volvulus | 0.0156 | 0.6042 | 1 | |
Echinococcus granulosus | anosmin 1 | 0.0156 | 0.6042 | 0.6042 |
Schistosoma mansoni | hypothetical protein | 0.0156 | 0.6042 | 0.6042 |
Brugia malayi | protein-tyrosine phosphatase Lar-like precursor, putative | 0.0156 | 0.6042 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0156 | 0.6042 | 1 |
Echinococcus multilocularis | anosmin 1 | 0.0156 | 0.6042 | 0.6042 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0156 | 0.6042 | 0.6042 |
Schistosoma mansoni | cell adhesion molecule | 0.0156 | 0.6042 | 0.6042 |
Echinococcus granulosus | Netrin receptor DCC | 0.0156 | 0.6042 | 0.6042 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0156 | 0.6042 | 1 |
Onchocerca volvulus | 0.0156 | 0.6042 | 1 | |
Echinococcus granulosus | Phosphotidylinositol phosphatase PTPRQ | 0.0156 | 0.6042 | 0.6042 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0156 | 0.6042 | 1 |
Schistosoma mansoni | titin | 0.0156 | 0.6042 | 0.6042 |
Echinococcus granulosus | titin | 0.0156 | 0.6042 | 0.6042 |
Echinococcus multilocularis | anosmin 1 | 0.0156 | 0.6042 | 0.6042 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0156 | 0.6042 | 1 |
Echinococcus multilocularis | anosmin 1 | 0.0156 | 0.6042 | 0.6042 |
Schistosoma mansoni | titin | 0.0156 | 0.6042 | 0.6042 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0156 | 0.6042 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.6042 | 1 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0156 | 0.6042 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0156 | 0.6042 | 0.6042 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0156 | 0.6042 | 1 |
Schistosoma mansoni | factor for adipocyte differentiation | 0.0156 | 0.6042 | 0.6042 |
Trypanosoma brucei | Fibronectin type III domain containing protein, putative | 0.0156 | 0.6042 | 0.5 |
Brugia malayi | myotactin form A | 0.0156 | 0.6042 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0156 | 0.6042 | 0.6042 |
Schistosoma mansoni | myosin-binding protein-related | 0.0156 | 0.6042 | 0.6042 |
Trypanosoma cruzi | Fibronectin type III domain containing protein, putative | 0.0156 | 0.6042 | 0.5 |
Brugia malayi | Lethal protein 805 | 0.0156 | 0.6042 | 1 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0156 | 0.6042 | 1 |
Echinococcus multilocularis | Netrin receptor DCC | 0.0156 | 0.6042 | 0.6042 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0156 | 0.6042 | 0.5 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0156 | 0.6042 | 1 |
Onchocerca volvulus | 0.0156 | 0.6042 | 1 | |
Schistosoma mansoni | tripartite motif protein trim9 | 0.0156 | 0.6042 | 0.6042 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase zeta | 0.0156 | 0.6042 | 0.6042 |
Onchocerca volvulus | 0.0156 | 0.6042 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.6042 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0156 | 0.6042 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.6042 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0156 | 0.6042 | 0.6042 |
Brugia malayi | hypothetical protein | 0.0156 | 0.6042 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.6042 | 1 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0156 | 0.6042 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0156 | 0.6042 | 1 |
Onchocerca volvulus | 0.0156 | 0.6042 | 1 | |
Brugia malayi | Fibronectin type III domain containing protein | 0.0156 | 0.6042 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0156 | 0.6042 | 0.6042 |
Echinococcus multilocularis | cell adhesion molecule | 0.0156 | 0.6042 | 0.6042 |
Brugia malayi | protein unc-22 | 0.0156 | 0.6042 | 1 |
Brugia malayi | hypothetical protein | 0.0156 | 0.6042 | 1 |
Schistosoma mansoni | hemicentin | 0.0156 | 0.6042 | 0.6042 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0156 | 0.6042 | 0.6042 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.6042 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0156 | 0.6042 | 1 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0156 | 0.6042 | 0.6042 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0156 | 0.6042 | 0.6042 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0156 | 0.6042 | 0.6042 |
Onchocerca volvulus | 0.0156 | 0.6042 | 1 | |
Echinococcus multilocularis | roundabout 2 | 0.0156 | 0.6042 | 0.6042 |
Schistosoma mansoni | cell adhesion molecule | 0.0156 | 0.6042 | 0.6042 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.6042 | 1 |
Loa Loa (eye worm) | CAMK protein kinase | 0.0156 | 0.6042 | 1 |
Echinococcus multilocularis | Fibronectin, type III | 0.0156 | 0.6042 | 0.6042 |
Echinococcus granulosus | cell adhesion molecule | 0.0156 | 0.6042 | 0.6042 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0156 | 0.6042 | 1 |
Echinococcus multilocularis | titin | 0.0156 | 0.6042 | 0.6042 |
Onchocerca volvulus | 0.0156 | 0.6042 | 1 | |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0156 | 0.6042 | 0.6042 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.6042 | 1 |
Echinococcus granulosus | Fibronectin type III | 0.0156 | 0.6042 | 0.6042 |
Schistosoma mansoni | receptor protein tyrosine phosphatase | 0.0156 | 0.6042 | 0.6042 |
Schistosoma mansoni | protein tyrosine phosphatase | 0.0156 | 0.6042 | 0.6042 |
Schistosoma mansoni | cell adhesion molecule | 0.0156 | 0.6042 | 0.6042 |
Echinococcus granulosus | Down syndrome cell adhesion molecule | 0.0156 | 0.6042 | 0.6042 |
Echinococcus multilocularis | titin | 0.0156 | 0.6042 | 0.6042 |
Loa Loa (eye worm) | lethal protein 805 | 0.0156 | 0.6042 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0156 | 0.6042 | 0.6042 |
Echinococcus multilocularis | Phosphotidylinositol phosphatase PTPRQ | 0.0156 | 0.6042 | 0.6042 |
Schistosoma mansoni | neuroglian | 0.0156 | 0.6042 | 0.6042 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.6042 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.6042 | 1 |
Onchocerca volvulus | 0.0156 | 0.6042 | 1 | |
Leishmania major | hypothetical protein, conserved | 0.0156 | 0.6042 | 0.5 |
Echinococcus granulosus | fibronectin type III domain-containing protein | 0.0156 | 0.6042 | 0.6042 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0156 | 0.6042 | 0.6042 |
Echinococcus multilocularis | fibronectin type III domain-containing protein | 0.0156 | 0.6042 | 0.6042 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0156 | 0.6042 | 1 |
Brugia malayi | myotactin form B | 0.0156 | 0.6042 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0156 | 0.6042 | 0.6042 |
Loa Loa (eye worm) | UNCoordinated family member | 0.0156 | 0.6042 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0156 | 0.6042 | 0.6042 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0156 | 0.6042 | 1 |
Brugia malayi | Protein-tyrosine phosphatase | 0.0156 | 0.6042 | 1 |
Echinococcus multilocularis | transfer RNA-Phe | 0.0156 | 0.6042 | 0.6042 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.6042 | 1 |
Schistosoma mansoni | factor for adipocyte differentiation | 0.0156 | 0.6042 | 0.6042 |
Schistosoma mansoni | titin | 0.0156 | 0.6042 | 0.6042 |
Echinococcus granulosus | neuroglian | 0.0156 | 0.6042 | 0.6042 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.6042 | 1 |
Onchocerca volvulus | 0.0156 | 0.6042 | 1 | |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.0156 | 0.6042 | 0.6042 |
Echinococcus multilocularis | Fibronectin type III domain containing protein | 0.0156 | 0.6042 | 0.6042 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.6042 | 1 |
Schistosoma mansoni | factor for adipocyte differentiation | 0.0156 | 0.6042 | 0.6042 |
Echinococcus granulosus | EG95 | 0.0156 | 0.6042 | 0.6042 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0156 | 0.6042 | 0.6042 |
Echinococcus granulosus | anosmin 1 | 0.0156 | 0.6042 | 0.6042 |
Echinococcus granulosus | Phosphotidylinositol phosphatase PTPRQ | 0.0156 | 0.6042 | 0.6042 |
Brugia malayi | Twik (KCNK-like) family of potassium channels, alpha subunit 30. | 0.0156 | 0.6042 | 1 |
Loa Loa (eye worm) | projectin | 0.0156 | 0.6042 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0156 | 0.6042 | 1 |
Onchocerca volvulus | 0.0156 | 0.6042 | 1 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0156 | 0.6042 | 1 |
Schistosoma mansoni | nephrin | 0.0156 | 0.6042 | 0.6042 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.6042 | 1 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0156 | 0.6042 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0156 | 0.6042 | 1 |
Echinococcus multilocularis | Netrin receptor DCC | 0.0156 | 0.6042 | 0.6042 |
Echinococcus granulosus | Netrin receptor DCC | 0.0156 | 0.6042 | 0.6042 |
Echinococcus granulosus | roundabout 2 | 0.0156 | 0.6042 | 0.6042 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.6042 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0156 | 0.6042 | 1 |
Echinococcus granulosus | titin | 0.0156 | 0.6042 | 0.6042 |
Echinococcus multilocularis | neuroglian | 0.0156 | 0.6042 | 0.6042 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.6042 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | 0.0156 | 0.6042 | 0.6042 |
Schistosoma mansoni | ephrin receptor | 0.0202 | 1 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0156 | 0.6042 | 1 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0156 | 0.6042 | 0.6042 |
Schistosoma mansoni | cell adhesion molecule | 0.0156 | 0.6042 | 0.6042 |
Echinococcus granulosus | contactin | 0.0156 | 0.6042 | 0.6042 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 50 uM | Cytotoxic concentration required to inhibit HEL cell growth by 50 % | ChEMBL. | 11212118 |
clogP | = 0.9 | Calculated partition coefficient (clogP) | ChEMBL. | 11212118 |
EC50 (functional) | = 3 uM | Compound was evaluated for the inhibition of VZV strains of OKA | ChEMBL. | 10579812 |
EC50 (functional) | = 3 uM | Effective concentration required for reduction of plaque formation of Varicella-Zoster Virus (OKA strain) | ChEMBL. | 11212118 |
EC50 (functional) | = 4.6 uM | Compound was evaluated for the inhibition of VZV strains of YS | ChEMBL. | 10579812 |
EC50 (functional) | = 4.6 uM | Effective concentration required for reduction of plaque formation of Varicella-Zoster Virus, (YS strain) | ChEMBL. | 11212118 |
EC50 (functional) | > 50 uM | Compound was evaluated for the inhibition of VZV (TK-) thymidine kinase-deficient strain 07 | ChEMBL. | 10579812 |
EC50 (functional) | > 50 uM | Compound was evaluated for the inhibition of VZV (TK-) thymidine kinase-deficient strain YS-R | ChEMBL. | 10579812 |
EC50 (functional) | > 50 uM | Effective concentration required for reduction of plaque formation of thymidine kinase deficient Varicella-Zoster Virus (071 strain) | ChEMBL. | 11212118 |
EC50 (functional) | > 50 uM | Effective concentration required for reduction of plaque formation of thymidine kinase deficient Varicella-Zoster Virus (YSR strain) | ChEMBL. | 11212118 |
IC50 (functional) | > 50 uM | Compound was evaluated for the anti-viral activity against HEL cells | ChEMBL. | 10579812 |
MCC (functional) | > 50 uM | Compound was evaluated for the cytotoxicity against HEL cells | ChEMBL. | 10579812 |
MCC (functional) | > 50 uM | Minimum cytotoxic concentration required to alter microscopically detectable HEL cell morphology | ChEMBL. | 11212118 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.