Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | receptor protein tyrosine phosphatase | 0.0223 | 0.4639 | 0.4639 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0223 | 0.4639 | 0.4639 |
Schistosoma mansoni | cell adhesion molecule | 0.0223 | 0.4639 | 0.4639 |
Schistosoma mansoni | titin | 0.0227 | 0.4912 | 0.4912 |
Schistosoma mansoni | nephrin | 0.0223 | 0.4639 | 0.4639 |
Echinococcus multilocularis | titin | 0.0227 | 0.4912 | 0.4912 |
Onchocerca volvulus | 0.0227 | 0.4912 | 1 | |
Echinococcus multilocularis | roundabout 2 | 0.0223 | 0.4639 | 0.4639 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.0223 | 0.4639 | 0.4639 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.0223 | 0.4639 | 0.4639 |
Schistosoma mansoni | hypothetical protein | 0.0223 | 0.4639 | 0.4639 |
Echinococcus granulosus | neuroglian | 0.0223 | 0.4639 | 0.4639 |
Echinococcus granulosus | roundabout 2 | 0.0223 | 0.4639 | 0.4639 |
Echinococcus granulosus | Fibronectin type III | 0.0223 | 0.4639 | 0.4639 |
Trypanosoma cruzi | Fibronectin type III domain containing protein, putative | 0.0223 | 0.4639 | 0.5 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0223 | 0.4639 | 0.4639 |
Schistosoma mansoni | nephrin | 0.0223 | 0.4639 | 0.4639 |
Echinococcus granulosus | Down syndrome cell adhesion molecule | 0.0223 | 0.4639 | 0.4639 |
Echinococcus granulosus | anosmin 1 | 0.0223 | 0.4639 | 0.4639 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0223 | 0.4639 | 0.4639 |
Echinococcus multilocularis | Down syndrome cell adhesion molecule | 0.0223 | 0.4639 | 0.4639 |
Echinococcus multilocularis | Fibronectin type III domain containing protein | 0.0223 | 0.4639 | 0.4639 |
Schistosoma mansoni | factor for adipocyte differentiation | 0.0223 | 0.4639 | 0.4639 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0227 | 0.4912 | 0.4912 |
Echinococcus granulosus | Netrin receptor DCC | 0.0223 | 0.4639 | 0.4639 |
Brugia malayi | protein unc-22 | 0.0227 | 0.4912 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0223 | 0.4639 | 0.4639 |
Echinococcus multilocularis | Netrin receptor DCC | 0.0223 | 0.4639 | 0.4639 |
Schistosoma mansoni | ephrin receptor | 0.0289 | 1 | 1 |
Echinococcus multilocularis | cell adhesion molecule | 0.0223 | 0.4639 | 0.4639 |
Echinococcus multilocularis | roundabout 2 | 0.0223 | 0.4639 | 0.4639 |
Trypanosoma brucei | Fibronectin type III domain containing protein, putative | 0.0223 | 0.4639 | 0.5 |
Schistosoma mansoni | protein tyrosine phosphatase | 0.0223 | 0.4639 | 0.4639 |
Echinococcus granulosus | titin | 0.0227 | 0.4912 | 0.4912 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0223 | 0.4639 | 0.4639 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0223 | 0.4639 | 0.4639 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | 0.0223 | 0.4639 | 0.4639 |
Echinococcus granulosus | roundabout 2 | 0.0223 | 0.4639 | 0.4639 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0227 | 0.4912 | 1 |
Echinococcus granulosus | fibronectin type III domain-containing protein | 0.0223 | 0.4639 | 0.4639 |
Echinococcus granulosus | nephrin | 0.0223 | 0.4639 | 0.4639 |
Echinococcus multilocularis | anosmin 1 | 0.0223 | 0.4639 | 0.4639 |
Echinococcus granulosus | cell adhesion molecule | 0.0223 | 0.4639 | 0.4639 |
Echinococcus multilocularis | neuroglian | 0.0223 | 0.4639 | 0.4639 |
Schistosoma mansoni | tripartite motif protein trim9 | 0.0223 | 0.4639 | 0.4639 |
Echinococcus granulosus | G1Y162 protein | 0.0223 | 0.4639 | 0.4639 |
Echinococcus granulosus | roundabout 2 | 0.0223 | 0.4639 | 0.4639 |
Schistosoma mansoni | cell adhesion molecule | 0.0223 | 0.4639 | 0.4639 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase zeta | 0.0223 | 0.4639 | 0.4639 |
Echinococcus multilocularis | usherin | 0.0223 | 0.4639 | 0.4639 |
Echinococcus granulosus | Phosphotidylinositol phosphatase PTPRQ | 0.0223 | 0.4639 | 0.4639 |
Echinococcus granulosus | Fibronectin type III domain containing protein | 0.0223 | 0.4639 | 0.4639 |
Schistosoma mansoni | hemicentin | 0.0223 | 0.4639 | 0.4639 |
Echinococcus multilocularis | Netrin receptor DCC | 0.0223 | 0.4639 | 0.4639 |
Echinococcus granulosus | titin | 0.0227 | 0.4912 | 0.4912 |
Schistosoma mansoni | cell adhesion molecule | 0.0223 | 0.4639 | 0.4639 |
Echinococcus multilocularis | titin | 0.0223 | 0.4639 | 0.4639 |
Schistosoma mansoni | cell adhesion molecule | 0.0223 | 0.4639 | 0.4639 |
Schistosoma mansoni | factor for adipocyte differentiation | 0.0223 | 0.4639 | 0.4639 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0223 | 0.4639 | 0.4639 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0223 | 0.4639 | 0.5 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0223 | 0.4639 | 0.4639 |
Echinococcus multilocularis | roundabout 2 | 0.0223 | 0.4639 | 0.4639 |
Echinococcus granulosus | Netrin receptor DCC | 0.0223 | 0.4639 | 0.4639 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0223 | 0.4639 | 0.4639 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0223 | 0.4639 | 0.4639 |
Schistosoma mansoni | titin | 0.0223 | 0.4639 | 0.4639 |
Echinococcus granulosus | Phosphotidylinositol phosphatase PTPRQ | 0.0223 | 0.4639 | 0.4639 |
Echinococcus multilocularis | anosmin 1 | 0.0223 | 0.4639 | 0.4639 |
Schistosoma mansoni | myosin-binding protein-related | 0.0223 | 0.4639 | 0.4639 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0223 | 0.4639 | 0.4639 |
Schistosoma mansoni | hypothetical protein | 0.0223 | 0.4639 | 0.4639 |
Trypanosoma cruzi | Fibronectin type III domain containing protein, putative | 0.0223 | 0.4639 | 0.5 |
Echinococcus multilocularis | Phosphotidylinositol phosphatase PTPRQ | 0.0223 | 0.4639 | 0.4639 |
Leishmania major | hypothetical protein, conserved | 0.0223 | 0.4639 | 0.5 |
Echinococcus granulosus | anosmin 1 | 0.0223 | 0.4639 | 0.4639 |
Echinococcus granulosus | usherin | 0.0223 | 0.4639 | 0.4639 |
Schistosoma mansoni | factor for adipocyte differentiation | 0.0223 | 0.4639 | 0.4639 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0289 | 1 | 1 |
Schistosoma mansoni | neuroglian | 0.0223 | 0.4639 | 0.4639 |
Loa Loa (eye worm) | CAMK protein kinase | 0.0227 | 0.4912 | 1 |
Echinococcus multilocularis | anosmin 1 | 0.0223 | 0.4639 | 0.4639 |
Schistosoma mansoni | titin | 0.0223 | 0.4639 | 0.4639 |
Echinococcus granulosus | EG95 | 0.0223 | 0.4639 | 0.4639 |
Echinococcus granulosus | anosmin 1 | 0.0223 | 0.4639 | 0.4639 |
Schistosoma mansoni | hypothetical protein | 0.0223 | 0.4639 | 0.4639 |
Echinococcus granulosus | contactin | 0.0223 | 0.4639 | 0.4639 |
Echinococcus multilocularis | Fibronectin, type III | 0.0223 | 0.4639 | 0.4639 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0227 | 0.4912 | 1 |
Echinococcus multilocularis | transfer RNA-Phe | 0.0223 | 0.4639 | 0.4639 |
Schistosoma mansoni | cell adhesion molecule | 0.0223 | 0.4639 | 0.4639 |
Echinococcus multilocularis | fibronectin type III domain-containing protein | 0.0223 | 0.4639 | 0.4639 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0227 | 0.4912 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 94 % | Binding affinity to human serum albumin | ChEMBL. | 24568313 |
IC50 (ADMET) | > 33 uM | Inhibition of CYP3A4 (unknown origin) | ChEMBL. | 24568313 |
IC50 (ADMET) | > 33 uM | Inhibition of CYP2C19 (unknown origin) | ChEMBL. | 24568313 |
IC50 (ADMET) | > 33 uM | Inhibition of CYP2D6 (unknown origin) | ChEMBL. | 24568313 |
IC50 (ADMET) | > 33 uM | Inhibition of CYP2C9 (unknown origin) | ChEMBL. | 24568313 |
IC50 (ADMET) | > 33 uM | Inhibition of CYP1A2 (unknown origin) | ChEMBL. | 24568313 |
T1/2 (ADMET) | >= 360 min | Half life in human hepatocytes | ChEMBL. | 24568313 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.